NISHINO Taskeshi 西野武志

Researcher Number	50097838
Other IDs
External Links
Affiliation (based on the past Project Information) *help	1992 – 2006: 京都薬科大学, 薬学部, 教授 2003: 京都薬科大学, 教授
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) Except Principal Investigator Biological Sciences / Bacteriology (including Mycology) / Bacteriology (including Mycology) / Biological pharmacy / 植物保護
Keywords	Principal Investigator キノロン薬 / MRSE / MRSA / Macrolide antibiotics / Multidrug resistance / Haemophilus influenzae / BLNAR / マクロライド薬 / MIC / 特異抗体 … More / AcrAB / 多剤耐性 / インフルエンザ菌 / 耐性機構 / β-lactam antibiotics / Quinolones / AcrAB overproducing strains / Specific antibody to AcrAB / Efflux pump systems / RND型排出タンパク質 / acrB / MATEファミリー / MFSファミリー / SMRファミリー / AcrA特異抗体 / AcrAB過剰発現株 / β-ラクタム薬 / AcrAB過剰発現体 / AcrAB特異抗体 / 異物排出システム / Outer membrane proteins / Specific antibody / Efflux pumps / 16員環 / 14員環 / 排出蛋白 / 外膜コンポーネント / 抗体 / 薬剤耐性 / 俳出蛋白 / AcrAB排出系 / 外膜蛋白 / 排出ポンプ / マクロライド系抗生物質 / Resistance / Quinolone / Topoisomerase IV / DNA gyrase / Topo IV / TopoIV / DNAジャイレース … More Except Principal Investigator Pseudomonas aeruginosa / 緑膿菌 / 多剤耐性 / 抗菌薬耐性 / 基質認識 / Antimicrobial resistance / MexC-MexD-OprJ / 多剤排出システム / multidrug efflux / multidrug resistance / Multidrug resistance / patogenicity factors / antibiotic resistance / RND multicomponennt-type efflux system / 病原性 / マルチコンポーネント型RND排出システム / Resistance / Quorum sensing / クォーラムセンシング / 排出システム / 発現制御 / RND / 異物排出 / Quorum sensing system / Disk Diffusion assay / virulence / Efflux system / 排出タンパク質 / ディスク検出システム / Molecular structure / Expression / Substrate recognition / Substrate specificity / Multicomponents / Mex efflux systems / 膜蛋白質 / キメラ / DNAシャフリング / トポロジー / 免疫沈降 / 臨床分離株 / アミノ酸置換 / キメラ排出システム / Mexシステム / マルチコンポーネント / 多剤排出 / MexA-MexB-OprM / deletion system / Multidrug efflux system / Deletion system / Multidrug effiux system / 遺伝子解離システム / mouse / rat / infection / Helicobacter pylori / 除菌 / 胃潰瘍 / 感染 / マウス / ラット / 感染モデル / ヘリコバクター・ピロリ / nfxC mutation / nfxB mutation / nalB mutation / NfxB変異 / NalB変異 / 薬剤排出オペロン / Efflux operon / Mulridrug resistance / nfxC変異 / nfxB変異 / nalB変異 / 薬剤排出 / 系統解析 / 血液感染 / ゲノム / セラチア菌 / 日和見感染菌 / RND型排出タンパク質 / 阻害薬 / 基質認識機構 / 分子構造 / トランスポーター / 能動的排出 / 外膜タンパク質 / Mex / 遺伝子発現 / 排出ポンプ / D2蛋白質 / 単クローン抗体 / 外膜 / OpcP2 / OpcP1 / OpcP0 / 遺伝子 / 透過孔形成能 / 再構成 / ポーリン蛋白質 / Pseudomonas cepacia Less

多剤排出システムを基盤にした多剤耐性菌感染症克服のための戦略の創生
- Principal Investigator
  
  後藤直正
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
Analysis of the efflux pump systems in the multidrug resistance of Haemophilus influenzaePrincipal Investigator
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
感染部位での異物排出システム群の発現解析を基盤にした多剤耐性緑膿菌感染症の克服
- Principal Investigator
  
  後藤直正
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
Studies on Involvement of Mex Efflux Systems of Pseudomonas aeruginosa on Antimicrobial Resistance and Virulence
- Principal Investigator
  
