Hiromichi Tanaka 田中博道

… Alternative Names

田中博通タナカヒロミチ

TANAKA Hiromichi 田中博道

田中博道タナカヒロミチ

Less

Researcher Number	50109477
Other IDs
External Links
Affiliation (Current)	2025: 昭和医科大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help	2003 – 2006: 昭和大学, 薬学部, 教授 1998: Showa University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授 1994 – 1997: 昭和大学, 薬学部, 助教授 1986 – 1987: 昭和大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Chemical pharmacy / Drug development chemistry / Chemical pharmacy Except Principal Investigator Drug development chemistry / Chemical pharmacy / 医薬分子機能学
Keywords	Principal Investigator HIV-1 / ヌクレオシド / organoaluminum reagent / アルミニウム試薬 / HIV / AIDS / NNRTI / エイズ / 生理活性 / 耐性ウイルス … More / リチウム化 / 逆転写酵素 / anti-HIV activity / stereoselectivity / antiviral drug / nucleoside / 求核置換反応 / 求電子付加 / 合成化学 / スタブジン / 抗HIV活性 / 立体選択性 / アルミニウム試剤 / 抗ウイルス薬 / unsaturated sugar nucleoside / epoxid e / branched sugar nucleoside / reverse transcriptase inhibito / antiviral activity / uncleoside / 合成 / 立体選択的 / 有機アルミニウム試剤 / 抗HIV / 抗ウイルス / 不飽和糖ヌクレオシド / 有機アルミニウム試薬 / エポキシド / 分岐糖ヌクレオシド / 逆転写酵素阻害剤 / 抗ウイルス作用 / Amino Acid Mutation / Resistant Virus / Allosteric Inhibitor / Reverse Transcriptase / アミノ酸変異 / アロステリック阻害剤 / 細胞性免疫抑制作用 / 細胞増殖阻止活性 / 親電子試剤 / プリンヌクレオシド / イミダゾールヌクレオシド / 第一相臨床試験 / X線結晶解析 / アロステリック阻害 / HEPT / アリルスズ化合物 / 炭素-炭素結合形成反応 / ウリジン / モノセレノアセタール / フラノース / 1,2-不斉誘起 / ラジカル反応 … More Except Principal Investigator ヌクレオシド / glycal / nucleoside / チミジン / チオグリコシル化 / グリカール / antiviral / antitumor / thymine / Pummerer reaction / sulfoxide / glycosidation / 有機シリコン試剤 / 置換反応 / グリコシル化反応 / チオ糖 / 分岐糖 / グリコシル化 / 求核置換反応 / 抗ウイルス活性 / スルホキシド / プンメラー反応 / anti-viral / reduction / lithiation / thymidine / thio-glycosidation / 抗ガン剤 / 血管新生阻害 / wittig反応 / リナウム化反応 / リチム化反応 / チオグリコシル化反応 / 抗ウイルス作用 / 還元 / リチウム化反応 / ナイトレン / 光化学 / リチウム化 / ウリジン / 酵素阻害 / ヌクレオチド / アノメリックラジカル / 面選択的親電子付加反応 / ラジカル反応 / 1,2-アシルオキシ転移 / 分岐糖ヌクレオシド / 炭素-炭素結合形成反応 / 双頭ヌクレオシド / 不飽和糖ヌクレオシド Less

Synthesis and Biological Activities of Sugar Modified 4'-Thionucleosides
- Principal Investigator
  
  HARAGUCHI Kazuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Development of the first anti-HIV drug from Japan : 4'-Ethynyl-d4T as the candidatePrincipal Investigator
- Principal Investigator
  
  TANAKA Hiromichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Synthesis of branched sugar nucleosides based on epoxy structure in the sugar portionPrincipal Investigator
- Principal Investigator
  
  TANAKA Hiromichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  School of Pharmaceutical Sciences, Showa University
Synthesis and Biological Activities of 4'-Thionucleosides branched at the Sugar Portion
- Principal Investigator
  
