Fujiwara Koichi 藤原広一

Researcher Number	40837853
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2022: 北海道大学, 薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator レゾルビン / 抗炎症活性 / 脂肪酸 / 構造活性相関研究 / 安定等価体 / 代謝安定化 / ω-3系脂肪酸 Except Principal Investigator 高分子間相互作用 / αヘリックス / ホールダマー … More / 膜透過性ペプチド / 環状ペプチド / ペプチドミメティクス / タンパク質間相互作用 / 三次元多様性 / シクロプロパン Less

炎症収束性脂質レゾルビンE2の安定化を基盤とした高活性等価体の創出Principal Investigator
- Principal Investigator
  
  藤原広一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Hokkaido University
Development of resolvin analogues as a metabolically stable equivalentPrincipal Investigator
- Principal Investigator
  
  Fujiwara Koichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Hokkaido University
Medicinal chemistry for developing molecules regulating interactions between biological macromolecules
- Principal Investigator
  
  Shuto Satoshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents.2022
- Author(s)
  (2)Arai S, Fujiwara K, Kojima M, Aoki-Saito H, Yatomi M, Saito T, Koga Y, Fukuda H, Watanabe M, Matsunaga S, Hisada T, Shuto S
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 87(15) Issue: 15 Pages: 10501-10508
- DOI
  10.1021/acs.joc.2c01110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08404, KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-22K08227, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-18K08382, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K06941, KAKENHI-PROJECT-21K15215
[Journal Article] Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside2022
- Author(s)
  H. Higashida, K. Furuhara, O. Lopatina, M. Gerasimenko, O. Hori, T. Hattori, Y. Hayashi, S. M. Cherepanov, A. A. Shabalova, A. B. Salmina, K. Minami, T. Yuhi, C. Tsuji, P. Y. Fu, Z. Liu, S. Luo, A. Zhang, S. Yokoyama, S. Shuto, M. Watanabe, K. Fujiwara, S. Munesue, A. Harashima, Y. Yamamoto
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 858070-858070
- DOI
  10.3389/fnins.2022.858070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-22K18540, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K07323
[Journal Article] esolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinaseAkt signaling pathway in adipocytesive2022
- Author(s)
  T. Shimizu, T. Saito, H. Aoki-Saito, H. Ikeda, T. Nakakura, H.to Fukuda, S.yota Arai, K.ouichi Fujiwara, Y.asuyo Nakajima, K. Horiguchi, S. Yamada, E. Ishida, T. Hisada, S. Shuto, M. Yamada
- Journal Title
  
  FASEB J.
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Synthesis of γ-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors2022
- Author(s)
  Keisuke Mitsui, Maria E. K. Lie, Naoki Saito, Koichi Fujiwara, Mizuki Watanabe, Petrine Wellendorph, Satoshi Shuto
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 23 Pages: 4151-5154
- DOI
  10.1021/acs.orglett.2c01346
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-19K06965
[Journal Article] S. Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane.2022
- Author(s)
  89.Nagata, M.; Watanabe, M.; Doi, R.; Uemura, M.; Ochiai, N.; Ichinose, W.; Fujiwara, K.; Kameda, T.; Sato, Y.; Takeuchi, K.; Shuto,
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: - Issue: 5 Pages: 970-980
- DOI
  10.1039/d2ob01715f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014, KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-20H03378
[Journal Article] Resolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinase/Akt signaling pathway in adipocytesive2022
- Author(s)
  281.T. Shimizu, T. Saito, H. Aoki-Saito, H. Ikeda, T. Nakakura, H.to Fukuda, S.yota Arai, K.ouichi Fujiwara, Y.asuyo Nakajima, K. Horiguchi, S. Yamada, E. Ishida, T. Hisada, S. Shuto, M. Yamada
- Journal Title
  
  FASEB J.
  
