KOKI Shigenobu 重信弘毅

… Alternative Names

Researcher Number	50012654
External Links
Affiliation (based on the past Project Information) *help	1993 – 2006: 東邦大学, 薬学部, 教授 1989 – 1990: 東邦大学, 薬学部, 教授 1987 – 1988: University of Tokyo Associate Professor., 薬学部, 助教授 1986: 東京大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology Except Principal Investigator General pharmacology / 応用薬理学・医療系薬学 / Biological pharmacy
Keywords	Principal Investigator 活動電位 / 心筋 / 変力作用 / エンドセリン / マウス心筋 / mouse myocardium / 筋小胞体 / ナトリウムイオン / カルシウムチャネル / プロスタグランジン … More Except Principal Investigator 共焦点レーザー走査顕微鏡 / カルシウムイオン / カルシウムスパーク / 蛍光プローブ / 心筋細胞 / マキシK_<Ca>チャネル / トロンボキサンA_2 / プロスタサイクリン / ブタ冠動脈 / モルモット大動脈 / cAMP / G-蛋白 / 血小板活性化因子 / 1S-メチルPAF / Phospholipass A_2 / Conformational Drug design / 血圧降下剤 / 抗血栓剤 / 抗炎症剤 / PAF抗体 / phospholipase 【A_2】 / L-酒石酸 / Platelet Activating Factor / 1(S)-Me-PAF / Phospholipase A_2 / Drug Design / Anti- hypertensive / Anti-coagulative / Anti-inflammative Less

Studies on the developmental and species difference of the cardiac function: return to chick embryonic myocardium and the integration of the studyPrincipal Investigator
- Principal Investigator
  
  SHIGENOBU Kouki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
Studies on the developmental and species difference of cardiac function : physiological specificity of mouse and generalization of species differencePrincipal Investigator
- Principal Investigator
  
  SHIGENOBU Koki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
STUDIES ON THE DEVELOPMENTAL AND SPECIES DIFFERENCE OF CARDIAC FUNCTION: FUNCTIONAL ROLE OF ENDOCARDIAL ENDOTHELIUM AND THE ANALYSIS OF PHYSIOLOGICAL SPECIFICITY OF MOUSE MYOCARDIAPrincipal Investigator
- Principal Investigator
  
  SHIGENOBU Koki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
Studies on the developmental and species difference of cardiac function : analysis of pharmacological and physiological specificity of mouse myocardiaPrincipal Investigator
- Principal Investigator
  
  KOKI Shigenobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  TOHO UNIVERSITY
血管作働性物質によるマキシK_<Ca>チャネル修飾機構の分子機序と生理的意義
- Principal Investigator
  
  田中芳夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Toho University
Studies on the developmental changes and species difference of cardiac function : analysis of the electrophysiological characteristics and specific responses to alpha-adrenergic stimulation in micePrincipal Investigator
- Principal Investigator
  
  KOKI Shigenobu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
発生・発達に伴う心臓機能の変化に関する生理学的・薬理学的研究Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
細胞内カルシウムスパーク現象の分子メカニズムの研究
- Principal Investigator
  
  川西徹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  国立衛生試験所
モルモット・ラット心筋の発生・発達に伴う電気的特性及び収縮機構の変化-イオンチャネルの変化と収縮へのCa^<2+>sourceの変化:両種の比較-Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
モルモット心筋の発生・発達に伴う電気的特性及び収縮機構の変化Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
モルモット心筋の発生および生後発育に伴う電気的特性および収縮機構の変化-Ion channel の変化と収縮へのCa^<2+>-sourceの変化-Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
心筋の薬物感受性変動を指標としたNeurotrophic Substanceの研究一器官培養法による発展的研究Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
心筋の薬物感受性変動を指標としたNeurotrophic Contralの研究-器官培養法の応用Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Toho University
正常心筋標本を用いたCa^<2+>イオンチャネルのイオン透過性と不活性化気候に関する研究。II発生薬理学的・比較生理学的研究Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
正常心筋標本を用いたCa2+イオンチャネルのイオン透過性と不活性化機構に関する研究Principal Investigator
- Principal Investigator
  
  重信弘毅
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Construction of Novel Agents having Anti-hypertensive, Nticoaqula- Factors
- Principal Investigator
  
  OHNO Masaji
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences, University of Tokyo

All 2007 2006 2005 2003

All Journal Article

[Journal Article] Involvement of the Na^+/Ca^<2+> exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400.2007
- Author(s)
  Tanaka, H., Shimada, H., Namekata, I., Kawanishi, T., Iida-Tanaka, N., Shigenobu, K
- Journal Title
  
  J. Pharmacol. Sci (in press)
- NAID
  10024312778
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors : possible involvement of store-operated Ca2+ entry.2007
- Author(s)
  Nishimaru K., Fujiki S., Tanaka Y., Shigenobu K
- Journal Title
  
