Ohshima Kenji 大島健司

… Alternative Names

大島健司オオシマケンジ

Less

Researcher Number	40817152
Other IDs	https://orcid.org/0000-0003-1114-386X
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 兵庫医科大学, 医学部, 教授 2023: 兵庫医科大学, 医学部, 教授 2019 – 2021: 大阪大学, 医学系研究科, 助教 2018: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / 0901:Oncology and related fields
Keywords	Principal Investigator 大腸がん / 腫瘍代謝 / シグナル伝達経路 / 転移 / ヒストンアセチル化 / ミトコンドリア / がん代謝 / 化学療法抵抗性 / がん浸潤 / D-glutamate cyclase … More / 代謝 / 浸潤 / C14orf159 / 癌代謝 / アミノ酸 / アポトーシス / 活性酸素 / セリンラセマーゼ / ピルビン酸 Less

Development of therapeutic strategies targeting metabolic plasticity of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  大島健司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Hyogo Medical University
Deciphering the metabolic determinants of colorectal cancer metastasisPrincipal Investigator
- Principal Investigator
  
  大島健司
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Hyogo Medical University
Function of D-glutamate cyclase in colorectal cancer metabolismPrincipal Investigator
- Principal Investigator
  
  Ohshima Kenji
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Osaka University
Regulation of cancer metabolism by D-amino acids or the enzymes which metabolize D-amino acidsPrincipal Investigator
- Principal Investigator
  
  Ohshima Kenji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Osaka University

All 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 実験医学2020
- Author(s)
  大島健司、森井英一
- Total Pages
  4
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18K15122
[Journal Article] Mitochondria govern histone acetylation in colorectal cancer2021
- Author(s)
  Ohshima Kenji、Oi Ryo、Nojima Satoshi、Morii Eiichi
- Journal Title
  
  The Journal of Pathology
  
  Volume: 256 Issue: 2 Pages: 164-173
- DOI
  10.1002/path.5818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16220, KAKENHI-PROJECT-19H03452
[Journal Article] がん細胞特異的代謝を標的とした治療戦略2021
- Author(s)
  大島健司、森井英一
- Journal Title
  
  Precision Medicine
  
  Volume: 4 Pages: 1202-1205
- Data Source
  KAKENHI-PROJECT-20K16220
[Journal Article] Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling2021
- Author(s)
  Ohshima Kenji、Oi Ryo、Okuzaki Daisuke、Motooka Daisuke、Shinohara Masakazu、Nojima Satoshi、Morii Eiichi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 125 Issue: 12 Pages: 1699-1711
- DOI
  10.1038/s41416-021-01582-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16220, KAKENHI-PROJECT-19H03452
[Journal Article] Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.2021
- Author(s)
  Ohshima K, Morii E.
- Journal Title
  
  Metabolites.
  
  Volume: 11 Issue: 1 Pages: 28-28
- DOI
  10.3390/metabo11010028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-20K16220
[Journal Article] Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine2020
- Author(s)
  Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-ichiro Ikeda, Eiichiro Fukusaki & Eiichi Morii
- Journal Title
  
  Nature Metabolism volume
  
  Volume: 2 Issue: 1 Pages: 81-96
- DOI
  10.1038/s42255-019-0156-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-18K15122, KAKENHI-PROJECT-19K16557, KAKENHI-PROJECT-19K16585
[Presentation] Serine racemase promotes colorectal cancer growth and is a new therapeutic target for colorectal cancer2021
- Author(s)
  大島健司
- Organizer
  Manchester Pathology 2021 (英国病理学会)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16220
[Presentation] 大腸がんの増殖と転移を司る新たな代謝酵素群2021
- Author(s)
  大島健司
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16220
[Presentation] ミトコンドリア局在タンパク質C14orf159の大腸がん細胞の浸潤・転移における機能2021
- Author(s)
  大島健司
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K16220
[Presentation] c14orf159 loss facilitates colorectal cancer cell invasion through upregulates Wnt signaling2020
- Author(s)
  大島健司
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16220
[Presentation] Serine racemase enhances colon cancer cell proliferation by maintaining mitochondrial mass2019
- Author(s)
  大島健司
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15122
[Presentation] Serine racemaseは細胞内ピルビン酸量を維持し大腸癌の増殖を促進する2019
- Author(s)
  大島健司
- Organizer
  第7回がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-18K15122
[Presentation] Serine racemaseはセリンからピルビン酸を産生し大腸癌の増殖を促進する2019
- Author(s)
  大島健司
- Organizer
  第2回医学系研究科・産業科学研究所懇話会
- Data Source
  KAKENHI-PROJECT-18K15122
[Presentation] Serine racemase is a potential new therapeutic target for colon cancer2018
- Author(s)
  大島健司
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15122
[Presentation] Serine racemase is a new therapeutic target for colon cancer2018
- Author(s)
  大島健司
- Organizer
  American Association for Cancer Research Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15122
[Presentation] D-セリン合成酵素 Serine racemase は大腸癌細胞の増殖を促進する2018
- Author(s)
  大島健司
- Organizer
  第15回日本病理学会カンファレンス
- Data Source
  KAKENHI-PROJECT-18K15122

1. 森井英一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ohshima Kenji 大島 健司

大島 健司 オオシマ ケンジ

Research Projects

Research Products

Co-Researchers

Development of therapeutic strategies targeting metabolic plasticity of colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering the metabolic determinants of colorectal cancer metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of D-glutamate cyclase in colorectal cancer metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of cancer metabolism by D-amino acids or the enzymes which metabolize D-amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 実験医学2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Mitochondria govern histone acetylation in colorectal cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] がん細胞特異的代謝を標的とした治療戦略2021

Author(s)

Journal Title

Data Source

[Journal Article] Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Serine racemase promotes colorectal cancer growth and is a new therapeutic target for colorectal cancer2021

Author(s)

Organizer

Data Source

[Presentation] 大腸がんの増殖と転移を司る新たな代謝酵素群2021

Author(s)

Organizer

Data Source

[Presentation] ミトコンドリア局在タンパク質C14orf159の大腸がん細胞の浸潤・転移における機能2021

Author(s)

Organizer

Data Source

[Presentation] c14orf159 loss facilitates colorectal cancer cell invasion through upregulates Wnt signaling2020

Author(s)

Organizer

Data Source

[Presentation] Serine racemase enhances colon cancer cell proliferation by maintaining mitochondrial mass2019

Author(s)

Organizer

Data Source

[Presentation] Serine racemaseは細胞内ピルビン酸量を維持し大腸癌の増殖を促進する2019

Author(s)

Ohshima Kenji 大島健司

大島健司オオシマケンジ