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Ohshima Kenji  大島 健司

… Alternative Names

大島 健司  オオシマ ケンジ

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Researcher Number 40817152
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-1114-386X
Affiliation (Current) 2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2025: 兵庫医科大学, 医学部, 教授
2023: 兵庫医科大学, 医学部, 教授
2019 – 2021: 大阪大学, 医学系研究科, 助教
2018: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 49030:Experimental pathology-related / 0901:Oncology and related fields
Keywords
Principal Investigator
大腸がん / 転移 / 腫瘍代謝 / ヒストンアセチル化 / ミトコンドリア / がん代謝 / シグナル伝達経路 / 化学療法抵抗性 / がん浸潤 / D-glutamate cyclase … More / 代謝 / 浸潤 / C14orf159 / 癌代謝 / アミノ酸 / アポトーシス / 活性酸素 / セリンラセマーゼ / ピルビン酸 Less
  • Research Projects

    (4 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (1 People)
  •  大腸がんの代謝可塑性を克服する新規がん治療法の開発Principal Investigator

    • Principal Investigator
      大島 健司
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Hyogo Medical University
  •  Deciphering the metabolic determinants of colorectal cancer metastasisPrincipal Investigator

    • Principal Investigator
      大島 健司
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0901:Oncology and related fields
    • Research Institution
      Hyogo Medical University
  •  Function of D-glutamate cyclase in colorectal cancer metabolismPrincipal Investigator

    • Principal Investigator
      Ohshima Kenji
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Osaka University
  •  Regulation of cancer metabolism by D-amino acids or the enzymes which metabolize D-amino acidsPrincipal Investigator

    • Principal Investigator
      Ohshima Kenji
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Osaka University

All 2021 2020 2019 2018

All Journal Article Presentation Book

  • [Book] 実験医学2020

    • Author(s)
      大島健司、森井英一
    • Total Pages
      4
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Journal Article] Mitochondria govern histone acetylation in colorectal cancer2021

    • Author(s)
      Ohshima Kenji、Oi Ryo、Nojima Satoshi、Morii Eiichi
    • Journal Title

      The Journal of Pathology

      Volume: 256 Issue: 2 Pages: 164-173

    • DOI

      10.1002/path.5818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16220, KAKENHI-PROJECT-19H03452
  • [Journal Article] がん細胞特異的代謝を標的とした治療戦略2021

    • Author(s)
      大島健司、森井英一
    • Journal Title

      Precision Medicine

      Volume: 4 Pages: 1202-1205

    • Data Source
      KAKENHI-PROJECT-20K16220
  • [Journal Article] Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling2021

    • Author(s)
      Ohshima Kenji、Oi Ryo、Okuzaki Daisuke、Motooka Daisuke、Shinohara Masakazu、Nojima Satoshi、Morii Eiichi
    • Journal Title

      British Journal of Cancer

      Volume: 125 Issue: 12 Pages: 1699-1711

    • DOI

      10.1038/s41416-021-01582-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16220, KAKENHI-PROJECT-19H03452
  • [Journal Article] Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.2021

    • Author(s)
      Ohshima K, Morii E.
    • Journal Title

      Metabolites.

      Volume: 11 Issue: 1 Pages: 28-28

    • DOI

      10.3390/metabo11010028

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-20K16220
  • [Journal Article] Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine2020

    • Author(s)
      Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara, Masako Kurashige, Keisuke Kawasaki, Yumiko Hori, Moyu Taniguchi, Yutaka Umakoshi, Daisuke Okuzaki, Naoki Wada, Jun-ichiro Ikeda, Eiichiro Fukusaki & Eiichi Morii
    • Journal Title

      Nature Metabolism volume

      Volume: 2 Issue: 1 Pages: 81-96

    • DOI

      10.1038/s42255-019-0156-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19555, KAKENHI-PROJECT-18K15122, KAKENHI-PROJECT-19K16557, KAKENHI-PROJECT-19K16585
  • [Presentation] Serine racemase promotes colorectal cancer growth and is a new therapeutic target for colorectal cancer2021

    • Author(s)
      大島健司
    • Organizer
      Manchester Pathology 2021 (英国病理学会)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16220
  • [Presentation] 大腸がんの増殖と転移を司る新たな代謝酵素群2021

    • Author(s)
      大島健司
    • Organizer
      第80回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K16220
  • [Presentation] ミトコンドリア局在タンパク質C14orf159の大腸がん細胞の浸潤・転移における機能2021

    • Author(s)
      大島健司
    • Organizer
      第110回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-20K16220
  • [Presentation] c14orf159 loss facilitates colorectal cancer cell invasion through upregulates Wnt signaling2020

    • Author(s)
      大島健司
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K16220
  • [Presentation] Serine racemase enhances colon cancer cell proliferation by maintaining mitochondrial mass2019

    • Author(s)
      大島健司
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Presentation] Serine racemaseは細胞内ピルビン酸量を維持し大腸癌の増殖を促進する2019

    • Author(s)
      大島健司
    • Organizer
      第7回がんと代謝研究会
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Presentation] Serine racemaseはセリンからピルビン酸を産生し大腸癌の増殖を促進する2019

    • Author(s)
      大島健司
    • Organizer
      第2回 医学系研究科 ・ 産業科学研究所 懇話会
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Presentation] Serine racemase is a potential new therapeutic target for colon cancer2018

    • Author(s)
      大島健司
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Presentation] Serine racemase is a new therapeutic target for colon cancer2018

    • Author(s)
      大島健司
    • Organizer
      American Association for Cancer Research Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15122
  • [Presentation] D-セリン合成酵素 Serine racemase は大腸癌細胞の増殖を促進する2018

    • Author(s)
      大島健司
    • Organizer
      第15回日本病理学会カンファレンス
    • Data Source
      KAKENHI-PROJECT-18K15122
  • 1.  森井 英一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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