YOSHII Yoshihiko 吉井與志彦

… Alternative Names

吉井輿志彦ヨシイヨシヒコ

吉井興志彦

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Researcher Number	50110507
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007: University of the Ryukyus, Faculty of Medicine, Professor 2004 – 2007: 琉球大学, 医学部, 教授 1997 – 2002: 琉球大学, 医学部, 教授 1999: Professor, Fucalty of Medicine, Ryukyu University 1994 – 1996: 筑波大学, 臨床医学系, 助教授 … More 1989 – 1992: 筑波大学, 臨床医学系, 助教授 1990: Univ. of Tsukuba, Inst. Clin. Med. Sci., Associate Prof., 臨末医学系, 助教授 1986 – 1988: Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 1986: 筑大, 臨床医学系, 講師 1985: 筑波大学, 臨医, 講師 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Radiation science / Cerebral neurosurgery / Radiation science
Keywords	Principal Investigator 陽子線 / 悪性脳腫瘍 / 抗腫瘍効果 / Proton Beam / in vitro / in vivo / 免疫組織化学 / ラジカル / clonality / oxidative stress … More / metalloprotease / アポトーシス / OHAP-1 / L-aminoacid oxidase / ハブ毒 / 脳腫瘍 / 9L-Gliosarcoma / 実験脳腫瘍 / BrdU / ACNU / 抗BrdU抗体 / ターゲティング治療 / 形態計測 / 動注療法 / ヘテロジェナイティー / in vivo診断 / ターゲティング / DNA量 / GFAP / 正常脳障害 / 超選択的動注療法 / Malignant Brain Tumor / Targeting Therapy / Morphometry / Antitumor Effect / Lntraartenal Therapy / Heterogeneity / In vivo Diagnosis / 電離放射線 / 活性酸素 / 抗酸化効果(剤) / 抗酸化因子 / DCFHDA / SOD / GST-Tc / Immunohistochemical / ラジカル刺激剤 / スカベンジャー薬剤 / 蛍光測定 / U251細胞 / CDDP / 細胞致死効果 / 神経膠腫細胞 / lonizing Radiation / Oxidative Stress (Oxidants) / Antioxidants / Immunohistochemistry / Scavengers / Glioma / 治療抵抗性因子 / 免疫組織学 / Clonality / 単一クローン / 防御因子 / DNA Ploidy / 治療予後 / gliomas / resistant factor / immunohistochemical study / Vitamin K2 / apoptsis / 沖縄ハブ毒 / L-amino acid oxidase / 血管内皮細胞 / グリオーマ細胞 / 酸化ストレス / 移植腫瘍 / グリオーマ / アミノ酸構造 / OHAP-I / OHAP-II / クリオーマ / 皮下移植腫瘍 / プロティン / 殺細胞効果 / Okinawa Habu venom / vascular endothel / glioma cell / apoptosis / 悪性神経膠腫 / p53 / カフェイン / 細胞周期 / ハブ毒素 / P53野生株 / MTT / P53変異株 / malignant glioma / Okinawa Habu / snake venom / cytotoxity / cell cycle / Caffeine / Argon-dye Laser / HPD / PDT外照射 / PDT内照射 / Argon-Dye Laser / Photofrin【I】 / 電磁波 / 内照射法 / Interstitial or extratumoral PDT / dye laser / Brain tumor / 晩発性脳放射線障害 / 症理組織学的変化 / CTーMRI画像 / 病態解析 / 予防、対策 / 放射線障害 / 組織学的変化 / 画像所見 / 治療法 / 病理組織 / 照射線量 / Gd-MRI / 年齢 / 脳腫瘍脳 / 放射線壊死 / 病理組織所見 / 脳血流 / Brain Tumor / Delayed Radiation Injury / Histopathology / CT-MRI imagings / Therapy … More Except Principal Investigator 脳腫瘍 / 難治性腫瘍 / 粒子線治療 / 細胞反応 / 組織反応 / Glioma / Glioblastoma / flg / anti-sense / Northern / Southern / B7 / costimulatory signal / gene therapy / glioblastoma / glioma / tumor vaccine / 膠芽腫 / p53 / p21 / 悪性神経膠腫 / 放射線治療 / FLG / Growth / 神経膠腫 / bFGF / 腫瘍増殖 / ワクチン療法 / 遺伝子治療 / Gene therapy / Tumor vaccine / 重粒子線 / 細胞死 / 細胞周期 / アポトーシス / Heavy Ion / High LET / DNA-PK / GLIOMA / HEAVY ION / HIGH LET / APOPTOSIS / High-LET / Charged Particle / Apoptosis / Brain tumor / High LET Charged Particle / Carbon beam / apoptosis / cell death / cell cycle / linear-quadratic / 超音波 / 脳血管内手術 / X線 / カテーテル / 動物実験 / 3次元イメージ / 脳動脈瘤 / Ultrasound / lntravascular Neurosurgery / X-ray / Catheter / Animal Experiment / 3-D imaging / 治療効果 / 低酸素 / High-grade gliomas / Radiotherapy / tumor response / Hypoxia / 脳・神経 / 血管内治療 / 脳波 / てんかん / 血管内導出電極 / 脳神経 / brain / endovascular therapy / electroencepharogram / epilepsy / endovascular electrode / 核磁気共鳴画像 / 中枢神経疾患 / 実験モデル / 脳内血腫 / Nuclear Magnetic Resonancce Image / Expelimental Brain Disease / Gd-DTPA / Intracerebral Hemorrhage / 下垂体腺腫 / 成長ホルモン / TRH / 免疫組織化学 / レーザー治療 / Pituitary adenoma / Growth hormone / Thyrotropin-releasing-hormone / Immunohistochemistry / モノクローナル抗体 / ヒト免疫グロブリン / マウス-ヒト細胞融合 / Human monoclonal antibody / malignant glioma / 陽子線治療 / 標識埋没法 / 放射線照射技術 / 照射技術 / Proton therapy Less

