HAZEKI Kaoru 櫨木薫

Researcher Number	50146007
Affiliation (based on the past Project Information) *help	2013: 広島大学, 医歯(薬)学総合研究科, 准教授 2012: 広島大学, 医歯薬保健学研究院(薬), 准教授 2012: 広島大学, 医歯薬保健学研究院, 准教授 2012: 広島大学, 大学院・医歯薬学保健学研究院, 准教授 2011: 広島大学, 大学院・医歯薬学総合研究科, 准教授 … More 2010 – 2011: 広島大学, 医歯学総合研究科, 准教授 2010: 広島大学, 医歯薬学総合研究科, 准教授 2004 – 2005: 広島大学, 医歯薬学総合研究科, 助手 1993 – 1997: 理化学研究所, 宇井特別研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy Except Principal Investigator Biological Sciences / 代謝生物化学 / Biological Sciences
Keywords	Principal Investigator チロシンキナーゼ / 食細胞 / ワ-トマニン / GTP結合蛋白質 / Fcγレセプター / PI-3-キナーゼ / Cbl / O_2-産生 / cyclic AMP (cAMP) / phosphatidylinositol 3-kinase … More / protein kinase C / epidermal growth factor / GTP-binding protein / tyrosine kinase / cellular signal transduction / Fcレセプター / サイクリックAMP(cAMP) / ホスファチジルイノシトール3-キナーゼ / プロテインキナーゼC / 上皮増殖因子 / GTP結合タンパク質 / 細胞内情報伝達 / RNA干渉 / タイムラプスイメージング / ファゴソーム / 貪食 / マクロファージ / shRNA / イノシトールリン脂質 / O_2^-産生 / 補体レセプター … More Except Principal Investigator cross-priming / IFN-β / cytotoxicity T lymphocytes / NK cell / antigen presenting cells / Antitumor immunity / Virus / TICAM-1(TRIF) / MyD88 / CTL誘導 / NK活性化 / 骨髄性樹状細胞 / Poly I:C(dsRNA) / IRF-3 / Toll様受容体 / 抗原掲示細胞 / 細胞障害性Tリンパ球 / NK細胞 / 抗原提示細胞 / がん免疫 / ウイルス / adrenergic receptor / pertussis toxin / protein tyrosine phosphorylation / PI 3-kinase / wortmannin / cell adhesion / cell differentiation / heterotrimeric G proteins / 百日咳毒素 / 3T3細胞 / HL-60細胞 / 細胞分化 / 肝蔵細胞 / Caチャネル / G蛋白質 / Gq / Gs / alpha_1アドレナリン受容体 / betaアドレナリン受容体 / 肝臓初代培養 / 3量体G蛋白質 / 細胞接着 / チロシンキナーゼ / ワ-トマニン / PI-3-キナーゼ / 細胞増殖 / GTP結合蛋白質 / 食細胞 / 肝臓細胞 / インターフェロン / TICAM-1経路 / MyD88 経路 / Toll-like receptor (TLR) / 腫瘍浸潤マクロファージ / 発がん・抗がん微小環境 / 自然免疫 / Toll-like receptor / 樹状細胞 / マクロファージ / 抗がん免疫 / パターン認識 / Toll like receptor Less

感染発がんを変調する宿主炎症応答機構
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Spatiotemporal regulation of phagocytosis by phosphoinositides;fluorescent microscopic analysis with shRNA knock down cellsPrincipal Investigator
- Principal Investigator
  
  HAZEKI Kaoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
Pattern recognition receptors on human dendritic cells that induce specific effector responses depending on microbes.
- Principal Investigator
  
  SEYA Thukasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  HOKKAIDO UNIVERSITY
Crosstalk between tyrosine kinase and GTP-Binding Protein Systems in Cellular Signal TransductionPrincipal Investigator
- Principal Investigator
  
  FUJIOKA Toshiyuki, 櫨木薫
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research (RIKEN)
食細胞において機能するホスファチジルイノシトール-3-キナーゼの多様性Principal Investigator
- Principal Investigator
  
  櫨木薫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
抗体依存性貪食作用におけるホスファチジルイノシトール-3-キナーゼの役割Principal Investigator
- Principal Investigator
  
  櫨木薫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
抗体および補体依存性貧食作用におけるホスファチジルイノシトール-3-キナーゼの役割Principal Investigator
- Principal Investigator
  
  櫨木薫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Signal Transduction Systems for Cell Proliferation, Differentiation and Adhesion with Emphasis upon the Role of GTP-binding Proteins
- Principal Investigator
  
  UI Michio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  代謝生物化学
- Research Institution
  The Institute of Physical and Chemical Chemical Research (RIKEN)
  The University of Tokyo

All 2012 2011 2010

All Journal Article Presentation

[Journal Article] Class-IA phosphoinositide 3-kinase p110βtriggers GPCR-induced superoxide production in p110γ-deficient murine neutrophils2012
- Author(s)
  Nigorikawa K, Hazeki K, Kumazawa T, Itoh Y, Hoshi M and Hazeki O
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 120 Pages: 270-279
- NAID
  10031147575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065
[Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012
- Author(s)
  Hazeki K.
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Issue: 22 Pages: 4010-4015
- DOI
  10.1016/j.febslet.2012.09.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-24659124
[Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012
- Author(s)
  Hazeki K, Nigorikawa K,Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Takasuga S and Hazeki O
- Journal Title
  
  FEBS lett
  
  Volume: 586 Pages: 4010-4015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065
[Journal Article] C5a controls TLR-induced IL-10 and IL-12 production independent of phosphatidyl- linositol 3-kinase2011
- Author(s)
  Okazaki N, Hazeki K, Izumi T, Nigorikawa K, Hazeki O
- Journal Title
  
  J Biochem
  
  Volume: 149 Pages: 265-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065
[Journal Article] Phosphoinositide 3-kinaseY controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011
- Author(s)
  K.Hazeki, et al
- Journal Title
  
  PLos ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590065
[Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011
- Author(s)
  Hazeki, K., Kametani, Y., et al, (11名中7番目)
- Journal Title
  
  PLoS One.
  
