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Hiromichi Tanaka  田中 博道

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… Alternative Names

田中 博通  タナカ ヒロミチ

TANAKA Hiromichi  田中 博道

田中 博道  タナカ ヒロミチ

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Researcher Number 50109477
Other IDs
External Links
Affiliation (Current) 2025: 昭和医科大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2003 – 2006: 昭和大学, 薬学部, 教授
1998: Showa University, School of Pharmaceutical Sciences, Professor, 薬学部, 教授
1994 – 1997: 昭和大学, 薬学部, 助教授
1986 – 1987: 昭和大学, 薬学部, 助教授
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Drug development chemistry / Chemical pharmacy
Except Principal Investigator
Drug development chemistry / Chemical pharmacy / 医薬分子機能学
Keywords
Principal Investigator
HIV-1 / ヌクレオシド / organoaluminum reagent / アルミニウム試薬 / HIV / AIDS / NNRTI / エイズ / 生理活性 / 耐性ウイルス … More / リチウム化 / 逆転写酵素 / anti-HIV activity / stereoselectivity / antiviral drug / nucleoside / 求核置換反応 / 求電子付加 / 合成化学 / スタブジン / 抗HIV活性 / 立体選択性 / アルミニウム試剤 / 抗ウイルス薬 / unsaturated sugar nucleoside / epoxid e / branched sugar nucleoside / reverse transcriptase inhibito / antiviral activity / uncleoside / 合成 / 立体選択的 / 有機アルミニウム試剤 / 抗HIV / 抗ウイルス / 不飽和糖ヌクレオシド / 有機アルミニウム試薬 / エポキシド / 分岐糖ヌクレオシド / 逆転写酵素阻害剤 / 抗ウイルス作用 / Amino Acid Mutation / Resistant Virus / Allosteric Inhibitor / Reverse Transcriptase / アミノ酸変異 / アロステリック阻害剤 / 細胞性免疫抑制作用 / 細胞増殖阻止活性 / 親電子試剤 / プリンヌクレオシド / イミダゾールヌクレオシド / 第一相臨床試験 / X線結晶解析 / アロステリック阻害 / HEPT / アリルスズ化合物 / 炭素-炭素結合形成反応 / ウリジン / モノセレノアセタール / フラノース / 1,2-不斉誘起 / ラジカル反応 … More
Except Principal Investigator
ヌクレオシド / glycal / nucleoside / チミジン / チオグリコシル化 / グリカール / antiviral / antitumor / thymine / Pummerer reaction / sulfoxide / glycosidation / 有機シリコン試剤 / 置換反応 / グリコシル化反応 / チオ糖 / 分岐糖 / グリコシル化 / 求核置換反応 / 抗ウイルス活性 / スルホキシド / プンメラー反応 / anti-viral / reduction / lithiation / thymidine / thio-glycosidation / 抗ガン剤 / 血管新生阻害 / wittig反応 / リナウム化反応 / リチム化反応 / チオグリコシル化反応 / 抗ウイルス作用 / 還元 / リチウム化反応 / ナイトレン / 光化学 / リチウム化 / ウリジン / 酵素阻害 / ヌクレオチド / アノメリックラジカル / 面選択的親電子付加反応 / ラジカル反応 / 1,2-アシルオキシ転移 / 分岐糖ヌクレオシド / 炭素-炭素結合形成反応 / 双頭ヌクレオシド / 不飽和糖ヌクレオシド Less
  • Research Projects

    (10 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (4 People)
  •  Synthesis and Biological Activities of Sugar Modified 4'-Thionucleosides

    • Principal Investigator
      HARAGUCHI Kazuhiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Showa University
  •  Development of the first anti-HIV drug from Japan : 4'-Ethynyl-d4T as the candidatePrincipal Investigator

    • Principal Investigator
      TANAKA Hiromichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Showa University
  •  Synthesis of branched sugar nucleosides based on epoxy structure in the sugar portionPrincipal Investigator

    • Principal Investigator
      TANAKA Hiromichi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      School of Pharmaceutical Sciences, Showa University
  •  Synthesis and Biological Activities of 4'-Thionucleosides branched at the Sugar Portion

    • Principal Investigator
      HARAGUCHI Kazuhiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Showa University
  •  Design and Synthesis of New Generation anti-HIV agents Based on the X-ray analysis of Inhibitor-RT ComplexesPrincipal Investigator

    • Principal Investigator
      TANAKA Hiromichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Showa University
  •  耐性ウイルスにも有効な次世代の非ヌクレオシド系逆転写酵素阻害剤の分子設計と合成Principal Investigator

    • Principal Investigator
      田中 博道
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Showa University
  •  ヌクレオシド糖部ラジカル反応における1,2-不斉誘起に関する研究Principal Investigator

    • Principal Investigator
      田中 博道
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Showa University
  •  真正双頭ヌクレオシドの合成とその機能に関する研究

    • Principal Investigator
      宮坂 貞
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Showa University
  •  リチウム化反応を用いる生理活性ヌクレオシドの合成Principal Investigator

    • Principal Investigator
      田中 博道
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Showa University
  •  酵素阻害活性を有するヌクレオシドおよびヌクレオチドの合成研究

