Akasaka Kazuyuki 赤坂一之

… Alternative Names

Researcher Number	50025368
Other IDs
External Links
Affiliation (Current)	2019: 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 2019: 京都府立大学, 生命環境科学研究科, 特任教授 2019: 近畿大学, 付置研究所, 教授
Affiliation (based on the past Project Information) *help	2017: 近畿大学, 先端技術総合研究所, 教授 2014: 近畿大学, 先端技術総合研究所, 客員教授 2012 – 2014: 近畿大学, 先端技術総合研究所, 教授 2002 – 2007: 近畿大学, 生物理工学部, 教授 2001 – 2003: 神戸大学, 自然科学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Biophysics / 生物物性学 / Science and Engineering / 構造化学 / Physical chemistry / Structural biochemistry Except Principal Investigator Biophysics / Organic chemistry / 広領域 / 物理化学一般 / Biophysics / Anesthesiology/Resuscitation studies / 応用生物化学・栄養化学
Keywords	Principal Investigator NMR / 高圧NMR / 温度ジャンプ / 低温変性 / 高圧 / 蛋白質 / 化学シフト / high pressure NMR / BPTI / 二次元NMR … More Except Principal Investigator 高圧NMR / 揺らぎ / 遺伝子工学 / NMR / 圧力効果 / 準安定状態 / 抗体 / 蛋白質 / 核磁気共鳴 / プロテアーゼ・インヒビター / gene engineering / 産業経済 / 自然と人工 / high pressure NMR / NGF / PrP106-126 / プロテアーゼインヒビター / ジメトキシパラシクロファン / リボヌクレアーゼA / 分子内回転 / 高圧石英セル / アセチルアセトン / ケト・エノール平衡 / プリオン蛋白質 / プリオン病 / 抗プリオン化合物 / 創薬 / 高圧 / 分子シミュレーション / 拡張アンサンブル法 / 蛋白質構造 / 反応座標 / 構造空間探索 / 蛋白質フォールディング / フォールディング / 分子動力学シミュレーション / DNA結合蛋白質 / X線結晶構造解析 / 蛋白工学 / 酵素阻害剤 / 部位指定変異 / バクテリア / 蛋白質の機能部位 / 蛋白質の構造 / 阜ロテイーゼ・インヒビター / プロテア-ゼ・インヒビタ- / protein engineering / enzyme inhibitor / protease inhibitor / site-directed mutagenesis / bacteria / functional site in a protein / protein structure / 自然と人間生活 / 文化人類学 / 文化交流 / 学際研究 / 環境と資源問題 / 21世紀の都市のイメージ / EC統合 / 自然と人為 / 日伊関係 / 文学・芸術・生活 / ルネッサンス / クロスカルチャ- / Nature and human life / Industrial economics / Anthropology / Cross culture / Interdisciplinary research / Nature and artifact / Environmental and resources constraint / Image of cities in 21st century / 二次元NMR / 液晶 / マイクロ波 / 温度ジャンプNMR / 相転移 / 双極子パターン / 双極子パタ-ン / 2D NMR / liquid crystal / microwave / temperature jump NMR / phase transition / dipolar pattern / 京都 / シエナシンポジウム / 自然科学部門 / 文学・芸術・人間学部門 / 法・経済学部門 / 岩倉使節団展 / 盆栽と写真展 / レオナルド以前展覧会 / レオナルド以前のレオナルド展覧会 / 学際領域研究 / 人間生活 / 人間学 / 異文化交流 / 文化交流人類学 / イメージ / Kyoto / Siena Symposium / Science Session / Humanity Session / Law / Economy Session Diplomatic Mission Exhibition / Bonsai and Artistic Photo Exhibition Prima di Leonardo Exhibition / Leonardo Prima di Leonardo Exhibition / 蛋白質折り畳み / モルテングロビュール / X線溶液散乱 / 蛋白質の変性 / ストップトフローCD / シャペロニン / 蛋白質変性 / 変性 / 静電的相互作用 / 疎水的相互作用 / 蛋白質非天然構造 / protein folding / molten globule / X-ray solution scattering / protein denturation / stopped-flow CD / chaperonine / 高圧NMRセル / 石英高圧セル / パラシクロファン / 活性化体積 / 圧力変形 / high pressure NMR cell / high pressure quartz cell / paracyclophane / pressure effects / activation volume / pressure-induced molecular deformation / 麻酔 / ガス麻酔薬 / 揮発性麻酔薬 / GABA_A受容体 / NMDA受容体 / nACh受容体 / 5-HT_3受容体 / GABAA受容体 / 麻酔薬 / ブピバカイン / 5-HT3受容体 / プロカイン / リドカイン / 亜酸化窒素 / キセノン / trk受容体 / Ras / 全身麻酔 / Anesthesia / Gaseous Anesthetics / volatile anesthetics / GABA_A Receptor / NMDA Receptor / nACh Receptor / 5-HT_3 Receptor / ブリオン / 中間体 / オリゴマー / NMR緩和時間 / 数論 / 生命科学理論 / 構造形成過程 / プリオン / パルス・ラベル / トレース公式 / 緩和時間 / 安定性 / ダイナミクス / リゾチーム / ユビキチン / 超高速パルスラベル / 活性型立体構造 / 高圧ジャンプ / ミリ秒揺らぎ / prion / high-pressure / CPMG relaxation / causative mutation / protein dynamics / number theory / プロテアーゼ / アミノアミルtRNA合成酵素 / アミラーゼ / 酵素一基質相互作用 / 蛍光滴定 / ストップトフロー / アミノアシルtRNA合成酵素 / 酵素ー基質相互作用 / 核磁気共鳴法 / 蛍光滴定法 / 化学修飾 / 酵素-基質相互作用 / 誘導適合 / 酵素 / グルコアミラーゼ / 基質特異性 / 蛋白質蛍光 / ストレプトミセス・ズブチリシン・インヒビター(SSI) / Proteases / Aminoacyl-tRNA synthetases / Amylases / Protease inhibitors / Enzyme-substrate interactions / Fluorescence titration / Stopped-flow method / 蛋白質工学 / プロテア-ゼインヒビタ- / ズブチリシンインヒビタ- / 金属プロテア-ゼインヒビタ- / 蛋白質の核磁気共鳴 / 蛋白質のX線結晶解析 / 酵素-インヒビタ-相互作用 / ズブチリシンインヒビター / 金属プロテアーゼインヒビター / 酵素-インヒビター相互作用 / 酵素ーインヒビター相互作用 / Protein Engineering / Site-directed Mutagenesis / Proteinase Inhibitor / Subtilisin Inhibitor / Metallo-proteinase Inhibitor / NMR of Proteins / X-ray Crystallography of Protein / Interaction of Enzyme and its inhibitor / 濃度ゆらぎ / 密度ゆらぎ / 化学反応 / 光散乱法 / 二成分溶液 / 局所電場 / 平衝定数 / レイリー散乱 / 放射線化学反応 / 電離 / 二成分溶液系 / ブリルアン散乱 / 溶液 / concentration fluctuation / density fluctuation / chemical processes / binary solutions / light scattering / local field / equilibrium constant / Rayleigh scattering / タンパク質 / 抗原認識機構 Less

