HASHIMOTO Makoto 橋本款

Researcher Number	50189502
Other IDs
Affiliation (based on the past Project Information) *help	2017: 東京都神経科学総合研究所, 副参事研究員 2016: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 2015: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野., 副参事研究員 2015: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究室長 2014: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, プロジェクトリーダー … More 2012 – 2013: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 2011: (財)東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 2011: 財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 2008 – 2010: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 2007: Tokyo Metropolitan Organization for Medical Research, TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH,TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCE, LAB DIRECTOR 2005 – 2006: (財)東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 2005 – 2006: 東京都神経研究所, 病態脳, 副参事研究員 Less
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences / Neurology Except Principal Investigator Neurochemistry/Neuropharmacology / Neuroscience in general / Neurophysiology and muscle physiology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator パーキンソン病 / シヌクレイン / 神経変性疾患 / 蛋白凝集 / アディポネクチン / リソソーム / 糖尿病 / シヌクレイノパチー / アルツハイマー病 / αシヌクレイン … More / ルイ小体 / トランスジェニックマウス / レビー小体型認知症 / 遺伝子変異 / レビー小体 / アミロイド / オートファゴソーム / BASAL GANGLIA / TRANSGENIC MICE / LYSOSOME / β-SYNUCLEIN / α-SYNUCLEIN / GENE MUTATION / NEURODEGENERRATION / SYNUCLEINOPATHY / DJ-1 / 淡蒼球 / α-シヌクレイン / β-シヌクレイン / シヌクレイノパチ- / トランスジェニック(tg)マウス / パーキンソン病（PD） / αシヌクレイン（αS） / アディポネクチン(APN) / 鼻腔投与 / βシヌクレイン / APPL1 / β-シヌクレイン(βS) / αシヌクレイン (αS) / パーキンソン病 (PD) / アディポネクチン (APN) / ワクチン / ゴーシェ病 / LC3 / Theaflavin / オートファジー / ポリフェノール … More Except Principal Investigator ストレス / 視床下部 / 酸化ストレス / ドーパミン / 黒質 / 慢性ストレス / 青斑核 / ノルアドレナリン / ミクログリア / パーキンソン病 / 鬱病 / 交感神経系 / 腹側被蓋野 / Inflammation / Neurodegenerative disease / Central Nervous System / Interleukin-18 / Microglia / Stress / 副腎 / IL-18 / 退行性神経変化 / 炎症反応 / 退行性神経疾患 / 中枢神経 / インターロイキン18 / マイクログリア / 脳内炎症 / 副腎ステロイド / 海馬 / 神経科学 / 神経免疫 / ニトロタイロシン / 脳内免疫 / アドレナリン受容体 / 3リピートタウ / αシヌクレイン / Pale neurite / 軸索 / 免疫電顕 / profile shift / tau isoform / 電子顕微鏡 / シヌクレイン / 神経変性疾患 Less

Investigation of microglia and chronic stress in the onset of Parkinson disease
- Principal Investigator
  
  Sugama Shuei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nippon Medical School
Therapeutic potential of the anti-neurodegeneration effect of benign adipokinesPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Makoto
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
A nasal injection of adiponectin: a novel therapeutic strategy against neurodegenerative diseasePrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
新規レビー小体型認知症モデルマウスを用いたワクチン療法の開発Principal Investigator
- Principal Investigator
  
  橋本款
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease
- Principal Investigator
  
  SUGAMA Shuei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nippon Medical School
Mechanism by which the pathogenesis of Parkinson's disease is stimulated by Gaucher's mutation.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Makoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
α-synuclein-positive neurites as an early diagnostic indicator
- Principal Investigator
  
  UCHIHARA Toshiki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Analyses of neuropathogenic effects ofβsynuclein using a novel mouse model of synucleinopathies and post mortem brainsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Makoto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
ポリフェノールのオートファジー促進作用とシヌクレノパチー治療への可能性Principal Investigator
- Principal Investigator
  
  橋本款
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
INVESTIGATION OF THE SYNERGIC EFFECT OF β-SYNUCLEIN WITH HSP27 ON NEUROPROTECTIONPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Makoto
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Does stress promotes neurodegenerative changes?
- Principal Investigator
  
