Saito Yoji 齊藤洋司

… Alternative Names

齊藤洋司サイトウヨウジ

SAITO Yoji 齊藤洋司

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Researcher Number	50162243
Other IDs
Affiliation (Current)	2025: 島根大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2023: 島根大学, 医学部, 特任教授 2018 – 2021: 島根大学, 学術研究院医学・看護学系, 教授 2009 – 2017: Shimane University, 医学部, 教授 2003 – 2004: SHIMANE UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 2000 – 2002: 島根医科大学, 医学部, 教授 1996 – 1998: Shimane Medical University, Anesthesiology, Associate Professor, 医学部, 助教授 1994 – 1995: 島根医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology Except Principal Investigator Anesthesiology/Resuscitation studies / Pain science
Keywords	Principal Investigator オピオイド / 脊髄 / モルヒネ / 耐性 / spinal cord / nitric oxide / 知覚過敏 / アロディニア / プロスタグランディン / グルタミン酸 … More / 中脳水道周囲灰白質 / 内臓痛 / 体性痛 / 神経障害性疼痛薬 / CIPN / 化学療法誘発性末梢神経障害 / がん疼痛 / オピイオド / レミフェンタニル / オキシコドン / 交差耐性 / MED system / non-noxious stimuli / noxious stimuli / tolerance / morphine / 非侵害刺激 / 侵害刺激 / MEDシステム / 非侵害性刺激 / 侵害性刺激 / hypersensitivity / prostaglandin / 痛覚過敏 / プロスタグランディンF_<2α> / 受容野 / 脊髄後角細胞 / 一酸化窒素 / プロスタグランデイン / Allodynia / Hyperalgesia / Prostaglandin / 疼痛過敏 / オープンフィールドテスト / ＱＯＬ / QOL / 社交性テスト / 明暗テスト / オープンフィールド / がん性疼痛 / 受容体細胞内動態 / 細胞内陥入 / 脊髄鎮痛 / μオピオイド受容体細胞内動態 / オピオイド作動薬 / 脊髄視床路 / 疼痛制御 / マイクロダイアリシス / 骨髄視床路 / ダルタミン酸 / 疼痛伝達 / 硬膜外鎮痛 / 硬膜外投与 … More Except Principal Investigator 脊髄 / モルヒネ / オピオイド / intrathecal administration / くも膜下投与 / local anesthetics / opioid / 硬膜外投与 / 局所麻酔薬 / 術後痛 / 痒み / 鎮痛 / 鎮痒 / 耐性 / 体温 / 術後鎮痛 / Opioid / Itch / TRPV1 / non-noxious stimulus / noxious stimulus / hyperalgesia / neuropathic pain / 非侵害性刺激 / 侵害性刺激 / 痛覚過敏 / 神経因性疼痛 / spinal dorsal horn / morphine tolerance / post-operative pain / 脊髄後角細胞 / 脊髄後角 / モルヒネ耐性 / spinal cord / neurotoxicity / epidural administration / 脊髓 / 神経毒性 / Calcium channel blocker / Receptive field / Spinal neuron / 受容野 / カルシウムチャンネル / visceral pain / somatic pain / epidural / ブピバカイン / フェンタニール / 内臓痛 / 体性痛 / 麻薬 / spinal / tolerance / NO / morphine / 一酸化窒素 / 副作用 / kappaオピオイド受容体作動薬 / 脊髄くも膜下腔 / κオピオイド受容体作動薬 / κオピオイド受容体 / GABA / グルタミン酸 Less

化学療法誘発性末梢神経障害に対するマルチモーダル戦略の科学的根拠を明らかにするPrincipal Investigator
- Principal Investigator
  
  齊藤洋司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Shimane University
Role of antipruritus and analgesia through TRPV1 channel
- Principal Investigator
  
  Imamachi Noritaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Shimane University
Elucidation of Opioid Cross-Tolerance in Cancer Pain ModelsPrincipal Investigator
- Principal Investigator
  
  Saito Yoji
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Shimane University
Antipruritus effect and antinociceptive effect of kappa opioid at the spinal level
- Principal Investigator
  
  Imamachi Noritaka
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Shimane University
Prognisis after anaogesic treatment for cancer painPrincipal Investigator
- Principal Investigator
  
  SAITO Yoji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane University
Clarify the role of mu receptor endocytosis in spinal analgesia and opioid tolerancePrincipal Investigator
- Principal Investigator
  
