ADACHI Yukihiko 足立幸彦

Researcher Number	50111026
External Links
Affiliation (based on the past Project Information) *help	2006: 三重大学, 大学院医学系研究科, リサーチアソシエイト 1998 – 2004: 三重大学, 医学部, 教授 1993 – 1995: KINKI UNIVERSITY SCHOOL OF MEDICINE.SECOND DEPARTMENT OF INTERNAL MEDICINE, ASSO, 医学部, 助教授 1992: 近畿大学. 医学部内科学II教室, 助教授
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Hygiene
Keywords	Principal Investigator organic anion transporting polypeptide / multidrug resistance-associated protein / fasting hyperbilirubinemia / UGT1A1 / Gilbert's syndrome / bilirubin / organic anion / Gilbert症候群 / ビリルビン / Uridine-diphosphate glucuronosyl transferase … More / polymorphism / transporter / 臓器相関 / short interfering RNA / Eisai hyperbilirubinuria / bilirubin UDP-glucronosyltransferase / stem cell / uridine-diphosphate glucuronosyltransferase / Gunn rat / polypeptide / organic anion transporting / Uridine-diphosphate glucuronosyltransferase / 遺伝子多型 / 遺伝子導入 / トランスポーター / gene mutation / Crigler-Najjar syndrome / 黄疸 / 高ビリルビン血症 / 人種差 / Crigler-Najjan症候群 / 体質性黄疸 / 遺伝子診断 / 血清ビリルビン / ビリルビンUDPグルクロン酸転移酵素 / 絶食高ビリルビン血症 / 遺伝子変異 / Crigler-Najjar症候群 / Rotor's syndrome / biliary excretion / UDP-glucuronosyltransferase / taurocholate / pravastatin / 閉塞性黄疸 / グルクロン酸抱合 / 胆汁中排泄 / 肝細胞内輸送 / Rotor症候群 / 胆汁排泄 / UDPグルクロン酸転移酵素 / タウロコール酸 / プラバスタチン / 有機アニオン … More Except Principal Investigator HEV / virus-like particle / MRP2 / UGT1A1 / VLP / 遺伝子治療 / Gunn rat / ATP / liver / 遺伝子導入 / E型肝炎ウイルス / 肝臓 / HEP / gene therapy / Crigler-Najjar syndrome / Crigler-Najjar症候群 / PRAVASTATIN / DUBIN-JOHNSON SYNDROME / BILE ACIDS / HYPERBILIRUBINEMIA / JAUNDICE / ORGANIC ANION / BILIARY EXCRETION / 毛細胆管 / ビリルビン / プラバスタチン / Dubin-Johnson症候群 / 胆汁酸 / 高ビリルビン血症 / 黄疸 / 有機陰イオン / 胆汁排泄 / リスク評価 / 発がん / がん予防 / バイオマーカー / 活性窒素種 / 感染 / 炎症 / DNA損傷 / 8-oxodG / 8-ニトログアニン Less

Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation
- Principal Investigator
  
  KAWANISHI Shosuke
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Suzuka University of Medical Science
Hepatic and renal expression of organic anion transporters during jaundice, and improvement of transcellular organic anion transport after transfection with Multidrug Resistance-associated Protein 2(MRP2) gene.Principal Investigator
- Principal Investigator
  
  ADACHI Yukihiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University
Establishment of liver-directed gene transfer by hepatitis E virus like particle
- Principal Investigator
  
  IMOTO Ichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University
Gene therapy in the Gunn rat model of Crigler-Najjar syndrome type-1
- Principal Investigator
  
  IMOTO Ichiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University
Relationship between UGT1A1 mutation and occurrence of Gilbert's syndromePrincipal Investigator
- Principal Investigator
  
  ADACHI Yukihiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Mie University
Studies on Hepatic Transport and Metabolism of Bilirubin, Bile Acids, and Other Organic Substances.Principal Investigator
- Principal Investigator
  
  ADACHI Yukihiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kinki University, Second Department of Internal Miedicine.
HEPAIOCYTE MEMBRANE TRANSPORT MECHANISM OF VARIOUS SUBSTANCES
- Principal Investigator
  
  YAMAMOTO Toshio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  SECOND DEPARTMENT OF INTERNAL MEDICINE.KINKI UNIVERSITY SCHOOL OF MEDICINE.

