HASHIMOTO Syuji 橋本修二

Researcher Number	50148334
Other IDs
Affiliation (Current)	2023: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 藤田医科大学, 医学部, 教授 2014 – 2017: 藤田保健衛生大学, 医学部, 教授 2015: 藤田保健衛生大学, 医学部衛生学講座, 教授 2009: 藤田保健衛生大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Epidemiology and preventive medicine Except Principal Investigator Epidemiology and preventive medicine / Biological Sciences
Keywords	Principal Investigator 保健医療統計 / 二次利用 / 匿名データ / 集計可能な内容 / 研究事例 / 統計 / 疫学 Except Principal Investigator 生活習慣病 / エピジェネティクス / DNAメチル化 … More / バイオマーカー / コーホート研究 / がん / 生活習慣 / 遺伝子型 / 生体指標 / 交互作用 / 匿名化 / コホート / 社会医学 / メチル化 / 遺伝子 / コホート研究 / 一般住民 / ＤＮＡメチル化 / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / 分子疫学 / ABCA1 / TXNIP / LPL / HIF / LINE-1 / BDNF / 縦断研究 Less

Development of secondary use of health and medical statisticsPrincipal Investigator
- Principal Investigator
  
  Hashimoto Shuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Fujita Health University
Longitudinal study on the relationship between the DNA methylation status of metabolism-related genes and the development of lifestyle-related diseases
- Principal Investigator
  
  SUZUKI Koji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Fujita Health University
Analysis of the methylation status of leukocytes DNA stored in a longitudial cohort study
- Principal Investigator
  
  Suzuki Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Fujita Health University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Study on supports for molecular cohort studies
- Principal Investigator
  
  HAMAJIMA Nobuyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2005 Other

All Journal Article Presentation

[Journal Article] Associations of occupation, employment type and company size with actions related to health examinations among Japanese employees2019
- Author(s)
  Seko R, Kawado M, Saito S, Shibuya T, Miyamoto M, Yamada H, Taniwaki H, Hashimoto S.
- Journal Title
  
  Industrial Health
  
  Volume: 57 Pages: 537-546
- DOI
  10.2486/indhealth.2018-0112
- NAID
  130007687417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09138
[Journal Article] Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population.2019
- Author(s)
  Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ando Y, Mizuno G, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Maeda K, Hashimoto S, Suzuki K.
- Journal Title
  
  Am J Clin Nutr
  
  Volume: 110 Pages: 1213-1219
- DOI
  10.1093/ajcn/nqz181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09139, KAKENHI-PROJECT-16H06277
[Journal Article] 手助けや見守りを要する者がいる世帯における世帯員の健康とストレスの状況―国民生活基礎調査の匿名データの解析―2019
- Author(s)
  世古留美, 宮本美穂, 齋藤彩那, 山田宏哉, 川戸美由紀, 谷脇弘茂, 橋本修二
- Journal Title
  
  厚生の指標
  
  Volume: 66(11) Pages: 1-5
- NAID
  40022025802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09138
[Journal Article] Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women2019
- Author(s)
  Fujii Ryosuke、Yamada Hiroya、Munetsuna Eiji、Yamazaki Mirai、Mizuno Genki、Tsuboi Yoshiki、Ohashi Koji、Ishikawa Hiroaki、Ando Yoshitaka、Hagiwara Chiharu、Maeda Keisuke、Hashimoto Shuji、Hamajima Nobuyuki、Suzuki Koji
- Journal Title
  
  Nutrition
  
  Volume: 65 Pages: 1-5
- DOI
  10.1016/j.nut.2019.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09139
[Journal Article] Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population.2018
- Author(s)
  Tsuboi Y, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Murase Y, Ohashi K, Ishikawa H, Kondo M, Inoue T, Hashimoto S, Hamajima N, Suzuki K.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 25 Issue: 12 Pages: 1231-1239
- DOI
  10.5551/jat.43570
- NAID
  130007539358
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09139, KAKENHI-PROJECT-16H06277
[Journal Article] GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm2016
- Author(s)
  Taki, K., Ohmuraya, M., Tanji, E., Komatsu, H., Hashimoto, D., Semba, K., Araki, K., Kawaguchi, Y., Baba, H. and Furukawa, T.
- Journal Title
  
  Oncogene.
  