  Volume: 6 Issue: 10 Pages: e26836-e26836
- DOI
  10.1371/journal.pone.0026836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21200079, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-22790055, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Presentation] PIKfyve による非メチル化 CpG の局在調節を介した TLR9 シグナルの制御2012
- Author(s)
  上原政文、櫨木薫、濁川清美、櫨木修
- Organizer
  第51回日本薬学会中国四国支部学術大会
- Place of Presentation
  松江
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] 食胞のホスファチジルイノシトール3-リン酸は主にPTENとPIKfyveによって除去される2012
- Author(s)
  温田晃子、櫨木薫、濁川清美、益田彩加、櫨木修
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] マクロファージによる感作赤血球の貪食におけるイノシトールリン脂質脱リン酸化酵素の役割の違い2012
- Author(s)
  瀬川智裕、櫨木薫、濁川清美、林美里、三宅美喜子、櫨木修
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] マスト細胞の機能制御におけるクラス2型PI3Kの役割2012
- Author(s)
  岡崎智子、濁川清美、櫨木薫、郭瑩、櫨木修
- Organizer
  第51回日本薬学会中国四国支部学術大会
- Place of Presentation
  松江
- Year and Date
  2012-11-11
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] PI3Kγによる非メチル化 CpG の細胞内局在と IL10 産生の制御2011
- Author(s)
  上原政文、櫨木薫、濁川清美、櫨木修
- Organizer
  第50回日本薬学会中国四国支部学術大会
- Place of Presentation
  高松
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] イノシトールリン脂質代謝酵素のノックダウンが食胞の PtdIns(3)P レベルに及ぼす影響2011
- Author(s)
  櫨木修、櫨木薫
- Organizer
  第10回生命科学研究会
- Place of Presentation
  高崎
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] マクロファージの貪食機能に対する PI3K サブタイプ特異的阻害薬の作用2011
- Author(s)
  石川由紀、高場雄貴、櫨木薫、濁川清美、櫨木修
- Organizer
  第50回日本薬学会中国四国支部学術大会
- Place of Presentation
  高松
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] イノシトールリン脂質代謝酵素のノックダウンが食胞のPtdlns(3)Pレベルに及ぼす影響2011
- Author(s)
  櫨木修
- Organizer
  第10回生命科学研究会
- Place of Presentation
  高崎
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] 好中球の活性酸素産生制御におけるクラスIA型PI3Kの役割2011
- Author(s)
  熊澤崇,濁川清美,櫨木薫,櫨木修
- Organizer
  第52回日本生化学会中国・四国支部例会
- Place of Presentation
  広島
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] マクロファージの食胞におけるPI(3)Pの動態2011
- Author(s)
  石川由紀、高場雄貴、櫨木薫、濁川清美、櫨木修
- Organizer
  第52回日本生化学会中国・四国支部例会
- Place of Presentation
  広島
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] マクロファージの貪食におけるイノシトールリン脂質の動態の解明2010
- Author(s)
  高場雄貴、櫨木薫、櫨木修
- Organizer
  第51回日本生化学会中国・四国支部例会
- Place of Presentation
  山口
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22590065
[Presentation] 好中球の活性酸素産生を制御する PI3-キナーゼサブタイプの解明2010
- Author(s)
  熊澤崇,濁川清美,櫨木薫,櫨木修
- Organizer
  第51回日本生化学会中国・四国支部例会
- Place of Presentation
  山口
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-22590065

1. SEYA Tsukasa (10301805)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MATSUMOTO Misako (30332456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUJIOKA Toshiyuki (20133770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. UI Michio (50001037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 志馬寛明 (70372133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. PENMETCHA Kumar (80357938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 多田周右 (00216970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 星野真一 (40219168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 櫨木修 (80142751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 榎本武美 (80107383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAZEKI Kaoru 櫨木 薫

Research Projects

Research Products

Co-Researchers

感染発がんを変調する宿主炎症応答機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatiotemporal regulation of phagocytosis by phosphoinositides;fluorescent microscopic analysis with shRNA knock down cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pattern recognition receptors on human dendritic cells that induce specific effector responses depending on microbes.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Crosstalk between tyrosine kinase and GTP-Binding Protein Systems in Cellular Signal TransductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

食細胞において機能するホスファチジルイノシトール-3-キナーゼの多様性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗体依存性貪食作用におけるホスファチジルイノシトール-3-キナーゼの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗体および補体依存性貧食作用におけるホスファチジルイノシトール-3-キナーゼの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Signal Transduction Systems for Cell Proliferation, Differentiation and Adhesion with Emphasis upon the Role of GTP-binding Proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Class-IA phosphoinositide 3-kinase p110βtriggers GPCR-induced superoxide production in p110γ-deficient murine neutrophils2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012

Author(s)

Journal Title

Data Source

[Journal Article] C5a controls TLR-induced IL-10 and IL-12 production independent of phosphatidyl- linositol 3-kinase2011

Author(s)

Journal Title

Data Source

[Journal Article] Phosphoinositide 3-kinaseY controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011

Author(s)

Journal Title

Data Source

[Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] PIKfyve による非メチル化 CpG の局在調節を介した TLR9 シグナルの制御2012

HAZEKI Kaoru 櫨木薫