  GOTOH Naomasa
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
異物排出システム群の連携作動解析による多剤耐性緑膿菌感染症の新規化学療法の開発
- Principal Investigator
  
  後藤直正
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
異物排出システム群の連携作動の解析と多剤耐性緑膿菌感染症克服への応用
- Principal Investigator
  
  後藤直正
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
Role of the efflux proteins in multidrug resistant Haemophilus influenzaePrincipal Investigator
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
Researches on molecular mechanisms of multicomponent efflux systems of Pseudomonas aeruginosa
- Principal Investigator
  
  GOTOH Naomasa
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences
joint-research on bacterial MDR efflux systems
- Principal Investigator
  
  GOTOH Naomasa
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
Establishment of Helicobacter pylori infection models in rats and mice
- Principal Investigator
  
  OKABE Susumu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Alterations in the DNA topoisomerase IV responsible for quinolone resistance in MRSA and MRSEPrincipal Investigator
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
Mechanisms of the multidrug resistance in Pseudomonas aeruginosa involved in drug efflux systems
- Principal Investigator
  
  GOTOH Naomasa, 後藤直正
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
MRSAおよびMRSEにおけるキノロン耐性機構Principal Investigator
- Principal Investigator
  
  西野武志
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kyoto Pharmaceutical University
緑脳菌およびセパシア菌の外膜透過孔形成蛋白質(ポーリン)の共通構造の解明
- Principal Investigator
  
  GOTOH Naomasa
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  植物保護
- Research Institution
  Kyoto Pharmaceutical University

All 2006 2005 2004

All Journal Article Book

[Book] 疾病と病態生理改定第2版10章感染症(橋本、佐藤、豊島編集)2006
- Author(s)
  西野武志
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-16590375
[Book] 細菌感染症の臨床と検査 18章細菌の機能と形態変化(五島瑳智子監修)2005
- Author(s)
  西野武志
- Publisher
  国際医学出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Book] 細菌感染症の臨床と検査「18章細菌の機能と形態変化」(五島瑳智子監修)2005
- Author(s)
  西野武志
- Publisher
  国際医学出版
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] 大腸菌2006
- Author(s)
  西野武志
- Journal Title
  
  Infection Front Vol.7
  
  Pages: 26-27
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] In vitro activity of a novel antimicrobial agent, TG44, for treatment of Helicobacter pylori infection.2006
- Author(s)
  Osamu Kamoda, Kinsei Anzai Jun-ichi Mizoguchi, Masatoshi Shiojiri, Toshiharu Yanagi, Takeshi Nishino, Shigeru Kamiya
- Journal Title
  
  Antimicrob. Agents Chemother. Vol.50
  
  Pages: 3062-3069
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] In vitro activity of a novel antimicrobial agent, TG44, for treatment of H. pylori infection.2006
- Author(s)
  O.Kamoda, M.Shiojiri, T.Yanagi, T.Nishino, S.Kamiya et al.
- Journal Title
  
  Antimicrob. Agents Chemother. 50・9
  
  Pages: 3062-3069
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] 肺炎桿菌2006
- Author(s)
  西野武志
- Journal Title
  
  Infection Front Vol.9
  
  Pages: 28-29
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] In vitro activity of a novel antimicrobial agent, TG44, for treatment of H. pylori infection.2006
- Author(s)
  O.kamoda, M.Shiojiri, T.Yanagi, T.Nishino, S.Kamiya et al.
- Journal Title
  
  Antimicrob. Agents Chemother. 50・9
  
  Pages: 3062-3069
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Chapter 18-The functions and morphological alterations of bacteria.2005
- Author(s)
  Takeshi Nishino
- Journal Title
  
  In clinical bacteriology and examination.( ed. Sachiko Gotoh) Kokusai Igaku Co.,Chapter 18
  
  Pages: 207-247
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Cooperation between alteration of DNA gyrase genes and overexpression of MexB and MexX confers high level fluoroquinolone resistance in P. aeruginosa.2005
- Author(s)
  Niga T., Yamagishi J., Gotoh N., Nishino T., Matsuhisa I.et al.
- Journal Title
  
  Microbiol.Immunol. 49・5
  
  Pages: 443-446
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] 化学療法-基礎と臨床-2005
- Author(s)
  西野武志, 桑原章吾
- Journal Title
  
