TAKAHASHI Mayumi 高橋眞由美

Researcher Number	50133632
Affiliation (based on the past Project Information) *help	2011 – 2014: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 2005 – 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 助手 2004: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare, Research associate, 福祉振興財団・東京都老人総合研究所, 助手 2003: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所・分子老化研究グループ, 研究助手 2000: (財)東京都老人総合研究所, 超微形態部門, 研究助手 1999 – 2000: 財団法人東京都老人総合研究所, 超微形態部門, 研究助手
Review Section/Research Field	Principal Investigator 細胞死(アポトーシス) / Neurology / Integrated Nutrition Science Except Principal Investigator General medical chemistry
Keywords	Principal Investigator CoQ / ミトコンドリア / ultradian rhythm / mitochondria / apoptosis / clk-1 gene / 長寿関連遺伝子 / Tet-offシステム / ウルトラディアンリズム / アポトーシス … More / clk-1遺伝子 / Adeno virus / Gene therapy / Knockout mouse / Mn-SOD / Superoxide / Dopaminergic neuron / Model mouse / Parkinson's disease / Tyrosine Hydroxylase / ES細胞 / 人口高齢化 / ドーパミン / アデノウイルス / 遺伝子治療 / ノックアウトマウス / MnSOD / 活性酸素 / ドーパミン系神経細胞 / 疾患モデルマウス / パーキンソン病 / マウス / 酸素消費 / 老化機構 / コエンザイムＱ / 酸素消費量 / ミトコンドリア機能低下 / クロック-1遺伝子 / トランスジェニックマウス / 骨格筋 / 脳 / 代謝 / コエンザイムQ / 老化 / 寿命 … More Except Principal Investigator Cre-loxP / ATP synthesis / Apoptosis / Respiratory complex / Mitochondria / Aging / Superoxide / Mn-SOD / 活性酸素 / ATP合成 / アポトーシス / 呼吸鎖複合体 / ミトコンドリア / 老化 / 活性酵素 / MnSOD Less

Effects of coenzyme Q on aging in mammlsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mayumi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Analysis of heart/muscle-specific Mn-SOD-deficient mice.
- Principal Investigator
  
  SHIRASAWA Takuji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Regulation of apoptosis through clk- 1 genePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mayumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
Preparation and analysis of model mice with Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mayumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2014 2013 2012 2011 2004 Other

All Journal Article Presentation Book

[Book] 時間薬理学による最新の治療戦略2013
- Author(s)
  高橋真由美
- Total Pages
  344
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-23617042
[Book] 時間薬理学による最新の治療戦略2013
- Author(s)
  高橋真由美(分担執筆）
- Total Pages
  351
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice2014
- Author(s)
  Kazuhide Takahashi, Yoshihiro Noda, Ikuroh Ohsawa, Takuji Shirasawa, Mayumi Takahashi
- Journal Title
  
  Experimental Gerontology
  
  Volume: 58 Pages: 146-153
- DOI
  10.1016/j.exger.2014.08.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Exogenous administration of coenzyme Q10 restores mitochondrial oxygen consumption in the aged mouse brain.2013
- Author(s)
  Kazuhide Takahashi, Mayumi Takahashi
- Journal Title
  
  Mechanisms of Aging and Development
  
  Volume: 134 Issue: 11-12 Pages: 580-580
- DOI
  10.1016/j.mad.2013.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous CoQ10.2012
- Author(s)
  Takahashi, M., Ogawara, M., Shimizu, T., Shirasawa, T.
- Journal Title
  
  Exp. Gerontol
  
  Volume: 47 Pages: 276-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Reversal of slow growth and heartbeat through restoration of mitochondrial functions in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.2012
- Author(s)
  1. Takahashi, M., Shimizu, T., Shirasawa, T.
- Journal Title
  
  Exp. Gerontol.
  
