Odaka Haruki 小高陽樹

Researcher Number	40831243
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 2019: 熊本大学, 発生医学研究所, 特定事業研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 46010:Neuroscience-general-related
Keywords	Principal Investigator 1細胞解析 / 糖鎖 / 中枢神経系 / 老化細胞 / 発達障害 / 神経発達障害 / グルココルチコイド / 脳オルガノイド / ミクログリア / iPS細胞 … More Except Principal Investigator … More iPS細胞 / グルコシルスフィンゴシン / ライソソーム / ゴーシェ病 / ミトコンドリア機能 / オートファジー / 酸化ストレス / ポストシナプス機能 / プレシナプス機能 / 神経型ゴーシェ病 / 神経細胞 / 中枢神経系の異常 / 中枢神経系 / 相互作用 / ニューロン / ミクログリア / ライソゾーム病 Less

脳内老化細胞の1細胞糖鎖解析による新規細胞表面マーカーの探索と糖鎖機能の解明Principal Investigator
- Principal Investigator
  
  小高陽樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Role of the interaction between microglia and neuron in the defected neuronal function in the lysosomal storage disease
- Principal Investigator
  
  NUMAKAWA Tadahiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Kumamoto University
Development of novel pathological analysis and medicine in neuropathic Gaucher disease.
- Principal Investigator
  
  城戸淳
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kumamoto University
Evaluation of in vitro prenatal stress hormone exposure model using microglia-containing cerebral spheroids.Principal Investigator
- Principal Investigator
  
  Odaka Haruki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
  Kumamoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book Patent

[Book] "Roles of Trk receptors, tyrosine kinase receptors for neurotrophins, in the developing CNS" , CHAPTER 3 in book "Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders"2023
- Author(s)
  Tadahiro Numakawa and Haruki Odaka
- Total Pages
  350
- Publisher
  Academic Press
- ISBN
  9780443186776
- Data Source
  KAKENHI-PROJECT-20K06857
[Book] Factors Affecting Neurodevelopment2021
- Author(s)
  Numakawa, T*　and Odaka, H.
- Total Pages
  750
- Publisher
  ELSEVIER
- ISBN
  9780128179864
- Data Source
  KAKENHI-PROJECT-20K06857
[Journal Article] Single‐Cell Glycan and RNA Sequencing (scGR‐seq)2023
- Author(s)
  Odaka Haruki、Tateno Hiroaki
- Journal Title
  
  Current Protocols
  
  Volume: 3 Issue: 5
- DOI
  10.1002/cpz1.777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-22K15660
[Journal Article] Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate–Protein Interactions2022
- Author(s)
  Odaka Haruki
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 34 Issue: 199 Pages: E63-E63
- DOI
  10.4052/tigg.2203.6E
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2022-05-27
- Language
  English
- Data Source
  KAKENHI-PROJECT-22K15660, KAKENHI-PROJECT-19K16263
[Journal Article] scGR-seq: Integrated analysis of glycan and RNA in single cells2022
- Author(s)
  Odaka Haruki、Ozaki Haruka、Tateno Hiroaki
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Issue: 1 Pages: 101179-101179
- DOI
  10.1016/j.xpro.2022.101179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16263
[Journal Article] The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases2022
- Author(s)
  Numakawa Tadahiro、Odaka Haruki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 14 Pages: 7726-7726
- DOI
  10.3390/ijms23147726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15660, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263
[Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022
- Author(s)
  Umemoto Terumasa、Johansson Alban、Ahmad Shah Adil Ishtiyaq、Hashimoto Michihiro、Kubota Sho、Kikuchi Kenta、Odaka Haruki、Era Takumi、Kurotaki Daisuke、Sashida Goro、Suda Toshio
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 8 Pages: 1-20
- DOI
  10.15252/embj.2021109463
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-21K08421, KAKENHI-PROJECT-22K15660, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-21K16272
[Journal Article] CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma2022
- Author(s)
  Odaka Haruki、Hiemori Keiko、Shimoda Asako、Akiyoshi Kazunari、Tateno Hiroaki
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 22 Issue: 1 Pages: 153-153
- DOI
  10.1186/s12876-022-02228-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12645, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-22H00585
[Journal Article] An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca2+ dynamics.2021
- Author(s)
  Odaka H, Numakawa T, Soga M, Kido J, Matsumoto S, Kajihara R, Okumiya T, Tani N, Tanoue Y, Fukuda T, Furuya H, Inoue T, Era T.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 152 Pages: 105279-105279
- DOI
  10.1016/j.nbd.2021.105279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08207, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263
[Journal Article] Platelet‐derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4‐based assays2021
- Author(s)
  Odaka Haruki、Hiemori Keiko、Shimoda Asako、Akiyoshi Kazunari、Tateno Hiroaki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 3 Pages: 741-752
- DOI
  10.1002/2211-5463.13068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16263
[Journal Article] Integrated analysis of glycan and RNA in single cells2021
- Author(s)
  Minoshima Fumi、Ozaki Haruka、Odaka Haruki、Tateno Hiroaki
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 8 Pages: 102882-102882
- DOI
  10.1016/j.isci.2021.102882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-19K20394
[Journal Article] Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection.2021
- Author(s)
  1)Numakawa T, Odaka H.
- Journal Title
  
