• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

KOKI Shigenobu  重信 弘毅

ORCIDConnect your ORCID iD *help
… Alternative Names

SHIGENORU Koki  重信 弘毅

Less
Researcher Number 50012654
External Links
Affiliation (based on the past Project Information) *help 1993 – 2006: 東邦大学, 薬学部, 教授
1989 – 1990: 東邦大学, 薬学部, 教授
1987 – 1988: University of Tokyo Associate Professor., 薬学部, 助教授
1986: 東京大学, 薬学部, 教授
Review Section/Research Field
Principal Investigator
General pharmacology / General pharmacology
Except Principal Investigator
General pharmacology / 応用薬理学・医療系薬学 / Biological pharmacy
Keywords
Principal Investigator
活動電位 / 心筋 / 変力作用 / エンドセリン / マウス心筋 / mouse myocardium / 筋小胞体 / ナトリウムイオン / カルシウムチャネル / プロスタグランジン … More / endothelin / action potential / Na+,Ca2+-交換反応 / SEA0400 / 薬物感受性 / 器官培養 / 筋収縮 / カルシウムイオン / マウス / 微小電極法 / アンジオテンシン / アンジオテンシンII / 交感神経α作用 / 心内膜内皮細胞 / alpha-adrenergic effect / endocardial endothelium / prostaglandin / Na+, Ca2+ exchange / α-作用 / ラット心筋 / 胎児期心筋 / 出生後心筋 / 交換神経支配 / 伝達物質 / β-受容体 / 神経支配 / サイクリックAMP / β受容体 / モルモット / 発達薬理 / モルモット心筋 / 発生・発達 / イオンチャネル / 低酸素 / シクロピアゾン酸 / 収縮 / 膜電流 / cyclopiazonic acid / 筋小胞体(SR) / カルシムウチャネル / カリウムチャネル / α-受容体 / Na / Ca交換機構 / 発生 / 発育 / 心室筋 / モルモット心室筋 / 幼若ラット心室筋 / 成熟ラット心室筋 / 発達 / 内皮細胞 / エンドセリンI, / アセチルコリン / 収縮機構 / 発達変化 / Myocardium / Mouse / Action potential / Sarcoplasmic reticulum / Postnatal development / Endothelial cells / Angiotensin / Endothelin / 交感神経α-作用 / Na^+,Ca^<2+>交換反応 / angiotensin I / Na, Ca^<2+>-交換反応 / Na^+,Ca^<2+>-交換反応 / alpha-adrenergic stimulation / positive inotropism / Na^+Ca2^<+->交換反応 / Na+,Ca2+-交換 / Rho kinase / inotropic response / α-stimulation / Na+,Ca2+-exchange / angiotensin / 鶏胚心筋 / 交換神経α作用 / T-型Ca2+チャネル / K+チャネル / 種差 / Na+,H+-交換反応 / 活動電位プラトー相 / 階段現象 / BigKチャネル / chick embryonic heart / Na+, Ca2+-exchanger / T-type Ca2+ channel / K+ channel / species difference … More
Except Principal Investigator
共焦点レーザー走査顕微鏡 / カルシウムイオン / カルシウムスパーク / 蛍光プローブ / 心筋細胞 / マキシK_<Ca>チャネル / トロンボキサンA_2 / プロスタサイクリン / ブタ冠動脈 / モルモット大動脈 / cAMP / G-蛋白 / 血小板活性化因子 / 1S-メチルPAF / Phospholipass A_2 / Conformational Drug design / 血圧降下剤 / 抗血栓剤 / 抗炎症剤 / PAF抗体 / phospholipase 【A_2】 / L-酒石酸 / Platelet Activating Factor / 1(S)-Me-PAF / Phospholipase A_2 / Drug Design / Anti- hypertensive / Anti-coagulative / Anti-inflammative Less
  • Research Projects