  Volume: in press Pages: 2407-2412
- DOI
  10.1038/onc.2015.294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-25640052, KAKENHI-PROJECT-25670653
[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database.2015
- Author(s)
  Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano KI, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M,Himi T, Hasegawa T, Imai K, Shinomura Y
- Journal Title
  
  Modern Rheumatology
  
  Volume: 27 Pages: 199-204
- DOI
  10.3109/14397595.2014.950036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861575, KAKENHI-PROJECT-15K10818, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.2015
- Author(s)
  Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, Yamada Y.
- Journal Title
  
  Carcinogenesis.
  
  Volume: 36 Pages: 719-29
- DOI
  10.1093/carcin/bgv060
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04721, KAKENHI-PROJECT-26830069, KAKENHI-PROJECT-24680091
[Journal Article] Generation and analysis of serine protease inhibitor Kazal type 3-cre driver mice2014
- Author(s)
  Sakata, K., Ohmuraya, M., Araki, K., Suzuki, C., Ida, S., Hashimoto, D., Wang, J., Uchiyama, Y., Baba, H. and Yamamura, K.
- Journal Title
  
  Exp. Anim.
  
  Volume: 63
- NAID
  130003391605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN2014
- Author(s)
  Nakano Y, Yokohira M, Hashimoto N, Yamakawa K, Kishi S, Ninomiya F, Kanie S, Saoo K, Imaida K
- Journal Title
  
  Exp. Toxicol. Pathol
  
  Volume: 66
- DOI
  10.1016/j.etp.2014.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.2013
- Author(s)
  Hotta H., Hamamura K., Yamashita K,. Shibuya H., Tokuda N., Hashimoto N., Furukawa K., Yamamoto N., Hattori H., Toyokuni S., Ueda M., Furukawa K.
- Journal Title
  
  Glycoconj J
  
  Volume: 30 Pages: 585-597
- DOI
  10.1007/s10719-012-9458-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Toxicity of Nicotine by Repeated Intratracheal Instillation to F344 Rats2012
- Author(s)
  Yokohira M, Nakano Y, Hashimoto N, Yamakawa K, Ninomiya F, Kishi S, Saoo K, Imaida K.
- Journal Title
  
  J Toxicol Pathol
  
  Volume: 25 Issue: 4 Pages: 257-263
- DOI
  10.1293/tox.25.257
- NAID
  130002499152
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Bias of vaccination coverage in a household questionnaire survey in Japan2005
- Author(s)
  Hashimoto S
- Journal Title
  