Understanding of antigen recognition mechanism of multispecific antibodies
- Principal Investigator
  
  KAMATARI Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Inhibition of a prion conversion by suppressing protein fluctuations using small-molecules
- Principal Investigator
  
  KAMATARI Yuji O.
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
A hybrid extended ensemble simulation study on the folding process of proteins
- Principal Investigator
  
  YONEZAWA Yasushige
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kinki University
圧力軸実験を主とするアミロイド形成と解離メカニズムの研究Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kinki University
蛋白質の水和と熱励起構造Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kinki University
INVESTIGATION OF THE MECHANISM OF AMYLOID FIBRIL FORMATION FROM PRESSURE EXPERIMENTSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  KINKI UNIVERSITY
New Concept on the Phase Space of the Protein : Experiments and Theory
- Principal Investigator
  
  KUWATA Kazuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Gifu University
Effects of general anesthetics on molecular dynamics and conformation of neuronal receptor channel protains - Molecular mechanism of general anesthesia -
- Principal Investigator
  
  MASHIMO Takashi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka University
New Development of Protein Research Based on Interatomic CavityPrincipal Investigator
- Principal Investigator
  
  GEKKO Kunihiko, 赤坂一之
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Hiroshima University
  Kobe University
蛋白質の基本構造に対する圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
High Pressure NMR Study on the Control of Organic Chemical Reaction by Pressure.
- Principal Investigator
  
  YAMADA Hiroaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Organic chemistry
- Research Institution
  Kobe University
蛋白質立体構造安定性に及ぼす圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Joint research on structural fluctuations in proteins-Studied by hydrogen isotope exchange and high pressure NMRPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biophysics
- Research Institution
  Kobe University
NMR Analysis of Pressure-Induced Structural Changes in PrioteinsPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KOBE UNIVERSITY
蛋白質変性に対する圧力効果Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
高圧力の印加による有機反応の加速と制御の基礎的研究
- Principal Investigator
  
  山田博昭
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Organic chemistry
- Research Institution
  Kobe University
Structures and Formation Mechanisms of Folding Intermediates of Proteins
- Principal Investigator
  
  KATAOKA Mikio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
DEVELOPMENT OF A PRESSURE-JUMP NMR APPARATUSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical chemistry
- Research Institution
  DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
温度ジャンプNMRによるヘムタンパク質の構造形成過程Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
JAPAN-ITALY PROGRAM ON FRONTIER FIELDS -NATURE AND HUMAN LIFE-
- Principal Investigator
  
  IMANISHI Yukio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
STUDIES ON NON-NATIVE STRUCTURES OF PROTEINSPrincipal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  DEPARTMENT OF CHEMISTRY,FACULTY OF SCIENCE,KOBE UNIVERSITY
温度ジャンプNMRによるヘムタンパク質多元構造のダイナミックスPrincipal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
温度ジャンプNMRを用いた金属タンパク質の多元的構造と反応過程制御の研究Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Japan-Italy Program on Frontier Fields Nature and Human Life
- Principal Investigator
  
  IMANISHI Yukio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Determination of structure and dynamics of liquid crystalline molecules by state-correlated 2D NMR spectroscopy
- Principal Investigator
  
  NAITO Akira
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物理化学一般
- Research Institution
  HIMEJI INSTITUTE OF TECHNOLOGY
高速温度ジャンプNMR装置の開発とそのタンパク質構造転移への応用Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  生物物性学
- Research Institution
  Kobe University
  Kyoto University
Research on the structure required for function of protease inhibitor proteins produced by bacteria by protein engineering
- Principal Investigator
  
  MIURA Kin-ichiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  GAKUSHUIN UNIVERSITY, FACULTY OF SCIENCE(INSTITUTE FOR BIOMOLECULAR SCIENCE)
  The University of Tokyo
Effect of Molecular Structure on Radiation-Induced Processes in Condensed Phase
- Principal Investigator
  
  SHIDA Tadamasa
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物理化学一般
- Research Institution
  KYOTO UNIVERSITY
recAタンパク質の動的構造と機能Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
Multi-disciplinary Studies with Protein Engineering Approaches on Proteinaceous Proteinase Inhibitors of Microbial Origin
- Principal Investigator
  
  HIROMI Keitaro
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Kyoto University
核酸-蛋白質相互作用のX線,NMRによる研究
- Principal Investigator
  
  田中勲
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Nagoya University
reCAタンパク質の動的構造と機能Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
相転移を利用した二次元NMR分光法の開発Principal Investigator
- Principal Investigator
  
  赤坂一之
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  構造化学
- Research Institution
  Kyoto University
Quantitative analysis of internal motions in proteins.Principal Investigator
- Principal Investigator
  
  AKASAKA Kazuyuki
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  生物物性学
- Research Institution
  Kyoto University
Dynamic Analysis of Enzyme Functions
- Principal Investigator
  
  HIROMI Keitaro
- Project Period (FY)
  1985 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  Kyoto University