  Volume: 36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect2021
- Author(s)
  274.K. Ishimura, H. Fukuda, K. Fujiwara, R. Muromoto, K. Hirashima, Y. Murakami, M. Watanabe, J. Ishihara, T. Matsuda, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 12 Pages: 1464-1469
- NAID
  120007186305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT12021
- Author(s)
  280.S. Kickinger, M. E. K. Lie, A. Suemasa, A. Al-Khawaja, K. Fujiwara, M. Watanabe, K. S. Wilhelmsen, C. B. Falk-Petersen, B. Frolund, S. Shuto, G. F. Ecker, P. Wellendorth
- Journal Title
  
  Front. Chem
  
  Volume: 16
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01014
[Journal Article] Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents2020
- Author(s)
  Murakami Yuto、Fukuda Hayato、Muromoto Ryuta、Hirashima Koki、Ishimura Kohei、Fujiwara Koichi、Ishihara Jun、Matsuda Tadashi、Watanabe Mizuki、Shuto Satoshi
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 11 Issue: 4 Pages: 479-484
- DOI
  10.1021/acsmedchemlett.9b00596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08360, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-20K06941, KAKENHI-PROJECT-19H01014
[Presentation] レゾルビンE4およびdeoxy体の合成研究2022
- Author(s)
  櫻田海都，藤原広一，渡邉瑞貴，周東智
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15215
[Presentation] 抗炎症脂質レゾルビンE2のベンゼン環置換による安定等価体の創製研究2022
- Author(s)
  田中伸英, 村上侑斗, 平島洸基, 福田隼, 藤原広一, 渡邉瑞貴, 室本竜太, 松田正, 周東智
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15215
[Presentation] 抗炎症収束性脂質レゾルビン類をプロトタイプとする創薬化学研究2021
- Author(s)
  藤原広、村上侑斗、池田紘之、福田隼、石原淳、渡邉瑞貴、周東智
- Organizer
  反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] 強力な抗炎症活性を有するレゾルビンE1の安定誘導体の創出研究2021
- Author(s)
  小坂篤生、藤原広一、渡邉瑞貴、周東智
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15215
[Presentation] 炎症収束脂質レゾルビンE3の安定等価体の創製研究2021
- Author(s)
  新井将太、藤原広一、福田隼、渡邉瑞貴、青木遥、矢冨正清、古賀康彦、齋藤従道、久田剛志、周東智
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16307
[Presentation] Design and Synthesis of Benzene Congeners of specialized pro-resolving lipid mediator resolvin E2 as its Stable Equivalents2021
- Author(s)
  Shinei Tanaka, Koichi Fujiwara, Yuto Murakami, Hayato Fukuda, Jun Ishihara, Mizuki Watanabe, Satoshi Shuto
- Organizer
  13th AFMC International Medicinal Chemistry Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15215
[Presentation] 炎症収束脂質レゾルビンE3の安定等価体の創製研究2020
- Author(s)
  新井将太、藤原広一、渡邉瑞貴、周東智
- Organizer
  第32回万有札幌シンポジウム　有機合成化学の道しるべ
- Data Source
  KAKENHI-PROJECT-19K16307
[Presentation] 炎症収束物質レゾルビンE2安定等価体の創製研究－連続スキップジエン構造のベンゼン環による置換－2020
- Author(s)
  田中伸英、村上侑斗、平島洸基、福田隼、藤原広一、渡邉瑞貴、室本竜太、松田正、周東智
- Organizer
  第6回北大・部局横断シンポジウム～若手研究者による生命と物質の融合を目指して！～
- Data Source
  KAKENHI-PROJECT-19K16307
[Presentation] 炎症収束性脂質レゾルビン類をプロトタイプとする創薬化学研究2020
- Author(s)
  藤原広一，村上侑斗，池田紘之，福田隼，石原淳，渡邉瑞貴，周東智
- Organizer
  反応と合成の進歩2020特別企画シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16307
[Presentation] 炎症収束性脂質レゾルビン類をプロトタイプとする創薬化学研究2020
- Author(s)
  藤原広一（助教）
- Organizer
  反応と合成の進歩2020特別企画シンポジウム
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] DEVELOPMENT OF MEMBRANE PERMEABLE CYCLIC PEPTIDES AS STAT3 DIMERIZATION INHIBITORS: A CONFORMATIONAL RESTRICTION STRATEGY FOR REGURATING PROTEIN-PROTEIN INTERACTIONS2019
- Author(s)
  Takayuki Osada, Kouhei Matsui, Koichi Fujiwara, Katsumi Ota, Akira Asai, Mizuki Watanabe, and Satoshi Shuto
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] 強力な抗炎症活性を有するレゾルビンE1の生体内における安定等価体の創出2019
- Author(s)
  小坂篤生, 藤原広一, 渡邉瑞貴, 周東智
- Organizer
  第54回天然物化学談話会
- Data Source
  KAKENHI-PROJECT-19K16307
[Presentation] スピロシクロプロパン構造を基盤としたαヘリックスミメティクスの創製研究2019
- Author(s)
  坂下遼太郎, 桑原智希, 藤原広一, 渡邉瑞貴, 周東智
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] シクロプロパンδ-アミノ酸を基盤とした新規フォルダマーの開発2019
- Author(s)
  永田真, 土井良平, 竹内恒、亀田倫史、藤原広一, 渡邉瑞貴, 周東智
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] Design and synthesis of selective BGT-1 inhibitors based on the conformational restriction strategy2019
- Author(s)
  三井桂佑,末政亮大,小林嵩明,Petrine Wellendorph,人羅菜津子,南雅文,藤原広一,渡邉瑞貴,周東智
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H01014
[Presentation] DESIGN AND SYNTHESIS OF NOVEL HELICAL FOLDAMERS BASED ON CYCLOPROPANE Δ-AMINO ACIDS2019
- Author(s)
  永田真, 竹内恒、土井良平、亀田倫史、藤原広一, 佐藤美洋, 渡邉瑞貴, 周東智
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H01014