    (16 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (9 People)
  •  Studies on the developmental and species difference of the cardiac function: return to chick embryonic myocardium and the integration of the studyPrincipal Investigator

    • Principal Investigator
      SHIGENOBU Kouki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  Studies on the developmental and species difference of cardiac function : physiological specificity of mouse and generalization of species differencePrincipal Investigator

    • Principal Investigator
      SHIGENOBU Koki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  STUDIES ON THE DEVELOPMENTAL AND SPECIES DIFFERENCE OF CARDIAC FUNCTION: FUNCTIONAL ROLE OF ENDOCARDIAL ENDOTHELIUM AND THE ANALYSIS OF PHYSIOLOGICAL SPECIFICITY OF MOUSE MYOCARDIAPrincipal Investigator

    • Principal Investigator
      SHIGENOBU Koki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  Studies on the developmental and species difference of cardiac function : analysis of pharmacological and physiological specificity of mouse myocardiaPrincipal Investigator

    • Principal Investigator
      KOKI Shigenobu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      TOHO UNIVERSITY
  •  血管作働性物質によるマキシK_<Ca>チャネル修飾機構の分子機序と生理的意義

    • Principal Investigator
      田中 芳夫
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Toho University
  •  Studies on the developmental changes and species difference of cardiac function : analysis of the electrophysiological characteristics and specific responses to alpha-adrenergic stimulation in micePrincipal Investigator

    • Principal Investigator
      KOKI Shigenobu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  発生・発達に伴う心臓機能の変化に関する生理学的・薬理学的研究Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  細胞内カルシウムスパーク現象の分子メカニズムの研究

    • Principal Investigator
      川西 徹
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      国立衛生試験所
  •  モルモット・ラット心筋の発生・発達に伴う電気的特性及び収縮機構の変化-イオンチャネルの変化と収縮へのCa^<2+>sourceの変化:両種の比較-Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  モルモット心筋の発生・発達に伴う電気的特性及び収縮機構の変化Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  モルモット心筋の発生および生後発育に伴う電気的特性および収縮機構の変化-Ion channel の変化と収縮へのCa^<2+>-sourceの変化-Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  心筋の薬物感受性変動を指標としたNeurotrophic Substanceの研究一器官培養法による発展的研究Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  心筋の薬物感受性変動を指標としたNeurotrophic Contralの研究-器官培養法の応用Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Toho University
  •  正常心筋標本を用いたCa^<2+>イオンチャネルのイオン透過性と不活性化気候に関する研究。II発生薬理学的・比較生理学的研究Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      The University of Tokyo
  •  正常心筋標本を用いたCa2+イオンチャネルのイオン透過性と不活性化機構に関する研究Principal Investigator

    • Principal Investigator
      重信 弘毅
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      The University of Tokyo
  •  Construction of Novel Agents having Anti-hypertensive, Nticoaqula- Factors

    • Principal Investigator
      OHNO Masaji
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Faculty of Pharmaceutical Sciences, University of Tokyo

All 2007 2006 2005 2003

All Journal Article

  • [Journal Article] Involvement of the Na^+/Ca^<2+> exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400.2007

    • Author(s)
      Tanaka, H., Shimada, H., Namekata, I., Kawanishi, T., Iida-Tanaka, N., Shigenobu, K
    • Journal Title

      J. Pharmacol. Sci (in press)

    • NAID

      10024312778

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors : possible involvement of store-operated Ca2+ entry.2007

    • Author(s)
      Nishimaru K., Fujiki S., Tanaka Y., Shigenobu K
    • Journal Title

      Pharmacology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2007

    • Author(s)
      Nouchi, H., Kaeriyama, S., Muramatsu, A., Sato, M., Hirose, K., Shimizu, N., Tanaka, H., Shigenobu, K.
    • Journal Title

      J. Pharmacol. Sci 103

      Pages: 75-82

    • NAID

      10024312068

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2007

    • Author(s)
      Nouchi, H., Kaeriyama, S., Muramatsu, A.…, Tanaka, H., Shigenobu, K.
    • Journal Title

