KIMURA TOSHIHIRO 木村俊寛

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Kimura Toshihiro 木村俊寛

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Researcher Number	40879904
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2023: 熊本大学, 大学院生命科学研究部(医), 寄附講座教員 2022: 熊本大学, 大学院生命科学研究部(医), 特任助教 2021: 熊本大学, 病院, 診療助手 2020: 熊本大学, 病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / 0901:Oncology and related fields
Keywords	Principal Investigator OX40L / OX40 / iPS-ML / メラノーマ / 免疫チェックポイント阻害薬 / 免疫細胞療法 / がん免疫療法 / 悪性黒色腫

遺伝子改変iPS由来ミエロイドラインと免疫チェックポイント阻害薬併用療法の開発Principal Investigator
- Principal Investigator
  
  木村俊寛
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kumamoto University
Development of Induced pluripotent stem cell-derived macrophages expressing OX40 ligand therapyPrincipal Investigator
- Principal Investigator
  
  Kimura Toshihiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy2024
- Author(s)
  Horiguchi Haruki、Kadomatsu Tsuyoshi、Yamashita Tomoya、Yumoto Shinsei、Horino Taichi、Sato Michio、Terada Kazutoyo、Miyata Keishi、Ichigozaki Yuki、Kimura Toshihiro、Fukushima Satoshi、Moroishi Toshiro、Oike Yuichi
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: Online ahead of print Issue: 6 Pages: 0-0
- DOI
  10.1038/s41417-024-00757-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-23K06638, KAKENHI-PROJECT-23K07511, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-21H04825
[Journal Article] Deciphering the role of adjuvant therapy in melanoma and its actual benefits2024
- Author(s)
  Fukushima Satoshi、Miyashita Azusa、Kimura Toshihiro、Kuriyama Haruka、Mizuhashi Satoru、Ichigozaki Yuki、Masuguchi Shinichi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 3 Pages: 335-342
- DOI
  10.1111/1346-8138.17093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-23K15271, KAKENHI-PROJECT-21K08351
[Journal Article] Effectiveness of trabectedin for radiation‐induced angiosarcoma of the breast refractory to several anticancer drugs2024
- Author(s)
  Matsuzaki Erina、Kajihara Ikko、Tomiguchi Mai、Kimura Toshihiro、Araki Seina、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: Online ahead of print Issue: 8
- DOI
  10.1111/1346-8138.17159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16285
[Journal Article] A case of melanoma complicated with uveitis induced by two types of BRAF/MEK inhibitors and nivolumab treatment2023
- Author(s)
  Obaru Chiaki、Kimura Toshihiro、Yamamura Manami、Kuriyama Haruka、Kashiwada‐Nakamura Kayo、Mizuhashi Satoru、Matsumura Tomoyo、Watanabe Takahiro、Inoue Toshihiro、Fukushima Satoshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 4
- DOI
  10.1111/1346-8138.17015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-23K15271, KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K09703
[Journal Article] Elevated circulating C‐X‐C motif chemokine ligand 1 DNA copies in psoriasis2023
- Author(s)
  Kuriyama Haruka、Myangat Tselmeg Mijiddorj、Kajihara Ikko、Shimada Shuichi、Kimura Toshihiro、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 4
- DOI
  10.1111/1346-8138.17013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16285
[Journal Article] A Japanese case of melanoma of unknown origin with a rare <i>BRAF</i><sup>V600R</sup> mutation was successfully treated with BRAF/MEK inhibitors2022
- Author(s)
  Kuriyama Haruka、Kimura Toshihiro、Mizuhashi Satoru、Nishimura Yuki、Kanemaru Hisashi、Kajihara Ikko、Makino Katsunari、Aoi Jun、Matsui Hirotaka、Fukushima Satoshi
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 16 Issue: 5 Pages: 256-257
- DOI
  10.5582/ddt.2022.01072
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2022-10-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-22K16285
[Journal Article] Future prospects for cancer immunotherapy using induced pluripotent stem cell‐derived dendritic cells or macrophages2022
- Author(s)
  Fukushima Satoshi、Miyashita Azusa、Kuriyama Haruka、Kimura Toshihiro、Mizuhashi Satoru、Kubo Yosuke、Nakahara Satoshi、Kanemaru Hisashi、Tsuchiya Nobuhiro、Mashima Hiroaki、Zhang Rong、Uemura Yasushi
- Journal Title
  
