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Nishimune Hiroshi  西宗 裕史

ORCIDConnect your ORCID iD *help
Researcher Number 40870043
Other IDs
Affiliation (Current) 2025: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2024: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長
Review Section/Research Field
Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related / Biological Sciences
Except Principal Investigator
Basic Section 59010:Rehabilitation science-related
Keywords
Principal Investigator
ラミニン / 神経筋接合部 / 筋萎縮性側索硬化症 / iPS細胞 / ALS / 幹細胞 / 運動神経 / アクティブゾーン
Except Principal Investigator
サルコペニア / 筋血流 … More / 機械的刺激 / 咽頭 / 血流 / 腰部交感神経 / サルコぺニア / 筋血管 / 筋収縮 / 張力 / 自律神経 / ラット / 老化 / 電気刺激 / 収縮力 / 反射 / 筋収縮力 / 圧受容器 / 大動脈 / 神経筋接合部 / 筋緊張 / 筋力 / 嚥下 / 骨格筋 / 交感神経 Less
  • Research Projects

    (3 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (4 People)
  •  Denervation mechanism and intervention methods of the ALS neuromuscular junctionPrincipal Investigator

    • Principal Investigator
      西宗 裕史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  シナプス分化因子と間葉系幹細胞によるALS神経変性の抑制メカニズムの解析Principal Investigator

    • Principal Investigator
      西宗 裕史
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  嚥下にともなう自律神経の活性化が骨格筋におよぼす作用とサルコペニア予防への応用

    • Principal Investigator
      堀田 晴美
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

All 2023 2022 2021 2020

All Journal Article Presentation Book

  • [Book] 実験医学、Vol.38, No.16、神経筋接合部の老化2020

    • Author(s)
      西宗裕史、Yomna Badawi
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Journal Article] Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex2023

    • Author(s)
      Inoue Ritsuko、Nishimune Hiroshi
    • Journal Title

      Cells

      Volume: 12 Issue: 17 Pages: 2142-2142

    • DOI

      10.3390/cells12172142

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-22K11306
  • [Journal Article] Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses2022

    • Author(s)
      Takikawa Kenji、Nishimune Hiroshi
    • Journal Title

      Biomolecules

      Volume: 12 Issue: 2 Pages: 1-25

    • DOI

      10.3390/biom12020179

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K15196, KAKENHI-PROJECT-20K22699, KAKENHI-PROJECT-19K24690
  • [Journal Article] Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation in the SOD1-G93A Rat Model of ALS2022

    • Author(s)
      Nishimune Hiroshi、Stanford Kimberly G、Chen Jie、Odum James D、Rorie Alexander D、Rogers Robert S、Wheatley Joshua L、Geiger Paige C、Stanford John A
    • Journal Title

      Degenerative Neurological and Neuromuscular Disease

      Volume: Volume 12 Pages: 145-155

    • DOI

      10.2147/dnnd.s388455

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Journal Article] Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord2021

    • Author(s)
      Tungtur Sudheer K.、Wilkins Heather M.、Rogers Robert S.、Badawi Yomna、Sage Jessica M.、Agbas Abdulbaki、Jawdat Omar、Barohn Richard J.、Swerdlow Russell H.、Nishimune Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11051-11051

    • DOI

      10.1038/s41598-021-90438-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

    • Author(s)
      Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
    • Journal Title

      Autophagy

      Volume: 17 Issue: 1 Pages: 1-382

    • DOI

      10.1080/15548627.2020.1797280

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06375, KAKENHI-PROJECT-19K07568, KAKENHI-PROJECT-20K06501, KAKENHI-PROJECT-20K06636, KAKENHI-PROJECT-20K07896, KAKENHI-PROJECT-20K21769, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-19H01042, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656, KAKENHI-PROJECT-18H02807, KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-18K06210, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-18K09427, KAKENHI-PROJECT-19K08851, KAKENHI-PROJECT-18KK0193, KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18H02901, KAKENHI-PROJECT-20H02990, KAKENHI-PUBLICLY-20H05504, KAKENHI-PROJECT-19H03471, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-20H03249, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-20K08460, KAKENHI-PROJECT-20K08662, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-19K24690, KAKENHI-PROJECT-23K21397
  • [Journal Article] Impairment mechanisms and intervention approaches for aged human neuromuscular junctions2020

    • Author(s)
      Yomna Badawi and Hiroshi Nishimune
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: 13 Pages: 568426-568426

    • DOI

      10.3389/fnmol.2020.568426

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Journal Article] A deletion in the N-terminal polymerizing domain of laminin β2 is a new mouse model of chronic nephrotic syndrome.2020

    • Author(s)
      Steven D Funk, Raymond H Bayer, Karen K McKee, Kazushi Okada, Hiroshi Nishimune, Peter D Yurchenco, Jeffrey H Miner.
    • Journal Title

      Kidney International

      Volume: 98 Issue: 1 Pages: 133-146

    • DOI

      10.1016/j.kint.2020.01.033

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] 筋萎縮性側索硬化症(ALS)の治療を目指した神経筋接合部の研究2023

    • Author(s)
      西宗裕史
    • Organizer
      国立長寿医療研究センターセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] Super-resolution imaging of synaptic proteins of neuromuscular junctions in adults and aged mice2023

    • Author(s)
      Naoko H. Tomioka, Yomna Badawi, Kenji Takikawa, Hiroshi Nishimune
    • Organizer
      International Association of Gerontology & Geriatrics-Asia Oceania Regional Congress2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] Super-resolution microscopic analysis of the active zone protein organization of the neuromuscular junction2023

    • Author(s)
      西宗裕史
    • Organizer
      2022年度 生理研研究会 ナノ・メゾスケールから捉えるシナプス制御機構の新展開
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] Expression mechanism analysis of synapse-organizers essential for maintaining motor function and neuromuscular junctions2023

    • Author(s)
      Tomoyuki Nakano, Kotaro Takeno, Yomna Badawi, Hiroshi Nishimune
    • Organizer
      International Association of Gerontology & Geriatrics-Asia Oceania Regional Congress2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] 筋萎縮性側索硬化症の治療を目指したヒト間葉系幹細胞の利用2023

    • Author(s)
      西宗裕史
    • Organizer
      山口大学医学部、メディバイオ事業研究会 第28回講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] Analysis of protein organization near the active zone of mouse NMJs2022

    • Author(s)
      西宗裕史
    • Organizer
      Molecular and Cell Biology of the Neuromuscular System, Guarda, Switzerland
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] 神経筋接合部におけるラミニンβ2鎖の機能2021

    • Author(s)
      西宗裕史
    • Organizer
      第53回日本結合組織学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K24690
  • [Presentation] A treatment strategy for ALS neuromuscular junction degeneration using human mesenchymal stem cells2020

    • Author(s)
      Yomna Badawi, Takashi Matsuda, Sudheer Tungtur, Tomohiro Tanaka, Rupal Soder, Kleiton Silv, Tadashi Yoshida, Richard Barohn, and Hiroshi Nishimune(発表者、西宗裕史)
    • Organizer
      第43回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-19K24690
  • 1.  堀田 晴美 (70199511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  重本 和宏 (40284400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  瀧川 健司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  相澤 修
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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