  SAITO Yoji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane University
A study of effects of morphine tolerance on spinal cord in the rat incisional pain model
- Principal Investigator
  
  KOSHIZAKI Masayuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  SHIMANE UNIVERSITY FACULTY OF MEDICINE
  Shimane Medical University
Effects of morphine administration on the rat neuropathic pain model
- Principal Investigator
  
  KIRIHARA Yumiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane University
  Shimane Medical University
疼痛伝達の制御回路に関する研究Principal Investigator
- Principal Investigator
  
  斉藤洋司
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Study of morphine tolerance at spinal level-approach to spinal plasticity-Principal Investigator
- Principal Investigator
  
  SAITO Yoji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Comparative neurotoxicity of drugs administered intrathecally and epidurally in rats
- Principal Investigator
  
  HASHIMOTO Keishi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
脊髄疼痛伝達の神経制御回路に関する研究Principal Investigator
- Principal Investigator
  
  斉藤洋司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
脊髄過敏形成と興奮性、抑制性神経伝達物質の変化に関する研究
- Principal Investigator
  
  HASHIMOTO Keishi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
硬膜外モルヒネにおける耐性形成の解明Principal Investigator
- Principal Investigator
  
  斉藤洋司
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Role of prostaglandins and nitric oxide in the spinal plasticityPrincipal Investigator
- Principal Investigator
  
  SAITO Yoji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Antinociceptive interaction between epidurally administered opioids and local anesthetics
- Principal Investigator
  
  KOSAKA Yoshihiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Effects of calcium channel blocker on the response properties of spinal dorsal horn neurons
- Principal Investigator
  
  YAMAMORI Yuji
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Modulation of the development of tolerance to morphine by NOSI
- Principal Investigator
  
  KIRIHARA Yumiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University
Role of prostaglandins on sensory transductionPrincipal Investigator
- Principal Investigator
  
  SAITO Yoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Shimane Medical University

All 2019 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 麻酔科　研修ノート改訂第3版　 18章　麻酔合併への対処　3　神経障害：全身麻酔、区域麻酔、体位2018
- Author(s)
  今町憲貴, 齊藤洋司
- Total Pages
  5
- Publisher
  診断と治療社
- ISBN
  9784787824011
- Data Source
  KAKENHI-PROJECT-17K09033
[Book] 麻酔科医のためのリスクを有する患者の周術期管理　1章リスクを有する患者での麻酔の考え方.1-5オピオイドを使いこなすために2018
- Author(s)
  今町憲貴, 齊藤洋司
- Total Pages
  10
- Publisher
  中山書店
- ISBN
  9784521743271
- Data Source
  KAKENHI-PROJECT-17K09033
[Book] 新　麻酔科研修の素朴な疑問に答えます　Ⅶ　局所麻酔薬・区域麻酔　077．局所麻酔薬の極量はどのようにして決められるか？2016
- Author(s)
  今町憲貴, 齊藤洋司
- Total Pages
  3
- Publisher
  メディカルサイエンス・インターナショナル
- Data Source
  KAKENHI-PROJECT-26460697
[Book] 脊髄におけるオピオイド鎮痛の基礎
- Author(s)
  橋本龍也, 齊藤洋司
- Publisher
  克誠堂出版(株)(印刷中)
- Data Source
  KAKENHI-PROJECT-21591972
[Journal Article] Effects of an intrathecal TRPV1 antagonist, SB366791, on morphine-induced itch, body temperature, and antinociception in mice</p>2019
- Author(s)
  Sakakibara Satoshi、Imamachi Noritaka、Sakakihara Manabu、Katsube Yukiko、Hattori Mai、Saito Yoji
- Journal Title
  
  Journal of Pain Research
  
  Volume: Volume 12 Pages: 2629-2636
- DOI
  10.2147/jpr.s217439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09033
[Journal Article] 帝王切開時の脊髄くも膜下オピオドによる痒みに対する予防的ペンタゾシン投与の効果2018
- Author(s)
  平林政人、土井克史、今町憲貴、岸本朋宗，齊藤洋司
- Journal Title
  
  麻酔
  
  Volume: 67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09033
[Journal Article] Chronic Postsurgical Pain After Inguinal Hernia Surgery: Association with the Acute Postsurgical Pain: A Preliminary Study Based on Questionnaires.2018
- Author(s)
  Imamachi N, Doi K, Watanab Y , Saito Y.
- Journal Title
  
