SASAKI Takeshi 佐々木毅

Researcher Number	50110656
Affiliation (based on the past Project Information) *help	2006 – 2007: TOHOKU UNIVERSITY, Professor Emeritus, Professor 2005 – 2006: 東北大学, 大学院医学系研究科, 教授 1999 – 2005: 東北大学, 大学院・医学系研究科, 教授 2002: 東北大学, 医学系研究科, 教授 1993 – 1998: DEPARTMENT OF CLINICAL AND LABORATORY MEDICINE, TOHOKU UNIV.SCH.MED.PROFESSOR, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator 内科学一般 / Laboratory medicine / Hematology / Biological Sciences / Laboratory medicine / 膠原病・アレルギー・感染症内科学 Except Principal Investigator 内科学一般 / Hematology / Hematology / Laboratory medicine / Virology / Immunology / Public health/Health science
Keywords	Principal Investigator 抗DNA抗体 / ヒトパルボウイルスB19 / 慢性関節リウマチ / rheumatoid arthritis / B19 / TNFα / anti-DNA antibody / 関節リウマチ / Ku80 / レセプター … More Except Principal Investigator RNAi / 全身性エリテマトーデス / ELISA / P53 / 骨髄間質細胞 / DNA microarray / siRNA / bone marrow stromal cells / delta-like 1 / 骨髄細胞 / 高密度大量培養 / ホローファイバー培養 / 自己抗体 / V遺伝子 / 全身性エリテマトーデス(SLE) / T細胞 / ディファレンシャル、ディスプレイ法 / 成人発症スティル病 / アンケート / データベース / 発熱 / 関節炎 / ヒト・パルボウイルス / 免疫酵素法 / ウエスタンブロット法 / 核酸重合反応法 / 免疫蛍光染色法 / パルボウイルス / 非免疫性胎児水腫 / 関節リウマチ / 血清診断 / ヒトパルボウイルス / B19 / VPー1 / PCR / ELISA法 / 蛍光抗体法 / アビジン・ビオチン / human parvovirus / Western blot / polymerase chain reaction / immunofluorescence staining / 免疫抑制 / IL-2受容体 / 単クロン抗体 / 移植免疫 / 免疫制御 / サイトカイン / γ鎖 / 可溶化型 / IL-2 / 増殖シグナル / Immune suppression / IL-2 receptor / Monoclonal antibody / Transplantation immunity / 慢性関節リウマチ / 免疫組織化学 / p53 / Rheumatoid arthritis / Immunohistochemistory / DNAマイクロアレイ / tenascin-C / Tenascun-C / 赤芽球造血 / 造血 / 骨髄 / 赤芽球 / heat shock protein / erythropoiesis / イソフラボン / 学歴 / コホート研究 / 予後 / 疫学 / ビタミンB6 / 食物繊維 / Systemic lupus erythematosus / Isoflavone / Educational level / Cohort study / Prognosis / Epidemiology / Vitamin B6 / Dietary fiber Less

新規エコー法による強皮症病変の評価法の開発Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
A cohort study of systemic lupus erythematosus for elucidating the association between intake of isoflavones and prognosis
- Principal Investigator
  
  MINAMI Yuko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Tohoku University
Identification of molecules determining the stromal-cell dependent hematopoiesis
- Principal Investigator
  
  KAMEOKA Junichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Mechanism for human parvovirus B19-induced rheumatoid arthjritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  TOHOKU UNIVERSITY
関節リウマチ発症におけるヒトパルボウイルスB19に関する研究Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Identification of molecules determining the stromal-cell dependent hematopoiesis
- Principal Investigator
  
  KAMEOKA Junichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  TOHOKU UNIVERSITY
成人発症スティル病の診断・治療・予後に関する集学的研究
- Principal Investigator
  
  江口勝美
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Nagasaki University
抗DNA抗体を用いたCD34陽性細胞への遺伝子導入Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Etiological agents responsible for systemic lupus erythrmatosusPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell LeukemiaPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
腫瘍マーカーとしてのカルシウム調節ホルモン・スタニオカルシンPrincipal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
Approarch for the viral agent responsible for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
全身性エリテマトーデスの予知的指標としての特異的遺伝子Principal Investigator
- Principal Investigator
  
  佐々木毅, ISHII Tomonori
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
組織特異的に発現するアンチセンスリボザイムによる治療Principal Investigator
- Principal Investigator
  
  佐々木毅
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Research for human parvovirus and rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Tumor inhibitory gene in rheumatoid arthritis
- Principal Investigator
  
  SHIBATA Shinobu, 高橋裕一
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
骨髄細胞の高密度大量培養に関する研究
- Principal Investigator
  
  ENDO Kazuyasu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tohoku University
Development of immunosuppressant drugs based on inhibition of IL-2 function
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY
The role of human parvovirus infection in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  TOHOKU UNIVERSITY
The Analysis for Human Autoantibody Producing System using Biotechnology.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Development of diagnostic methods for human parvovirus infection
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Virology
- Research Institution
  Tohoku Univeristy
Analysis of regulatory mechanism for autoantibody production by using human T and B cell clones.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  TOHOKU UNIVERSITY
Specific elimination of anti-DNA antibody-producing cells in systemic lupus erythematosus.Principal Investigator
- Principal Investigator
  