      J. Pharmacol. Sci. 103

      Pages: 75-82

    • NAID

      10024312068

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Involvement of the Na^+/Ca^<2+> exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA04002007

    • Author(s)
      Tanaka, H., Shimada, H., Namekata, I.…‥N., Shigenobu, K
    • Journal Title

      J. Pharmacol. Sci. (in press)

    • NAID

      10024312778

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Endocardial endothelium-dependent positive inotropy by Ca2+ pump inhibitors : possible involvement of store-operated Ca2+ entry2007

    • Author(s)
      Nishimaru K., Fujiki S., Tanaka Y., Shigenobu K.
    • Journal Title

      Pharmacology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Quantitative fluorescence measurement of cardiac Na^+/Ca^2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells2006

    • Author(s)
      Namekata, I., Kawanishi, T., Iida-Tanaka, N., Tanaka, H., Shigenobu,K
    • Journal Title

      J.Pharmacol.Sci. 101

      Pages: 356-360

    • NAID

      10018236708

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Muscarinic receptor subtypes mediating positive and negative inotropy in the developing chick ventricle.2006

    • Author(s)
      Nouchi, H., Kaeriyama, S., Muramatsu, A., Tanaka, H., Shigenobu,K.
    • Journal Title

      J.Pharmacol.Sci. 103

      Pages: 75-82

    • NAID

      10024312068

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca^2+ overload.2006

    • Author(s)
      Namekata, I., Shimada, H., Kawanishi, T., Tanaka, H., Shigenobu,K
    • Journal Title

      Eur.J.Pharmacol., 533

      Pages: 108-115

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Enhancement of methoxamine-induced contractile responses of rat ventricle in streptozotocin-induced diabetes is associated with α 1A adrenoceptor upregulation.2006

    • Author(s)
      Kamata, K., Satoh, T., Matsumoto, T., Tanaka, H., Shigenobu,K.
    • Journal Title

      Acta. Physiol. Scand 188

      Pages: 173-183

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a apecific inhibitor of Na+-Ca2+ exchanger.2005

    • Author(s)
      Tanaka, H., Namekata, I., - - -., Shigenobu, K.
    • Journal Title

      Naunyn-Schmiedeberg's Arch.Pharmacol., 371

      Pages: 526-534

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Pharmacological properties of the developing chick myocardium.2005

    • Author(s)
      Nouchi, H., Tanaka, H., Shigenobu, K.
    • Journal Title

      Trends in Comparative Biochem & Physiol 11

      Pages: 37-45

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Pharmacological properties of the developing chick myocardium2005

    • Author(s)
      Nouchi, H., Tanaka, H., Shigenobu, K.
    • Journal Title

      Trends in Comparative Biochem & Physiol 11

      Pages: 37-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger.2005

    • Author(s)
      Tanaka, H., Namekata, I., Takeda, K., Kazama, A., Shimizu, Y., Moriwaki, R., Hirayama, W., Sato, A., Kawanishi, T., Shigenobu, K.
    • Journal Title

      Naunyn-Schmiedeberg's Arch., Pharmacol. 371

      Pages: 526-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] T-type calcium channels and drug development.2005

    • Author(s)
      Tanaka H, Shigenobu K.
    • Journal Title

      J. Pharmacol. Sci. 99

      Pages: 214-220

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Comparison of the inhibitory effects of docosahexenoic acid (DHA) on U46619- and phnylephrine-induced contractions in guinea-pig aorta.2005

    • Author(s)
      Otsuka, K., Tanaka, Y., Tanaka, H., Koike, K., Shigenobu, K.
    • Journal Title

      Biol.Pharm.Bull. 28

      Pages: 1298-2300

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractory period and action potential duration in guinea pig myocardium.2005

