CHEN Yu 陳ヨ

… Alternative Names

陳ヨチンヨ

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Researcher Number	40838900
Affiliation (Current)	2025: 東京薬科大学, 生命科学部, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員 2019 – 2020: 国立研究開発法人国立がん研究センター, 研究所, 特任研究員
Review Section/Research Field	Principal Investigator 0905:Surgery of the organs maintaining homeostasis and related fields / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 膵臓神経内分泌腫瘍 / 下垂体神経内分泌腫瘍 / neuroendocrine tumor / Akt / PHLDA3 / 神経内分泌腫瘍 Except Principal Investigator p53 / がん抑制遺伝子 / PHLDA3 / 神経内分泌腫瘍抑制 / Akt / 神経内分泌腫瘍 / がん

下垂体神経内分泌腫瘍におけるp53-PHLDA3経路の機能解明と新規治療薬の開発Principal Investigator
- Principal Investigator
  
  陳ヨ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  National Cancer Center Japan
非機能性膵神経内分泌腫瘍の肝転移メカニズム解明と新規治療標的同定Principal Investigator
- Principal Investigator
  
  陳ヨ
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0905:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  National Cancer Center Japan
Mechanism of neuroendocrine tumor suppression by the tumor suppressor gene PHLDA3
- Principal Investigator
  
  Ohki Rieko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
PHLDA3遺伝子とMEN1遺伝子による神経内分泌腫瘍抑制機構の解明Principal Investigator
- Principal Investigator
  
  陳ヨ
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan

All 2023 2022 2020 2019

All Journal Article Presentation Book

[Book] Heat Shock Proteins in Signaling Pathways, Heat Shock Proteins2019
- Author(s)
  Tatsuya Kawase, Yu Chen, Rieko Ohki
- Total Pages
  20
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19K16732
[Journal Article] Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors2023
- Author(s)
  Chen Yu、Yamamoto Tatsuki、Takahashi Yura、Moro Tomoka、Tajima Tomoko、Sakaguchi Yukiko、Sakata Naoaki、Yokoyama Akihiko、Hijioka Susumu、Sada Akane、Tabata Yuko、Ohki Rieko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 9 Pages: 1-13
- DOI
  10.1038/s41419-023-06123-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19644, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-23K24368
[Journal Article] PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis2022
- Author(s)
  Saito Megumi、Sada Akane、Fukuyo Masaki、Aoki Kiyono、Okumura Kazuhiro、Tabata Yuko、Chen Yu、Kaneda Atsushi、Wakabayashi Yuichi、Ohki Rieko
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 142 Issue: 21 Pages: 02271-5
- DOI
  10.1016/j.jid.2021.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-19K07494, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H03523, KAKENHI-PROJECT-20F20414, KAKENHI-PROJECT-18K07080, KAKENHI-PROJECT-20K07605
[Journal Article] p53-PHLDA3-Akt Network: The Key Regulators of Neuroendocrine Tumorigenesis.2020
- Author(s)
  Yu Chen and Rieko Ohki*.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 11 Pages: 4098-4098
- DOI
  10.3390/ijms21114098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03523, KAKENHI-PROJECT-18F18758, KAKENHI-PROJECT-20F20414, KAKENHI-PROJECT-19K16732, KAKENHI-PROJECT-16H06276
[Journal Article] Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.2020
- Author(s)
  Shiori Suzuki, Shuichi Tsutsumi, Yu Chen, Chikako Ozeki, Atsushi Okabe, Tatsuya Kawase, Hiroyuki Aburatani and Rieko Ohki.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 451-466
- DOI
  10.1111/cas.14279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03587, KAKENHI-PROJECT-18F18758, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H03523, KAKENHI-PROJECT-19K16732
[Journal Article] Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation2020
- Author(s)
  Shotaro Yamano, Makoto Kimura, Yu Chen, Naoko Imamoto, Rieko Ohki
- Journal Title
  
