Nishiguchi Yukiko 西口由希子

Researcher Number	40867727
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 奈良県立医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 糖化HMGB1 / HMGB1 / 胃癌 / がん転移 / A1C / 膵癌 / 大腸癌 / 糖尿病 / 抗がん剤 / ミトコンドリア鉄 … More / ミトコンドリア / デオキシコール酸 / RAGE / 酸化型HMGB1 / エチルピルビン酸 / タンシノン / CML-HMGB1 / 酸化HMGB1 / 薬剤耐性 / シスプラチン Less

Roles of glycated HMGB1 in gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  西口由希子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nara Medical University
Inhibition of cisplatin resistance by HMGB1 targeting in gastric cancerPrincipal Investigator
- Principal Investigator
  
  Nishiguchi Yukiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nara Medical University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Lauric Acid Overcomes Hypoxia-Induced Gemcitabine Chemoresistance in Pancreatic Ductal Adenocarcinoma2023
- Author(s)
  Takagi Tadataka、Fujiwara-Tani Rina、Mori Shiori、Kishi Shingo、Nishiguchi Yukiko、Sasaki Takamitsu、Ogata Ruiko、Ikemoto Ayaka、Sasaki Rika、Ohmori Hitoshi、Luo Yi、Bhawal Ujjal Kumar、Sho Masayuki、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 8 Pages: 7506-7506
- DOI
  10.3390/ijms24087506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09341, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-22K16497, KAKENHI-PROJECT-23K19900, KAKENHI-PROJECT-21K06926, KAKENHI-PROJECT-21K10238, KAKENHI-PROJECT-22K11396, KAKENHI-PROJECT-21K10237, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-22H04922
[Journal Article] Short telomere lesions with dysplastic metaplasia histology may represent precancerous lesions of Helicobacter pylori-positive gastric mucosa2023
- Author(s)
  Fujiwara-Tani R, Takagi T, Mori S, Kishi S, Nishiguchi Y, Sasaki T, Ikeda M, Nagai K, Bhawal UK, Ohmori H, Fujii K, Kuniyasu H
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24(4) Issue: 4 Pages: 3182-3182
- DOI
  10.3390/ijms24043182
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K10238, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-22K16497, KAKENHI-PROJECT-23K19900, KAKENHI-PROJECT-21K11223, KAKENHI-PROJECT-22K11396, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-22H04922
[Journal Article] Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer2022
- Author(s)
  Ogata Ruiko、Mori Shiori、Ohmori Hitoshi、Kishi Shingo、Fujiwara-Tani Rina、Sasaki Takamitsu、Nishiguchi Yukiko、Nakashima Chie、Goto Kei、Kawahara Isao、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  Oncotarget
  