All 2007 2005 2004 2003

All Journal Article Book

[Book] 肝疾患 Review 20042004
- Author(s)
  小林由直, 黒田誠, 足立幸彦
- Total Pages
  237
- Publisher
  日本メディカルセンター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients2007
- Author(s)
  Fujita N, Horiike S, Sugimoto R,Tanaka H, Iwasa M, Kobayashi Y,Hasegawa K, Ma N, Kawanishi S, Adachi Y, Kaito M
- Journal Title
  
  Free Radic Biol Med. 42(3)
  
  Pages: 353-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390179
[Journal Article] Hepatic uptake of bilirubin revisited.2005
- Author(s)
  Yukihiko Adachi, Yoshinao Kobayashi
- Journal Title
  
  Hepatol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] Increased hepatic and renal expression of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rat2004
- Author(s)
  Kuroda M., Kobayashi Y., Tanaka Y, Itani T, Mifuji R, Araki J, Kaito M, Adachi Y
- Journal Title
  
  Journal of Gastroenterology and Hepatology 19
  
  Pages: 146-153
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] Modulation of organic anion transporting polypeptide 1 and multidrug resistance protein 3 expression in the liver and kidney of Gunn rats.2004
- Author(s)
  Higuchi K, Kobayashi Y, Kuroda M, Tanaka Y, Itani T, Araki J, Mifuji K, Kaito M, Adachi Y
- Journal Title
  
  Hepatology Research 29
  
  Pages: 60-66
- NAID
  10018024061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] Genetic polymorphisms of bilirubin uridine diphoshate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects2004
- Author(s)
  Takeuchi K, Kobayashi Y, Tamaki S, Ishihara, T, Maruo Y, Araki J, Mifuji R, Itani T, Kuroda M, Sato H, Kaito M, Adachi Y
- Journal Title
  
  Journal of Gastroenterology and Hepatology 19
  
  Pages: 1023-1028
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] 体質性黄疸2003
- Author(s)
  小林由直, 足立幸彦
- Journal Title
  
  肝臓 44
  
  Pages: 483-491
- NAID
  130000875238
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178
[Journal Article] Expression of hepatobiliary organic anion transporters and bilirubin-conjugating enzymes in differentiating embryonic stem cells.2003
- Author(s)
  Tanaka Y., Yoshikawa M., Kobayashi Y, Kuroda M, Kaito M, Shiroi A, Yamao J, Fukui H, Ishizuka S, Adachi Y
- Journal Title
  
  Biochemical and Biophysical Research Communication 309
  
  Pages: 324-330
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370178

1. TAMAKI Sigenori (80260602)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. YAMAMOTO Toshio (50088522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. IMOTO Ichiro (90176511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAWANISHI Shosuke (10025637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MURATA Mariko (10171141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OIKAWA Shinji (10277006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIRAKU Yusuke (30324510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHNISHI Shiho (80511914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NANNO Tatsuo (40189220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOBAYASHI Yoshinao (70378298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

ADACHI Yukihiko 足立 幸彦

Research Projects

Research Products

Co-Researchers

Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hepatic and renal expression of organic anion transporters during jaundice, and improvement of transcellular organic anion transport after transfection with Multidrug Resistance-associated Protein 2(MRP2) gene.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of liver-directed gene transfer by hepatitis E virus like particle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy in the Gunn rat model of Crigler-Najjar syndrome type-1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relationship between UGT1A1 mutation and occurrence of Gilbert's syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on Hepatic Transport and Metabolism of Bilirubin, Bile Acids, and Other Organic Substances.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HEPAIOCYTE MEMBRANE TRANSPORT MECHANISM OF VARIOUS SUBSTANCES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝疾患 Review 20042004

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients2007

Author(s)

Journal Title

Data Source

[Journal Article] Hepatic uptake of bilirubin revisited.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased hepatic and renal expression of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rat2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Modulation of organic anion transporting polypeptide 1 and multidrug resistance protein 3 expression in the liver and kidney of Gunn rats.2004

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Genetic polymorphisms of bilirubin uridine diphoshate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] 体質性黄疸2003

Author(s)

Journal Title

ADACHI Yukihiko 足立幸彦