  SASAKI Takeshi
- Project Period (FY)
  1984 – 1985
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University

All 2006 2000

All Journal Article

[Journal Article] Identification of Tenascin-C as a Key Molecule Determining the Stromal Cell -Dependent Erythropoiesis2006
- Author(s)
  Masanori Seki, Junichi Kameoka, Shinichiro Takahashi, Hideo Harigae, Nobuaki Yanai, Masuo Obinata, Takeshi Sasaki
- Journal Title
  
  Experimental Hematology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590992
[Journal Article] Anti-K-ras rybozyme induced a growth inhibition and an increaseα chemosensitivity of human colon cancer cells.2000
- Author(s)
  Funato, T., Sasaki, T., et al.
- Journal Title
  
  Cancer Gene Therapy 165
  
  Pages: 495-500
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] In vitro leukemia cell models of Ara-C resistance.2000
- Author(s)
  T.Funato, J.Satou, Y.Nishiyama, S.Fujimaki, T.Miura, M.Kaku, T.Sasaki.
- Journal Title
  
  Leukemia Research 24
  
  Pages: 535-541
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Chemically modified ribozyme to V gene inhibits anti-DNA production and the formation of immune deposits caused by lupus lymphocytes.2000
- Author(s)
  Suzuki, Y., Sasaki, T., et al.
- Journal Title
  
  J.Immunol. 165
  
  Pages: 5900-5905
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein.2000
- Author(s)
  Takahashi, S, Sasaki, T., et al.
- Journal Title
  
  Biochem.Biophy.Res.Com. 273
  
  Pages: 596-602
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Chemically modified ribozyme to V gene inhibits anti-DNA production and the formation of immune deposits caused by lupus lymphocytes.2000
- Author(s)
  Y.Suzuki, T.Funato, Y.Munakata, K.Sato, Y.Hirabayashi, T.Ishii, N.Takasawa, T.Ootaka, T.Saito, T.Sasaki.
- Journal Title
  
  J Immunol 165
  
  Pages: 5900-5905
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] In vitro leukemia cell models of Ara-C resistance.2000
- Author(s)
  Funato, T., Sasaki, T., et al.
- Journal Title
  
  Leukemia Research 24
  
  Pages: 535-541
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein.2000
- Author(s)
  S.Takahashi, K.Furuyama, A.Kobayashi, S.Taketani, H.Harigae, M.Yamamoto, K.Igarashi, T.Sasaki, N.Hayashi
- Journal Title
  
  Biochem biophys Res Commun 273
  
  Pages: 596-602
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012
[Journal Article] Anti-K-ras rybozyme induces a growth inhibition and an increased chemosensitivity of human colon cancer cells.2000
- Author(s)
  T.Funato, T.Ishii, M.Kambe, K.J.Scanlon, T.Sasaki.
- Journal Title
  
  Cancer Gene Therapy 7
  
  Pages: 495-500
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307012

1. KAMEOKA Junichi (30261621)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. SHIBATA Shinobu (00271932)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. ISHII Tomonori (10282138)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. HARIGAE Hideo (50302146)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MUNAKATA Yasuhiko (20271950)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. FUNATO Tadao (70165455)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
7. ENDO Kazuyasu (60125507)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. ISHII Keiko (00291253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
10. TAKAHASHI Yuichi (80261535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SANO Hiroshi (20178809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OKAMURA Kunihiro (90124560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAMURA Masataka (30180392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATOMI Susumu (00154120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ASAO Hironobu (80250744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KITAGAWA Yoshichika (10006752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAKAHASHI Shinichiro (40375069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MINAMI Yuko (60239316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 星野淳 (60241600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 無量井泰 (00241638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 江口勝美 (30128160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 竹内勤 (50179610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小池隆夫 (80146795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 長澤浩平 (00108721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 宮坂信之 (30157622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 宮村耕一 (70323029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 八重樫伸生 (00241597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 仁木賢 (60241626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SHIRAISHI Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SASAKI Takeshi 佐々木 毅

Research Projects

Research Products

Co-Researchers

新規エコー法による強皮症病変の評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for human parvovirus B19-induced rheumatoid arthjritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

関節リウマチ発症におけるヒトパルボウイルスB19に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗DNA抗体を用いたCD34陽性細胞への遺伝子導入Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Etiological agents responsible for systemic lupus erythrmatosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antinucleic aid antibody gene therapy for rheumatoid Arthritis and adult T cell LeukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍マーカーとしてのカルシウム調節ホルモン・スタニオカルシンPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approarch for the viral agent responsible for rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性エリテマトーデスの予知的指標としての特異的遺伝子Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

組織特異的に発現するアンチセンスリボザイムによる治療Principal Investigator

Principal Investigator

SASAKI Takeshi 佐々木毅