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AKASAKA Kazuyuki  赤坂 一之

ORCIDConnect your ORCID iD *help
Researcher Number 50025368
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2017: 近畿大学, 先端技術総合研究所, 教授
2014: 近畿大学, 先端技術総合研究所, 客員教授
2012 – 2014: 近畿大学, 先端技術総合研究所, 教授
2002 – 2007: 近畿大学, 生物理工学部, 教授
2001 – 2003: 神戸大学, 自然科学研究科, 教授 … More
1997 – 2000: 神戸大学, 大学院・自然科学研究科, 教授
1998: 神戸大学, 大学院自然科学研究科, 教授
1992 – 1996: KOBE UNIVERSITY PROFESSOR, 理学部, 教授
1986 – 1991: 京都大学, 理学部, 助教授
1986: 京大, 理学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Biophysics / 生物物性学 / Science and Engineering / 構造化学 / Physical chemistry / Structural biochemistry
Except Principal Investigator
Biophysics / Organic chemistry / 広領域 / 物理化学一般 / Biophysics / Anesthesiology/Resuscitation studies / 応用生物化学・栄養化学
Keywords
Principal Investigator
NMR / 高圧NMR / 温度ジャンプ / 低温変性 / 高圧 / 蛋白質 / 化学シフト / high pressure NMR / BPTI / 二次元NMR … More / ミオグロビン / 円二色性 / 圧力変性 / 水素結合 / マイクロ波 / リボヌクレアーゼA / 相転移 / タンパク質 / 水和 / リゾチーム / SSI / ニワトリリゾチーム / 圧力解離 / 活性化体積 / 内部運動 / NOE / 揺らぎ / 主鎖コンフォメーション / アンフォールディング / 状態相関二次元NMR / タンパク質構造転移 / タンパク質変性 / リボヌクレア-ゼA / マイクロ波加熱 / 液晶 / タンパク質の熱変性 / 金属タンパク質 / 高次構造形成 / 温度ジュンプ / 抵温変性 / 高次構造 / アポミオグロビン / リボクヌレアーゼA / 体積変化 / 比熱変化 / ヘリックス / スピン緩和 / メリチン / バクテリオロドプシン / グルマリン / ユビキチン / NEDD8 / 熱励起構造 / 準安定構造 / 局所変性構造 / 可変圧力NMR / 分子内キャビティー / キャビティー計算プログラム / キャビティーの水和 / キャビティーの進化的設計 / ユービキチンの構造揺らぎ / 構造揺らぎの可視化 / 加圧下の立体構造解析 / 遅い構造の揺らぎ / アミロイド線維 / プロトフィブリル形成 / 熱変性 / シード / 部分モル体積変化 / アミロイド線維の成長機構 / SS結合欠損変異 / アミロイド / プロトフィブリル / 活性化圧縮率 / recAタンパク質 / ATP-δ-S / 一重鎖DNA / 自己会合 / 温度ジャンプNMR / 生体高分子の相転移 / タンパク質の巻き戻り / タンパク質高次構造の崩れ / RNase A / recAタンパク質の内部運動領域 / recAタンパク質のカルボキシル末端断片 / recAタンパク質とATP-γ-Sとの結合 / recAタンパク質と一重鎖DNAとの結合 / ^1HNMR / ^<31>PNMR / x線溶液散乱 / 円二色性分光 / メタノール変性 / シトクロームC / サチライシンインヒビター / リボヌクレアーゼ / X線溶液散乱 / Streptomyces Subtilisin Inhibitor / Cytochrome c / 膜融合ペプチド / タンパク質の構造 / タンパク質の変性 / S-S結合 / X線小角散乱 / x ray scattering / circular dichroism / cold denaturation / pressure denaturation / temperature jump / denaturation by methanol / 圧力ジャンプ / 変性 / 構造変化 / 蛋白質変性 / 蛋白質構造 / ケト-エノール平衡 / プロトンNMR / 高圧変性 / Ribonuclease A. / 熱力学 / 小角x線散乱 / HIGH PRESSURE / PRESSURE JUMP / DENATURATION / STRUCTURAL CHANGES / PROTEIN STRUCTIRE / ウシ脾臓トリブシンインヒビター / N-15 NMR / 牛脾臓トリプシンインヒビター / 15N pressure shift / shortening