OHASHI Hirofumi 大橋啓史

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Ohashi Hirofumi 大橋啓史

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Researcher Number	40866761
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所ワクチン開発研究センター, 研究員
Affiliation (based on the past Project Information) *help	2024: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 研究員 2021 – 2022: 国立感染症研究所, 治療薬・ワクチン開発研究センター, 研究員 2020: 東京理科大学, 理工学部応用生物科学科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related
Keywords	Principal Investigator SARS-CoV-2 / infection / cell free / cell-to-cell / J6/JFH1 / JFH1 / ウイルス伝播 / 脂肪滴 / Lipid droplets / HCV

新型コロナウイルス感染細胞における複製小器官形成の分子メカニズム解析Principal Investigator
- Principal Investigator
  
  大橋啓史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Institute of Infectious Diseases
The analysis for the HCV propagation strategy from the infected cells to uninfected cellsPrincipal Investigator
- Principal Investigator
  
  Ohashi Hirofumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Institute of Infectious Diseases
  Tokyo University of Science

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication2023
- Author(s)
  Nakajima Shogo、Ohashi Hirofumi、Akazawa Daisuke、Torii Shiho、Suzuki Rigel、Fukuhara Takasuke、Watashi Koichi
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 2 Pages: 452-452
- DOI
  10.3390/v15020452
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15458, KAKENHI-PROJECT-20K16267
[Journal Article] Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.22022
- Author(s)
  Ohashi H、Hishiki T、Akazawa D、Kim KS、Woo J、Shionoya K、Tsuchimoto K、Iwanami S、Moriyama S、Kinoshita H、Yamada S、Kuroda Y、Yamamoto T、Kishida N、Watanabe S、Hasegawa H、Ebihara H、Suzuki T、Maeda K、Fukushi S、Takahashi Y、Iwami S、Watashi K
- Journal Title
  
  Antiviral Research
  
  Volume: 205 Pages: 105372-105372
- DOI
  10.1016/j.antiviral.2022.105372
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07532, KAKENHI-PROJECT-22KJ2816, KAKENHI-PROJECT-20K16267
[Journal Article] Cyclic Phthalate Esters as Liver X Receptor Antagonists with Anti-hepatitis C Virus and Anti-severe Acute Respiratory Syndrome Coronavirus 2 Properties2022
- Author(s)
  Saito Shiki、Ohashi Hirofumi、Nakamura Kou、Otagaki Junichiro、Nishioka Kazane、Nishiuchi Kota、Nakamura Ayaka、Tsurukawa Yukine、Shibasaki Hisanobu、Murakami Hironobu、Nagane Masaki、Okada Maiko、Kuramochi Kouji、Watashi Koichi、Kamisuki Shinji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 10 Pages: 679-683
- DOI
  10.1248/cpb.c22-00345
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05299, KAKENHI-PROJECT-20K05868, KAKENHI-PROJECT-20K16267
[Journal Article] Development of novel monoclonal antibodies against nsp12 of SARS-CoV-22022
- Author(s)
  Machitani Mitsuhiro、Takei Junko、Kaneko Mika K.、Ueki Saori、Ohashi Hirofumi、Watashi Koichi、Kato Yukinari、Masutomi Kenkichi
- Journal Title
  
  Virology Journal
  
  Volume: 19 Issue: 1
- DOI
  10.1186/s12985-022-01948-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16267
[Journal Article] Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro2021
- Author(s)
  Ohashi Hirofumi、Wang Feng、Stappenbeck Frank、Tsuchimoto Kana、Kobayashi Chisa、Saso Wakana、Kataoka Michiyo、Yamasaki Masako、Kuramochi Kouji、Muramatsu Masamichi、Suzuki Tadaki、Sureau Camille、Takeda Makoto、Wakita Takaji、Parhami Farhad、Watashi Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 3163-3163
- DOI
  10.3390/ijms22063163
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16267, KAKENHI-PROJECT-19J21455
[Journal Article] Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids2021
- Author(s)
  Hayashi Tsuyoshi、Murakami Kosuke、Hirano Junki、Fujii Yoshiki、Yamaoka Yoko、Ohashi Hirofumi、Watashi Koichi、Estes Mary K.、Muramatsu Masamichi
- Journal Title
  