All 2016 2015 2014 2013 2012 2008 2007 2006 2005 2004 2002

All Journal Article Presentation Book

[Book] 「第13章　揺らぐ蛋白質構造を捉える-高圧NMR」（CSJカレントレビュー　第17号『極限環境の生命科学』）2014
- Author(s)
  赤坂一之, 前野覚大
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24570180
[Book] 第2節タンパク質（進化する食品高圧加工技術～基礎から最新の応用事例まで～）2013
- Author(s)
  赤坂一之・前野覚大
- Total Pages
  314
- Publisher
  エヌ・ティー・エス社
- Data Source
  KAKENHI-PROJECT-24570180
[Book] 「9章　高圧力NMR」（寺島正秀編：揺らぎ・ダイナミクスと生体機能）2013
- Author(s)
  北原　亮、赤坂一之
- Total Pages
  368
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24570180
[Book] Protein Folding Protocols in Methods in Molecular Biology Vol.350 (edited by Yawen Bai and Ruth Nussinov) (Humana Press Inc.)2006
- Author(s)
  赤坂一之 (M.Lassalle)
- Publisher
  The Use of High pressure NMR to Study in Protein Folding
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Application of high pressure NMR in the study of protein structure and dynamics2016
- Author(s)
  H. Li，Y. O. Kamatari，R. Kitahara，K. Akasaka
- Journal Title
  
  Chinese Journal of Magnetic Resonance
  
  Volume: 33 Pages: 1-26
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07024
[Journal Article] Structural fluctuation of proteins induced by thermodynamic perturbation2015
- Author(s)
  Fumio Hirata, Kazuyuki Akasaka
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 142
- DOI
  10.1063/1.4906071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Cavity as a source of conformational fluctuation and high-energy state: High-pressure NMR study of a cavity-enlarged mutant of T4Lysozyme2015
- Author(s)
  Maeno A, Sindhikara D, Hirata F, Otten R, Dahlquist FW, Yokoyama S, Akasaka K, Mulder FA, Kitahara R.
- Journal Title
  
  Biophysical Journal
  
  Volume: 108 Pages: 133-145
- DOI
  10.1016/j.bpj.2014.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025
[Journal Article] Pressure and Protein Dynamism2014
- Author(s)
  K. Akasaka
- Journal Title
  
  High Pressure Research
  
  Volume: 34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein2014
- Author(s)
  Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R.
- Journal Title
  
  Prion
  
  Volume: 8(4) Pages: 314-318
- DOI
  10.4161/pri.32081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25450444, KAKENHI-PROJECT-25640029
[Journal Article] Tyrosine/tyrosinate fluorescence at 700MPa: A pressure unfolding study of chicken ovomucoid at pH122013
- Author(s)
  Maeno A, Matsuo H, Akasaka K.
- Journal Title
  
  Biophys Chem.
  
  Volume: 183 Pages: 57-63
- DOI
  10.1016/j.bpc.2013.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] 高圧NMR で探る蛋白質のダイナミズム2013
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術
  
  Volume: 23 Pages: 3-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] 高圧NMRで探る蛋白質のダイナミズム2013
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術
  
  Volume: 23 Pages: 3-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Exploring the folding energy landscape with pressure2013
- Author(s)
  K. Akasaka, R. Kitahara, Y. O. Kamatari
- Journal Title
  
  Archives of biochemistry and biophysics
  
  Volume: 531 Pages: 110-115
- DOI
  10.1016/j.abb.2012.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PUBLICLY-23107729
[Journal Article] Pressure-induced chemical shifts as probes for conformational fluctuations2013
- Author(s)
  Kitahara R, Hata K, Li H, Williamson MP, Akasaka K.
- Journal Title
  
  Progress in nuclear magnetic resonance spectroscopy
  
  Volume: 71 Pages: 35-58
- DOI
  10.1016/j.pnmrs.2012.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25840025, KAKENHI-PUBLICLY-23107729
[Journal Article] 高圧蛋白質NMR2012
- Author(s)
  赤坂一之
- Journal Title
  
  NMR (Bulletin of the Nuclear Magnetic Resonance Society of Japan)
  
  Volume: 3 Pages: 38-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570180
[Journal Article] Direct evidence of generation and accumulation of β-sheet-rich prion protein in ScN2a cells de novo illuminated by human IgG1 antibody recognizing β-form but not α-form of prion protein.2012
- Author(s)
  Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima, Kazuhisa Sugimura.
- Journal Title
  
  The journal of biological chemistry.
  