  HARAGUCHI Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Design and Synthesis of New Generation anti-HIV agents Based on the X-ray analysis of Inhibitor-RT ComplexesPrincipal Investigator
- Principal Investigator
  
  TANAKA Hiromichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
耐性ウイルスにも有効な次世代の非ヌクレオシド系逆転写酵素阻害剤の分子設計と合成Principal Investigator
- Principal Investigator
  
  田中博道
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
ヌクレオシド糖部ラジカル反応における1,2-不斉誘起に関する研究Principal Investigator
- Principal Investigator
  
  田中博道
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
真正双頭ヌクレオシドの合成とその機能に関する研究
- Principal Investigator
  
  宮坂貞
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Showa University
リチウム化反応を用いる生理活性ヌクレオシドの合成Principal Investigator
- Principal Investigator
  
  田中博道
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University
酵素阻害活性を有するヌクレオシドおよびヌクレオチドの合成研究
- Principal Investigator
  
  宮坂貞
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University

All 2006 2005 2004 2003 Other

All Journal Article

[Journal Article] Nucleophilic Substitution at the 4'-Position of Nucleosides : New Access to a Promising Anti-HIV Agent 2',3'-Didehydro-3'-deoxy- 4'-ethynylthymidine2006
- Author(s)
  Kazuhiro Haraguchi, Masanori Sumino, Hiromichi Tanaka
- Journal Title
  
  Journal of Organic Chemistry Vol. 71
  
  Pages: 4433-4438
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] A Practical Synthesis of 4'-Thioribonucleosides2006
- Author(s)
  Yuichi Yoshimura, Tetsuya Kuze, Mari Ueno, Fumiko Komiya, Kazuhiro Haraguchi, Hiromichi Tanaka, Fumitaka Kano, Kohei Yamada, Kazuhiro Asami, Nobuaki Kaneko, Hiroki Takahata
- Journal Title
  
  Tetrahedron Letters Vol. 47
  
  Pages: 591-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Anti versus Syn Opening of Epoxides Derived from 9-(3-Deoxy-β-D- glycero-pent-3-enofuranosyl)adenine with Me_3Al : Factors Controlling the Stereoselectivity2006
- Author(s)
  Yutaka Kubota, Kazuhiro Haraguchi, Mayumi Kunikata, Mari Hayashi, Masaomi Ohkawa, Hiromichi Tanaka
- Journal Title
  
  Journal of Organic Chemistry Vol. 71
  
  Pages: 1099-1103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Nucleophilic Substitution of 4'-Acetoxy-4'-thionucleosides : a New Access to 4'-Substituted 4'-Thiothymidines2006
- Author(s)
  Kazuhiro Haraguchi, Hisashi Shimada, Hiromichi Tanaka
- Journal Title
  
  Nucleic Acids Symposium Series No. 50
  
  Pages: 115-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Synthesis of Novel 4'-Carbon-substituted BCA Derivatives Based on Radical Cyclization2006
- Author(s)
  Hiroki Kumamoto, Nonoko Takahashi, Tomomi Shimamura, Hiromichi Tanaka
- Journal Title
  
  Nucleic Acids Symposium Series No. 50
  
  Pages: 117-118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Synthesis and Anti-Human Immunodeficiency Virus Activity of 4'-Branched (±)-4'-Thiostavudines2006
- Author(s)
  Hiroki Kumamoto, Takahito Nakai, Kazuhiro Haraguchi, Kazuo T. Nakamura, Hiromichi Tanaka, Masanori Baba, Yung-Chi Cheng
- Journal Title
  
  Journal of Medicinal Chemistry Vol. 49
  
  Pages: 7861-7867
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted Nucleosides : Development of a Highly Active Anti-HIV Agent 2',3'-Didehydro-3'-deoxy- 4'-ethynylthymidine2005
- Author(s)
  Kazuhiro Haraguchi, Shingo Takeda, Masanori Sumino, Hiromichi Tanaka, Ginger E. Dutschman, Yung-Chi Cheng, Takao Nitanda, Masanori Baba
- Journal Title
  