  Shimane Journal of Medicine Science
  
  Volume: 34 (3) Pages: 93-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460697
[Journal Article] The Incidence of Chronic Postsurgical Pain After Inguinal Hernia Surgery: Association with the Acute Postsurgical Pain: A Preliminary Study Based on Questionnaires.2018
- Author(s)
  Imamachi N, Doi K, Watanab Y , Saito Y.
- Journal Title
  
  Shimane Journal of Medicine Science
  
  Volume: 34 Pages: 93-97
- NAID
  120006425805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09033
[Journal Article] Prophylactic Pentazocine Reduces the Incidence of Pruritus After Cesarean Delivery Under Spinal Anesthesia With Opioids: A Prospective Randomized Clinical Trial.2017
- Author(s)
  Hirabayashi M, Doi K, Imamachi N, Kishimoto T, Saito Y.
- Journal Title
  
  Anesth Analg.
  
  Volume: 124(6) Issue: 6 Pages: 1930-1934
- DOI
  10.1213/ane.0000000000002060
- NAID
  40021733047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460697
[Journal Article] Effects of Intrathecal κ-Opioid Receptor Agonist on Morphine-Induced Itch and Antinociception in Mice.2016
- Author(s)
  Sakakihara M, Imamachi N, Saito Y.
- Journal Title
  
  Reg Anesth Pain Med.
  
  Volume: 41 Issue: 1 Pages: 69-74
- DOI
  10.1097/aap.0000000000000326
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460697
[Journal Article] Reply to Dr Ruan2016
- Author(s)
  Imamachi N, Saito Y
- Journal Title
  
  Reg Anesth Pain Med
  
  Volume: 41 Issue: 3 Pages: 414-5
- DOI
  10.1097/aap.0000000000000383
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460697
[Presentation] 帝王切開術中の低酸素頻度の発生頻度と危険因子の検討2018
- Author(s)
  稲場　聡、今町憲貴、平林政人、榊原賢司、土井克史、齊藤洋司
- Organizer
  日本麻酔科学会第65回学術集会
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] The Incidence of Hypoxia During Cesarean Delivery Under Spinal Anesthesia2018
- Author(s)
  Hirabayashi M, Imamachi N,,Inaba I,Sakakibara S,Doi K, Saito Y
- Organizer
  American Society of Anesthesiologists 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] エムラクリームが予定帝王切開術患者の局所麻酔・硬膜外麻酔時痛に及ぼす影響：前向き無作為化二重盲検比較試験2018
- Author(s)
  上田陽子、土井克史、岸本朋宗、今町憲貴、齊藤洋司
- Organizer
  日本麻酔科学会第65回学術集会
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] 帝王切開時の脊髄くも膜下オピオイドによる痒みに対する予防的ペンタゾシン投与の効果2018
- Author(s)
  平林政人、土井克史、今町憲貴、岸本朋宗、齊藤洋司
- Organizer
  日本麻酔科学会第65回学術集会
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] Systemic Morphine Induces Cross-Tolerance to Remifentanil Analgesic Effect on Both Somatic and Visceral Stimuli in Rats.2017
- Author(s)
  79）Hideaki Mori, Tetsuro Nikai, Tatsuya Hashimoto, Motohide Furuya, Mai Hattori, Yukiko Katsube, Yoji Saito
- Organizer
  American society of Anesthesiologists, Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10937
[Presentation] 帝王切開術中の低酸素血症の発生頻度と脊髄くも膜下オピオイドとの関連性2017
- Author(s)
  稲場聡、今町憲貴、平林政人、榊原賢司、齊藤洋司
- Organizer
  島根麻酔医学会第32回大会
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] 帝王切開術中に脊髄くも膜下フェンタニルにより生じた痒みの治療に難渋した２症例2017
- Author(s)
  宇賀田圭、今町憲貴、榊原賢司、榊原学、土井克史、齊藤洋司
- Organizer
  日本区域麻酔学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-17K09033
[Presentation] Effects of intrathecal kappa opioid receptor agonist on intrathecal morphine-induced analgesia in a mouse model of the plantar incisional pain.2015
- Author(s)
  Sakakihara M, Imamachi N, Saito Y
- Organizer
  American Society of Anesthesiologists 2015
- Place of Presentation
  San Diego　（Ｕ.S.A)
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460697
[Presentation] マウス足底術後痛モデルにおけるモルヒネに対する脊髄くも膜下腔κオピオイド受容体作動薬の鎮痛効果の検討2015
- Author(s)
  榊原学, 今町憲貴, 角田尚紀, 服部舞, 勝部由貴子, 齊藤洋司
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸市（神戸ポートピアホテル・神戸国際展示場）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26460697
[Presentation] Characteristics of pain-related behavior in chronic inflammatory model and cancer pain model in mice.2013
- Author(s)
  Katsube Y, Nikai T, Ota J, Saito Y
- Organizer
  American society of Anesthesiologists, Annual meeting
- Place of Presentation
  San Francisco （United States of America）
- Data Source
  KAKENHI-PROJECT-24592296
[Presentation] STUDY OF BONE CANCER PAIN MODEL IN MICE: COMPARISON BY STRAIN AND SEX2012
- Author(s)
  1. Yumiko Kirihara, 2. Mayumi Takechi, 3. Kaoru Kurosaki, 4. Yuta Kobayashi and 5. Yoji Saito
- Organizer
  世界疼痛学会
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-24592296
[Presentation] 基礎研究からみた各種オピオイドの特徴2011
- Author(s)
  橋本龍也、齊藤洋司
- Organizer
  第21回日本ペインクリニック学会中国四国合同地方会
- Place of Presentation
  高知市総合あんしんセンター
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21591972
[Presentation] マウス骨癌性疼痛モデルにおける自発痛および疼痛関連行動の検討
- Author(s)
  二階哲朗, 勝部由貴子, 太田淳一, 齊藤洋司
- Organizer
  日本麻酔科学会第61回学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-24592296
[Presentation] 脊髄レベルでのモルヒネによる鎮痛・鎮静効果に対するκオピオイド受容体作動薬の効果
- Author(s)
  榊原　学,　今町　憲貴,　齊藤　洋司
- Organizer
  日本区域麻酔学会第1回学術集会
- Place of Presentation
  岡山県岡山市岡山コンベンションセンター
- Year and Date
  2014-04-25 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26460697