    • Principal Investigator
      宮坂 貞
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Showa University

All 2006 2005 2004 2003 Other

All Journal Article

  • [Journal Article] Nucleophilic Substitution at the 4'-Position of Nucleosides : New Access to a Promising Anti-HIV Agent 2',3'-Didehydro-3'-deoxy- 4'-ethynylthymidine2006

    • Author(s)
      Kazuhiro Haraguchi, Masanori Sumino, Hiromichi Tanaka
    • Journal Title

      Journal of Organic Chemistry Vol. 71

      Pages: 4433-4438

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] A Practical Synthesis of 4'-Thioribonucleosides2006

    • Author(s)
      Yuichi Yoshimura, Tetsuya Kuze, Mari Ueno, Fumiko Komiya, Kazuhiro Haraguchi, Hiromichi Tanaka, Fumitaka Kano, Kohei Yamada, Kazuhiro Asami, Nobuaki Kaneko, Hiroki Takahata
    • Journal Title

      Tetrahedron Letters Vol. 47

      Pages: 591-594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Anti versus Syn Opening of Epoxides Derived from 9-(3-Deoxy-β-D- glycero-pent-3-enofuranosyl)adenine with Me_3Al : Factors Controlling the Stereoselectivity2006

    • Author(s)
      Yutaka Kubota, Kazuhiro Haraguchi, Mayumi Kunikata, Mari Hayashi, Masaomi Ohkawa, Hiromichi Tanaka
    • Journal Title

      Journal of Organic Chemistry Vol. 71

      Pages: 1099-1103

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Nucleophilic Substitution of 4'-Acetoxy-4'-thionucleosides : a New Access to 4'-Substituted 4'-Thiothymidines2006

    • Author(s)
      Kazuhiro Haraguchi, Hisashi Shimada, Hiromichi Tanaka
    • Journal Title

      Nucleic Acids Symposium Series No. 50

      Pages: 115-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Synthesis of Novel 4'-Carbon-substituted BCA Derivatives Based on Radical Cyclization2006

    • Author(s)
      Hiroki Kumamoto, Nonoko Takahashi, Tomomi Shimamura, Hiromichi Tanaka
    • Journal Title

      Nucleic Acids Symposium Series No. 50

      Pages: 117-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Synthesis and Anti-Human Immunodeficiency Virus Activity of 4'-Branched (±)-4'-Thiostavudines2006

    • Author(s)
      Hiroki Kumamoto, Takahito Nakai, Kazuhiro Haraguchi, Kazuo T. Nakamura, Hiromichi Tanaka, Masanori Baba, Yung-Chi Cheng
    • Journal Title

      Journal of Medicinal Chemistry Vol. 49

      Pages: 7861-7867

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted Nucleosides : Development of a Highly Active Anti-HIV Agent 2',3'-Didehydro-3'-deoxy- 4'-ethynylthymidine2005

    • Author(s)
      Kazuhiro Haraguchi, Shingo Takeda, Masanori Sumino, Hiromichi Tanaka, Ginger E. Dutschman, Yung-Chi Cheng, Takao Nitanda, Masanori Baba
    • Journal Title

      Nucleosides, Nucleotides, and Nucleic Acids Vol. 24

      Pages: 343-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Synthesis of (±)-4'-Ethynyl and 4'-Cyano Carbocyclic Analogues of Stavudine (d4T)2005

    • Author(s)
      Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Takao Nitanda, Masanori Baba, Ginger E. Dutschman, Yung-Chi Cheng
    • Journal Title

      Nucleosides, Nucleotides, and Nucleic Acids Vol. 24, No. 2

      Pages: 73-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Anti-human immunodeficiency virus type 1 Activity and Resistance Profile of 2',3'-didehydro3'-Deoxy-4'-ethynylthymidine in vitro2005

    • Author(s)
      Nitanda, T., Wang X., Kumamoto, H., Haraguchi, K., Tanaka, H., Cheng, Y.-C., Baba, M.
    • Journal Title

      Antimicrob. Agents Chemother 49

      Pages: 3355-3360

    • Data Source
      KAKENHI-PROJECT-17590093
  • [Journal Article] 4'-Ethynylstavudine (4'-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity against drug-resistance mutants2005

    • Author(s)
      Hiromichi Tanaka, Kazuhiro Haraguchi, Hiroki Kumamoto, Masanori Baba, Yung-Chi Cheng
    • Journal Title

      Antiviral Chemistry and Chemotherapy Vol. 16

      Pages: 217-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Synthesis of 4'-Substituted Cordycepins2005

    • Author(s)
      Yutaka Kubota, Mayumi Kunikata, Rumi Ohsawa, Yuria Odajima, Kazuhiro Haraguchi, Hiromichi Tanaka
    • Journal Title

      Nucleic Acids Symposium Series No. 49

      Pages: 111-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Anti-Human Immunodeficiency Virus Type 1 Activity and Resistance Profile of 2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine in vitro2005