of hydrogen bond / 13C pressure shift / conformational flexibility / 1H pressure shift / 主鎖コンフォーメーション / 核オーバーハウザー効果 / 立体構造 / protein structure / 15N chemical shift / hydrogen bond / conformational change / local unfolding / ジヒドロ葉酸還元酵素 / 圧縮率 / 原子間の空間 / ゆらぎ / 酵素機能 / "open"構造 / 原子間の空隙 / NMR化学シフト / モジュール / 蛋白質立体構造 / dihydrofolate reductase / compressibility / cavity / flexibility / enzyme function / アミロイドプロトフィブリル / 圧力ジャンプNMR / 高圧蛍光 / プロトフィブリルの圧力解離 / 解離の活性化体積 / 変異型トランスサイレチン / トランスサイレチンの熱力学安定 / ニワトリリゾチームのS-S / 圧力によるプロトフィブリルの解 / プロトフィブリル解離の活性化体 / トランスサイレチンの変異型 / ニワトリリゾチーム変異体 / 原子間顕微鏡 / amyloid protofibril / hen lysozyme / pressure-jump NMR / high pressure fluorescence / pressure dissociation of protofibrils / activation volume for dissociation / transthyretin mutant / thermodynamic stability of transthyretin / タンパク質の内部運動 / タンパク質の同位体標識 / 遺伝子工学 / 重水素NMR / ズブチリシンインヒビター / 酵素-阻害剤相互作用 / プロテアーゼインヒビター / 個体タンパク質の水和 / 重水素化タンパク質 / トリプトファン / 重水素化 / 放線菌 / 微生物培養 / Internal motions in proteins / Stable isotope labeling of proteins / Site-directed mutagenesis / Deuterium NMR / Subtilisin inhibitor … More
Except Principal Investigator
高圧NMR / 揺らぎ / 遺伝子工学 / NMR / 圧力効果 / 準安定状態 / 抗体 / 蛋白質 / 核磁気共鳴 / プロテアーゼ・インヒビター / gene engineering / 産業経済 / 自然と人工 / high pressure NMR / NGF / PrP106-126 / プロテアーゼインヒビター / ジメトキシパラシクロファン / リボヌクレアーゼA / 分子内回転 / 高圧石英セル / アセチルアセトン / ケト・エノール平衡 / プリオン蛋白質 / プリオン病 / 抗プリオン化合物 / 創薬 / 高圧 / 分子シミュレーション / 拡張アンサンブル法 / 蛋白質構造 / 反応座標 / 構造空間探索 / 蛋白質フォールディング / フォールディング / 分子動力学シミュレーション / DNA結合蛋白質 / X線結晶構造解析 / 蛋白工学 / 酵素阻害剤 / 部位指定変異 / バクテリア / 蛋白質の機能部位 / 蛋白質の構造 / 阜ロテイーゼ・インヒビター / プロテア-ゼ・インヒビタ- / protein engineering / enzyme inhibitor / protease inhibitor / site-directed mutagenesis / bacteria / functional site in a protein / protein structure / 自然と人間生活 / 文化人類学 / 文化交流 / 学際研究 / 環境と資源問題 / 21世紀の都市のイメージ / EC統合 / 自然と人為 / 日伊関係 / 文学・芸術・生活 / ルネッサンス / クロスカルチャ- / Nature and human life / Industrial economics / Anthropology / Cross culture / Interdisciplinary research / Nature and artifact / Environmental and resources constraint / Image of cities in 21st century / 二次元NMR / 液晶 / マイクロ波 / 温度ジャンプNMR / 相転移 / 双極子パターン / 双極子パタ-ン / 2D NMR / liquid crystal / microwave / temperature jump NMR / phase transition / dipolar pattern / 京都 / シエナシンポジウム / 自然科学部門 / 文学・芸術・人間学部門 / 法・経済学部門 / 岩倉使節団展 / 盆栽と写真展 / レオナルド以前展覧会 / レオナルド以前のレオナルド展覧会 / 学際領域研究 / 人間生活 / 人間学 / 異文化交流 / 文化交流人類学 / イメージ / Kyoto / Siena Symposium / Science Session / Humanity Session / Law / Economy Session Diplomatic Mission Exhibition / Bonsai and Artistic Photo Exhibition Prima di Leonardo Exhibition / Leonardo Prima di Leonardo Exhibition / 蛋白質折り畳み / モルテングロビュール / X線溶液散乱 / 蛋白質の変性 / ストップトフローCD / シャペロニン / 蛋白質変性 / 変性 / 静電的相互作用 / 疎水的相互作用 / 蛋白質非天然構造 / protein folding / molten globule / X-ray solution scattering / protein denturation / stopped-flow CD / chaperonine / 高圧NMRセル / 石英高圧セル / パラシクロファン / 活性化体積 / 圧力変形 / high pressure NMR cell / high pressure quartz cell / paracyclophane / pressure effects / activation volume / pressure-induced molecular deformation / 麻酔 / ガス麻酔薬 / 揮発性麻酔薬 / GABA_A受容体 / NMDA受容体 / nACh受容体 / 5-HT_3受容体 / GABAA受容体 / 麻酔薬 / ブピバカイン / 5-HT3受容体 / プロカイン / リドカイン / 亜酸化窒素 / キセノン / trk受容体 / Ras / 全身麻酔 / Anesthesia / Gaseous Anesthetics / volatile anesthetics / GABA_A Receptor / NMDA Receptor / nACh Receptor / 5-HT_3 Receptor / ブリオン / 中間体 / オリゴマー / NMR緩和時間 / 数論 / 生命科学理論 / 構造形成過程 / プリオン / パルス・ラベル / トレース公式 / 緩和時間 / 安定性 / ダイナミクス / リゾチーム / ユビキチン / 超高速パルスラベル / 活性型立体構造 / 高圧ジャンプ / ミリ秒揺らぎ / prion / high-pressure / CPMG relaxation / causative mutation / protein dynamics / number theory / プロテアーゼ / アミノアミルtRNA合成酵素 / アミラーゼ / 酵素一基質相互作用 / 蛍光滴定 / ストップトフロー / アミノアシルtRNA合成酵素 / 酵素ー基質相互作用 / 核磁気共鳴法 / 蛍光滴定法 / 化学修飾 / 酵素-基質相互作用 / 誘導適合 / 酵素 / グルコアミラーゼ / 基質特異性 / 蛋白質蛍光 / ストレプトミセス・ズブチリシン・インヒビター(SSI) / Proteases / Aminoacyl-tRNA synthetases / Amylases / Protease inhibitors / Enzyme-substrate interactions / Fluorescence titration / Stopped-flow method / 蛋白質工学 / プロテア-ゼインヒビタ- / ズブチリシンインヒビタ- / 金属プロテア-ゼインヒビタ- / 蛋白質の核磁気共鳴 / 蛋白質のX線結晶解析 / 酵素-インヒビタ-相互作用 / ズブチリシンインヒビター / 金属プロテアーゼインヒビター / 酵素-インヒビター相互作用 / 酵素ーインヒビター相互作用 / Protein Engineering / Site-directed Mutagenesis / Proteinase Inhibitor / Subtilisin Inhibitor / Metallo-proteinase Inhibitor / NMR of Proteins / X-ray Crystallography of Protein / Interaction of Enzyme and its inhibitor / 濃度ゆらぎ / 密度ゆらぎ / 化学反応 / 光散乱法 / 二成分溶液 / 局所電場 / 平衝定数 / レイリー散乱 / 放射線化学反応 / 電離 / 二成分溶液系 / ブリルアン散乱 / 溶液 / concentration fluctuation / density fluctuation / chemical processes / binary solutions / light scattering / local field / equilibrium constant / Rayleigh scattering / タンパク質 / 抗原認識機構 Less
  • Research Projects