  Medical Corner 116・2
  
  Pages: 6-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Accumulations of mutations in both gyrB and parE gene is associated with high-level resistance to novobiocin in Staphylococcus aureus.2005
- Author(s)
  Mika Fujimoto-Nakamura, Hideaki Ito, Yoshihiro Oyamada, Takeshi Nishino, Jun-ichi Yamagishi
- Journal Title
  
  Antimicrob. Agents Chemother. Vol.49
  
  Pages: 3810-3815
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Accumulations of mutations in both gyrB and parE gene is associated with high-level resistance to novobiocin in S.aureus2005
- Author(s)
  M.Fujimoto-Nakamura, H.Itoh, Y.Oyamada, T.Nishino, J.Yamagishi
- Journal Title
  
  Antimicrob. Agents Chemother. 49
  
  Pages: 3810-3815
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Moxifloxacinのin vitroおよびin vivo抗菌力2005
- Author(s)
  西野武志, 大槻雅子
- Journal Title
  
  日本化学療法学会雑誌 53・S-3
  
  Pages: 1-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction.2005
- Author(s)
  K.Yoneda, H.Chikumi, T.Murata, N.Gotoh, T.Nishino et al.
- Journal Title
  
  FEMS Microbiol. Lett. 243
  
  Pages: 125-131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction.2005
- Author(s)
  Kazuhiko Yoneda, Hiroki Chikumi, Takeshi Murata, Naomasa Gotoh, Hiroyuki Yamamoto, Hiromitsu Fujiwara, Takeshi Nishino, Eiji Shimizu
- Journal Title
  
  FEMS Microbiol. Lett. Vol.243
  
  Pages: 125-131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] Chemotherapy-the basis and clinical field of antimicrobial agents2005
- Author(s)
  Takeshi Nishino, Shogo Kuwahara
- Journal Title
  
  Medical Corner Vol. 116, No.2
  
  Pages: 6-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] In vitro and in vivo antibacterial activity of moxifloxacin, a novelquinolone antibacterial agent2005
- Author(s)
  Takeshi Nishino, Masako Otsuki
- Journal Title
  
  Jpn.J.Chemother Vol. 53
  
  Pages: 1-15
- NAID
  10017083498
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] バンコマイシン耐性腸球菌(VRE)2004
- Author(s)
  西野武志
- Journal Title
  
  医学のあゆみ Vol.209,No.9
  
  Pages: 516-518
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] 肺炎レンサ球菌2004
- Author(s)
  西野武志
- Journal Title
  
  Infection Front Vol.1
  
  Pages: 22-23
- Data Source
  KAKENHI-PROJECT-16590375
[Journal Article] マクロライド系抗菌薬はなぜ一部のグラム陰性菌に抗菌力を示すのか2004
- Author(s)
  西野武志
- Journal Title
  
  Infection & Technology No.14
  
  Pages: 11-13
- Data Source
  KAKENHI-PROJECT-16590375

1. GOTOH Naomasa (30121560)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
2. MASAKO Otsuki (30121552)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. TSUJIMOTO Hideto (10257777)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. GOTOH Naomasa (30121156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 福島淳 (00181256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OGAWA Michihiro (00411033)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TSUDA Masataka (90172022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKABE Susumu (90012624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAHASHI Satoru (20268098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中野妙 (70278448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. POOLE R.Keith

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. PECHERE Jean

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. PECHERE Jean-Claude

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KEITH Poole

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NISHINO Taskeshi 西野 武志

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Analysis of the efflux pump systems in the multidrug resistance of Haemophilus influenzaePrincipal Investigator

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Role of the efflux proteins in multidrug resistant Haemophilus influenzaePrincipal Investigator

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Alterations in the DNA topoisomerase IV responsible for quinolone resistance in MRSA and MRSEPrincipal Investigator

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MRSAおよびMRSEにおけるキノロン耐性機構Principal Investigator

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[Book] 疾病と病態生理 改定第2版10章 感染症(橋本、佐藤、豊島編集)2006

Author(s)

NISHINO Taskeshi 西野武志

[Book] 疾病と病態生理改定第2版10章感染症(橋本、佐藤、豊島編集)2006

[Book] 細菌感染症の臨床と検査 18章細菌の機能と形態変化(五島瑳智子監修)2005

[Book] 細菌感染症の臨床と検査「18章細菌の機能と形態変化」(五島瑳智子監修)2005