ZWAMA MARTIJN ＺＷＡＭＡＭＡＲＴＩＪＮ

… Alternative Names

Zwama Martijn ZWAMA MARTIJN

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Researcher Number	40827052
Other IDs	https://orcid.org/0000-0001-9081-382X
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 特任准教授(常勤)
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 産業科学研究所, 特任准教授(常勤) 2023: 大阪大学, 産業科学研究所, 特任准教授(常勤) 2018 – 2022: 大阪大学, 産業科学研究所, 特任助教(常勤)
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / 0801:Pharmaceutical sciences and related fields
Keywords	Principal Investigator RND / Pathogens / MDR / Transporter / Multidrug resistance / Multidrug Resistance / Transporters / Bacteria / Evolution / AcrB … More / Inhibitor / Efflux Pump / Efflux pumps / Antibiotics / Adaptation / Phylogenetics / Resistance / Antibiotic / Regulation / Efflux pump inhibitor / Haemophilus influenzae / Phylogenesis / Efflux pump Less

Investigating Universal Binding Mechanisms of Drug Efflux Pumps to Develop Broad-Spectrum Inhibitors and Overcome Multidrug-Resistant Bacterial InfectionsPrincipal Investigator
- Principal Investigator
  
  ZWAMA MARTIJN
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  The University of Osaka
Study of clinically over-expressed and chimeric RND multidrug efflux pumps from Acinetobacter baumannii and Pseudomonas aeruginosaPrincipal Investigator
- Principal Investigator
  
  ZWAMA MARTIJN
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka University
Characterization of unstudied RND-type multidrug efflux pumps from pathogenic microorganismsPrincipal Investigator
- Principal Investigator
  
  Zwama Martijn
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Osaka University
Mechanism, evolution and regulation of multidrug resistancePrincipal Investigator
- Principal Investigator
  
  Zwama Martijn
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Development of a bacterial release compound assay for prevention and early detection of bacteria-derived diseases2024
- Author(s)
  S. Yamasaki, N. Koga, T. Hosomi, M. Zwama, C. Jirayupa, T. Yanagida, K. Nishino
- Journal Title
  
  Medical Science Digest
  
  Volume: 50 Pages: 41-43
- Data Source
  KAKENHI-PROJECT-23K14346
[Journal Article] Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa2023
- Author(s)
  Yamasaki Seiji、Zwama Martijn、Yoneda Tomohiro、Hayashi-Nishino Mitsuko、Nishino Kunihiko
- Journal Title
  
  Microbiology
  
  Volume: 169 Issue: 6 Pages: 001322-001322
- DOI
  10.1099/mic.0.001322
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14346, KAKENHI-PROJECT-21K16318, KAKENHI-PROJECT-23K21717, KAKENHI-PROJECT-23K27322
[Journal Article] Comprehensive analysis of the binding site for efflux transporter inhibitors in Pseudomonas aeruginosa2023
- Author(s)
  Seiji Yamasaki, Martijn Zwama, Naoki Koga, Keisuke Sakurai, Ryosuke Nakashima, Akihito Yamaguchi, Kunihiko Nishino
- Journal Title
  
  Bio Clinica
  
  Volume: 38 Pages: 74-78
- Data Source
  KAKENHI-PROJECT-23K14346
[Journal Article] Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles2022
- Author(s)
  Zwama Martijn、Nishino Kunihiko
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 66 Issue: 4
- DOI
  10.1128/aac.02392-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19831, KAKENHI-PROJECT-20K16242
[Journal Article] Inhibitor binding pits analysis of bacterial multidrug efflux transporters for new drug development2022
- Author(s)
  Yamasaki Seiji、Zwama Martijn、Koga Naoki、Sakurai Keisuke、Nakashima Ryosuke、Yamaguchi Akihito、Nishino Kunihiko
- Journal Title
  
  Precision Medicine
  
  Volume: 59 Pages: 56-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16242
[Journal Article] Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding2022
- Author(s)
  Yamasaki Seiji、Koga Naoki、Zwama Martijn、Sakurai Keisuke、Nakashima Ryosuke、Yamaguchi Akihito、Nishino Kunihiko
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 66 Issue: 11
- DOI
  10.1128/aac.00672-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19831, KAKENHI-PROJECT-21K16318, KAKENHI-PROJECT-20K16242
[Journal Article] Function and Inhibitory Mechanisms of Multidrug Efflux Pumps2021
- Author(s)
  Nishino Kunihiko、Yamasaki Seiji、Nakashima Ryosuke、Zwama Martijn、Hayashi-Nishino Mitsuko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 737288-737288
- DOI
  10.3389/fmicb.2021.737288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14902, KAKENHI-PROJECT-20K16242, KAKENHI-PROJECT-21K16318, KAKENHI-PROJECT-23K21717
[Journal Article] Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time2021
- Author(s)
  Zwama Martijn、Nishino Kunihiko
- Journal Title
  