  SUGAMA Shuei
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Nippon Medical School

[Book] 脳内環境辞典2017
- Author(s)
  高松芳樹、小池和佳子、藁谷正明、杉野弘、橋本款
- Total Pages
  2
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-25290019
[Book] 「遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発」2014
- Author(s)
  高松　芳樹,関山　一成, 橋本　款
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-25290019
[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014
- Author(s)
  高松芳樹、関山一成、橋本款
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-25640030
[Book] Role of autophagy in P2X7 receptor-mediated maturation and unconventional secretion of Il-1b in microglia Hayat, M. A. (Ed.)2014
- Author(s)
  Takenouchi T, Sekiyama K Tsukimoto M, Iwamaru Y, Fujita M, Sugama S, Kitani H, *Hashimoto M.
- Publisher
  ISBN
- Data Source
  KAKENHI-PROJECT-25290019
[Book] 「遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発」2014
- Author(s)
  高松　芳樹,関山　一成, 橋本　款.
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PUBLICLY-24111555
[Book] Ibuprofen: Clinical Pharmacology, Medical Uses and Adverse Effects.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M.
- Publisher
  InTech
- Data Source
  KAKENHI-PUBLICLY-24111555
[Book] Emerging Drugs and Targets for Parkinson's Disease.2013
- Author(s)
  Takenouchi T, Sekiyama K, Fujita M, Sugama S, Iwamaru Y, Kitani H, Hashimoto M.
- Publisher
  The Royal Society of Chemistry
- Data Source
  KAKENHI-PUBLICLY-24111555
[Book] Emerging Drugs and Targets for Parkinson's Disease.2013
- Author(s)
  Takenouchi T, Sekiyama K, Fujita M, Sugama S, Iwamaru Y, Kitani H, Hashimoto M.
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-25640030
[Book] Ibuprofen: Clinical Pharmacology, Medical Uses and Adverse Effects.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-25640030
[Book] αシヌクレインの生理作用.2013
- Author(s)
  関山　一成, 高松　芳樹, 橋本　款.
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PUBLICLY-24111555
[Book] Emerging Drugs and Targets for Parkinson's Disease.2013
- Author(s)
  Takenouchi T, Sekiyama K, Fujita M, Sugama S, Iwamaru Y, Kitani H, Hashimoto M.
- Publisher
  The Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-25290019
[Book] αシヌクレインの生理作用.2013
- Author(s)
  関山　一成, 高松　芳樹, 橋本　款
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-25290019
[Book] αシヌクレインの生理作用2013
- Author(s)
  関山一成、高松芳樹、橋本款
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-25640030
[Book] Ibuprofen: Clinical Pharmacology, Medical Uses and Adverse Effects.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-25290019
[Book] Gangliosides as a Double-Edged Sword in Neurodegenerative Disease. Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets.(Suzanne De La Monte, Ed.)2011
- Author(s)
  Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Wei J, Hashimoto M
- Publisher
  InTech : Rijeka
- Data Source
  KAKENHI-PROJECT-21300135
[Book] Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets. (Suzanne De La Monte, Ed.)2011
- Author(s)
  Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Wei J, Hashimoto M.
- Total Pages
  4
- Publisher
  InTech:Rijeka
- Data Source
  KAKENHI-PROJECT-23659462
[Book] Protein chaperones and protection from neurodegenerative diseases2011
- Author(s)
  Hashimoto M, et al
- Total Pages
  39
- Publisher
  John Wiely & Sons : New York
- Data Source
  KAKENHI-PROJECT-21300135
[Book] Chaperone and Anti-Chaperone Properties of Synuclein : Implications for Development, Aging, and Neurodegenerative Disease. Protein chaperones and protection from neurodegenerative diseases.(Stephan N. Witt, Ed)2011
- Author(s)
  Hashimoto M, Sekiyama K, Sekigawa A, Fujita M
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Evolvability of amyloidogenic proteins in human brain2018
- Author(s)
  Hashimoto M, Ho G, Sugama S, Takamatsu Y, Shimizu Y, Takenouchi T, Waragai M, Masliah E
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 62 Issue: 1 Pages: 73-83
- DOI
  10.3233/jad-170894
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Potential application of centrifuges to protect the CNS in space and on earth2018
- Author(s)
  Hashimoto M, Ho G, Shimizu Y, Sugama S, Takenouchi T, Waragai M, Wei J, Takamatsu Y
- Journal Title
  
  Curr Alzheimer Res
  
  Volume: 15 Issue: 6 Pages: 544-551
- DOI
  10.2174/1567205015666171229225501
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783
[Journal Article] Importance of adiponectin activity in the pathogenesis of Alzheimer's disease2017
- Author(s)
  Waragai M, Ho G, Takamatsu Y, Sekiyama K, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 4 Issue: 8 Pages: 591-600
- DOI
  10.1002/acn3.436
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-15K09820
[Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016
- Author(s)
  Sekiyama K, Takamatsu Y, Koike W, Waragai M, Takenouchi T, Sugama S, Hashimoto M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: in press Issue: 3 Pages: 831-841
- DOI
  10.3233/jad-151015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K09820
[Journal Article] Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer’s Disease.2016
- Author(s)
  Waragai M, Adame A, Trinh I, Sekiyama K, Takamatsu Y, Une K, Masliah E, Hashimoto M
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: in press Issue: 4 Pages: 1453-1459
- DOI
  10.3233/jad-151116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-15K09820
[Journal Article] Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases.2016
- Author(s)
  Takamatsu Y, Ho G, Koike W, Sugama S, Takenouchi T, Waragai M, Wei J, Sekiyama K, Hashimoto M.
- Journal Title
  
  npj Parkinson’s Disease
  
  Volume: 3 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41531-016-0001-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K06783
[Journal Article] Protection against neurodegenerative diseases on Earth and in space2016
- Author(s)
  Takamatsu Y, Koike W, Takenouchi T, Sugama S, Waragai M, Wei J, Sekiyama K,Hashimoto M.
- Journal Title
  
  npj Microgravity
  
  Volume: 2 Issue: 1 Pages: 16013-16013
- DOI
  10.1038/npjmgrav.2016.13
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033
[Journal Article] Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease2016
- Author(s)
  Sugama S, Sekiyama K, Kodama T, Takamatsu Y, Takenouchi T, Hashimoto M, Conti B, Kakinuma Y
- Journal Title
  
  Brain Behav Immun
  
  Volume: 51 Pages: 39-46
- DOI
  10.1016/j.bbi.2015.08.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25460333, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-16K08560
[Journal Article] Role of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.2015
- Author(s)
  Sekigawa A, Takamatsu Y, Sekiyama K, Hashimoto M.
- Journal Title
  
  Biomolecules.
  
  Volume: 5 Issue: 2 Pages: 1000-1011
- DOI
  10.3390/biom5021000
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25290019
[Journal Article] シヌクレイントランスジェニックマウス2015
- Author(s)
  関山一成, 橋本　款.
- Journal Title
  
  月刊　細胞
  
  Volume: 47　(1) Pages: 16-19
- Data Source
  KAKENHI-PROJECT-25290019
[Journal Article] Gaucher-Associated Parkinsonism.2015
- Author(s)
  Li Y, Li P, Liang H, Zhao Z, Hashimoto M, Wei J.
- Journal Title
  
  Cell Mol Neurobiol.
  
  Volume: 35 (6) Issue: 6 Pages: 755-761
- DOI
  10.1007/s10571-015-0176-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019
[Journal Article] Extracellular ATP induces unconventional release of glyceraldehyde-3-phosphate dehydrogenase from microglial cells2015
- Author(s)
  Takenouchi T, Tsukimoto M, Iwamaru Y, Sugama S, Sekiyama K, Sato M, Kojima S, Hashimoto M, Kitani H
- Journal Title
  
  Immunol Lett
  
  Volume: 167 Issue: 2 Pages: 116-124
- DOI
  10.1016/j.imlet.2015.08.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-25450521
[Journal Article] Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.2015
- Author(s)
  Toki Y, Takenouchi T, Harada H, Tanuma S, Kitani H, Kojima S, Tsukimoto M.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 458(4) Issue: 4 Pages: 771-776
- DOI
  10.1016/j.bbrc.2015.02.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590125, KAKENHI-PROJECT-25450521, KAKENHI-PROJECT-25460156, KAKENHI-PROJECT-25290019
[Journal Article] Inflammasome activation by danger signals: extracellular ATP and pH2014
- Author(s)
  Takenouchi T, Tsukimoto M, Hashimoto M, Kitani H.
- Journal Title
  
  Inflammasome
  
  Volume: 1 (1) Pages: 2300-2312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290019
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of a-Synucleinopathies2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Pages: 479-489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies.2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M.
- Journal Title
  
  Ann Clin Transl Neurol.
  