  Volume: 287巻 Pages: 14023-14039
- DOI
  10.1074/jbc.m111.318352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790435, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482
[Journal Article] Novel aspects of protein conformational fluctuations revealed by variable pressure NMR2007
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  High Pressure Bioscience and Biotechnology Proceedings of the 4th International Conference on High Pressure Bioscience and Biotechnology 1
  
  Pages: 8-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Pressure dissociation kinetics of amyloid protofibrils.2007
- Author(s)
  赤坂一之, 橘秀樹 (Abdul Raziq Abdul Latif)
- Journal Title
  
  Biophysical Journal 94
  
  Pages: 323-329
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Amyloid protofibril is highly voluminous and compressible.2007
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  Biochemistry 46
  
  Pages: 10444-10450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  Hua, L., Akasaka, K.
- Journal Title
  
  Biochim.Biophys.Acta (Special issue) (In press)
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation.2006
- Author(s)
  赤坂一之 (K.Akasaka)
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (Guest Editor : A. Joshua Wand) 108
  
  Pages: 1814-1835
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  Hua, L., Akasaka, K.
- Journal Title
  
  Biochim.Biophys.Acta (Special issue) (in press)
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] The use of high pressure NMR to study protein folding.2006
- Author(s)
  Lassalle, M.W., Akasaka, K.
- Journal Title
  
  Method in Molecular Biology (in press)
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006
- Author(s)
  K.Akasaka
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Conformational fluctuations of proteins revealed by variable pressure NMR.2006
- Author(s)
  赤坂一之 (H. Li)
- Journal Title
  
  Biochimica et Biophysica Acta 1764
  
  Pages: 331-345
- Data Source
  KAKENHI-PROJECT-18031040
[Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築。2006
- Author(s)
  北原亮, 横山茂之, 赤坂一之
- Journal Title
  
  分光研究 55・1
  
  Pages: 10-20
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Cold denaturation of ubiquitin at high pressure2006
- Author(s)
  Kitahara R., Okuno, A., Kato, M., Taniguchi Y., Yokoyama, S., Akasaka, K.
- Journal Title
  
  Magnetic Resonance in Chemistry. (In press)
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Probing Conformational Fluctuation of Proteins by Pressure Perturbation2006
- Author(s)
  K.Akasaka
- Journal Title
  
  Chemical Reviews Thematic Issue "Protein Dynamics and Folding" (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] 可変圧力NMR法による新しい蛋白質構造パラダイムの構築2006
- Author(s)
  北原亮, 横山茂之, 赤坂一之
- Journal Title
  
  分光研究 55・1
  
  Pages: 10-20
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] NMR snapshots of a fluctuating protein structure. Ubiquitin at 30 bar - 3kbar2005
- Author(s)
  Ryo Kitahara, Shigeyuki Yokoyama Kazuyuki Akasaka
- Journal Title
  
  Journal of Molecular Biology 347
  
  Pages: 277-285
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Pressure-jump NMR study of dissociation and association of amyloid protofibrils.2005
- Author(s)
  Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K.
- Journal Title
  
  Journal of Molecular Biology 349
  
  Pages: 916-921
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Pressure jump NMR study of dissociation and association of amyloid protofibrils.2005
- Author(s)
  Kamatari, Y.O., Yokoyama, S., Tachibana, H., Akasaka, K
- Journal Title
  
  Journal of Molecular Biology 349
  
  Pages: 916-921
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Slow conformational dynamics in the Hamster prion protein.2004
- Author(s)
  Kazuo Kuwata, Yuji O.Kamatari, Kazuyuki Akasaka, Thomas L.James
- Journal Title
  
  Biochemistry 43
  
  Pages: 4439-4446
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] Infrequent cavity-forming fluctuations in HPr from Staphylococcus carnosus revealed by pressure and temperature-dependent tyrosine ring-flips.2004
- Author(s)
  Mineyuki Hattori, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka
- Journal Title
  