  mSphere
  
  Volume: 6 Issue: 6
- DOI
  10.1128/msphere.00623-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07520, KAKENHI-PROJECT-20K16267
[Journal Article] Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome- related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro2021
- Author(s)
  Kaho Shionoya, Masako Yamasaki, View ORCID ProfileShoya Iwanami, Yusuke Ito, Shuetsu Fukushi, Hirofumi Ohashi, Wakana Saso, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Shingo Iwami, Yoshimasa Takahashi, Tadaki Suzuki, Masamichi Muramatsu, Makoto Takeda, Takaji Wakita, Koichi Watashi
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 1 Pages: 1-1
- DOI
  10.3389/fmicb.2021.651403
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J12155, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-20K05712, KAKENHI-PROJECT-20K16267
[Journal Article] Estimation of the incubation period of COVID-19 using viral load data.2021
- Author(s)
  Ejima K, Kim KS, Ludema C, Bento AI, Iwanami S, Fujita Y, Ohashi H, Koizumi Y, Watashi K, Aihara K, Nishiura H, Iwami S.
- Journal Title
  
  Epidemics.
  
  Volume: 35 Pages: 100454-100454
- DOI
  10.1016/j.epidem.2021.100454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16267, KAKENHI-PUBLICLY-20H05042
[Journal Article] Potential Anti-COVID-19 Agents, Cepharanthine and Nelfinavir, and Their Usage for Combination Treatment2021
- Author(s)
  H. Ohashi, K. Watashi, W. Saso, K. Shionoya, et al.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 335-337
- DOI
  10.1016/j.isci.2021.102367
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05712, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-19J12155, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-18K07055, KAKENHI-PROJECT-20K05755, KAKENHI-PROJECT-20K16267, KAKENHI-PROJECT-23K21721
[Journal Article] Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives2021
- Author(s)
  Nishiuchi Kota、Ohashi Hirofumi、Nishioka Kazane、Yamasaki Masako、Furuta Masateru、Mashiko Takumi、Tomoshige Shusuke、Ohgane Kenji、Kamisuki Shinji、Watashi Koichi、Kuramochi Kouji
- Journal Title
  
  Journal of Natural Products
  
  Volume: 85 Issue: 1 Pages: 284-291
- DOI
  10.1021/acs.jnatprod.1c01120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-21K05299, KAKENHI-PROJECT-20K15949, KAKENHI-PROJECT-20K16267
[Journal Article] Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma2020
- Author(s)
  S. Iwanami, K. Kitagawa, H. Ohashi, Y. Asai, K. Shionoya, W. Saso, K. Nishioka, H. Inaba, S. Nakaoka, T. Wakita, O. Diekmann, S. Iwami and K. Watashi
- Journal Title
  
  PLoS Biology
  
  Volume: 18(7) Issue: 7 Pages: 3000562-3000562
- DOI
  10.1371/journal.pbio.3000562
- NAID
  120006872724
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K03614, KAKENHI-PROJECT-20K08369, KAKENHI-PROJECT-20K16267, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-19J12319, KAKENHI-PROJECT-19J21455, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-18H01139, KAKENHI-PUBLICLY-20H05042, KAKENHI-PROJECT-16H04845
[Presentation] 植物由来天然物と類縁体のRNAウイルス増殖への作用と効果の解析2020
- Author(s)
  大橋啓史
- Organizer
  JBA植物バイオ研究会勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16267

1. HISHIKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 林豪士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中嶋章悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 稲葉寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHASHI Hirofumi 大橋 啓史

Ohashi Hirofumi 大橋 啓史

Research Projects

Research Products

Co-Researchers

新型コロナウイルス感染細胞における複製小器官形成の分子メカニズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The analysis for the HCV propagation strategy from the infected cells to uninfected cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclic Phthalate Esters as Liver X Receptor Antagonists with Anti-hepatitis C Virus and Anti-severe Acute Respiratory Syndrome Coronavirus 2 Properties2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Development of novel monoclonal antibodies against nsp12 of SARS-CoV-22022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome- related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimation of the incubation period of COVID-19 using viral load data.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential Anti-COVID-19 Agents, Cepharanthine and Nelfinavir, and Their Usage for Combination Treatment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 植物由来天然物と類縁体のRNAウイルス増殖への作用と効果の解析2020

Author(s)

Organizer

Data Source

OHASHI Hirofumi 大橋啓史

Ohashi Hirofumi 大橋啓史