    (35 results)
  • Research Products

    (46 results)
  • Co-Researchers

    (83 People)
  •  Understanding of antigen recognition mechanism of multispecific antibodies

    • Principal Investigator
      KAMATARI Yuji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biophysics
    • Research Institution
      Gifu University
  •  Inhibition of a prion conversion by suppressing protein fluctuations using small-molecules

    • Principal Investigator
      KAMATARI Yuji O.
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biophysics
    • Research Institution
      Gifu University
  •  A hybrid extended ensemble simulation study on the folding process of proteins

    • Principal Investigator
      YONEZAWA Yasushige
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biophysics
    • Research Institution
      Kinki University
  •  圧力軸実験を主とするアミロイド形成と解離メカニズムの研究Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Kinki University
  •  蛋白質の水和と熱励起構造Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Kinki University
  •  INVESTIGATION OF THE MECHANISM OF AMYLOID FIBRIL FORMATION FROM PRESSURE EXPERIMENTSPrincipal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      KINKI UNIVERSITY
  •  New Concept on the Phase Space of the Protein : Experiments and Theory

    • Principal Investigator
      KUWATA Kazuo
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      Gifu University
  •  Effects of general anesthetics on molecular dynamics and conformation of neuronal receptor channel protains - Molecular mechanism of general anesthesia -

    • Principal Investigator
      MASHIMO Takashi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Osaka University
  •  New Development of Protein Research Based on Interatomic CavityPrincipal Investigator

    • Principal Investigator
      GEKKO Kunihiko, 赤坂 一之
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      Hiroshima University
      Kobe University
  •  蛋白質の基本構造に対する圧力効果Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kobe University
  •  High Pressure NMR Study on the Control of Organic Chemical Reaction by Pressure.

    • Principal Investigator
      YAMADA Hiroaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Organic chemistry
    • Research Institution
      Kobe University
  •  蛋白質立体構造安定性に及ぼす圧力効果Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  Joint research on structural fluctuations in proteins-Studied by hydrogen isotope exchange and high pressure NMRPrincipal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biophysics
    • Research Institution
      Kobe University
  •  NMR Analysis of Pressure-Induced Structural Changes in PrioteinsPrincipal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      KOBE UNIVERSITY
  •  蛋白質変性に対する圧力効果Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  高圧力の印加による有機反応の加速と制御の基礎的研究

    • Principal Investigator
      山田 博昭
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Organic chemistry
    • Research Institution
      Kobe University
  •  Structures and Formation Mechanisms of Folding Intermediates of Proteins

    • Principal Investigator
      KATAOKA Mikio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Biophysics
    • Research Institution
      Osaka University
  •  DEVELOPMENT OF A PRESSURE-JUMP NMR APPARATUSPrincipal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Physical chemistry
    • Research Institution
      DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
  •  温度ジャンプNMRによるヘムタンパク質の構造形成過程Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  JAPAN-ITALY PROGRAM ON FRONTIER FIELDS -NATURE AND HUMAN LIFE-

    • Principal Investigator
      IMANISHI Yukio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kyoto University
  •  STUDIES ON NON-NATIVE STRUCTURES OF PROTEINSPrincipal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Biophysics
    • Research Institution
      DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
  •  温度ジャンプNMRによるヘムタンパク質多元構造のダイナミックスPrincipal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  温度ジャンプNMRを用いた金属タンパク質の多元的構造と反応過程制御の研究Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  Japan-Italy Program on Frontier Fields Nature and Human Life