    • Author(s)
      Mtsuda, T., Takeda, K, - - - - Shigenobu, K
    • Journal Title

      J.Pharmacol.Sci. 98

      Pages: 33-40

    • NAID

      10025727826

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium.2005

    • Author(s)
      Namekata, I., Nakamura, H., Shimada, H., Tanaka, H., Shigenobu, K.
    • Journal Title

      Life Sciences 77

      Pages: 312-324

    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger.2005

    • Author(s)
      Tanaka, H., Namekata, I., Takeda, K., Kazama, …T., Shigenobu, K.
    • Journal Title

      Naunyn-Schmiedeberg's Arch. Pharmacol. 371

      Pages: 526-534

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590229
  • [Journal Article] Species difference in myocardial excitation-contractin coupling featuring the mouse2003

    • Author(s)
      Tanaka, H., Shigenobu, K.
    • Journal Title

      Current Topics in Pharmacology Vol.7

      Pages: 247-256

    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Atrio-ventricular difference in myocardial excitation-contraction coupling-influence of T-tubules and endocardial endothelium.2003

    • Author(s)
      Tanaka, H., Kawanishi, T., Shigenobu, K.
    • Journal Title

      Recent Res.Devel.Physiol. 1

      Pages: 253-262

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Optical bioimaging : from living tissue to a single molecule : atrio-ventricular difference in myocardial excitation-contraction coupling-sequential versus simultaneous activation of SR Ca2+ release units.2003

    • Author(s)
      Tanaka, H., Kawanishi, T., Shigenobu, K.
    • Journal Title

      J.Pharmacol.Sci. 93

      Pages: 248-252

    • NAID

      10012544819

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Inhibition of agonist-induced positive inotropy by a selective Rho-associated kinase inhibitor, Y-27632.2003

    • Author(s)
      Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
    • Journal Title

      J.Pharmacol.Sci. 92

    • NAID

      130000073980

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Optical bioimaging : from living tissue to a single molecule : atrio-ventricular difference in myocardial excitation-contraction coupling - sequential versus simultaneous activation of SR Ca2+ release units.2003

    • Author(s)
      Tanaka, H., Kawanishi, T., Shigenobu, K.
    • Journal Title

      Journal of Pharmacological Sciences 93

      Pages: 248-252

    • NAID

      10012544819

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Inhibition of agonist-induced positive inotropy by a selective Rho-associated kinase inhibitor, Y-27632.2003

    • Author(s)
      Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
    • Journal Title

      Journal of Pharmacological Sciences 92

      Pages: 424-427

    • NAID

      130000073980

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor mediated negative inotropy in adult mouse ventricle.2003

    • Author(s)
      Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
    • Journal Title

      J.Pharmacol.Sci. 92

      Pages: 196-202

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Species difference in myocardial excitation-contraction coupling featuring the mouse.2003

    • Author(s)
      Tanaka, H., Shigenobu, K.
    • Journal Title

      Current Topics in Pharmacology 7

      Pages: 247-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Species difference in myocardial excitation-contraction coupling featuring the mouse.2003

    • Author(s)
      Tanaka, H., Kawanishi, T., Shigenobu, K.
    • Journal Title

      Current Topics in Pharmacology 7

      Pages: 247-256

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • [Journal Article] Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor mediated negative inotropy in adult mouse ventricle.2003

    • Author(s)
      Nishimaru, K., Tanaka, Y., Tanaka, H., Shigenobu, K.
    • Journal Title

      Journal of Pharmacological Sciences 92

      Pages: 196-202

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590235
  • 1.  OHNO Masaji (00111550)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  WAKU Keizo (90013854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  INOUE Keizo (30072937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  NOJIMA Shoshichi (70090470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  川西 徹 (40124383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  早川 堯夫 (50124392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  田中 芳夫 (60188349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  森 弘
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MORI Hiroshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to connect your ORCID iD to this researcher?
* This action can be performed only by the researcher themselves.

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi