TAKAHASHI Koki 高橋孝喜

Researcher Number	50171484
External Links
Affiliation (based on the past Project Information) *help	2008: 東京大学, 医学部・附属病院, 教授 2006 – 2007: 東京大学, 医学部附属病院, 教授 1998 – 1999: 沖中記念成人病研究所, 研究員 1995: 冲中記念成人病研究所, 主任研究員 1993 – 1995: 沖中記念成人病研究所, 主任研究員 … More 1992: 東京大学, 医学部(病), 講師 1991: 東京大学, 医学部(病), 助手 1990: 東京大学, 医学部・輸血部, 助手 1989: 東京大学, 医学部, 助手 1988 – 1989: 東京大学, 医学部(病), 助手 Less
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator Laboratory medicine / Hematology / Applied pharmacology / Digestive surgery / 医学一般
Keywords	Principal Investigator 組識修復 / 組織修復 / 植皮術 / 血管手術 / 止血効果 / 自己血輸血 / 自己フィブリン糊 / ブリアート族 / HLA / 民族移動 / 東アジア / 主要組織適合抗原 … More Except Principal Investigator … More Platelet Transfusion / Platelet Allo-antibody / 血小板輸血不応答 / 血小板輸血 / 血小板抗体 / 血小板型 / 大腸癌 / HLA / Appropriate size / Haplotypes / Unrelated donor pool / Donor pool / Bone marrow transplantation / HLA matched platelet transfusion / HLA適合提供者 / HLAハプロタイプ / 非血縁ドナ-・プ-ル / ドナ-・プ-ル / 適正規模 / ハプロタイプ / 非血縁ドナー・プール / ドナー・プール / 骨髄移植 / HLA適合血小板輸血 / Neonatal Alloimmune Thrombocytopenia / Pletelet Allo-antigen / 新生児血小板減少症紫斑病 / 血小板(HPA) / 新生児血小板減少紫斑病 / Neonatal Alliommune Thrombocytopenia / Platelet Allo-antigen / 新生児血小板減少症柴斑病 / 血小板型(HPA) / 新生児血小板減少性紫斑病 / 複合的抗癌薬 / 複合的抗癌治療 / 胃癌 / 血管新生 / プラウノトール / HSE / 血管新生阻害 / p53 / アポトーシス / 抗癌剤感受性 / hRFI / 内皮細胞 / 樹状細胞 / HUVEC / Surforaphane / ワクチン / 個別化治療 / 集学的治療 / 血管内皮前駆細胞 / 選択性セロトニン受容体阻害薬 / ゾレドロン酸 / スルフォラファン / 血管内皮細胞 / 腫瘍血管 / 地域差 / 家系調査 / 韓国人 / 中国人 / 日本人 / 東アジア / 採血後貧血からの回復 / 赤血球産生能 / 他家血輸血の完全回避 / 術前自己血貯血法 / 投与量、投与回数依存性 / ヒトエリスロポエチン / 採血後貧血 / スイッチバック式採血、戻し輸血法 / 術前貯血法 / 自己輸血法 Less

植物由来イソプレノイドの抗腫瘍効果および抗血管新生作用についての検討
- Principal Investigator
  
  津野寛和
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Treatment strategy for colorectal cancer targeted to the tumor vessel
- Principal Investigator
  
  NAGAWA Hirokazu
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Screening of anti-platelet antibodies and prospective study of neonatal alloimmune thrombocytopenia
- Principal Investigator
  
  SHIBATA Yoichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Clinical Significance of Platelet Allo-antibodies.
- Principal Investigator
  
  SHIBATA Yoichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Tokyo
主要組織適合抗原システムからみた東アジアにおける民族移動Principal Investigator
- Principal Investigator
  
  高橋孝喜
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
自己フィブリン糊製剤の外科手術への応用使用Principal Investigator
- Principal Investigator
  
  桑田昇治, 高橋孝喜
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
主要組織適合抗原システムからみた東アジアにおける民族移動
- Principal Investigator
  
  TOKUNAGA Katsushi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ヒトエリスロポエチンを利用した術前自己血貯血法の確立
- Principal Investigator
  
  黒川高秀
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医学一般
- Research Institution
  The University of Tokyo
DETERMINATION OF FREQUENCIES OF HLA HAPLOTYPES IN TOHOKU AREA BASED ON FAMILY STUDY AND EVALUTION OF AN APPROPRIATE SIZE OF UNRELATED DONOR POOL FOR HLA-MATCHED PLATELET TRANSFUSION AND BONE MARROW TRANSPLANTATION
- Principal Investigator
  
  JUJI Takeo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells2009
- Author(s)
  Nishikawa T. Tsuno NH. Tsuchiya T. Yoneyama S. Yamada J. Shuno Y. Okaji Y. Tanaka J. Kitayama J. Takahashi K. Nagawa H.
- Journal Title
  
  Annals of Surgical Oncology 16(2)
  
  Pages: 534-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation2009
- Author(s)
  Yamada J. Tsuno NH. Kitayama J. Tsuchiya T. Yoneyama S. Asakage M. Okaji Y. Shuno Y. Nishikawa T. Tanaka J. Takahashi K. Nagawa H.
- Journal Title
  
  Journal of Surgical Research 151(1)
  
  Pages: 115-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Pilot study of anti-angiogenic vaccine using fixed whole endothelium in patients with progressive malignancy after failure of conventional therapy2008
- Author(s)
  Okaji Y, Tsuno NH, Tanaka M, Yoneyama S, Matsuhashi M, Kitayama J.. Saito S, Nagura Y, Tsuchiya T, Yamada J, Tanaka J, Yoshikawa N, Nishikawa T, Shuno Y, Todo T, Saito N, Takahashi K, Nagawa H.
- Journal Title
  
