TSUTSUMI HAYAMA 堤隼馬

Researcher Number	40903274
Other IDs
Affiliation (Current)	2025: 北里大学, 感染制御科学府, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 北里大学, 感染制御科学府, 特任助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 生合成 / 天然物 / ゲノム解析 / 生合成遺伝子クラスター / バイオインフォマティクス / 二次代謝産物 / ゲノムマイニング / 耐性遺伝子

Construction of tools for the prediction of natural products biosynthesisPrincipal Investigator
- Principal Investigator
  
  堤隼馬
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kitasato University
Prediction and analysis of natural product biosynthetic clusters which cannot be predicted by conventional methodsPrincipal Investigator
- Principal Investigator
  
  堤隼馬
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kitasato University
耐性遺伝子を指標とした微生物資源からの新規薬剤シーズの探索Principal Investigator
- Principal Investigator
  
  堤隼馬
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Kitasato University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Akedanones A?C, In Vitro and In Vivo Antiplasmodial 2,3-Dihydronaphthoquinones Produced by Streptomyces sp. K20-01872024
- Author(s)
 Kimura So-ichiro、Watanabe Yoshihiro、Kikuchi Yuta、Shibasaki Shiori、Tsutsumi Hayama、Inahashi Yuki、Hokari Rei、Ishiyama Aki、Iwatsuki Masato
- Journal Title
 
 Journal of Natural Products
 
 Volume: - Issue: 4 Pages: 994-1002
- DOI
 10.1021/acs.jnatprod.3c01285
- Data Source
 KAKENHI-PROJECT-22K15305
[Journal Article] A new tetronomycin analog, broad‐spectrum and potent antibiotic against drug‐resistant Gram‐positive bacteria2024
- Author(s)
  Kimishima Aoi、Tsuruoka Iori、Tsutsumi Hayama、Honsho Masako、Honma Sota、Matsui Hidehito、Sugamata Miho、Wasuwanich Paul、Inahashi Yuki、Hanaki Hideaki、Asami Yukihiro
- Journal Title
  