  Experimental Dermatology
  
  Volume: 32 Issue: 3 Pages: 290-296
- DOI
  10.1111/exd.14729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16285, KAKENHI-PROJECT-21K08351
[Journal Article] Relationship between Type 2 diabetes mellitus and aggressiveness of melanoma2022
- Author(s)
  Kaneko Akira、Kanemaru Hisashi、Mizuhashi Satoru、Kimura Toshihiro、Kuriyama Haruka、Sawamura Soichiro、Kajihara Ikko、Makino Katsunari、Miyashita Azusa、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 106 Issue: 1 Pages: 65-67
- DOI
  10.1016/j.jdermsci.2022.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-22K16285
[Journal Article] Amelanotic melanoma of the nail apparatus complicated with digital mucous cyst2021
- Author(s)
  Takei Itsuki、Sawamura Soichiro、Kimura Toshihiro、Makino Takamitsu、Aoi Jun、Kajihara Ikko、Nishimura Yuki、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi
- Journal Title
  
  Australasian Journal of Dermatology
  
  Volume: 63 Issue: 1
- DOI
  10.1111/ajd.13679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-21K08351
[Journal Article] Immune cell therapy against disseminated melanoma by utilizing induced pluripotent stem cell-derived myeloid cell lines producing interferon-beta or interleukin-15/interleukin-15 receptor alpha2021
- Author(s)
  Mizuhashi S, Kubo Y, Fukushima S, Kanemaru H, Nakahara S, Miyasita A, Ishibashi T, Kuriyama H, Kimura T, Masuguchi S, Zhang R, Iwama T, Nakatsura T, Uemura Y, Senju S, Ihn H.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: - Issue: 2 Pages: 133-136
- DOI
  10.1016/j.jdermsci.2021.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08301, KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-20K09186
[Journal Article] Immunotherapy with 4-1BBL-Expressing iPS Cell-Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma2021
- Author(s)
  Kuriyama H, Fukushima S, Kimura T, Kanemaru H, Miyashita A, Okada E, Kubo Y, Nakahara S, Tokuzumi A, Nishimura Y, Kajihara I, Makino K, Aoi J, Masuguchi S, Tsukamoto H, Inozume T, Zhang R, Nakatsura T, Uemura Y, Senju S, Ihn H.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22(4) Issue: 4 Pages: 1958-1958
- DOI
  10.3390/ijms22041958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301, KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850
[Journal Article] A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells2021
- Author(s)
  Hisashi Kanemaru, Yukari Mizukami, Akira Kaneko, Hidemi Tagawa, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 9 Pages: 103067-103067
- DOI
  10.1016/j.isci.2021.103067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-21K08351
[Journal Article] Liquid biopsy-based analysis by ddPCR and CAPP-Seq in melanoma patients2021
- Author(s)
  Akira Kaneko, Hisashi Kanemaru, Ikko Kajihara, Tselmeg Mijiddorj, Hitomi Miyauchi, Haruka Kuriyama, Toshihiro Kimura, Soichiro Sawamura, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 102 Issue: 3 Pages: 158-166
- DOI
  10.1016/j.jdermsci.2021.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-21K08351
[Journal Article] Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma2020
- Author(s)
  Haruka Kuriyama, Satoshi Fukushima, Toshihiro Kimura, Etsuko Okada, Takayuki Ishibashi, Satoru Mizuhashi, Hisashi Kanemaru, Ikko Kajihara, Katsunari Makino, Azusa Miyashita, Jun Aoi, Seiji Okada, Hironobu Ihn, Kanako Kita
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 100(2) Issue: 2 Pages: 110-119
- DOI
  10.1016/j.jdermsci.2020.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-18K08301
[Journal Article] Induced pluripotent stem cell‐derived myeloid cells expressing OX40 ligand amplify antigen‐specific T cells in advanced melanoma2020
- Author(s)
  Kimura Toshihiro、Fukushima Satoshi、Okada Etsuko、Miyashita Azusa、Tsukamoto Hirotake、Uemura Yasushi、Senju Satoru、Ihn Hironobu
- Journal Title
  
