Ooki Takuya 大木拓也

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大木拓也オオキタクヤ

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Researcher Number	40897021
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 博士研究員 2021: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 合成致死 / 液-液相分離（LLPS） / オルタナティブスプライシング / BRCAness / 卵巣がん / 乳がん / 液液相分離(LLPS) / PARP阻害剤 / YAP1

Hippo-YAP経路を利用したBRCAness陽性がんの新規合成致死療法開発Principal Investigator
- Principal Investigator
  
  大木拓也
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Microbial Chemistry Research Foundation
  The University of Tokyo

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells2023
- Author(s)
  Takahashi-Kanemitsu Atsushi、Lu Mengxue、Knight Christopher Takaya、Yamamoto Takayoshi、Hayashi Takuo、Mii Yusuke、Ooki Takuya、Kikuchi Ippei、Kikuchi Akira、Barker Nick、Susaki Etsuo A.、Taira Masanori、Hatakeyama Masanori
- Journal Title
  
  Science Signaling
  
  Volume: 16 Issue: 794
- DOI
  10.1126/scisignal.abp9020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15526, KAKENHI-PROJECT-21H04804
[Journal Article] Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins2021
- Author(s)
  Ooki Takuya、Hatakeyama Masanori
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 2 Pages: 100430-100430
- DOI
  10.1016/j.xpro.2021.100430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-21K15526
[Journal Article] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis2021
- Author(s)
  S Imai, T Ooki, N Murata-Kamiya, D Komura, K Tahmina, W Wu, Atsushi Takahashi-Kanemitsu, C T Knight, A Kunita, N Suzuki, A Del Valle, M Tsuboi, M Hata, Y Hayakawa, N Ohnishi, K Ueda, M Fukayama, T Ushiku, S Ishikawa, M Hatakeyama
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 29 Issue: 6 Pages: 1-18
- DOI
  10.1016/j.chom.2021.04.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-19K07535, KAKENHI-PROJECT-21H04804, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-20K07422, KAKENHI-PROJECT-21K19474, KAKENHI-PROJECT-21K15526, KAKENHI-PROJECT-20K09712
[Presentation] The Helicobacter pylori CagA oncoprotein inhibits DNA damage-induced apoptosis through Hippo signal activation.2022
- Author(s)
  Naoko Kamiya, Takuya Ooki, Masanori Hatakeyama.
- Organizer
  12th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15526

1. 畠山昌則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 高橋昌史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ooki Takuya 大木拓也

大木拓也オオキタクヤ

Research Projects

Research Products

Co-Researchers

Hippo-YAP経路を利用したBRCAness陽性がんの新規合成致死療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Helicobacter pylori CagA oncoprotein inhibits DNA damage-induced apoptosis through Hippo signal activation.2022

Author(s)

Organizer

Data Source

Ooki Takuya 大木 拓也

大木 拓也 オオキ タクヤ

Research Projects

Research Products

Co-Researchers

Hippo-YAP経路を利用したBRCAness陽性がんの新規合成致死療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Helicobacter pylori CagA oncoprotein inhibits DNA damage-induced apoptosis through Hippo signal activation.2022

Author(s)

Organizer

Data Source

Ooki Takuya 大木拓也

大木拓也オオキタクヤ