    • Principal Investigator
      IMANISHI Yukio
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kyoto University
  •  Determination of structure and dynamics of liquid crystalline molecules by state-correlated 2D NMR spectroscopy

    • Principal Investigator
      NAITO Akira
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物理化学一般
    • Research Institution
      HIMEJI INSTITUTE OF TECHNOLOGY
  •  高速温度ジャンプNMR装置の開発とそのタンパク質構造転移への応用Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      生物物性学
    • Research Institution
      Kobe University
      Kyoto University
  •  Research on the structure required for function of protease inhibitor proteins produced by bacteria by protein engineering

    • Principal Investigator
      MIURA Kin-ichiro
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      広領域
    • Research Institution
      GAKUSHUIN UNIVERSITY, FACULTY OF SCIENCE(INSTITUTE FOR BIOMOLECULAR SCIENCE)
      The University of Tokyo
  •  Effect of Molecular Structure on Radiation-Induced Processes in Condensed Phase

    • Principal Investigator
      SHIDA Tadamasa
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      物理化学一般
    • Research Institution
      KYOTO UNIVERSITY
  •  recAタンパク質の動的構造と機能Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyoto University
  •  Multi-disciplinary Studies with Protein Engineering Approaches on Proteinaceous Proteinase Inhibitors of Microbial Origin

    • Principal Investigator
      HIROMI Keitaro
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      広領域
    • Research Institution
      Kyoto University
  •  核酸-蛋白質相互作用のX線,NMRによる研究

    • Principal Investigator
      田中 勲
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Nagoya University
  •  reCAタンパク質の動的構造と機能Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyoto University
  •  相転移を利用した二次元NMR分光法の開発Principal Investigator

    • Principal Investigator
      赤坂 一之
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      構造化学
    • Research Institution
      Kyoto University
  •  Quantitative analysis of internal motions in proteins.Principal Investigator

    • Principal Investigator
      AKASAKA Kazuyuki
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      生物物性学
    • Research Institution
      Kyoto University
  •  Dynamic Analysis of Enzyme Functions

    • Principal Investigator
      HIROMI Keitaro
    • Project Period (FY)
      1985 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      Kyoto University

All 2016 2015 2014 2013 2012 2008 2007 2006 2005 2004 2002

All Journal Article Presentation Book

  • [Book] 「第13章 揺らぐ蛋白質構造を捉える-高圧NMR」(CSJカレントレビュー 第17号『極限環境の生命科学』)2014

    • Author(s)
      赤坂一之, 前野覚大
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Book] 第2節タンパク質(進化する食品高圧加工技術~基礎から最新の応用事例まで~)2013

    • Author(s)
      赤坂一之・前野覚大
    • Total Pages
      314
    • Publisher
      エヌ・ティー・エス社
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Book] 「9章 高圧力NMR」(寺島正秀編:揺らぎ・ダイナミクスと生体機能)2013

    • Author(s)
      北原 亮、赤坂一之
    • Total Pages
      368
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Book] Protein Folding Protocols in Methods in Molecular Biology Vol.350 (edited by Yawen Bai and Ruth Nussinov) (Humana Press Inc.)2006

    • Author(s)
      赤坂一之 (M.Lassalle)
    • Publisher
      The Use of High pressure NMR to Study in Protein Folding
    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] Application of high pressure NMR in the study of protein structure and dynamics2016

    • Author(s)
      H. Li,Y. O. Kamatari,R. Kitahara,K. Akasaka
    • Journal Title

      Chinese Journal of Magnetic Resonance

      Volume: 33 Pages: 1-26

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07024
  • [Journal Article] Structural fluctuation of proteins induced by thermodynamic perturbation2015

