YUKOI Toshio 横井利夫

… Alternative Names

YOKOI Toshio 横井利夫

横井利夫ヨコイトシオ

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Researcher Number	50122255
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2012: 神戸学院大学, 薬学部, 教授 1998 – 2001: 神戸学院大学, 薬学部, 教授 1994 – 1996: 神戸学院大学, 薬学部, 助教授
Review Section/Research Field	Except Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemical pharmacy
Keywords	Except Principal Investigator 抗腫瘍活性 / 核磁気共鳴法 / 構造解明 / μ-opioid receptor agoniat / dimethyltyrosine / diamine derivartives / endomorphine derivatives / pyrazinone derivatives / opioid mimetics / 二機能性リガンド … More / δ-オピオイドレセプターアンタゴニスト / エンドモルーフィン誘導体 / オピオイドミナティクス / 皮下投与 / 鎮痛薬 / μ-オピオイドレセプターアゴニスト / ジメチルチロシン / ジアミン誘導体 / エンドモルフィン誘導体 / ピラジノン誘導体 / オピオイドミメティクス / DNA polymerase阻害 / DNA polymerase 阻害 / ソマトスタチン配列 / 疎水性 / 分子設計 / コンフォメーション解析 / 酵素安定性 / オピオイド受容体 / エンドモルフィン / 伝承民間薬 / 成分研究 / 中国産植物 / β-フェニルイソセリン / オキセタン環 / abeotaxane / タキソール / 植物成分 / Taxus Chinensis / タキソ-ル / 分子力場計算 / 立体配座 / ジテルペン / Taxus chinensis / 中国産イチイ科植物 Less

Search for the anti-tumor derivatives containing the somatostatin sequence focusing on the hydrophobic index
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design of agonists and antagonists for opioid receptors based on the structures of endomorphins
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design and synthesis of μ-selective opioidomimetic peptides
- Principal Investigator
  
  OKADA Yoshio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kobe Gakuin University
抗腫瘍活性を志向した中国産植物成分の化学的研究
- Principal Investigator
  
  冨士薫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto University
抗腫瘍活性ジテルペノイドの検索、構造並びに化学変換に関する研究
- Principal Investigator
  
  冨士薫 (富士薫)
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University

All 2012 2011 2010 2008 2007

All Journal Article Presentation Patent

[Journal Article] Synthesis and anticancer activities of lipophilic somatostatin derivatives. Peptide2012; Proceedings of the 32nd European Peptide Symposium, Edited by Kokotos2012
- Author(s)
  Imazumi H., Suyama T., Takami D., Hidaka K., Miyazaki A., Yokoi T., Kuriyama I., Yoshida H., Mizushina Y., Tsuda Y.
- Journal Title
  
  G., et al.
  
  Pages: 666-667
- URL
  http://www.eurpepsoc.com/symposis.proceedigs
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] Inhibitory effect of somatostatin peptide analogues on DNA polymerase activity and human cancer cell proliferation.2010
- Author(s)
  Kuriyama I., Miyazaki A., Tsuda Y., Yokoi T., Okada Y., Takeuchi T., Sugawara F., Yoshida H., Mizushina Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 30 Pages: 4841-4850
- URL
  http://ar.iiarjournals.org/contact/by/year
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111
[Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages: 6199-6201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  J. Med. Chem 51
  
  Pages: 5121-5124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007
- Author(s)
  Shiotani, K., Miyazaki A., Li, T., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Jinsmaa, Y., Lazarus, L.H., Okada, Y
- Journal Title
  
  Med. Chem 3
  
  Pages: 583-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007
- Author(s)
  Shiotani, K., Li, T., Miyazaki, A., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Lazarus, L.H., Okada, Y
- Journal Title
  
  Chem. Lett 17
  
  Pages: 5768-5771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Patent] 新規なオピオイド誘導体2010
- Inventor(s)
  岡田芳男, 津田裕子, 横井利夫
- Industrial Property Rights Holder
  帝国製薬株式会社
- Acquisition Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] 脂溶性に富むソマトスタチン誘導体の合成と抗腫瘍活性.2012
- Author(s)
  陶山泰治郎,稲住瞳,高見大介,日高興士,宮崎杏奈,横井利夫,栗山磯子,吉田弘美,水品善之,津田裕子.
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Synthesis and anticancer activities of lipophilic somatostatin derivatives.2012
- Author(s)
  Inazumi H., Suyama T., Takami D., Hidaka K., Miyazaki A., Yokoi T., Kuriyama I., Yoshida H., Mizushina Y., Tsuda Y.
- Organizer
  The 32nd European Peptide Symposium
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] 疎水性を指標としたソマトスタチン誘導体の合成と生物活性.2012
- Author(s)
  越智文也、北岡健二、宮崎杏奈、横井利夫、日高興士、栗山磯子、吉田弘美、水品善之、津田裕子.
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590111
[Presentation] Somatostatin derivatives that exhibit inhibitory effects on DNA polymerae and human cancer cell proliferation.2011
- Author(s)
  Ochi F., Kitaoka K., Miyazaki A., Yokoi T., Hidaka K., Kuriyama I., Yoshida H, Mizushina Y., Tsuda Y.
- Organizer
  14th Peptide Forum
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590111

1. TSUDA Yuko (10098478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. OKADA Yoshio (60068236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 冨士薫 (20027056)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 川端猛夫 (50214680)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 田中圭 (50093266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 孫漢董

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MIZUSHINA Yoshiyuki (20307705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. MIYAZAKI Anna (00340919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 新宮徹朗 (20068216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 池田潔 (40168125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 陳紀軍

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ハオ小江

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 李波

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 趙勤実

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YUKOI Toshio 横井 利夫

YOKOI Toshio 横井 利夫

横井 利夫 ヨコイ トシオ

Research Projects

Research Products

Co-Researchers

Search for the anti-tumor derivatives containing the somatostatin sequence focusing on the hydrophobic index

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design of agonists and antagonists for opioid receptors based on the structures of endomorphins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and synthesis of μ-selective opioidomimetic peptides

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗腫瘍活性を志向した中国産植物成分の化学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗腫瘍活性ジテルペノイドの検索、構造並びに化学変換に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Synthesis and anticancer activities of lipophilic somatostatin derivatives. Peptide2012; Proceedings of the 32nd European Peptide Symposium, Edited by Kokotos2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] Inhibitory effect of somatostatin peptide analogues on DNA polymerase activity and human cancer cell proliferation.2010

Author(s)

Journal Title

URL

Data Source

[Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007

Author(s)

Journal Title

Data Source

[Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007

Author(s)

Journal Title

Data Source

[Patent] 新規なオピオイド誘導体2010

Inventor(s)

Industrial Property Rights Holder

Acquisition Date

Data Source

[Presentation] 脂溶性に富むソマトスタチン誘導体の合成と抗腫瘍活性.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Synthesis and anticancer activities of lipophilic somatostatin derivatives.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 疎水性を指標としたソマトスタチン誘導体の合成と生物活性.2012

Author(s)

Organizer

Place of Presentation

YUKOI Toshio 横井利夫

YOKOI Toshio 横井利夫

横井利夫ヨコイトシオ