  Pharmacology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2007
- Author(s)
  Nouchi, H., Kaeriyama, S., Muramatsu, A., Sato, M., Hirose, K., Shimizu, N., Tanaka, H., Shigenobu, K.
- Journal Title
  
  J. Pharmacol. Sci 103
  
  Pages: 75-82
- NAID
  10024312068
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2007
- Author(s)
  Nouchi, H., Kaeriyama, S., Muramatsu, A.…, Tanaka, H., Shigenobu, K.
- Journal Title
  
  J. Pharmacol. Sci. 103
  
  Pages: 75-82
- NAID
  10024312068
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Involvement of the Na^+/Ca^<2+> exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA04002007
- Author(s)
  Tanaka, H., Shimada, H., Namekata, I.…‥N., Shigenobu, K
- Journal Title
  
  J. Pharmacol. Sci. (in press)
- NAID
  10024312778
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors : possible involvement of store-operated Ca2+ entry2007
- Author(s)
  Nishimaru K., Fujiki S., Tanaka Y., Shigenobu K.
- Journal Title
  
  Pharmacology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Quantitative fluorescence measurement of cardiac Na^+/Ca^2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells2006
- Author(s)
  Namekata, I., Kawanishi, T., Iida-Tanaka, N., Tanaka, H., Shigenobu,K
- Journal Title
  
  J.Pharmacol.Sci. 101
  
  Pages: 356-360
- NAID
  10018236708
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2006
- Author(s)
  Nouchi, H., Kaeriyama, S., Muramatsu, A., Tanaka, H., Shigenobu,K.
- Journal Title
  
  J.Pharmacol.Sci. 103
  
  Pages: 75-82
- NAID
  10024312068
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca^2+ overload.2006
- Author(s)
  Namekata, I., Shimada, H., Kawanishi, T., Tanaka, H., Shigenobu,K
- Journal Title
  
  Eur.J.Pharmacol., 533
  
  Pages: 108-115
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Enhancement of methoxamine-induced contractile responses of rat ventricle in streptozotocin-induced diabetes is associated with α 1A adrenoceptor upregulation.2006
- Author(s)
  Kamata, K., Satoh, T., Matsumoto, T., Tanaka, H., Shigenobu,K.
- Journal Title
  
  Acta. Physiol. Scand 188
  
  Pages: 173-183
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a apecific inhibitor of Na+-Ca2+ exchanger.2005
- Author(s)
  Tanaka, H., Namekata, I., - - -., Shigenobu, K.
- Journal Title
  
  Naunyn-Schmiedeberg's Arch.Pharmacol., 371
  
  Pages: 526-534
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Pharmacological properties of the developing chick myocardium.2005
- Author(s)
  Nouchi, H., Tanaka, H., Shigenobu, K.
- Journal Title
  
  Trends in Comparative Biochem ＆ Physiol 11
  
  Pages: 37-45
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Pharmacological properties of the developing chick myocardium2005
- Author(s)
  Nouchi, H., Tanaka, H., Shigenobu, K.
- Journal Title
  
  Trends in Comparative Biochem ＆ Physiol 11
  
  Pages: 37-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger.2005
- Author(s)
  Tanaka, H., Namekata, I., Takeda, K., Kazama, A., Shimizu, Y., Moriwaki, R., Hirayama, W., Sato, A., Kawanishi, T., Shigenobu, K.
- Journal Title
  
  Naunyn-Schmiedeberg's Arch., Pharmacol. 371
  
  Pages: 526-534
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] T-type calcium channels and drug development.2005
- Author(s)
  Tanaka H, Shigenobu K.
- Journal Title
  
  J. Pharmacol. Sci. 99
  
  Pages: 214-220
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Comparison of the inhibitory effects of docosahexenoic acid (DHA) on U46619- and phnylephrine-induced contractions in guinea-pig aorta.2005
- Author(s)
  Otsuka, K., Tanaka, Y., Tanaka, H., Koike, K., Shigenobu, K.
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1298-2300
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractory period and action potential duration in guinea pig myocardium.2005
- Author(s)
  Mtsuda, T., Takeda, K, - - - - Shigenobu, K
- Journal Title
  
  J.Pharmacol.Sci. 98
  
  Pages: 33-40
- NAID
  10025727826
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium.2005
- Author(s)
  Namekata, I., Nakamura, H., Shimada, H., Tanaka, H., Shigenobu, K.
- Journal Title
  
  Life Sciences 77
  
  Pages: 312-324
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger.2005
- Author(s)
  Tanaka, H., Namekata, I., Takeda, K., Kazama, …T., Shigenobu, K.
- Journal Title
  
  Naunyn-Schmiedeberg's Arch. Pharmacol. 371
  
  Pages: 526-534
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590229
[Journal Article] Species difference in myocardial excitation-contractin coupling featuring the mouse2003
- Author(s)
  Tanaka, H., Shigenobu, K.
- Journal Title
  