  Volume: 13 Issue: 1 Pages: 122-135
- DOI
  10.18632/oncotarget.28170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06926, KAKENHI-PROJECT-22K11396, KAKENHI-PROJECT-22K11423, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-22K16497, KAKENHI-PROJECT-22K17655, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K19349
[Journal Article] Gemcitabine Resistance in Pancreatic Ductal Carcinoma Cell Lines Stems from Reprogramming of Energy Metabolism2022
- Author(s)
  Fujiwara-Tani Rina、Sasaki Takamitsu、Takagi Tadataka、Mori Shiori、Kishi Shingo、Nishiguchi Yukiko、Ohmori Hitoshi、Fujii Kiyomu、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 14 Pages: 7824-7824
- DOI
  10.3390/ijms23147824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11223, KAKENHI-PROJECT-22K11396, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-22K16497, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K17661
[Journal Article] BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer2021
- Author(s)
  Fujiwara-Tani Rina、Okamoto Ayaka、Katsuragawa Hiroyuki、Ohmori Hitoshi、Fujii Kiyomu、Mori Shiori、Kishi Shingo、Sasaki Takamitsu、Nakashima Chie、Kawahara Isao、Hojo Yudai、Nishiguchi Yukiko、Mori Takuya、Mizumoto Takeshi、Nagai Kenta、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 23 Pages: 12724-12724
- DOI
  10.3390/ijms222312724
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-21K20808, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-21K06926, KAKENHI-PROJECT-21K11223, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K19349, KAKENHI-PROJECT-21K17496
[Journal Article] Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer2021
- Author(s)
  Ogata Ruiko、Mori Shiori、Kishi Shingo、Sasaki Rika、Iwata Naoya、Ohmori Hitoshi、Sasaki Takamitsu、Nishiguchi Yukiko、Nakashima Chie、Goto Kei、Kawahara Isao、Fujiwara-Tani Rina、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 225-225
- DOI
  10.3390/ijms23010225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-19K19915, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-21K20808, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-20K17661
[Journal Article] Role of Glycated High Mobility Group Box-1 in Gastric Cancer2021
- Author(s)
  Kishi Shingo、Nishiguchi Yukiko、Honoki Kanya、Mori Shiori、Fujiwara-Tani Rina、Sasaki Takamitsu、Fujii Kiyomu、Kawahara Isao、Goto Kei、Nakashima Chie、Kido Akira、Tanaka Yasuhito、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 10 Pages: 5185-5185
- DOI
  10.3390/ijms22105185
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-19K19915, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-21K20808, KAKENHI-PROJECT-18K10753, KAKENHI-PROJECT-21K06926, KAKENHI-PROJECT-21K11223, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K19349, KAKENHI-PROJECT-21K17496
[Journal Article] Enhancement of Anti-Tumoral Immunity by β-Casomorphin-7 Inhibits Cancer Development and Metastasis of Colorectal Cancer2021
- Author(s)
  Mori Shiori、Fujiwara-Tani Rina、Kishi Shingo、Sasaki Takamitsu、Ohmori Hitoshi、Goto Kei、Nakashima Chie、Nishiguchi Yukiko、Kawahara Isao、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 15 Pages: 8232-8232
- DOI
  10.3390/ijms22158232
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-19K19915, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-21K20808, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-21K06926, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K19349
[Journal Article] Effect of Proton Pump Inhibitors on Colorectal Cancer2020
- Author(s)
  Sasaki Takamitsu、Mori Shiori、Kishi Shingo、Fujiwara-Tani Rina、Ohmori Hitoshi、Nishiguchi Yukiko、Hojo Yudai、Kawahara Isao、Nakashima Chie、Fujii Kiyomu、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3877-3877
- DOI
  10.3390/ijms21113877
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-20K19349, KAKENHI-PROJECT-18K17726, KAKENHI-PROJECT-16H06276
[Journal Article] Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/Polyps with Dysplasia2020
- Author(s)
  Fujiwara-Tani Rina、Fujii Kiyomu、Mori Shiori、Kishi Shingo、Sasaki Takamitsu、Ohmori Hitoshi、Nakashima Chie、Kawahara Isao、Nishiguchi Yukiko、Mori Takuya、Sho Masayuki、Kondoh Masuo、Luo Yi、Kuniyasu Hiroki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 11 Pages: 3840-3840
- DOI
  10.3390/ijms21113840
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-18K16671, KAKENHI-PROJECT-16H06276
[Journal Article] Targeting claudin‐4 enhances chemosensitivity in breast cancer2020
- Author(s)
  Luo Yi、Kishi Shingo、Sasaki Takamitsu、Ohmori Hitoshi、Fujiwara‐Tani Rina、Mori Shiori、Goto Kei、Nishiguchi Yukiko、Mori Takuya、Kawahara Isao、Kondoh Masuo、Kuniyasu Hiroki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 5 Pages: 1840-1850
- DOI
  10.1111/cas.14361
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16671, KAKENHI-PROJECT-18K17726, KAKENHI-PROJECT-16H05164, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-19K19915, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-20K18007, KAKENHI-PROJECT-20K19349, KAKENHI-PROJECT-17K19923
[Journal Article] Clostridium perfringens enterotoxin induced claudin-4 to activate YAP in oral squamous cell carcinomas.2020
- Author(s)
  Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y, Kirita T, Kuniyasu H
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 4 Pages: 309-321
- DOI
  10.18632/oncotarget.27424
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09539, KAKENHI-PROJECT-19K10272, KAKENHI-PROJECT-17K19923, KAKENHI-PROJECT-18K16671, KAKENHI-PROJECT-18K17726, KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K11260, KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K19332, KAKENHI-PROJECT-20K17661
[Journal Article] Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma2020
- Author(s)
  Fujiwara-Tani Rina、Sasaki Takamitsu、Fujii Kiyomu、Luo Yi、Mori Takuya、Kishi Shingo、Mori Shiori、Matsushima-Otsuka Sayako、Nishiguchi Yukiko、Goto Kei、Kawahara Isao、Kondoh Masuo、Sho Masayuki、Kuniyasu Hiroki
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 31 Pages: 2982-2994
- DOI
  10.18632/oncotarget.27674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21659, KAKENHI-PROJECT-19K16564, KAKENHI-PROJECT-20K17661, KAKENHI-PROJECT-18K10788, KAKENHI-PROJECT-16H06276
[Presentation] Mitochondrial Iron(II) Accumulation of Anticancer Drugs and Combination Effects of Pterostilbene.2023
- Author(s)
  Nishiguchi Y, Mori S, Fujiwara-Tani R, Hojo Y, Takagi T, Ogata R, Kishi S, Kuniyasu H
- Organizer
  82th Annual Meeting of Japanese Association for Cancer, Yokohama, 2023.9.21-23
- Data Source
  KAKENHI-PROJECT-22K16497
[Presentation] Pterostilbene enhances anticancer effect of lapatinib in gastric cancer cell lines.2023
- Author(s)
  Nishiguchi Y, Rina Fujiwara-Tani, Shiori Mori, Sho M, Hiroki Kuniyasu
- Organizer
  International Gastric Cancer Congress 2023, Yokohama, Japan, 2023.6.14-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16497
[Presentation] Pterostilbene enhances anticancer effect of lapatinib in gastric cancer cell lines.2023
- Author(s)
  Nishiguchi Y, Rina Fujiwara-Tani, Shiori Mori, Sho M, Hiroki Kuniyasu
- Organizer
  International Gastric Cancer Congress 2023, Yokohama, Japan, 2023.6.14-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] マウス胃癌モデルにおけるスニチニブ心筋毒性に対するプテロスチルベンの心筋保護作用2022
- Author(s)
  川原勲、北條雄大、額賀翔太、岸真五、森汐莉、谷里奈、佐々木隆光、藤井澄、西口由希子、中嶋千恵、篠原尚、國安弘基
- Organizer
  第111回日本病理学会総会、神戸市（ハイブリッド開催）、2022.4.14-16
- Data Source
  KAKENHI-PROJECT-22K16497
[Presentation] マウス胃癌モデルにおけるスニチニブ心筋毒性に対するプテロスチルベンの心筋保護作用2022
- Author(s)
  川原勲、北條雄大、額賀翔太、岸真五、森汐莉、谷里奈、佐々木隆光、藤井澄、西口由希子、中嶋千恵、篠原尚、國安弘基
- Organizer
  第111回日本病理学会総会、神戸市（ハイブリッド開催）、2022.4.14-16
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] Pterostilbene enhance anticancer effect of Lapatinib in gastric cancer.2022
- Author(s)
  Nishiguchi Y, Mori S, Kishi S, Takagi T, Nakashima C, Fujiwara-Tani R, Kuniyasu H
- Organizer
  81th Annual Meeting of Japanese Association for Cancer, Yokohama, 2022.9.29-10.1
- Data Source
  KAKENHI-PROJECT-22K16497
[Presentation] Pterostilbene enhance anticancer effect of Lapatinib in gastric cancer.2022
- Author(s)
  Nishiguchi Y, Mori S, Kishi S, Takagi T, Nakashima C, Fujiwara-Tani R, Kuniyasu H
- Organizer
  81th Annual Meeting of Japanese Association for Cancer, Yokohama, 2022.9.29-10.1
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] Role of glycated high mobility group box-1 in gastric cancer.2021
- Author(s)
  Nishiguchi Y, Kishi S, Mori S, Takagi T, Hojo Y, Sasaki T, Fujii K, Nakashima C, Luo Y, Fujiwara-Tani R, Kuniyasu H
- Organizer
  80th Annual Meeting of Japanese Association for Cancer
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] Role of glycated high mobility group box-1 in gastric cancer.2021
- Author(s)
  Nishiguchi Y, Kishi S, Mori S, Takagi T, Hojo Y, Sasaki T, Fujii K, Nakashima C, Luo Y, Fujiwara-Tani R, Kuniyasu H
- Organizer
  第32回日本消化器癌発生学会・第10回国際消化器癌発生学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] Combined effect of sunitinib and pterostilbene on gastric cancer cells.2021
- Author(s)
  Hojo Y, Mori S, Kishi S, Nishiguchi Y, Takagi T, Fujiwara-Tani R, Shinohara H, Kuniyasu H
- Organizer
  80th Annual Meeting of Japanese Association for Cancer
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] 胃癌におけるHMGB1抑制物質によるシスプラチン効果増強についての検討2020
- Author(s)
  西口由希子、谷里奈、岸真五、笹平智則、松本壮平、若月幸平、庄雅之、國安弘基
- Organizer
  第119回日本外科学会
- Data Source
  KAKENHI-PROJECT-20K17661
[Presentation] 胃癌におけるHMGB1抑制物質によるシスプラチン効果増強についての検討2020
- Author(s)
  西口由希子、谷里奈、岸真五、笹平智則、松本壮平、若月幸平、庄雅之、國安弘基
- Organizer
  第75回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-20K17661