  Antibiotics
  
  Volume: 10 Issue: 7 Pages: 774-774
- DOI
  10.3390/antibiotics10070774
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16242
[Journal Article] Proximal binding pocket Arg717 substitutions in Escherichia coli AcrB cause clinically relevant divergencies in resistance profiles2021
- Author(s)
  Zwama Martijn、Nishino Kunihiko
- Journal Title
  
  bioRxiv
  
  Volume: 12.16 Pages: 473095-473095
- DOI
  10.1101/2021.12.16.473095
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16242
[Journal Article] Identification of Genetic Variants via Bacterial Respiration Gas Analysis2020
- Author(s)
  Koga Naoki、Hosomi Takuro、Zwama Martijn、Jirayupat Chaiyanut、Yanagida Takeshi、Nishino Kunihiko、Yamasaki Seiji
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 581571-581571
- DOI
  10.3389/fmicb.2020.581571
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19451, KAKENHI-PROJECT-18K14902, KAKENHI-PROJECT-20K16242
[Journal Article] Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB2019
- Author(s)
  Zwama Martijn、Yamaguchi Akihito、Nishino Kunihiko
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 340-340
- DOI
  10.1038/s42003-019-0564-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19451, KAKENHI-PROJECT-19K21223
[Journal Article] Molecular mechanisms of AcrB-mediated multidrug export2018
- Author(s)
  Zwama Martijn、Yamaguchi Akihito
- Journal Title
  
  Research in Microbiology
  
  Volume: 169 Issue: 7-8 Pages: 372-383
- DOI
  10.1016/j.resmic.2018.05.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21223
[Presentation] Phylogenetic analysis and environmental adaption of multidrug efflux pumps2020
- Author(s)
  Martijn Zwama
- Organizer
  The 93rd annual meeting of Japanese Society for Bacteriology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21223
[Presentation] The evolution of RND transporters2019
- Author(s)
  Zwama Martijn
- Organizer
  Hong Kong University
- Data Source
  KAKENHI-PROJECT-19K21223
[Presentation] The evolution of RND transporters2019
- Author(s)
  Martijn Zwama
- Organizer
  Hong Kong University
- Data Source
  KAKENHI-PROJECT-19K21223

1. NISHINO Mitsuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 西野邦彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 山崎聖司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 青木工太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ZWAMA MARTIJN ＺＷＡＭＡ ＭＡＲＴＩＪＮ

Zwama Martijn ZWAMA MARTIJN

Research Projects

Research Products

Co-Researchers

Investigating Universal Binding Mechanisms of Drug Efflux Pumps to Develop Broad-Spectrum Inhibitors and Overcome Multidrug-Resistant Bacterial InfectionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of clinically over-expressed and chimeric RND multidrug efflux pumps from Acinetobacter baumannii and Pseudomonas aeruginosaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of unstudied RND-type multidrug efflux pumps from pathogenic microorganismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism, evolution and regulation of multidrug resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Development of a bacterial release compound assay for prevention and early detection of bacteria-derived diseases2024

Author(s)

Journal Title

Data Source

[Journal Article] Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosa2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of the binding site for efflux transporter inhibitors in Pseudomonas aeruginosa2023

Author(s)

Journal Title

Data Source

[Journal Article] Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitor binding pits analysis of bacterial multidrug efflux transporters for new drug development2022

Author(s)

Journal Title

Data Source

[Journal Article] Spatial Characteristics of the Efflux Pump MexB Determine Inhibitor Binding2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Function and Inhibitory Mechanisms of Multidrug Efflux Pumps2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proximal binding pocket Arg717 substitutions in Escherichia coli AcrB cause clinically relevant divergencies in resistance profiles2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Genetic Variants via Bacterial Respiration Gas Analysis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB2019

Author(s)

Journal Title

DOI

ZWAMA MARTIJN ＺＷＡＭＡＭＡＲＴＩＪＮ