Predicting the tumor response to radiotherapy for high-grade gliomas: Clinical significance of hypoxia-related genes
- Principal Investigator
  
  OGAWA Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  University of the Ryukyus
Clinical application and renovation of endovascular electrode for endovascular electroencepharogram used for the detection of the focus of epilepsy
- Principal Investigator
  
  HYODO Akio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
The antiproliferative effect of Okinawa Habu Apoxin Protein-1 (OHAP-1) on human glioma cellsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
Apoptotic effect by specific proteins extracted from Okinawa Habu (Trimeresurus Flavoviridis) snake venom into glioma and vascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of the Ryukyus
Development of Intravascular Ultrasound Dimensional Imaging System with Diagnostic Support and Its Application for Intravascular Neurosurgery
- Principal Investigator
  
  HYODO Akio
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE KYUKYUS
  University of Tsukuba
Sensitivity of malignant gliom cells against accelerated heavy ion beams
- Principal Investigator
  
  TSUBOI Koji
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Clinicopathological study in the relationship among sensitivity, clonality, and growth potential after treatment in human gliomasPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE RYUKYUS
Vaccine therapy for malignant glioma with costimulatory signal genemodified syngenic glioma cells
- Principal Investigator
  
  MIYAGI Koichi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF THE RYUKYUS
Oncological study for brain tumors by using Proton radiosurgery and enhanced drugs to oxidative stressPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Molecular analysis of flg and its products for targeted therapy on brain tumors
- Principal Investigator
  
  TSUBOI Koji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.Principal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba, Institution of Clinical Medicine
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
粒子線治療展開のための基礎的研究
- Principal Investigator
  
  増田康治
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
Delayed Radiation Injury to the Brain : In Relation to Therapeutic View PointPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihiko
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Clinical device for accurate irradiation of tumors in deep-seated organs in proton beam therapy.
- Principal Investigator
  
  KITAGAWA Toshio
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  University of Tsukuba
陽子線応用による悪性脳腫瘍の選択的治療法に関する基礎的臨床的研究Principal Investigator
- Principal Investigator
  
  吉井与志彦
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  University of Tsukuba
Basic Study of Laser-Treatment for GH-Producing Pituitary Adenoma Using Fluorescein-TRH
- Principal Investigator
  
  TOMONO Yuji
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  UNIVERSITY OF TSUKUBA
Human monoclonal antibody against human, malignant glioma obtained from mouse-human hetero hybridoma system
- Principal Investigator
  
  NAKAGAWA Kunio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tsukuba
Experimental and Clinical Study for Brain Tumor Treatment by Using both external energy and porphyrine drugsPrincipal Investigator
- Principal Investigator
  
  YOSHII Yoshihoko
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  University of Tsukuba
Investigation of expelimental brain diseases with nuclear magnetic resonance images.
- Principal Investigator
  