  Current Topics in Pharmacology Vol.7
  
  Pages: 247-256
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Atrio-ventricular difference in myocardial excitation-contraction coupling-influence of T-tubules and endocardial endothelium.2003
- Author(s)
  Tanaka, H., Kawanishi, T., Shigenobu, K.
- Journal Title
  
  Recent Res.Devel.Physiol. 1
  
  Pages: 253-262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Optical bioimaging : from living tissue to a single molecule : atrio-ventricular difference in myocardial excitation-contraction coupling-sequential versus simultaneous activation of SR Ca2+ release units.2003
- Author(s)
  Tanaka, H., Kawanishi, T., Shigenobu, K.
- Journal Title
  
  J.Pharmacol.Sci. 93
  
  Pages: 248-252
- NAID
  10012544819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Inhibition of agonist-induced positive inotropy by a selective Rho-associated kinase inhibitor, Y-27632.2003
- Author(s)
  Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
- Journal Title
  
  J.Pharmacol.Sci. 92
- NAID
  130000073980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Optical bioimaging : from living tissue to a single molecule : atrio-ventricular difference in myocardial excitation-contraction coupling - sequential versus simultaneous activation of SR Ca2+ release units.2003
- Author(s)
  Tanaka, H., Kawanishi, T., Shigenobu, K.
- Journal Title
  
  Journal of Pharmacological Sciences 93
  
  Pages: 248-252
- NAID
  10012544819
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Inhibition of agonist-induced positive inotropy by a selective Rho-associated kinase inhibitor, Y-27632.2003
- Author(s)
  Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
- Journal Title
  
  Journal of Pharmacological Sciences 92
  
  Pages: 424-427
- NAID
  130000073980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor mediated negative inotropy in adult mouse ventricle.2003
- Author(s)
  Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
- Journal Title
  
  J.Pharmacol.Sci. 92
  
  Pages: 196-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Species difference in myocardial excitation-contraction coupling featuring the mouse.2003
- Author(s)
  Tanaka, H., Shigenobu, K.
- Journal Title
  
  Current Topics in Pharmacology 7
  
  Pages: 247-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Species difference in myocardial excitation-contraction coupling featuring the mouse.2003
- Author(s)
  Tanaka, H., Kawanishi, T., Shigenobu, K.
- Journal Title
  
  Current Topics in Pharmacology 7
  
  Pages: 247-256
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590235
[Journal Article] Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor mediated negative inotropy in adult mouse ventricle.2003
- Author(s)
  Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
- Journal Title
  
  Journal of Pharmacological Sciences 92
  
  Pages: 196-202
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590235

1. OHNO Masaji (00111550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. WAKU Keizo (90013854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. INOUE Keizo (30072937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NOJIMA Shoshichi (70090470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川西徹 (40124383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 早川堯夫 (50124392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中芳夫 (60188349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 森弘

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOKI Shigenobu 重信 弘毅

SHIGENORU Koki 重信 弘毅

Research Projects

Research Products

Co-Researchers

Studies on the developmental and species difference of the cardiac function: return to chick embryonic myocardium and the integration of the studyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the developmental and species difference of cardiac function : physiological specificity of mouse and generalization of species differencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDIES ON THE DEVELOPMENTAL AND SPECIES DIFFERENCE OF CARDIAC FUNCTION: FUNCTIONAL ROLE OF ENDOCARDIAL ENDOTHELIUM AND THE ANALYSIS OF PHYSIOLOGICAL SPECIFICITY OF MOUSE MYOCARDIAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the developmental and species difference of cardiac function : analysis of pharmacological and physiological specificity of mouse myocardiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管作働性物質によるマキシK_<Ca>チャネル修飾機構の分子機序と生理的意義

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the developmental changes and species difference of cardiac function : analysis of the electrophysiological characteristics and specific responses to alpha-adrenergic stimulation in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発生・発達に伴う心臓機能の変化に関する生理学的・薬理学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内カルシウムスパーク現象の分子メカニズムの研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モルモット・ラット心筋の発生・発達に伴う電気的特性及び収縮機構の変化-イオンチャネルの変化と収縮へのCa^<2+>sourceの変化:両種の比較-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モルモット心筋の発生・発達に伴う電気的特性及び収縮機構の変化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モルモット心筋の発生および生後発育に伴う電気的特性および収縮機構の変化-Ion channel の変化と収縮へのCa^<2+>-sourceの変化-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋の薬物感受性変動を指標としたNeurotrophic Substanceの研究一器官培養法による発展的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋の薬物感受性変動を指標としたNeurotrophic Contralの研究-器官培養法の応用Principal Investigator

Principal Investigator

Project Period (FY)

KOKI Shigenobu 重信弘毅

SHIGENORU Koki 重信弘毅