    • Author(s)
      Fumio Hirata, Kazuyuki Akasaka
    • Journal Title

      J. Chem. Phys.

      Volume: 142

    • DOI

      10.1063/1.4906071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4Lysozyme2015

    • Author(s)
      Maeno A, Sindhikara D, Hirata F, Otten R, Dahlquist FW, Yokoyama S, Akasaka K, Mulder FA, Kitahara R.
    • Journal Title

      Biophysical Journal

      Volume: 108 Pages: 133-145

    • DOI

      10.1016/j.bpj.2014.11.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025
  • [Journal Article] Pressure and Protein Dynamism2014

    • Author(s)
      K. Akasaka
    • Journal Title

      High Pressure Research

      Volume: 34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] Pressure-assisted dissociation and degradation of “proteinase K-resistant” fibrils prepared by seeding with scrapie-infected hamster prion protein2014

    • Author(s)
      Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R.
    • Journal Title

      Prion

      Volume: 8(4) Pages: 314-318

    • DOI

      10.4161/pri.32081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25450444, KAKENHI-PROJECT-25640029
  • [Journal Article] Tyrosine/tyrosinate fluorescence at 700MPa: A pressure unfolding study of chicken ovomucoid at pH122013

    • Author(s)
      Maeno A, Matsuo H, Akasaka K.
    • Journal Title

      Biophys Chem.

      Volume: 183 Pages: 57-63

    • DOI

      10.1016/j.bpc.2013.07.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] 高圧NMR で探る蛋白質のダイナミズム2013

    • Author(s)
      赤坂一之
    • Journal Title

      高圧力の科学と技術

      Volume: 23 Pages: 3-12

    • NAID

      10031156142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] 高圧NMRで探る蛋白質のダイナミズム2013

    • Author(s)
      赤坂一之
    • Journal Title

      高圧力の科学と技術

      Volume: 23 Pages: 3-13

    • NAID

      10031156142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] Exploring the folding energy landscape with pressure2013

    • Author(s)
      K. Akasaka, R. Kitahara, Y. O. Kamatari
    • Journal Title

      Archives of biochemistry and biophysics

      Volume: 531 Pages: 110-115

    • DOI

      10.1016/j.abb.2012.11.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180, KAKENHI-PUBLICLY-23107729
  • [Journal Article] Pressure-induced chemical shifts as probes for conformational fluctuations2013

    • Author(s)
      Kitahara R, Hata K, Li H, Williamson MP, Akasaka K.
    • Journal Title

      Progress in nuclear magnetic resonance spectroscopy

      Volume: 71 Pages: 35-58

    • DOI

      10.1016/j.pnmrs.2012.12.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025, KAKENHI-PUBLICLY-23107729
  • [Journal Article] 高圧蛋白質NMR2012

    • Author(s)
      赤坂一之
    • Journal Title

      NMR (Bulletin of the Nuclear Magnetic Resonance Society of Japan)

      Volume: 3 Pages: 38-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Journal Article] Direct Evidence of Generation and Accumulation of β-Sheet-rich Prion Protein in Scrapie-infected Neuroblastoma Cells with Human IgG1 Antibody Specific for β-Form Prion Protein2012

    • Author(s)
      Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura.
    • Journal Title

      The journal of biological chemistry.

      Volume: 287巻 Pages: 14023-14039

    • DOI

      10.1074/jbc.m111.318352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790435, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482
  • [Journal Article] Novel aspects of protein conformational fluctuations revealed by variable pressure NMR2007

    • Author(s)
      Kazuyuki Akasaka
    • Journal Title

      High Pressure Bioscience and Biotechnology Proceedings of the 4th International Conference on High Pressure Bioscience and Biotechnology 1

      Pages: 8-12

    • NAID

      130004951208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] Pressure dissociation kinetics of amyloid protofibrils.2007