  Volume: 47 Issue: 6 Pages: 425-431
- DOI
  10.1016/j.exger.2012.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] 寿命：究極の生体リズム2011
- Author(s)
  高橋真由美
- Journal Title
  
  ファルマシア
  
  Volume: 47(7) Pages: 654-658
- NAID
  110009900993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617042
[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q2004
- Author(s)
  Daisuke Nakai, Takahiko Shimizu, Hidetoshi Nojiri, Satoshi Uchiyama, Hideo Koike, Mayumi Takahashi, Katsuiku Hirokawa, Takuji Shirasawa
- Journal Title
  
  Aging Cell vol.3
  
  Pages: 273-281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603009
[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q2004
- Author(s)
  Daisuke Nakai, Takahiko Shimizu, Hidetoshi Nojiri, Satoshi Uchiyama, Hideo Koike, Mayumi Takahashi, Katsuiku Hirokawa, Takuji Shirasawa
- Journal Title
  
  Aging Cell 2
  
  Pages: 273-281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603009
[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q.2004
- Author(s)
  D.Nakai, T.Shimizu, H.Nojiri, S.Uchiyama, H.Koike, M.Takahashi, K.Hirokawa, T.Shirasawa
- Journal Title
  
  Aging Cell 3
  
  Pages: 273-281
- Data Source
  KAKENHI-PROJECT-15603009
[Presentation] 加齢に伴うマウス脳ミトコンドリア機能の低下は水溶性コエンザイムQ10飲水投与により回復する2013
- Author(s)
  高橋　真由美、大澤　郁朗、高橋　和秀
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] コエンザイムQ10はclk-1変異線虫の寿命延長と行動リズム遅延及びclk-1欠損マウスの生体リズム遅延を完全レスキューする.2012
- Author(s)
  1. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
- Organizer
  第35回日本基礎老化学会大会
- Place of Presentation
  東邦大学
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] コエンザイムQの新たな機能：生体リズムと寿命の調節.2012
- Author(s)
  2. 高橋真由美、小河原緑、清水孝彦、白澤卓二.
- Organizer
  第35回日本分子生物学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] 加齢に伴うマウス脳ミトコンドリアの機能低下と水溶性CoQ10による回復
- Author(s)
  高橋　真由美・大澤　郁朗・高橋　和秀
- Organizer
  第11回日本コエンザイムQ協会研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] clk-1トランスジェニックマウスにおける寿命延長とミトコンドリア機能低下
- Author(s)
  高橋和秀、野田義博、大澤郁朗、白澤卓二、高橋真由美
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-05 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23617042
[Presentation] clk-1トランスジェニックマウスにおける筋ミトコンドリア機能低下と寿命延長
- Author(s)
  高橋和秀、野田義博、大澤郁朗、白澤卓二、高橋真由美
- Organizer
  第38回基礎老化学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-06-13 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-23617042

1. SHIRASAWA Takuji (80226323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. OGAWARA Midori (60100111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MORIIZUMI Eiko (20322711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 白沢卓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

TAKAHASHI Mayumi 高橋 眞由美

Research Projects

Research Products

Co-Researchers

Effects of coenzyme Q on aging in mammlsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of heart/muscle-specific Mn-SOD-deficient mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of apoptosis through clk- 1 genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preparation and analysis of model mice with Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 時間薬理学による最新の治療戦略2013

Author(s)

Total Pages

Publisher

Data Source

[Book] 時間薬理学による最新の治療戦略2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exogenous administration of coenzyme Q10 restores mitochondrial oxygen consumption in the aged mouse brain.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous CoQ10.2012

Author(s)

Journal Title

Data Source

[Journal Article] Reversal of slow growth and heartbeat through restoration of mitochondrial functions in clk-1-deficient mouse embryos by exogenous administration of coenzyme Q10.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 寿命：究極の生体リズム2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q.2004

Author(s)

Journal Title

Data Source

[Presentation] 加齢に伴うマウス脳ミトコンドリア機能の低下は水溶性コエンザイムQ10飲水投与により回復する2013

Author(s)

Organizer

Place of Presentation

TAKAHASHI Mayumi 高橋眞由美