  Chemistry & Biodiversity
  
  Volume: 21 Issue: 2
- DOI
  10.1002/cbdv.202301834
- Data Source
  KAKENHI-PROJECT-22K15305, KAKENHI-PROJECT-21K06616
[Journal Article] Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products2023
- Author(s)
  Kikuchi Yuta、Kawashima Miku、Iwatsuki Masato、Kimishima Aoi、Tsutsumi Hayama、Asami Yukihiro、Inahashi Yuki
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 6 Pages: 316-323
- DOI
  10.1038/s41429-023-00609-y
- Data Source
  KAKENHI-PROJECT-22K15305
[Journal Article] Rediscovery of tetronomycin as a broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria2023
- Author(s)
  Aoi Kimishima, Iori Tsuruoka, Hiroki Kanto, Hayama Tsutsumi, Naoaki Arima, Kazunari Sakai, Miho Sugamata, Hidehito Matsui, Yoshihiro Watanabe, Masato Iwatsuki, Masako Honsho, Kamrun Naher, Yuki Inahashi, Hideaki Hanaki, Yukihiro Asami
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 12 Pages: 11556-11563
- DOI
  10.1021/acsomega.3c00651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06616, KAKENHI-PROJECT-22K15305
[Journal Article] Re-evaluation and a Structure?Activity Relationship Study for the Selective Anti-anaerobic Bacterial Activity of Luminamicin toward Target Identification2023
- Author(s)
  Kimishima Aoi、Negami Sota、Tsuruoka Iori、Tsutsumi Hayama、Matsui Hidehito、Sugamata Miho、Kondo Naozumi、Honsho Masako、Sakai Kazunari、Honma Sota、Naher Kamrun、Watanabe Yoshihiro、Iwatsuki Masato、Inahashi Yuki、Hanaki Hideaki、Asami Yukihiro
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: 9 Issue: 8 Pages: 1602-1609
- DOI
  10.1021/acsinfecdis.3c00173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15305, KAKENHI-PROJECT-23K06184
[Journal Article] Insights into the structure?activity relationship of a type III secretion system inhibitor, aurodox2022
- Author(s)
  Kimishima Aoi、Hagimoto Daichi、Honsho Masako、Watanabe Yoshihiro、Iwatsuki Masato、Tsutsumi Hayama、Inahashi Yuki、Naher Kamrun、Sakai Kazunari、Kuwae Asaomi、Abe Akio、Asami Yukihiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 69 Pages: 128779-128779
- DOI
  10.1016/j.bmcl.2022.128779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15305, KAKENHI-PROJECT-20K07485
[Journal Article] Enzymatic synthesis of non-natural flavonoids by combining geranyl pyrophosphate C6-methyltransferase and aromatic prenyltransferase2022
- Author(s)
  Tsutsumi Hayama、Urano Naoki、Katsuyama Yohei、Ohnishi Yasuo
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 9 Pages: 1270-1275
- DOI
  10.1093/bbb/zbac099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15305, KAKENHI-PLANNED-22H05130
[Presentation] ゲノムマイニングによる新規プレニル化lasso peptideの発見2024
- Author(s)
  堤隼馬、稲橋佑起
- Organizer
  日本農芸化学会 2024年度大会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] ゲノムマイニングによる新規プレニル化lasso peptideの発見2024
- Author(s)
  堤隼馬、稲橋佑起
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PUBLICLY-23H04561
[Presentation] ISOLATION OF NATURAL PRODUCTS FROM THE GENUS TUMEBACILLUS, NEW MICROBIAL SOURCE SELECTED BY GENOME ANALYSIS2023
- Author(s)
  Yuta Kikuchi, Miku Kawashima, Masato Iwatsuki, Aoi Kimishima, Hayama Tsutsumi, Yukihiro Asami, Yuki Inahashi
- Organizer
  4th International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] ゲノム情報および分子ネットワークを利用した希少放線菌からの新規天然物探索2023
- Author(s)
  菊池雄太、渡邊善洋、堤隼馬、伊藤翔、岩月正人、稲橋佑起
- Organizer
  第65回有機天然物討論会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] SELECTIVE ISOLATION OF RARE ACTINOMYCETES USING AGAR MEDIUM CONTAINING LYSOZYME AND SEARCH FOR NOVEL BIOACTIVE COMPOUNDS2023
- Author(s)
  Yuta Awano, Hiroki Kanto, Akira Take, Yuta Kikuchi, Aoi Kimishima, Hayama Tsutsumi, Masato Iwatsuki, Yukihiro Asami, Yuki Inahashi
- Organizer
  4th International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] ゲノム情報に基づく放線菌の二次代謝産物生合成能力の網羅的解析2023
- Author(s)
  菊池雄太、堤隼馬、稲橋佑起
- Organizer
  2023年度 (第37回) 日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] 無水マレイン酸とポリケタイド骨格を特徴としたルミナミシンの生合成研究2023
- Author(s)
  鈴木澪央那、堤隼馬、石井皓大、小牧彩乃、山川結加、廣瀬友靖、砂塚敏明、稲橋佑起
- Organizer
  2023年度 (第37回) 日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] ゲノム情報に基づく放線菌の二次代謝産物生合成能力の網羅的解析2023
- Author(s)
  菊池雄太、堤隼馬、稲橋佑起
- Organizer
  第37回 (2023年度) 日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-23H04561
[Presentation] 無水マレイン酸とポリケタイド骨格を特徴としたルミナミシンの生合成研究2023
- Author(s)
  鈴木澪央那、堤隼馬、石井皓大、小牧彩乃、山川結加、廣瀬友靖、砂塚敏明、稲橋佑起
- Organizer
  第37回 (2023年度) 日本放線菌学会
- Data Source
  KAKENHI-PUBLICLY-23H04561
[Presentation] ゲノム情報および分子ネットワークを利用した希少放線菌からの新規天然物探索2023
- Author(s)
  菊池雄太、渡邊善洋、堤隼馬、伊藤翔、岩月正人、稲橋佑起
- Organizer
  第65回有機天然物討論会
- Data Source
  KAKENHI-PUBLICLY-23H04561
[Presentation] 希少放線菌を対象とした二次代謝産物生合成能力の網羅的解析および新規天然物の探索2023
- Author(s)
  菊池雄太、渡邊善洋、川口彩乃、堤隼馬、伊藤翔、岩月正人、稲橋佑起
- Organizer
  日本農芸化学会2023年度広島大会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] Lysozyme添加寒天培地により分離される放線菌の網羅的解析2022
- Author(s)
  粟野友太、菅藤裕貴、武晃、菊池雄太、君嶋葵、堤隼馬、岩月正人、浅見行弘、稲橋佑起
- Organizer
  2022年度 (第36回) 日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] 希少放線菌を対象とした二次代謝産物生合成能力の網羅的解析2022
- Author(s)
  菊池雄太、堤隼馬、稲橋佑起
- Organizer
  2022年度 (第36回) 日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K15305
[Presentation] 希少放線菌からの新規天然物の探索2022
- Author(s)
  春日晟伸、堤隼馬、菅藤裕貴、粟野友太、勝山陽平、大西康夫、稲橋佑起
- Organizer
  2022年度 (第36回) 日本放線菌学会
- Data Source
  KAKENHI-PROJECT-22K15305