    • Author(s)
      赤坂一之, 橘 秀樹 (Abdul Raziq Abdul Latif)
    • Journal Title

      Biophysical Journal 94

      Pages: 323-329

    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] Amyloid protofibril is highly voluminous and compressible.2007

    • Author(s)
      Kazuyuki Akasaka
    • Journal Title

      Biochemistry 46

      Pages: 10444-10450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006

    • Author(s)
      Hua, L., Akasaka, K.
    • Journal Title

      Biochim.Biophys.Acta (Special issue) (In press)

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation.2006

    • Author(s)
      赤坂一之 (K.Akasaka)
    • Journal Title

      Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (Guest Editor : A. Joshua Wand) 108

      Pages: 1814-1835

    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006

    • Author(s)
      Hua, L., Akasaka, K.
    • Journal Title

      Biochim.Biophys.Acta (Special issue) (in press)

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] The use of high pressure NMR to study protein folding.2006

    • Author(s)
      Lassalle, M.W., Akasaka, K.
    • Journal Title

      Method in Molecular Biology (in press)

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006

    • Author(s)
      K.Akasaka
    • Journal Title

      Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006

    • Author(s)
      赤坂一之 (H. Li)
    • Journal Title

      Biochimica et Biophysica Acta 1764

      Pages: 331-345

    • Data Source
      KAKENHI-PROJECT-18031040
  • [Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築。2006

    • Author(s)
      北原 亮, 横山茂之, 赤坂一之
    • Journal Title

      分光研究 55・1

      Pages: 10-20

    • NAID

      10016735137

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] Cold denaturation of ubiquitin at high pressure2006

    • Author(s)
      Kitahara R., Okuno, A., Kato, M., Taniguchi Y., Yokoyama, S., Akasaka, K.
    • Journal Title

      Magnetic Resonance in Chemistry. (In press)

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006

    • Author(s)
      K.Akasaka
    • Journal Title

      Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築2006

    • Author(s)
      北原亮, 横山茂之, 赤坂一之
    • Journal Title

      分光研究 55・1

      Pages: 10-20

    • NAID

      10016735137

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] NMR snapshots of a fluctuating protein structure. Ubiquitin at 30 bar - 3kbar2005

    • Author(s)
      Ryo Kitahara, Shigeyuki Yokoyama Kazuyuki Akasaka
    • Journal Title

      Journal of Molecular Biology 347

      Pages: 277-285

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] Pressure-jump NMR study of dissociation and association of amyloid protofibrils.2005

    • Author(s)
      Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K.
    • Journal Title

      Journal of Molecular Biology 349

      Pages: 916-921

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] Pressure jump NMR study of dissociation and association of amyloid protofibrils.2005

    • Author(s)
      Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K
    • Journal Title

      Journal of Molecular Biology 349

      Pages: 916-921

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] Slow conformational dynamics in the Hamster prion protein.2004

    • Author(s)
      Kazuo Kuwata, Yuji O.Kamatari, Kazuyuki Akasaka, Thomas L.James
    • Journal Title

      Biochemistry 43

      Pages: 4439-4446

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] Infrequent cavity-forming fluctuations in HPr from Staphylococcus carnosus revealed by pressure and temperature-dependent tyrosine ring-flips.2004

    • Author(s)
      Mineyuki Hattori, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka
    • Journal Title

      Protein Science 13

      Pages: 3104-3114

    • Data Source
      KAKENHI-PROJECT-16041244
  • [Journal Article] Pressure-dissociable reversible assembly of naturally denatured lysozyme is a precursor for amyloid fibrils.2004

    • Author(s)
      Tara N.Niraula, Takashi Konno, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka, Hideki Tachibana
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 4089-4093

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] 可変圧力NMRが明かす蛋白質の新しい概念2004

    • Author(s)
      赤坂一之
    • Journal Title

      高圧力の科学と技術 13

      Pages: 328-334

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] High pressure NMR spectroscopy for characterizing non-native conformers of proteins2004

