UMEHARA ATSUSHI 梅原厚志

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Umehara Atsushi 梅原厚志

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Researcher Number	40847018
Other IDs
Affiliation (Current)	2025: 東北大学, 生命科学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2024: 東北大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields Except Principal Investigator Basic Section 38040:Bioorganic chemistry-related
Keywords	Principal Investigator 海洋天然物 / 全合成 / ケトンカップリング / イリジマシド / ポルチミン / アミド / カップリング / 遷移金属触媒 / クロスカップリング / ニッケル触媒 … More / ジルコノセン / ニッケル / ケトン合成 / 収束的合成 / 触媒反応 / 炭素-炭素結合形成 / 環状酸無水物 / ケトカルボン酸 / ビススピロアセタール … More Except Principal Investigator 微量検出法 / 全合成 / カリブ海型シガトキシン / モノクローナル抗体 / 食中毒シガテラ / シガテラ中毒 / 抗体作製 / シガテラ食中毒 Less

Synthetic studies on Caribbean ciguatoxin for prevention and treatment of ciguatera seafood poisoning
- Principal Investigator
  
  佐々木誠
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Tohoku University
精密制御クロスカップリングを用いる生物活性海洋天然物群の新規合成戦略の確立Principal Investigator
- Principal Investigator
  
  梅原厚志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
Synthetic Strategies for Bioactive Marine Natural Products Using Highly Controlled Cross-CouplingPrincipal Investigator
- Principal Investigator
  
  Umehara Atsushi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
Studies toward the total synthesis of Caribbean ciguatoxin for the development of a highly sensitive antibody-based immunoassy
- Principal Investigator
  
  Makoto Sasaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Tohoku University
Development of Nobel construction method of bis-spiroacetalPrincipal Investigator
- Principal Investigator
  
  Umehara Atsushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 月刊 [化学]2023
- Author(s)
  梅原厚志, 佐々木誠
- Total Pages
  6
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-23K14314
[Journal Article] DMAPO/Boc2O‐Mediated One‐Pot Direct N1‐Acylation of Indazole with Carboxylic Acids: A Practical Synthesis of N1‐Functionalized Alkyl Indazoles2024
- Author(s)
  Umehara Atsushi、Shimizu Soma、Sasaki Makoto
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2024 Issue: 18
- DOI
  10.1002/ejoc.202400123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14314
[Journal Article] DMAPO/Boc 2 O‐Mediated One‐Pot Direct N ‐Acylation of Less Nucleophilic N ‐Heterocycles with Carboxylic Acids2023
- Author(s)
 Umehara Atsushi、Shimizu Soma、Sasaki Makoto
- Journal Title
 
 ChemCatChem
 
 Volume: 15 Issue: 5
- DOI
 10.1002/cctc.202201596
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-21K15219, KAKENHI-PROJECT-23K14314
[Journal Article] Synthesis of Bulky N‐Acyl Heterocycles by DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Less Nucleophilic N‐Heterocycles with α‐Fully Substituted Carboxylic Acids2023
- Author(s)
  Umehara Atsushi、Shimizu Soma、Sasaki Makoto
- Journal Title
  
  Advanced Synthesis & Catalysis
  
  Volume: 365 Issue: 14 Pages: 2367-2376
- DOI
  10.1002/adsc.202300487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14314
[Journal Article] Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam2021
- Author(s)
  Umehara Atsushi、Ueda Hirofumi、Tokuyama Hidetoshi
- Journal Title
  
  Tetrahedron
  
  Volume: 79 Pages: 131809-131809
- DOI
  10.1016/j.tet.2020.131809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06936, KAKENHI-PUBLICLY-20H04800, KAKENHI-PROJECT-18H02549, KAKENHI-PROJECT-19K23620
[Journal Article] Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners2019
- Author(s)
  Atsushi Umehara and Yoshito Kishi
- Journal Title
  
  Chemistry Letters
  
  Volume: 48 Issue: 8 Pages: 947-950
- DOI
  10.1246/cl.190405
- NAID
  130007687732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23620
[Presentation] DMAPO触媒とBoc2Oを用いる含窒素複素環化合物とカルボン酸のone-pot縮合反応2023
- Author(s)
  志水颯真, 梅原厚志, 佐々木誠
- Organizer
  第52回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] Synthetic studies on irijimasides using Ni-catalyzed ketone coupling2023
- Author(s)
  Tomoya Suwa, Atsushi Umehara, Makoto Sasaki
- Organizer
  令和5年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO触媒とBoc2Oを用いるインドールとカルボン酸の高効率one-pot縮合反応の開発2023
- Author(s)
  梅原厚志, 志水颯真, 佐々木誠
- Organizer
  日本薬学会第143年会 (札幌)
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] Studies toward the Total Synthesis of Portimine2023
- Author(s)
  Daisuke Sato, Atsushi Umehara, Makoto Sasaki
- Organizer
  令和5年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] イリジマシド類の全合成研究2023
- Author(s)
  諏訪朝也, 梅原厚志, 佐々木誠
- Organizer
  日本薬学会第143年会 (札幌)
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] Ni触媒によるケトンカップリング反応を駆使したイリジマシド類の収束的全合成研究2023
- Author(s)
  諏訪朝也, 梅原厚志, 佐々木誠
- Organizer
  第34回万有仙台シンポジウム
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO/Boc2O-mediated one-pot direct N-Acylation of less nucleophilic N-hetarocycles with carboxylic acids2023
- Author(s)
  Soma Shimizu, Atushi Umehara, Makoto Sasaki
- Organizer
  令和5年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] ポルチミンの不斉全合成研究2023
- Author(s)
  佐藤大亮, 梅原厚志, 佐々木誠
- Organizer
  第52回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO 触媒と Boc2O を用いる低反応性窒素求核剤とカルボン酸の化学選択的 one-pot 縮合反応2023
- Author(s)
  梅原厚志, 志水颯真, 佐々木誠
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO 触媒と Boc2O を用いる低反応性窒素求核剤とカルボン酸の化学選択的 one-pot 縮合反応2023
- Author(s)
  梅原厚志, 志水颯真, 佐々木誠
- Organizer
  日本薬学会第144年会 (横浜)
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO触媒とBoc2Oを用いる低反応性窒素求核剤とカルボン酸の高効率one-pot縮合反応の開発2023
- Author(s)
  志水颯真, 梅原厚志, 佐々木誠
- Organizer
  日本薬学会第143年会 (札幌)
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] Synthetic studies on irijimasides using Ni-catalyzed ketone coupling2023
- Author(s)
  Tomoya Suwa, Atsushi Umehara, Makoto Sasaki
- Organizer
  IKCOC-15
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO 触媒と Boc2O を用いる低反応性窒素求核剤とカルボン酸の化学選択的 one-pot 縮合反応の開発2023
- Author(s)
  志水颯真, 梅原厚志, 佐々木誠
- Organizer
  創薬懇話会 2023 in 湯河原
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] Studies toward the Total Synthesis of Portimine2023
- Author(s)
  Daisuke Sato, Atsushi Umehara, Makoto Sasaki
- Organizer
  IKCOC-15
- Data Source
  KAKENHI-PROJECT-23K14314
[Presentation] DMAPO触媒とBoc2Oを用いるインドールとカルボン酸の高効率one-pot縮合反応の開発2022
- Author(s)
  志水颯真, 梅原厚志, 佐々木誠
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] DMAPO触媒とBoc2Oを用いる低反応性窒素求核剤とカルボン酸の高効率one-pot縮合反応の開発2022
- Author(s)
  志水颯真, 梅原厚志, 佐々木誠
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] ポルチミンの不斉全合成研究2022
- Author(s)
  佐藤大亮, 梅原厚志, 佐々木誠
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] イリジマシド類の全合成研究2022
- Author(s)
  諏訪朝也, 梅原厚志, 佐々木誠
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K15219
[Presentation] ポルチミンのエナンチオ選択的な全合成研究2021
- Author(s)
  佐藤大亮、梅原厚志、佐々木誠
- Organizer
  令和3年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20H02919
[Presentation] カリブ海型シガトキシンの合成研究 KLMN環部フラグメントの合成2020
- Author(s)
  梅原厚志、岩崎浩太郎、荒井啓介、佐々木誠
- Organizer
  第 62 回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K23620
[Presentation] カリブ海型シガトキシンの合成研究：KLMN環部フラグメントの合成2020
- Author(s)
  梅原厚志、岩崎浩太郎、荒井啓介、佐々木誠
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-20H02919
[Presentation] Halichondrinの収束的合成を可能にする穏和なケトンカップリング2020
- Author(s)
  梅原厚志
- Organizer
  第31回万有仙台シンポジウム
- Data Source
  KAKENHI-PROJECT-19K23620
[Presentation] 穏和な新規反応が可能にする生物活性天然物の高効率全合成2020
- Author(s)
  梅原厚志
- Organizer
  武田薬品プロセスケミストリーデベロップメントシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K23620
[Presentation] Halichondrinの収束的合成を可能にする穏和なケトンカップリング2019
- Author(s)
  梅原厚志
- Organizer
  第 61 回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K23620

1. Makoto Sasaki (80235267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. UEDA Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UMEHARA ATSUSHI 梅原 厚志

Umehara Atsushi 梅原 厚志

Research Projects

Research Products

Co-Researchers

Synthetic studies on Caribbean ciguatoxin for prevention and treatment of ciguatera seafood poisoning

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

精密制御クロスカップリングを用いる生物活性海洋天然物群の新規合成戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic Strategies for Bioactive Marine Natural Products Using Highly Controlled Cross-CouplingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies toward the total synthesis of Caribbean ciguatoxin for the development of a highly sensitive antibody-based immunoassy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Nobel construction method of bis-spiroacetalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 月刊 [化学]2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] DMAPO/Boc2O‐Mediated One‐Pot Direct N1‐Acylation of Indazole with Carboxylic Acids: A Practical Synthesis of N1‐Functionalized Alkyl Indazoles2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DMAPO/Boc <sub>2</sub> O‐Mediated One‐Pot Direct <i>N</i> ‐Acylation of Less Nucleophilic <i>N</i> ‐Heterocycles with Carboxylic Acids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Bulky N‐Acyl Heterocycles by DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Less Nucleophilic N‐Heterocycles with α‐Fully Substituted Carboxylic Acids2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] DMAPO触媒とBoc2Oを用いる含窒素複素環化合物とカルボン酸のone-pot縮合反応2023

Author(s)

Organizer

Data Source

[Presentation] Synthetic studies on irijimasides using Ni-catalyzed ketone coupling2023

Author(s)

Organizer

Data Source

[Presentation] DMAPO触媒とBoc2Oを用いるインドールとカルボン酸の高効率one-pot縮合反応の開発2023

Author(s)

Organizer

Data Source

[Presentation] Studies toward the Total Synthesis of Portimine2023

Author(s)

UMEHARA ATSUSHI 梅原厚志

Umehara Atsushi 梅原厚志

[Presentation] DMAPO 触媒と Boc2O を用いる低反応性窒素求核剤とカルボン酸の化学選択的 one-pot 縮合反応の開発2023