CHIKUMA Masahiko 千熊正彦

Researcher Number	50025699
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008 – 2010: Osaka University of Pharmaceutical Sciences, 薬学部, 学長 2001 – 2006: 大阪薬科大学, 薬学部, 教授 1990 – 1998: Osaka University of Pharmaceutical Sciences Department of Pharmaceutical Sciences Professor, 薬学部, 教授 1989: 大阪薬科大学, 薬学部, 助教授 1986 – 1987: 大阪薬科大学, 助教授
Review Section/Research Field	Principal Investigator Physical pharmacy / Physical pharmacy Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator 白金錯体 / シスプラチン / 複核錯体 / 核酸 / 制がん剤 / DNA / Bioinorganic chemistry / Platinum complex / Cisplatin / 生物無機化学 … More / Anticancer agent / Dinuclear complex / 金属錯体 / Anticancer platinum complex / 制癌剤 / 非共有結合性相互作用 / 抗がん剤 / 気管支肺胞洗浄液 / イムノアッセイ / 希土類錯体 / 核酸塩基 / substitution reaction of platinum complex / Non-covalent interaction with DNA / Antitumor agent / Cisplatin resistance / 正方平面型白金錯体の置換反応 / プロトネーション / 制癌活性白金錯体 / シスプラチン耐性がん / 制がん活性白金錯体 / 転位反応 / 置換反応 / 白金錯体の置換反応 / 核酸の非共有結合性相互作用 / シスプラチン耐性 / apoptosis / antitumor agents / drug resistance / electrostatic interaction / dinuclear complexes / platinum complexes / cisplatin / アポトーシス / 薬剤耐性 / 静電的相互作用 / Sequence specificity / 抗がん白金錯体 / 塩基認識能 / 抗がん性白金錯体 / Cisplatin-resistant cancer cells / シスプラチン耐性癌 / ピラゾール錯体 / 核酸-金属錯体 / 白金ジアミン錯体 / 制癌性白金錯体 / シスプラチン耐性癌細胞 / Equilibrium constant / Kinetics / Hydroxo-bridged complex / 制がん制 / ヒドロキソ架橋複核錯体 / 平衡定数 / 反応速度 / ヒドロキソ架橋錯体 / Lanthanide complex / Alizarin fluorine blue / Pre-concentration / Ion exchange resin / Sorbent / Flow injection analysis / Fluoride / 雨水 / デスフェリオキサミン / フッ素吸着剤 / フッ素イオン / ランタニド金属錯体 / ランタンド金属錯体 / アリザリンフルオリンブル- / 予備濃縮 / イオン交換樹脂 / 吸着剤 / フロ-インジェクション分析 / フッ素 / 複核白金錯体 / 分子認識 / 物理系薬学 / インターフェロン / 二官能性キレート試薬 / 時間分解蛍光イムノアッセイ / デスモシン / ユウロピウム / 時間分解蛍光免疫測定 … More Except Principal Investigator HPLC / Determination Method / Metabolism / Model Reaction / Selenotrisulfide / Biologically Relevant Thiol / Selenium / 環境試料 / 螢光分析 / NBDF / チオール / ペニシラミンセレノトリスルフィド / 必須元素 / 蛍光検出 / 高速液体クロマトグラフィー / 定量法 / 代謝 / モデル反応 / セレノトリスルフィド / 生体関連チオール / セレン Less

Multiple Recognition of DNA by dinuclear platinum complexes with effective cell growth inhibition in cisplatin resistant cell linesPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Novel reactions of hydroxo-bridged dinuclear platinum complexes with antitumor activityPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Interaction of new dinuclear platinum complexes effective to cisplatin-resistant tumor cell lines with DNA.Principal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Local Distortion of DNA regulated by Dinuclear Platinum Complexes with High Sequence Specificity and Cytotoxicity against Cancer CellsPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
希土類キレートを標識剤とする生体成分および薬物のイムノアッセイに関する研究Principal Investigator
- Principal Investigator
  