  J Epidemiol 15
  
  Pages: 15-19
- Data Source
  KAKENHI-PROJECT-17015018
[Presentation] 住民健診受診者における飲酒習慣と白血球中TXNIP遺伝子のDNAメチル化率との関連2020
- Author(s)
  前田圭介, 山田宏哉, 宗綱栄二, 山崎未来, 安藤嘉崇, 水野元貴, 大橋鉱二, 石川浩章, 藤井亮輔, 坪井良樹, 萩原千晴, 橋本修二, 浜島信之, 鈴木康司
- Organizer
  第30回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民を対象とした脂質クオリティとABCA1遺伝子DNAメチル化率との関連2020
- Author(s)
  藤井亮輔, 山田宏哉, 宗綱栄二, 山崎未来, 安藤嘉崇, 水野元貴, 大橋鉱二, 石川浩章, 前田圭介, 萩原千晴, 橋本修二, 鈴木康司
- Organizer
  第90回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民を対象としたABCA1遺伝子のメチル化関連SNPおよびn-3多価不飽和脂肪酸摂取量とHDLコレステロールとの関連2020
- Author(s)
  藤井亮輔, 山田宏哉, 安藤嘉崇, 山崎未来, 宗綱栄二, 水野元貴, 大橋鉱二, 石川浩章, 前田圭介, 萩原千晴, 橋本修二, 鈴木康司
- Organizer
  第30回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 住民健診受診者における糖代謝指標値と白血球中TXNIP遺伝子のDNAメチル化率との関連2019
- Author(s)
  前田圭介、山田宏哉、宗綱栄二、山崎未来、水野元貴、大橋鉱二、石川浩章、安藤嘉崇、藤井亮輔、萩原千晴、橋本修二、浜島信之、鈴木康司
- Organizer
  第29回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] Dietary vegetables and vitamins intakes are associated with ABCA1 promoter DNA methylation in women2019
- Author(s)
  Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Koji Ohashi, Hiroaki Ishikawa, Yoshitaka Ando, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
- Organizer
  第29回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 住民健診受診者における喫煙習慣と白血球中TXNIP遺伝子のDNAメチル化率との関連2019
- Author(s)
  前田圭介, 山田宏哉, 藤井亮輔, 坪井良樹, 萩原千晴, 橋本修二, 浜島信之, 鈴木康司
- Organizer
  第78回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民を対象としたBDNF遺伝子DNAメチル化率と血清カロテノイド値との関連2019
- Author(s)
  萩原千晴, 山田宏哉, 藤井亮輔, 前田圭介, 橋本修二, 浜島信之, 鈴木康司
- Organizer
  第78回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 職域健診の受診とその後の対応の関連要因2019
- Author(s)
  世古留美，宮本美穂，加藤勝子, 山田宏哉，川戸美由紀，谷脇弘茂，橋本修二
- Organizer
  藤田学園医学会
- Data Source
  KAKENHI-PROJECT-17K09138
[Presentation] 一般住民を対象とした脂肪酸の推定摂取量とABCA1遺伝子DNAメチル化率との関連2019
- Author(s)
  藤井亮輔, 山田宏哉, 宗綱栄二, 大橋鉱二, 石川浩章, 橋本修二, 鈴木康司
- Organizer
  第51回藤田医学会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 要介護者のいる世帯における世帯員の健康とストレスの状況2018
- Author(s)
  世古留美，宮本美穂，加藤勝子, 山田宏哉，川戸美由紀，谷脇弘茂，橋本修二
- Organizer
  藤田学園医学会
- Data Source
  KAKENHI-PROJECT-17K09138
[Presentation] 一般住民を対象としたビタミンE摂取量とABCA1遺伝子DNAメチル化率との関連2018
- Author(s)
  鈴木康司、山田宏哉、藤井亮輔、坪井良樹、前田圭介、萩原千晴、橋本修二、浜島信之
- Organizer
  第77回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民を対象としたABCA1遺伝子DNAメチル化率と血清HDLコレステロール値との関連2018
- Author(s)
  藤井亮輔、山田宏哉、宗綱栄二、山崎未来、坪井良樹、大橋鉱二、石川浩章、安藤嘉崇、前田圭介、萩原千晴、橋本修二、鈴木康司
- Organizer
  第50回藤田学園医学会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 住民健診受診者における白血球中ABCA1遺伝子のDNAメチル化率と動脈硬化指標との関連2018
- Author(s)
  坪井良樹, 山田宏哉, 宗綱栄二, 山崎未来, 近藤真里, 太田駿瑠, 服部裕次, 大橋鉱二, 、石川浩章, 市野直浩, 刑部恵介, 杉本恵子, 井上　孝, 橋本修二, 浜島信之, 鈴木康司
- Organizer
  第28回日本疫学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民における野菜・果物類摂取頻度と白血球中TXNIP遺伝子のDNAメチル化率との関連2018
- Author(s)
  前田圭介、山田宏哉、藤井亮輔、坪井良樹、萩原千晴、橋本修二、浜島信之、鈴木康司
- Organizer
  第77回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 一般住民を対象としたBDNF遺伝子DNAメチル化率と認知機能との関連2018
- Author(s)
  萩原千晴、山田宏哉、藤井亮輔、近藤真理、前田圭介、橋本修二、浜島信之、鈴木康司
- Organizer
  第77回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 白血球中lipoprotein lipase遺伝子のDNAメチル化率と脂肪摂取量との関連2017
- Author(s)
  坪井良樹, 山田宏哉, 近藤真里, 橋本修二, 浜島信之, 若井建志, 鈴木康司
- Organizer
  第76回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] LINE-1 hypermethylation in Leukocyte Associated with Increasing of Cancer Mortality Rate in a Japanese Population2017
- Author(s)
  Tsuboi Y, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Kondo M, Inoue T, Hashimoto S, Hamajima N, Suzuki K.
- Organizer
  The 21st International Epidemiological Association World Congress of Epidemiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] 住民健診受診者における白血球DNAメチル化レベルと糖代謝指標値との関連2017
- Author(s)
  鈴木康司, 山田宏哉, 宗綱栄二, 山崎未来, 坪井良樹, 近藤真里, 水野元貴, 村瀬悠里, 近藤奏子, 太田駿瑠, 大橋鉱二, 石川浩章, 井上孝, 橋本修二, 浜島信之
- Organizer
  第27日本疫学会学術総会
- Place of Presentation
  ベルクラシック甲府（山梨県甲府市）
- Year and Date
  2017-01-25
- Data Source
  KAKENHI-PROJECT-26293144