1. 君嶋葵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 浅見行弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUTSUMI HAYAMA 堤 隼馬

Research Projects

Research Products

Co-Researchers

Construction of tools for the prediction of natural products biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction and analysis of natural product biosynthetic clusters which cannot be predicted by conventional methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

耐性遺伝子を指標とした微生物資源からの新規薬剤シーズの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Akedanones A?C, <i>In Vitro</i> and <i>In Vivo</i> Antiplasmodial 2,3-Dihydronaphthoquinones Produced by <i>Streptomyces</i> sp. K20-01872024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new tetronomycin analog, broad‐spectrum and potent antibiotic against drug‐resistant Gram‐positive bacteria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rediscovery of tetronomycin as a broad-spectrum and potent antibiotic against drug-resistant Gram-positive bacteria2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Re-evaluation and a Structure?Activity Relationship Study for the Selective Anti-anaerobic Bacterial Activity of Luminamicin toward Target Identification2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insights into the structure?activity relationship of a type III secretion system inhibitor, aurodox2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymatic synthesis of non-natural flavonoids by combining geranyl pyrophosphate C6-methyltransferase and aromatic prenyltransferase2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] ゲノムマイニングによる新規プレニル化lasso peptideの発見2024

Author(s)

Organizer

Data Source

[Presentation] ゲノムマイニングによる新規プレニル化lasso peptideの発見2024

Author(s)

Organizer

Data Source

[Presentation] ISOLATION OF NATURAL PRODUCTS FROM THE GENUS TUMEBACILLUS, NEW MICROBIAL SOURCE SELECTED BY GENOME ANALYSIS2023

Author(s)

Organizer

Data Source

[Presentation] ゲノム情報および分子ネットワークを利用した希少放線菌からの新規天然物探索2023

Author(s)

Organizer

Data Source

[Presentation] SELECTIVE ISOLATION OF RARE ACTINOMYCETES USING AGAR MEDIUM CONTAINING LYSOZYME AND SEARCH FOR NOVEL BIOACTIVE COMPOUNDS2023

Author(s)

Organizer

Data Source

[Presentation] ゲノム情報に基づく放線菌の二次代謝産物生合成能力の網羅的解析2023

Author(s)

Organizer

TSUTSUMI HAYAMA 堤隼馬