  千熊正彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University of Pharmaceutical Sciences
Binding Mode of New Dinuclear Platinum Complexes Effective against Cisplatin-resistant Cancer Cells with DNAPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
希土類キレートを標識剤とする生体成分および薬物のイムノアッセイに関する研究Principal Investigator
- Principal Investigator
  
  千熊正彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University of Pharmaceutical Sciences
日金ジアミンジアクア錯体の溶液内反応の精密解析および核酸塩基認識との関連Principal Investigator
- Principal Investigator
  
  千熊正彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Kinetic and Equilibrium Studies on Formation of Hydroxo-bridged Dinuclear Platinum Complexes and Their Chemical ReactivitiesPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
A Few Systems for Flow Injection Analysis Monitoring Submicro Amounts of Fluoride IonsPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Masahiko
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Analysis of Reaction with Biologically Relevant Thiols as a Model Reaction for Metabolism of Selenium
- Principal Investigator
  
  TANAKA Hisashi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto University

All 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book Patent

[Book] 希土類の材料技術ハンドブック2008
- Author(s)
  千熊正彦(分担執筆)
- Publisher
  (株)エヌ・テイ・エス
- Data Source
  KAKENHI-PROJECT-20590045
[Book] 生命元素事典2006
- Author(s)
  千熊正彦
- Publisher
  オーム社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590037
[Book] 化学系薬学 I 化学物質の性質と反応2005
- Author(s)
  千熊正彦(分担執筆)
- Total Pages
  353
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-16590037
[Journal Article] The phosphate clamp : A Small and independent motif for nucleic acid backbone recognition2011
- Author(s)
  Komeda S., Moulaei T., Chikuma M., Odani A., Kipping R., Farrell N.P., Williams L.D.
- Journal Title
  
  Nucleic Acids Res 39
  
  Pages: 325-36
- Data Source
  KAKENHI-PROJECT-20590045
[Journal Article] A tetrazolato-bridged dinuclear platinum(II) complex exhibits markedly high in vivo antitumor activity against pancreatic cancer2011
- Author(s)
  Komeda S., Lin Y-L., Chikuma M.
- Journal Title
  
  ChemMedChem 6
  
  Pages: 987-990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590045
[Journal Article] Novel and simple loading of cisplatin into liposomes and targeting tumor endothelial cells2010
- Author(s)
  Hirai M., Minematsu H., Hiramatsu Y., Kitagawa H., Otani T., Iwashita S., Kudoh T., Chen L., Li Y., Okada M., Salomon D .S. , Igarashi K., Chikuma M., Seno M.
- Journal Title
  
  International Journal Pharmaceutics 391
  
  Pages: 274-283
- Data Source
  KAKENHI-PROJECT-20590045
[Journal Article] Characteristic effect of anticancer dinuclear platinum(II) complex on the higher-order structure of DNA2009
- Author(s)
  Kida N., Katsuda Y., Yoshikawa Y., Komeda S., Sato T., Saito Y., Chikuma M., Suzuki M., Imanaka T., Yoshikawa K.
- Journal Title
  
  Journal of Bioinorganic Chemistry 15(5)
  
  Pages: 701-707
- Data Source
  KAKENHI-PROJECT-20590045
[Journal Article] Cisplatin and its analogues induce a significant change in the higher-order structure of long duplex DNA2009
- Author(s)
  Katsuda Y., Yoshikawa Y., Sato T., Saito Y., Chikuma M., Suzuki M., Imanaka T., Yoshikawa K.
- Journal Title
  
  Chemical Physics Letters 473(1-3)
  
  Pages: 155-159
- Data Source
  KAKENHI-PROJECT-20590045
[Journal Article] 次世代抗がん性白金錯体の開発研究2007
- Author(s)
  千熊正彦
- Journal Title
  