  International journal of molecular science
  
  Volume: 22 Issue: 11 Pages: 5719-5719
- DOI
  10.3390/ijms22115719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263
[Journal Article] Novel Drug Candidates Improve Ganglioside Accumulation and Neural Dysfunction in GM1 Gangliosidosis Models with Autophagy Activation2020
- Author(s)
  Ryutaro Kajihara, Tadahiro Numakawa, Haruki Odaka, Yuji Yaginuma, Noemi Fusaki, Toshika Okumiya, Hirokazu Furuya, Seiji Inui, and Takumi Era
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 5 Pages: 1-15
- DOI
  10.1016/j.stemcr.2020.03.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15369, KAKENHI-PROJECT-20K06857, KAKENHI-PROJECT-19K16263, KAKENHI-PROJECT-18K06264
[Journal Article] Presynaptic Dysfunction in Neurons Derived from Tay-Sachs iPSCs.2019
- Author(s)
  Kozo Matsushita, Tadahiro Numakawa, Haruki Odaka, Ryutaro Kajihara, Minami Soga, Shiro Ozasa, Kimitoshi Nakamura, Hiroshi Mizuta, Takumi Era
- Journal Title
  
  Neuroscience
  
  Volume: 414 Pages: 128-140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16263
[Patent] ミクログリア含有大脳オルガノイドの作製方法2024
- Inventor(s)
  小高陽樹、舘野浩章
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-19K16263
[Patent] ミクログリア含有大脳オルガノイドの作製方法2023
- Inventor(s)
  小高陽樹、舘野浩章
- Industrial Property Rights Holder
  国立研究開発法人産業技術総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-19K16263
[Presentation] １細胞糖鎖/RNAシーケンシング法によるiPS細胞由来神経細胞に混入する未分化細胞の糖鎖マーカー開発2024
- Author(s)
  小高　陽樹, 舘野　浩章
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K15660
[Presentation] ミクログリア含有ヒト大脳オルガノイドによる胎生期ストレスホルモン曝露モデルの解析2023
- Author(s)
  小高陽樹
- Organizer
  第 22 回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K16263
[Presentation] 1細胞糖鎖-RNAシーケンシング法によるiPS細胞由来神経細胞の解析2023
- Author(s)
  小高　陽樹, 舘野　浩章
- Organizer
  第１7回東北糖鎖研究会
- Data Source
  KAKENHI-PROJECT-22K15660
[Presentation] ミクログリア含有ヒト大脳オルガノイドによる胎生期ストレスホルモン曝露モデルの解析2023
- Author(s)
  小高陽樹
- Organizer
  第 22 回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K15660
[Presentation] １細胞糖鎖-RNA同時プロファイリング技術（scGR-seq）の開発（Simultaneous profiling of glycan and RNA in single cells）2021
- Author(s)
  小高陽樹
- Organizer
  第44回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16263
[Presentation] 個々の細胞の糖鎖とRNAを同時解析する技術(scGR-seq)の開発2021
- Author(s)
  小高陽樹
- Organizer
  第40回日本糖質学会年会（鹿児島）
- Data Source
  KAKENHI-PROJECT-19K16263

1. NUMAKAWA Tadahiro (40425690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 城戸淳 (70721215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 梶原隆太郎 (00738221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 松本志郎 (70467992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 曽我美南 (80768002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 梅本晃正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 下田麻子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Odaka Haruki 小高 陽樹

Research Projects

Research Products

Co-Researchers

脳内老化細胞の1細胞糖鎖解析による新規細胞表面マーカーの探索と糖鎖機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the interaction between microglia and neuron in the defected neuronal function in the lysosomal storage disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel pathological analysis and medicine in neuropathic Gaucher disease.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of in vitro prenatal stress hormone exposure model using microglia-containing cerebral spheroids.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] "Roles of Trk receptors, tyrosine kinase receptors for neurotrophins, in the developing CNS" , CHAPTER 3 in book "Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders"2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Factors Affecting Neurodevelopment2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Single‐Cell Glycan and RNA Sequencing (scGR‐seq)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide CRISPR/Cas9 Screening Identifies KDM2B as a Modifier of Heparan Sulfate–Protein Interactions2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] scGR-seq: Integrated analysis of glycan and RNA in single cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An iPSC-based neural model of sialidosis uncovers glycolytic impairment-causing presynaptic dysfunction and deregulation of Ca2+ dynamics.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelet‐derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4‐based assays2021

Author(s)

Odaka Haruki 小高陽樹

[Presentation] １細胞糖鎖/RNAシーケンシング法によるiPS細胞由来神経細胞に混入する未分化細胞の糖鎖マーカー開発2024

[Presentation] １細胞糖鎖-RNA同時プロファイリング技術（scGR-seq）の開発（Simultaneous profiling of glycan and RNA in single cells）2021