  NOSE Tadao
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Institute of Clinical Medicine, Tsukuba University,

All 2007 2006

All Journal Article Presentation

[Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chem otherapy for high-grade gliomas2006
- Author(s)
  Ogawa K, Yoshii Y, Murayama S, et al.
- Journal Title
  
  British Journal of Cancer 95
  
  Pages: 862-868
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas: a prospective study.2006
- Author(s)
  Ogawa K, Yoshii Y, Toita T, Saito A, Kakinohana Y, Iraha S, Sugimoto K, Tsuchida Y, Tamaki W, Adachi G, Hyodo A, Murayama S.
- Journal Title
  
  Anticancer Research 26
  
  Pages: 2457-2462
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.2006
- Author(s)
  Ogawa K, Yoshii Y, Inoue O, Toita T, Saito A, Kakinohana Y, Adachi G, Iraha S, Tamaki W, Sugimoto K, Hyodo A, Murayama S.
- Journal Title
  
  British Journal of Cancer 95
  
  Pages: 862-868
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas : a prospective study2006
- Author(s)
  Ogawa K, Yoshii Y, Tsuchida Y Murayama S, et al.
- Journal Title
  
  Anticancer Research 26
  
  Pages: 2457-2462
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591386
[Presentation] 脳腫瘍治療の最前線悪性グリオーマに対する放射線治療、HBOと化学療法の併用療法第II相試験2007
- Author(s)
  小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
- Organizer
  第45回日本癌治療学会
- Place of Presentation
  京都
- Year and Date
  2007-10-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591386
[Presentation] 悪性グリオーマに対する放射線照射とHBOの併用療法2006
- Author(s)
  小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
- Organizer
  第41回日本高気圧環境・潜水医学会
- Place of Presentation
  沖縄
- Year and Date
  2006-10-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591386

1. TSUBOI Koji (90188615)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NAKAGAWA Kunio (40092077)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HYODO A (40167606)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAITO Atsushi (40305199)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NOSE Tadao (10009699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 増田康治 (10037377)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 阿部光幸 (00025587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 坪内進 (70073137)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 鈴木捷三 (30012743)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 大原弘 (20160608)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. HAYAKAWA Y (90101740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MARUHASHI A (30114135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TOMONO Yuuji (70110335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MIYAGI Koichi (60102274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TSURUSHIMA Hideo (50315470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. TSUCHIDA Yukihiro (90363663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
17. NOSAKI Masatosi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. ISHIKAWA Y (10026932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TSUJII H (50088853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. AOYAGI Kazumasa (40114029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TADANO Masayuki (80179712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MAKINO Yoshihiro (60039930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ANDO Koichi (00159526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ITO Etsuo (40031968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MIYATA Seizou (90015066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SUN L.K. (40325840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OGAWA Kazuhiko (40253984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
28. KINJO Takao (30284962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ENOMOTO Takao (10134230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. HOMMA Kazuhiro (80357970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KUSUMI Takenori (70015882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KOZIMA Seiiji (90134204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. INOUE Yukinobu (00015570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ISHIZAKA Shouzo (10062499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. KITAGAWA Toshio (80076942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. NISHIDA Masato (00110875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. OTANI Mikinobu (80133081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ARIMOTO Takuro (50168027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. TAKASE Yasuhiro (50075339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. OHARA Kiyoshi (10034125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. OGATA Takesaburou (60009115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 銘苅晋 (50200316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 田邊将夫 (30049077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 石川悟 (70168194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 金子実 (00111378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. OKUNO Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHII Yoshihiko 吉井 與志彦

吉井 輿志彦 ヨシイ ヨシヒコ

吉井 興志彦

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The antiproliferative effect of Okinawa Habu Apoxin Protein-1 (OHAP-1) on human glioma cellsPrincipal Investigator

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Apoptotic effect by specific proteins extracted from Okinawa Habu (Trimeresurus Flavoviridis) snake venom into glioma and vascular endothelial cellsPrincipal Investigator

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Clinicopathological study in the relationship among sensitivity, clonality, and growth potential after treatment in human gliomasPrincipal Investigator

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Oncological study for brain tumors by using Proton radiosurgery and enhanced drugs to oxidative stressPrincipal Investigator

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Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.Principal Investigator

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Delayed Radiation Injury to the Brain : In Relation to Therapeutic View PointPrincipal Investigator

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YOSHII Yoshihiko 吉井與志彦

吉井輿志彦ヨシイヨシヒコ

吉井興志彦