  金属 77・3
  
  Pages: 299-304
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590037
[Journal Article] A kinetic study on the reactions of azole-bridged dinuclear platinum(II) complexes with Gunosine 5' -monophosphate2004
- Author(s)
  S.Komeda, H.Yamane, M.Chikuma, J.Reedijik
- Journal Title
  
  European J.Inorganic Chemistry
  
  Pages: 4828-4835
- Data Source
  KAKENHI-PROJECT-16590037
[Patent] 白金錯体化合物およびその利用2010
- Inventor(s)
  米田誠治, 千熊正彦
- Industrial Property Rights Holder
  天真堂製薬(株), (株)ヤクルト本社
- Industrial Property Number
  2009-550001
- Filing Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-20590045
[Patent] 白金錯体化合物およびその利用2010
- Inventor(s)
  米田誠治,千熊正彦
- Industrial Property Rights Holder
  天真堂製薬(株),(株)ヤクルト本社
- Industrial Property Number
  2009-550001
- Filing Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-20590045
[Presentation] 制がん活性を有する白金錯体の開発と分析化学2009
- Author(s)
  千熊正彦
- Organizer
  日本分析化学会近畿支部第1回支部講演会
- Place of Presentation
  大阪市
- Year and Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-20590045
[Presentation] Targeting E-selectin expressed on endothelial cells in tumor region with cisplatin-liposomes conjugated with Sialyl Lewis X2009
- Author(s)
  千熊正彦
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Denver
- Year and Date
  2009-04-22
- Data Source
  KAKENHI-PROJECT-20590045
[Presentation] カチオン性ポリアミン架橋白金(II)複核錯体とDNAとの結合様式に関する研究2008
- Author(s)
  千熊正彦
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-20590045
[Presentation] 制がん活性を有する陽電荷白金錯体と核酸との非共有結合性相互作用2008
- Author(s)
  千熊正彦
- Organizer
  第58回錯体化学討論会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20590045
[Presentation] シスプラチン耐性がんに有効な白金錯体の多様な核酸認識2008
- Author(s)
  千熊正彦
- Organizer
  第2回バイオ関連化学合同シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590045

1. SATO Takaji (80257899)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. SAITO Yoshihiro (90186974)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. KOMEDA Seiji (60425056)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 小南悟郎

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANAKA Hisashi (50025673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIBUKAWA Akimasa (30170913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAGAWA Terumichi (70025708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

CHIKUMA Masahiko 千熊 正彦

Research Projects

Research Products

Co-Researchers

Multiple Recognition of DNA by dinuclear platinum complexes with effective cell growth inhibition in cisplatin resistant cell linesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel reactions of hydroxo-bridged dinuclear platinum complexes with antitumor activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of new dinuclear platinum complexes effective to cisplatin-resistant tumor cell lines with DNA.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Local Distortion of DNA regulated by Dinuclear Platinum Complexes with High Sequence Specificity and Cytotoxicity against Cancer CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

希土類キレートを標識剤とする生体成分および薬物のイムノアッセイに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Binding Mode of New Dinuclear Platinum Complexes Effective against Cisplatin-resistant Cancer Cells with DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

希土類キレートを標識剤とする生体成分および薬物のイムノアッセイに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

日金ジアミンジアクア錯体の溶液内反応の精密解析および核酸塩基認識との関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kinetic and Equilibrium Studies on Formation of Hydroxo-bridged Dinuclear Platinum Complexes and Their Chemical ReactivitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Few Systems for Flow Injection Analysis Monitoring Submicro Amounts of Fluoride IonsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Reaction with Biologically Relevant Thiols as a Model Reaction for Metabolism of Selenium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 希土類の材料技術ハンドブック2008

Author(s)

Publisher

Data Source

[Book] 生命元素事典2006

Author(s)

Publisher

Description

Data Source

[Book] 化学系薬学 I 化学物質の性質と反応2005

Author(s)

Total Pages

CHIKUMA Masahiko 千熊正彦