  Nucleosides, Nucleotides, and Nucleic Acids Vol. 24
  
  Pages: 343-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Synthesis of (±)-4'-Ethynyl and 4'-Cyano Carbocyclic Analogues of Stavudine (d4T)2005
- Author(s)
  Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Takao Nitanda, Masanori Baba, Ginger E. Dutschman, Yung-Chi Cheng
- Journal Title
  
  Nucleosides, Nucleotides, and Nucleic Acids Vol. 24, No. 2
  
  Pages: 73-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Anti-human immunodeficiency virus type 1 Activity and Resistance Profile of 2',3'-didehydro3'-Deoxy-4'-ethynylthymidine in vitro2005
- Author(s)
  Nitanda, T., Wang X., Kumamoto, H., Haraguchi, K., Tanaka, H., Cheng, Y.-C., Baba, M.
- Journal Title
  
  Antimicrob. Agents Chemother 49
  
  Pages: 3355-3360
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity against drug-resistance mutants2005
- Author(s)
  Hiromichi Tanaka, Kazuhiro Haraguchi, Hiroki Kumamoto, Masanori Baba, Yung-Chi Cheng
- Journal Title
  
  Antiviral Chemistry and Chemotherapy Vol. 16
  
  Pages: 217-221
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Synthesis of 4'-Substituted Cordycepins2005
- Author(s)
  Yutaka Kubota, Mayumi Kunikata, Rumi Ohsawa, Yuria Odajima, Kazuhiro Haraguchi, Hiromichi Tanaka
- Journal Title
  
  Nucleic Acids Symposium Series No. 49
  
  Pages: 111-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine in vitro2005
- Author(s)
  Takao Nitanda, Xin Wang, Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Yung-Chi Cheng, Masanori Baba
- Journal Title
  
  Antimicrobial Agents and Chemotherapy Vol. 49, No. 8
  
  Pages: 3355-3360
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] 4'-Ethynylstavudine(4'-Ed4T) Has Potent Anti-HIV-1 Activity with Reduced Toxicity and Shows a Unique Activity Profile against Drug-Resistant Mutants2005
- Author(s)
  Tanaka, H., Haraguchi, K., Kumamoto, H., Baba, M., Cheng, Y.C.
- Journal Title
  
  Antiviral Chemistry & Chemotherapy 16
  
  Pages: 217-221
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 4'-Ethynylstavudine has potent anti-HIV activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants2005
- Author(s)
  H.Tanaka et al.
- Journal Title
  
  Antiviral Chemistry and Chemotherapy 16巻
  
  Pages: 217-221
- Data Source
  KAKENHI-PROJECT-17590094
[Journal Article] Synthesis of (±)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T)2005
- Author(s)
  H.Kumamoto, K.Kato, K.Haraguchi, H.Tanaka, T.Nitanda, M.Baba, G.E.Dutschman, Y.-C.Cheng
- Journal Title
  
  Nucleosides, Nucleotides, an d Nucleic Acids 24 (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Synthesis of (±)-4'-Ethnyl and 4'-Cyano carbocyclic analogues of Stavudine(d4T)2005
- Author(s)
  Kumamoto, H., Haraguchi, K., Tanaka, H., Nitanda, T., Baba M., Dutschman G.E., Cheng, Y.-C.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 73-83
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] 5-Exo versus 6-Endo Cyclization of Nucleoside 2-Sila-5-hexenyl radicals: Reaction of 6-(Bromomethyl)dimetylisilyl 1',2'-Unsaturated uridines2005
- Author(s)
  Ogamino, J., Mizunuma, H., Kumamoto, H., Takeda, S., Haraguchi, K., Nakamura, K.T., Sugiyama, H., Tanaka, H.
- Journal Title
  
  J.Org.Chem. 70
  
  Pages: 1684-1690
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted Nucleosides: Development of a Highly Active Anti-HIV Agent2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine2005
- Author(s)
  Haraguchi, K., Takeda, S., Sumino, M., Tanaka, H., Dutschman G.E., Cheng, Y.-C., Nitanda, T., Baba M.
- Journal Title
  