1. LUO Yi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. OOMORI Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. YAMAMOTO Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 国安弘基

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. 岸真五

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 谷里奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
7. 藤井澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. バワールウジャール

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 桐田忠昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishiguchi Yukiko 西口 由希子

Research Projects

Research Products

Co-Researchers

Roles of glycated HMGB1 in gastrointestinal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of cisplatin resistance by HMGB1 targeting in gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Lauric Acid Overcomes Hypoxia-Induced Gemcitabine Chemoresistance in Pancreatic Ductal Adenocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Short telomere lesions with dysplastic metaplasia histology may represent precancerous lesions of Helicobacter pylori-positive gastric mucosa2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gemcitabine Resistance in Pancreatic Ductal Carcinoma Cell Lines Stems from Reprogramming of Energy Metabolism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Glycated High Mobility Group Box-1 in Gastric Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of Anti-Tumoral Immunity by β-Casomorphin-7 Inhibits Cancer Development and Metastasis of Colorectal Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Proton Pump Inhibitors on Colorectal Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/Polyps with Dysplasia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting claudin‐4 enhances chemosensitivity in breast cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clostridium perfringens enterotoxin induced claudin-4 to activate YAP in oral squamous cell carcinomas.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma2020

Author(s)

Journal Title

DOI

Nishiguchi Yukiko 西口由希子