[Presentation] 白血球LPL遺伝子のメチル化率と頸動脈内膜中膜複合体厚との関連2017
- Author(s)
  鈴木康司, 山田宏哉, 坪井良樹, 近藤真里, 橋本修二, 浜島信之
- Organizer
  第76回日本公衆衛生学会総会
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] LPL methylation levels in leukocyte and fatty liver in a Japanese population2017
- Author(s)
  Yamada H, Suzuki K, Yamazaki M, Tsuboi Y, Kondo M, Hamajima N, Hashimoto S.
- Organizer
  The 21st International Epidemiological Association World Congress of Epidemiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09139
[Presentation] LINE-1 DNA methylation levels in leukocyte and hyperglycemia in a Japanese population.2016
- Author(s)
  Suzuki K., Yamada H., Munetsuna E., Yamazaki M., Tsuboi Y., Kondo K., Ohashi K., Ishikawa H., Mizuno G., Murase Y., Kondo K., Ichino N., Sugimoto K., Osakabe K., Inoue T., Hashimoto S., Hamajima N.
- Organizer
  14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress
- Place of Presentation
  Taipei (China)
- Year and Date
  2016-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293144
[Presentation] SPINK1ノックインマウスではオートファジー機能不全により慢性膵炎が惹起される
- Author(s)
  坂田和也, 大村谷昌樹, 荒木喜美, 高城克暢, 橋本大輔, 近本亮, 山村研一, 馬場秀夫
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] CHOP欠損による慢性炎症からの膵線維化進展
- Author(s)
  高城克暢, 大村谷昌樹, 橋本大輔, 東孝暁, 坂本慶太, 坂田和也, 新田英利, 林洋光, 近本亮, 別府透, 荒木喜美, 山村研一, 馬場秀夫
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-221S0001

1. HAMAJIMA Nobuyuki (30172969)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. WATANABE Yoshiyuki (00191809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ARISAWA Koukiti (30203384)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TANAKA Keitarou (50217022)

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HASHIMOTO Syuji 橋本 修二

Research Projects

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Co-Researchers

Development of secondary use of health and medical statisticsPrincipal Investigator

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Longitudinal study on the relationship between the DNA methylation status of metabolism-related genes and the development of lifestyle-related diseases

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Analysis of the methylation status of leukocytes DNA stored in a longitudial cohort study

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Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

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Study on supports for molecular cohort studies

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[Journal Article] Associations of occupation, employment type and company size with actions related to health examinations among Japanese employees2019

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[Journal Article] Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population.2019

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[Journal Article] 手助けや見守りを要する者がいる世帯における世帯員の健康とストレスの状況―国民生活基礎調査の匿名データの解析―2019

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NAID

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[Journal Article] Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women2019

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[Journal Article] Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population.2018

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[Journal Article] GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm2016

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[Journal Article] Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadenitis: results from the SMART database.2015

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[Journal Article] Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.2015

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[Journal Article] Generation and analysis of serine protease inhibitor Kazal type 3-cre driver mice2014

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HASHIMOTO Syuji 橋本修二