    • Author(s)
      Y.O.Kamatari, R.Kitahara, H.Yamada, S.Yokoyama, K.Akasaka
    • Journal Title

      Methods 34

      Pages: 133-143

    • Data Source
      KAKENHI-PROJECT-16370054
  • [Journal Article] High-Pressure NMR offers the new view of the protein structure.2002

    • Author(s)
      Kazuyuki Akasaka
    • Journal Title

      Seibutu Buturi 42(5)

      Pages: 206-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380314
  • [Journal Article] 解説 新しいタンパク質構造の世界をひらく高圧NMR2002

    • Author(s)
      赤坂一之
    • Journal Title

      生物物理 42

      Pages: 206-211

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14380314
  • [Presentation] タンパク質機能発現におけるキャビティの重要性2014

    • Author(s)
      鎌足雄司, 赤坂一之, 李華
    • Organizer
      第14回日本蛋白質科学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-06-27
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] “非生物的揺らぎ”から“生物的揺らぎ”へ:そのからくりを問う。シンポジウム:生物ダイナミズムの源泉を問う―“非生物的揺らぎ”が生み出す“生物的揺らぎ”2013

    • Author(s)
      赤坂一之
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] 分子動力学法を用いた高圧下におけるc-Myb タンパク質とキャビティ内水分子の変動解析2013

    • Author(s)
      曽我部 拓哉, 吉田 久, 赤坂 一之
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] Revealing protein dynamics with high-pressure NMR2013

    • Author(s)
      Kazuyuki Akasaka
    • Organizer
      European High Pressure Research Group International Meeting (EHPRG51)
    • Place of Presentation
      London, UK
    • Invited
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] タンパク質の揺らぎの源としてのキャビティと水和2013

    • Author(s)
      鎌足雄司, 李華, 赤坂一之
    • Organizer
      第18回 生物関連高圧研究会シンポジウム
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] システインの添加が高圧下フィシン処理鶏卵白アレルゲンの分解性の向上とアレルゲン性の低減に及ぼす影響2013

    • Author(s)
      蛭田あゆみ, 原崇, 赤坂一之, 西海理之
    • Organizer
      第18回 生物関連高圧研究会シンポジウム
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24570180
  • [Presentation] Pressure and the Protein World2008

    • Author(s)
      Kazuyuki Akasaka
    • Organizer
      Proteins Under Pressure
    • Place of Presentation
      Santa Fe, USA
    • Data Source
      KAKENHI-PROJECT-18031040
  • 1.  YAMADA Hiroaki (90030767)
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  • 51.  OHMAE Eiji (30284152)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  GO Michiko (70037290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  MASHIMO Takashi (60157188)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 54.  UCHIDA Ichiro (00232843)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  SAKO Yasushi (20215700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 56.  YANAGIDA Toshio (30089883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  ANDO Yukio (20253742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 58.  OHNISHI Masatake (90026576)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 59.  ISHII Shin-ichi (90001031)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 60.  SHIDA Tadamasa (60025484)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 61.  MOMOSE Takamasa (10200354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 62.  KATO Tatsuhisa (80175702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 63.  ISHIGURO Naotaka (00109521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 64.  田中 勲 (70093052)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 65.  西村 信哉 (00263286)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 66.  MARCHIANO Grazia
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 67.  WOODWARD Clare K.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 68.  北原 亮
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 69.  LIONELLO F.P
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 70.  ELENA BUSI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 71.  BUSI Elena
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 72.  MRCHIANO Grazia
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 73.  PUNZO Lionello F.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 74.  SANDRO Brioc
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 75.  FRANCO Punzo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 76.  PUNZO Lionello farnco
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 77.  LIONELLO Fra
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 78.  CLARE K. Woo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 79.  ISHIBASHI Ishibashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 80.  ATARASHI Ryuichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 81.  YAMANAKA Hitoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 82.  橋口 周平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 83.  西田 教行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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