  Nucleosides, Nucleotides and Nucleic Acids 24
  
  Pages: 343-347
- Data Source
  KAKENHI-PROJECT-17590093
[Journal Article] Synthesis and anti-HIV activity of 4'-eyano-2',3'-di-dehydro-3'-deoxythymidine2004
- Author(s)
  K.Haraguchi, Y.Itoh, S.Takeda, Y.Honma, H.Tanaka, T.Nitanda, M.Baba, G.B.Dutschamn, Y.-C.Cheng
- Journal Title
  
  Nucleosides, Nucleotides, and Nucleic Acids 23
  
  Pages: 647-654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Ring opening of nucleoside 1',2'-epoxidcs with organo-aluminum reagents: stereoselective entry to ribonucleosides branched at the anomerie position2004
- Author(s)
  K.Haraguchi, Y.Kubota, H.Tanaka
- Journal Title
  
  Journal of Organic Chemistry 69
  
  Pages: 1831-1836
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity2004
- Author(s)
  G.E.Dutschman, S.F.Grill, E.A.Gullen, K.Haraguchi, S.Takeda, H.Tanaka, M.Baba, Y.-C.Cheng
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 48
  
  Pages: 1640-1646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine2003
- Author(s)
  K.Haraguchi, S.Takeda, H.Tanaka, T.Nitanda, M.Baba, G.E.Dutschman, Y.-C.Cheng
- Journal Title
  
  Bioorganoc Medicical Chemistry Letters 13
  
  Pages: 3775-3777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Ring opening of 4',5'-epoxynucleosides: a novel stereo-selective entry to 4'-C-branched nucleosides2003
- Author(s)
  K.Haraguchi, S.Takeda, H.Tanaka
- Journal Title
  
  Organic Letters 5
  
  Pages: 1339-1402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590020
[Journal Article] Synthetic Use of Epoxy-sugar Nucleosides
- Author(s)
  Hiromichi Tanaka, Yutaka Kubota, Shingo Takeda, Kazuhiro Haraguchi
- Journal Title
  
  Nucleosides, Nucleotides, and Nucleic Acids (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590094

1. HARAGUCHI Kazuhiro (10218638)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. 宮坂貞 (70053808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 早川弘之 (40180955)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 佐藤和恵 (90053941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results

Hiromichi Tanaka 田中 博道

田中 博通 タナカ ヒロミチ

TANAKA Hiromichi 田中 博道

田中 博道 タナカ ヒロミチ

Research Projects

Research Products

Co-Researchers

Synthesis and Biological Activities of Sugar Modified 4'-Thionucleosides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the first anti-HIV drug from Japan : 4'-Ethynyl-d4T as the candidatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of branched sugar nucleosides based on epoxy structure in the sugar portionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and Biological Activities of 4'-Thionucleosides branched at the Sugar Portion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and Synthesis of New Generation anti-HIV agents Based on the X-ray analysis of Inhibitor-RT ComplexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

耐性ウイルスにも有効な次世代の非ヌクレオシド系逆転写酵素阻害剤の分子設計と合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヌクレオシド糖部ラジカル反応における1,2-不斉誘起に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

真正双頭ヌクレオシドの合成とその機能に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リチウム化反応を用いる生理活性ヌクレオシドの合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

酵素阻害活性を有するヌクレオシドおよびヌクレオチドの合成研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Nucleophilic Substitution at the 4'-Position of Nucleosides : New Access to a Promising Anti-HIV Agent 2',3'-Didehydro-3'-deoxy- 4'-ethynylthymidine2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Practical Synthesis of 4'-Thioribonucleosides2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Anti versus Syn Opening of Epoxides Derived from 9-(3-Deoxy-β-D- glycero-pent-3-enofuranosyl)adenine with Me_3Al : Factors Controlling the Stereoselectivity2006

Author(s)

Journal Title

Hiromichi Tanaka 田中博道

田中博通タナカヒロミチ

TANAKA Hiromichi 田中博道

田中博道タナカヒロミチ