1. Shuto Satoshi (70241346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 渡邉瑞貴 (20507173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. 小松康雄 (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 後藤佑樹 (70570604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 青木悠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 福田隼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Koichi 藤原 広一

Research Projects

Research Products

Co-Researchers

炎症収束性脂質レゾルビンE2の安定化を基盤とした高活性等価体の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of resolvin analogues as a metabolically stable equivalentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Medicinal chemistry for developing molecules regulating interactions between biological macromolecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E3, an Endogenous Pro-Resolving Lipid Mediator, as Its Stable Equivalents.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] esolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinaseAkt signaling pathway in adipocytesive2022

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of γ-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S. Helix-forming aliphatic homo-δ-peptide foldamers based on the conformational restriction effects of cyclopropane.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Resolvin E3 ameliorates insulin resistance via the phosphatidylinositol‐3‐kinase/Akt signaling pathway in adipocytesive2022

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of Resolvin E1 and Its Conformationally Restricted Cyclopropane Congeners with Potent Anti-Inflammatory Effect2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT12021

Author(s)

Journal Title

Data Source

[Journal Article] Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] レゾルビンE4およびdeoxy体の合成研究2022

Author(s)

Organizer

Data Source

[Presentation] 抗炎症脂質レゾルビンE2のベンゼン環置換による安定等価体の創製研究2022

Author(s)

Organizer

Data Source

[Presentation] 抗炎症収束性脂質レゾルビン類をプロトタイプとする創薬化学研究2021

Author(s)

Organizer

Data Source

[Presentation] 強力な抗炎症活性を有するレゾルビンE1の安定誘導体の創出研究2021

Author(s)

Organizer

Data Source

Fujiwara Koichi 藤原広一

[Presentation] 炎症収束物質レゾルビンE2安定等価体の創製研究－連続スキップジエン構造のベンゼン環による置換－2020

[Presentation] 強力な抗炎症活性を有するレゾルビンE1の生体内における安定等価体の創出2019