1. KIRIHARA Yumiko (90234400)

# of Collaborated Projects: 11 results

# of Collaborated Products: 1 results
2. HASHIMOTO Tatsuya (00372681)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. DOI Katsusi (20304272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NAKATANI Toshihiko (90237305)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MIYAMOTO Hiroshi (20297005)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. IMAMACHI Noritaka (40325048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
7. UCHIDA Hiroshi (70176692)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KOSIZAKI Masayuki (40294376)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HASHIMOTO Keishi (60252920)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. YAMAMORI Yuji (80230598)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 原かおる (50271052)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. NIKAI Tetsuro (20314643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOSAKA Yoshihiro (20045355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山中真波 (30304281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 豊田浩作 (30322225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 柳谷忠雄 (10243429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 坂口泰子 (20322224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 森英明 (40713764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 山本花子 (00808876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 勝部由貴子 (20896659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Sakakihara Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. hattori Mai

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Saito Yoji 齊藤 洋司

齊藤 洋司 サイトウ ヨウジ

SAITO Yoji 齊藤 洋司

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化学療法誘発性末梢神経障害に対するマルチモーダル戦略の科学的根拠を明らかにするPrincipal Investigator

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Elucidation of Opioid Cross-Tolerance in Cancer Pain ModelsPrincipal Investigator

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Prognisis after anaogesic treatment for cancer painPrincipal Investigator

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Clarify the role of mu receptor endocytosis in spinal analgesia and opioid tolerancePrincipal Investigator

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疼痛伝達の制御回路に関する研究Principal Investigator

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Study of morphine tolerance at spinal level-approach to spinal plasticity-Principal Investigator

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脊髄疼痛伝達の神経制御回路に関する研究Principal Investigator

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硬膜外モルヒネにおける耐性形成の解明Principal Investigator

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Saito Yoji 齊藤洋司

齊藤洋司サイトウヨウジ

SAITO Yoji 齊藤洋司

[Book] 麻酔科　研修ノート改訂第3版　 18章　麻酔合併への対処　3　神経障害：全身麻酔、区域麻酔、体位2018

[Book] 麻酔科医のためのリスクを有する患者の周術期管理　1章リスクを有する患者での麻酔の考え方.1-5オピオイドを使いこなすために2018

[Book] 新　麻酔科研修の素朴な疑問に答えます　Ⅶ　局所麻酔薬・区域麻酔　077．局所麻酔薬の極量はどのようにして決められるか？2016