  Experimental Cell Research
  
  Volume: 386 Issue: 1 Pages: 111686-111686
- DOI
  10.1016/j.yexcr.2019.111686
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06235, KAKENHI-INTERNATIONAL-15K21744, KAKENHI-PLANNED-15H05929, KAKENHI-PROJECT-17H03587, KAKENHI-PROJECT-18H02442, KAKENHI-PROJECT-18F18758, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K16732
[Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.2019
- Author(s)
  Kojima M, Chen Y, Ikeda K, Tsukada Y, Takahashi D, Kawano S, Amemiya K, Ito M, Ohki R, Ochiai A.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 2040-2040
- DOI
  10.1038/s41598-018-37707-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07035, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K16732, KAKENHI-PROJECT-17H03587, KAKENHI-PROJECT-18F18758
[Presentation] Modified p53 pathway promotes the malignant progression of PanNET by activating the Akt pathway and altering metabolism2023
- Author(s)
  Yu Chen, Sadahiro Iwabuchi, Akihiko Yokoyama, Nobuyoshi Hiraoka, Yasuhito Arai, Keita Iida,Tohru Kiyono, Mariko Okada, Shinichi Hashimoto, Rieko Ohki
- Organizer
  The 10th International MDM2 Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19644
[Presentation] Modified p53 pathway promotes the malignant progression of PanNET by activating the Akt pathway and altering metabolism2023
- Author(s)
  Yu Chen, Sadahiro Iwabuchi, Tohru Kiyono, Nobuyoshi Hiraoka, Keita Iida, Yasuhito Arai, Akihiko Yokoyama, Mariko Okada, Shinichi Hashimoto, Rieko Ohki
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K19644
[Presentation] 改造されたp53経路はAkt経路活性化と代謝変化を引き起こすことで膵神経内分泌腫瘍の悪性化を促進する2023
- Author(s)
  チンヨ, 大木理恵子
- Organizer
  第9回がんと代謝研究会 in 松山
- Data Source
  KAKENHI-PROJECT-23K19644
[Presentation] Induction of an undifferentiated state in medullary thyroid carcinoma through dual inactivation of Rb-PHLDA3 in parafollicular C cells2023
- Author(s)
  Walied Kamel, Yu Chen, Akane Sada, Yuko Tabata, Yukiko Sakaguchi, Tomoko Tajima, Chiaki Takahashi, Rieko Ohki
- Organizer
  The 10th International MDM2 Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19644
[Presentation] 肝臓がんにおけるPHLDA familyの機能解析2023
- Author(s)
  小林直矢, 青木清乃, チンヨ, 山本雅大, 塩川大介, 大木理恵子
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K19644
[Presentation] PHLDA3は膵島細胞の分化と代謝を制御することで非機能性膵神経内分泌腫瘍の悪性化を抑制する2022
- Author(s)
  チンヨ、大木理恵子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03523
[Presentation] PHLDA3 suppresses the malignant progression of non-functional PanNET by regulating cell differentiation and metabolism.2022
- Author(s)
  Yu Chen, Rieko Ohki
- Organizer
  The 18th International p53 workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03523
[Presentation] Akt dysregulation by loss of PHLDA3 is an important determinant of pancreatic neuroendocrine tumor progression.2020
- Author(s)
  Yu Chen, Sadahiro Iwabuchi, Tohru Kiyono, Shigeyuki Magi, Yasuhito Arai, Akihiko Yokoyama, Mariko Okada, Shinichi Hashimoto, Kentaro Semba, Rieko Ohki.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03523
[Presentation] Akt dysregulation by loss of PHLDA3 is an important determinant of pancreatic neuroendocrine tumor progression2020
- Author(s)
  Yu Chen#, Sadahiro Iwabuchi, Tohru Kiyono, Shigeyuki Magi, Yasuhito Arai, Akihiko Yokoyama, Mariko Okada, Shinichi Hashimoto, Kentaro Semba, Rieko Ohk
- Organizer
  The 79th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K16732
[Presentation] Akt dysregulation by loss of PHLDA3 is an important determinant of pancreatic neuroendocrine tumor progression2020
- Author(s)
  Yu Chen, Sadahiro Iwabuchi, Tohru Kiyono, Shigeyuki Magi, Yasuhito Arai, Akihiko Yokoyama, Mariko Okada, Shinichi Hashimoto, Kentaro Semba, Rieko Ohki
- Organizer
  The 79th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K16732
[Presentation] Unraveling the mechanisms of pancreatic neuroendocrine tumorigenesis using a new mouse model2019
- Author(s)
  Yu Chen, Sadahiro Iwabuchi, Tohru Kiyono, Shigeyuki Magi, Yasuhito Arai, Akihiko Yokoyama, Mariko Okada, Shinichi Hashimoto, Kentaro Semba, Rieko Ohki
- Organizer
  The 78th Annual Meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19K16732

1. Ohki Rieko (70356252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 清野透 (10186356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小嶋基寛 (30338470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 木村誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

CHEN Yu 陳 ヨ

陳 ヨ チン ヨ

Research Projects

Research Products

Co-Researchers

下垂体神経内分泌腫瘍におけるp53-PHLDA3経路の機能解明と新規治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

非機能性膵神経内分泌腫瘍の肝転移メカニズム解明と新規治療標的同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of neuroendocrine tumor suppression by the tumor suppressor gene PHLDA3

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PHLDA3遺伝子とMEN1遺伝子による神経内分泌腫瘍抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Heat Shock Proteins in Signaling Pathways, Heat Shock Proteins2019

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] p53-PHLDA3-Akt Network: The Key Regulators of Neuroendocrine Tumorigenesis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Modified p53 pathway promotes the malignant progression of PanNET by activating the Akt pathway and altering metabolism2023

Author(s)

Organizer

Data Source

[Presentation] Modified p53 pathway promotes the malignant progression of PanNET by activating the Akt pathway and altering metabolism2023

Author(s)

Organizer

Data Source

[Presentation] 改造されたp53経路はAkt経路活性化と代謝変化を引き起こすことで膵神経内分泌腫瘍の悪性化を促進する2023

Author(s)

Organizer

Data Source

[Presentation] Induction of an undifferentiated state in medullary thyroid carcinoma through dual inactivation of Rb-PHLDA3 in parafollicular C cells2023

Author(s)

Organizer

Data Source

CHEN Yu 陳ヨ

陳ヨチンヨ