  Eur J Cancer 44(3)
  
  Pages: 383-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model2007
- Author(s)
  Yoneyama S. Okaji Y. Tsuno NH. Kawai K. Yamashita H. Tsuchiya T. Yamada J. Sunami E. Osada T. Kitayama J. Takahashi K. Nagawa H.
- Journal Title
  
  Eur J Surg Oncol 33(10)
  
  Pages: 1191-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells2006
- Author(s)
  Asakage M. Tsuno NH. Kitayama J. Kawai K. Okaji Y. Yazawa K. Kaisaki S. Osada T. Watanabe T. Takahashi K. Nagawa H.
- Journal Title
  
  Cancer Immunology, Immunotherapy 55(6)
  
  Pages: 708-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis2006
- Author(s)
  Asakage M. Tsuno NH. Kitayama J. Tsuchiya T. Yoneyama S. Yamada J. Okaji Y. Kaisaki S. Osada T. Takahashi K. Nagawa H.
- Journal Title
  
  Angiogenesis 9(2)
  
  Pages: 83-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Anti-angiogenic properties of plaunotol.2005
- Author(s)
  Kawai K, Tsuno NH, Kitayama J, Takahashi K, Nagawa H, et al.
- Journal Title
  
  Anticancer Drugs. 2005 Apr;16(4) : 401-7. 16(4)
  
  Pages: 401-407
- Data Source
  KAKENHI-PROJECT-18659156
[Journal Article] 先端のバイオ研究を知る2005
- Author(s)
  大梶祐頼, 津野寛和, 高橋孝喜, 名川弘一
- Journal Title
  
  テクノ・トレンド新たな癌治療法の開発腫瘍血管内皮細胞・腫瘍内マクロファージの選択的分離についてバイオテクノロジージャーナル 5(4)
  
  Pages: 457-459
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 選択的5-HT4受容体アゴニストによる抗血管新生作用2008
- Author(s)
  西川武司, 津野寛和, 須並英二, 北山丈二, 高橋孝喜, 名川弘一
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 腫瘍血管の形成スルフォラファンは前アポトーシスタンパク質Baxを活性化し内皮前駆細胞のアポトーシスを誘導する2007
- Author(s)
  西川武司, 津野寛和, 高橋孝喜, 北山丈二, 名川弘一
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 癌に対する血管新生標的治療の現状と将来内皮細胞ワクチンは腫瘍血管内皮細胞に対する免疫応答を誘導する2006
- Author(s)
  津野寛和, 大梶祐頼, 朝蔭正宏, 田中実, 米山さとみ, 土屋剛史, 山田純, 北山丈二, 藤堂具紀, 渡辺聡明, 名川弘一, 高橋孝喜
- Organizer
  第107回日本外科学会
- Place of Presentation
  東京
- Year and Date
  2006-03-31
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] スルフォラファンのアポトーシスによる内皮細胞増殖抑制2006
- Author(s)
  朝蔭正宏, 津野寛和, 北山丈二, 川合一茂, 谷澤健太郎, 大梶祐頼, 土屋剛史, 米山さとみ, 山田純, 高橋孝喜, 名川弘一
- Organizer
  第64回日本癌学会総会
- Year and Date
  2006-09-29
- Data Source
  KAKENHI-PROJECT-17209045

1. TSUNO Hirokazu (50282637)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. KUWATA Shoji (00241993)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. JUJI Takeo (20009997)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TOKUNAGA Katsushi (40163977)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHIBATA Yoichi (30010474)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KITAYAMA Joji (20251308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
7. NAGAWA Hirokazu (80228064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
8. TAKEI Yoshiki (10372369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 脇本信博 (90191733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SUNAMI Eiji (70345205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. MAEJIMA Masamoto (10251307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAZAKI Hiroshi (00134007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 黒川高秀 (90010298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 幕内晴朗 (10111543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小塚裕 (10126055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 釣田義一郎 (80345206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡邉聡明 (80210920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 上條亜紀 (30361489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AKAZA Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 渡辺聡明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAHASHI Koki 高橋 孝喜

Research Projects

Research Products

Co-Researchers

植物由来イソプレノイドの抗腫瘍効果および抗血管新生作用についての検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment strategy for colorectal cancer targeted to the tumor vessel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of anti-platelet antibodies and prospective study of neonatal alloimmune thrombocytopenia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical Significance of Platelet Allo-antibodies.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

主要組織適合抗原システムからみた東アジアにおける民族移動Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

自己フィブリン糊製剤の外科手術への応用使用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

主要組織適合抗原システムからみた東アジアにおける民族移動

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ヒトエリスロポエチンを利用した術前自己血貯血法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DETERMINATION OF FREQUENCIES OF HLA HAPLOTYPES IN TOHOKU AREA BASED ON FAMILY STUDY AND EVALUTION OF AN APPROPRIATE SIZE OF UNRELATED DONOR POOL FOR HLA-MATCHED PLATELET TRANSFUSION AND BONE MARROW TRANSPLANTATION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells2009

Author(s)

Journal Title

Data Source

[Journal Article] Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation2009

Author(s)

Journal Title

Data Source

[Journal Article] Pilot study of anti-angiogenic vaccine using fixed whole endothelium in patients with progressive malignancy after failure of conventional therapy2008

Author(s)

Journal Title

Data Source

[Journal Article] A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model2007

Author(s)

Journal Title

Data Source

[Journal Article] Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells2006

Author(s)

Journal Title

Data Source

[Journal Article] Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis2006

Author(s)

Journal Title

Data Source

TAKAHASHI Koki 高橋孝喜