    • Author(s)
      Takao Nitanda, Xin Wang, Hiroki Kumamoto, Kazuhiro Haraguchi, Hiromichi Tanaka, Yung-Chi Cheng, Masanori Baba
    • Journal Title

      Antimicrobial Agents and Chemotherapy Vol. 49, No. 8

      Pages: 3355-3360

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] 4'-Ethynylstavudine(4'-Ed4T) Has Potent Anti-HIV-1 Activity with Reduced Toxicity and Shows a Unique Activity Profile against Drug-Resistant Mutants2005

    • Author(s)
      Tanaka, H., Haraguchi, K., Kumamoto, H., Baba, M., Cheng, Y.C.
    • Journal Title

      Antiviral Chemistry & Chemotherapy 16

      Pages: 217-221

    • Data Source
      KAKENHI-PROJECT-17590093
  • [Journal Article] 4'-Ethynylstavudine has potent anti-HIV activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants2005

    • Author(s)
      H.Tanaka et al.
    • Journal Title

      Antiviral Chemistry and Chemotherapy 16巻

      Pages: 217-221

    • Data Source
      KAKENHI-PROJECT-17590094
  • [Journal Article] Synthesis of (±)-4'-ethynyl and 4'-cyano carbocyclic analogues of stavudine (d4T)2005

    • Author(s)
      H.Kumamoto, K.Kato, K.Haraguchi, H.Tanaka, T.Nitanda, M.Baba, G.E.Dutschman, Y.-C.Cheng
    • Journal Title

      Nucleosides, Nucleotides, an d Nucleic Acids 24 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Synthesis of (±)-4'-Ethnyl and 4'-Cyano carbocyclic analogues of Stavudine(d4T)2005

    • Author(s)
      Kumamoto, H., Haraguchi, K., Tanaka, H., Nitanda, T., Baba M., Dutschman G.E., Cheng, Y.-C.
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids 24

      Pages: 73-83

    • Data Source
      KAKENHI-PROJECT-17590093
  • [Journal Article] 5-Exo versus 6-Endo Cyclization of Nucleoside 2-Sila-5-hexenyl radicals: Reaction of 6-(Bromomethyl)dimetylisilyl 1',2'-Unsaturated uridines2005

    • Author(s)
      Ogamino, J., Mizunuma, H., Kumamoto, H., Takeda, S., Haraguchi, K., Nakamura, K.T., Sugiyama, H., Tanaka, H.
    • Journal Title

      J.Org.Chem. 70

      Pages: 1684-1690

    • Data Source
      KAKENHI-PROJECT-17590093
  • [Journal Article] A New Approach to the Synthesis of 4'-Carbon-substituted Nucleosides: Development of a Highly Active Anti-HIV Agent2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine2005

    • Author(s)
      Haraguchi, K., Takeda, S., Sumino, M., Tanaka, H., Dutschman G.E., Cheng, Y.-C., Nitanda, T., Baba M.
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids 24

      Pages: 343-347

    • Data Source
      KAKENHI-PROJECT-17590093
  • [Journal Article] Synthesis and anti-HIV activity of 4'-eyano-2',3'-di-dehydro-3'-deoxythymidine2004

    • Author(s)
      K.Haraguchi, Y.Itoh, S.Takeda, Y.Honma, H.Tanaka, T.Nitanda, M.Baba, G.B.Dutschamn, Y.-C.Cheng
    • Journal Title

      Nucleosides, Nucleotides, and Nucleic Acids 23

      Pages: 647-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Ring opening of nucleoside 1',2'-epoxidcs with organo-aluminum reagents: stereoselective entry to ribonucleosides branched at the anomerie position2004

    • Author(s)
      K.Haraguchi, Y.Kubota, H.Tanaka
    • Journal Title

      Journal of Organic Chemistry 69

      Pages: 1831-1836

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity2004

    • Author(s)
      G.E.Dutschman, S.F.Grill, E.A.Gullen, K.Haraguchi, S.Takeda, H.Tanaka, M.Baba, Y.-C.Cheng
    • Journal Title

      Antimicrobial Agents and Chemotherapy 48

      Pages: 1640-1646

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine2003

    • Author(s)
      K.Haraguchi, S.Takeda, H.Tanaka, T.Nitanda, M.Baba, G.E.Dutschman, Y.-C.Cheng
    • Journal Title

      Bioorganoc Medicical Chemistry Letters 13

      Pages: 3775-3777

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Ring opening of 4',5'-epoxynucleosides: a novel stereo-selective entry to 4'-C-branched nucleosides2003

    • Author(s)
      K.Haraguchi, S.Takeda, H.Tanaka
    • Journal Title

      Organic Letters 5

      Pages: 1339-1402

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590020
  • [Journal Article] Synthetic Use of Epoxy-sugar Nucleosides

    • Author(s)
      Hiromichi Tanaka, Yutaka Kubota, Shingo Takeda, Kazuhiro Haraguchi
    • Journal Title

      Nucleosides, Nucleotides, and Nucleic Acids (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590094
  • 1.  HARAGUCHI Kazuhiro (10218638)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 2.  宮坂 貞 (70053808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  早川 弘之 (40180955)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  佐藤 和恵 (90053941)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results

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