  Pigment Cell & Melanoma Research
  
  Volume: - Issue: 5 Pages: 744-755
- DOI
  10.1111/pcmr.12887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16345, KAKENHI-PROJECT-19K21328, KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-20K22850, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301
[Journal Article] Methyl-CpG binding domain protein 3: a new diagnostic marker and potential therapeutic target of melanoma2020
- Author(s)
  Takayuki Ishibashi, Ikko Kajihara, Satoru Mizuhashi, Haruka Kuriyama, Toshihiro Kimura, Hisashi Kanemaru, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Satoshi Fukushima, Kanako Kita, Hironobu Ihn
- Journal Title
  
  BioScience Trends
  
  Volume: 14 Issue: 5 Pages: 390-395
- DOI
  10.5582/bst.2020.01048
- NAID
  130007935965
- ISSN
  1881-7815, 1881-7823
- Year and Date
  2020-10-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-18K08301
[Journal Article] BATF2 expression as a novel marker for invasive phenotype in malignant melanoma2020
- Author(s)
  Hidemi Tagawa, Hisashi Kanemaru, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Azusa Miyashita, Jun Aoi, Satoshi Fukushima, Hironobu Ihn
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47(10) Issue: 10 Pages: 372-373
- DOI
  10.1111/1346-8138.15495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850, KAKENHI-PROJECT-18K08301
[Presentation] IPS cell-derived myeloid cells expressing OX40 ligand amplify tumor-infiltrating T cells in advanced melanoma2021
- Author(s)
  Toshihiro Kimura
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22850
[Presentation] 悪性黒色腫に対するiPS細胞由来OX40L導入マクロファージ療法の開発2020
- Author(s)
  木村　俊寛
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K22850

1. FUKUSHIMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 金丸央

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 尹浩信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 宮下梓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 植村靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 張エイ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA TOSHIHIRO 木村 俊寛

Kimura Toshihiro 木村 俊寛

Research Projects

Research Products

Co-Researchers

遺伝子改変iPS由来ミエロイドラインと免疫チェックポイント阻害薬併用療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Induced pluripotent stem cell-derived macrophages expressing OX40 ligand therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deciphering the role of adjuvant therapy in melanoma and its actual benefits2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effectiveness of trabectedin for radiation‐induced angiosarcoma of the breast refractory to several anticancer drugs2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of melanoma complicated with uveitis induced by two types of BRAF/MEK inhibitors and nivolumab treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated circulating C‐X‐C motif chemokine ligand 1 DNA copies in psoriasis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Japanese case of melanoma of unknown origin with a rare <i>BRAF</i><sup>V600R</sup> mutation was successfully treated with BRAF/MEK inhibitors2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Future prospects for cancer immunotherapy using induced pluripotent stem cell‐derived dendritic cells or macrophages2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between Type 2 diabetes mellitus and aggressiveness of melanoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amelanotic melanoma of the nail apparatus complicated with digital mucous cyst2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immune cell therapy against disseminated melanoma by utilizing induced pluripotent stem cell-derived myeloid cell lines producing interferon-beta or interleukin-15/interleukin-15 receptor alpha2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunotherapy with 4-1BBL-Expressing iPS Cell-Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells2021

Author(s)

Journal Title

DOI

Data Source

KIMURA TOSHIHIRO 木村俊寛

Kimura Toshihiro 木村俊寛