  Protein Science 13
  
  Pages: 3104-3114
- Data Source
  KAKENHI-PROJECT-16041244
[Journal Article] Pressure-dissociable reversible assembly of naturally denatured lysozyme is a precursor for amyloid fibrils.2004
- Author(s)
  Tara N.Niraula, Takashi Konno, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka, Hideki Tachibana
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 4089-4093
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] 可変圧力NMRが明かす蛋白質の新しい概念2004
- Author(s)
  赤坂一之
- Journal Title
  
  高圧力の科学と技術 13
  
  Pages: 328-334
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] High pressure NMR spectroscopy for characterizing non-native conformers of proteins2004
- Author(s)
  Y.O.Kamatari, R.Kitahara, H.Yamada, S.Yokoyama, K.Akasaka
- Journal Title
  
  Methods 34
  
  Pages: 133-143
- Data Source
  KAKENHI-PROJECT-16370054
[Journal Article] High-Pressure NMR offers the new view of the protein structure.2002
- Author(s)
  Kazuyuki Akasaka
- Journal Title
  
  Seibutu Buturi 42(5)
  
  Pages: 206-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Journal Article] 解説新しいタンパク質構造の世界をひらく高圧NMR2002
- Author(s)
  赤坂一之
- Journal Title
  
  生物物理 42
  
  Pages: 206-211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380314
[Presentation] タンパク質機能発現におけるキャビティの重要性2014
- Author(s)
  鎌足雄司, 赤坂一之, 李華
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] “非生物的揺らぎ”から“生物的揺らぎ”へ：そのからくりを問う。シンポジウム：生物ダイナミズムの源泉を問う―“非生物的揺らぎ”が生み出す“生物的揺らぎ”2013
- Author(s)
  赤坂一之
- Organizer
  第51回日本生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] 分子動力学法を用いた高圧下におけるc-Myb タンパク質とキャビティ内水分子の変動解析2013
- Author(s)
  曽我部拓哉, 吉田久, 赤坂一之
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Revealing protein dynamics with high-pressure NMR2013
- Author(s)
  Kazuyuki Akasaka
- Organizer
  European High Pressure Research Group International Meeting (EHPRG51)
- Place of Presentation
  London, UK
- Invited
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] タンパク質の揺らぎの源としてのキャビティと水和2013
- Author(s)
  鎌足雄司, 李華, 赤坂一之
- Organizer
  第18回生物関連高圧研究会シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] システインの添加が高圧下フィシン処理鶏卵白アレルゲンの分解性の向上とアレルゲン性の低減に及ぼす影響2013
- Author(s)
  蛭田あゆみ, 原崇, 赤坂一之, 西海理之
- Organizer
  第18回生物関連高圧研究会シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-24570180
[Presentation] Pressure and the Protein World2008
- Author(s)
  Kazuyuki Akasaka
- Organizer
  Proteins Under Pressure
- Place of Presentation
  Santa Fe, USA
- Data Source
  KAKENHI-PROJECT-18031040

1. YAMADA Hiroaki (90030767)

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Akasaka Kazuyuki 赤坂 一之

AKASAKA Kazuyuki 赤坂 一之

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圧力軸実験を主とするアミロイド形成と解離メカニズムの研究Principal Investigator

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蛋白質の水和と熱励起構造Principal Investigator

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INVESTIGATION OF THE MECHANISM OF AMYLOID FIBRIL FORMATION FROM PRESSURE EXPERIMENTSPrincipal Investigator

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New Development of Protein Research Based on Interatomic CavityPrincipal Investigator

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蛋白質の基本構造に対する圧力効果Principal Investigator

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蛋白質立体構造安定性に及ぼす圧力効果Principal Investigator

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Joint research on structural fluctuations in proteins-Studied by hydrogen isotope exchange and high pressure NMRPrincipal Investigator

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NMR Analysis of Pressure-Induced Structural Changes in PrioteinsPrincipal Investigator

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Akasaka Kazuyuki 赤坂一之

AKASAKA Kazuyuki 赤坂一之