  Volume: 1(7) Pages: 479-489
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25290019
[Journal Article] Role of genomics in translational research for Parkinson's disease.2014
- Author(s)
  Sekiyama, K., Takamatsu, Y., Waragai, M., Hashimoto, M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 452 (2) Issue: 2 Pages: 226-235
- DOI
  10.1016/j.bbrc.2014.06.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-26640033
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathie2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada A, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Issue: 7 Pages: 479-489
- DOI
  10.1002/acn3.77
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-26640033
[Journal Article] Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice2014
- Author(s)
  Hagino Y., Kasai S, Masayo F, Setogawa S, Yamaura H,Yanagihara D, Hashimoto M, Kobayashi K, Meltzer H, Ikeda K
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: - Issue: 5 Pages: 1-10
- DOI
  10.1038/npp.2014.295
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09496, KAKENHI-PROJECT-24590741, KAKENHI-PROJECT-24650205, KAKENHI-PROJECT-24659549, KAKENHI-PUBLICLY-25116532, KAKENHI-PROJECT-25290019, KAKENHI-PLANNED-26112002, KAKENHI-PROJECT-26293347
[Journal Article] Biomarkers for the diagnosis and management of Parkinson's disease2013
- Author(s)
  Waragai M, Sekiyama K, Fujita M, Tokuda T, Hashimoto M
- Journal Title
  
  Expert Opin Med Diagn
  
  Volume: 7 Issue: 1 Pages: 71-83
- DOI
  10.1517/17530059.2013.733694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591252, KAKENHI-PUBLICLY-24111555, KAKENHI-PROJECT-25290019
[Journal Article] Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies.2013
- Author(s)
  Sekigawa A, Takamatsu Y, Sekiyama K, Takenouchi T, Sugama S, Waragai M, Fujita M, Hashimoto M
- Journal Title
  
  Oxid Med Cell Longev
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462
[Journal Article] Dual effects of beta-synuclein in the pathogenesis of Parkinson's disease2013
- Author(s)
  Akio Sekigawa, Kazunai Sekiyama, Masayo Fujita, Yoshiki Takamatsu, Albert R. La Spada Eliezer Maslah, Makoto Hashimotoi
- Journal Title
  
  Annals of Neurology
  
  Volume: 74 Pages: 306-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640030
[Journal Article] Biomarkers for the diagnosis and management of Parkinson's disease2013
- Author(s)
  Waragai M, Sekiyama K, Fujita M, Tokuda T, Hashimoto M.
- Journal Title
  
  Expert Opin Med Diagn.
  
  Volume: 1 Pages: 71-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640030
[Journal Article] Diversity of mitochondrial pathology in a mouse model of axonal degeneration in synucleinopathies2013
- Author(s)
  Sekigawa A
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2013 Pages: 817807-817807
- DOI
  10.1155/2013/817807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462, KAKENHI-PUBLICLY-24111555, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044
[Journal Article] Dual effects of β-synuclein on the pathogenesis of Parkinson's disease2013
- Author(s)
  Sekigawa A, Sekiyama K, Takamatsu Y, Fujita M, Hashimoto M
- Journal Title
  
  Ann Neurol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462
[Journal Article] Dual effects of βsynuclein in the pathogenesis of Parkinson's disease2013
- Author(s)
  Akio Sekigawa, Kazunari Sekiyama, Masayo Fujita, Yoshiki Takamatsu, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
- Journal Title
  
  Annals of Neurology
  
  Volume: 7 Issue: 2 Pages: 306-306
- DOI
  10.1002/ana.23936
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111555, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25830044
[Journal Article] Corticosteroids limit microglial activation occurring during acute stress2012
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Conti B, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 232 Pages: 13-20
- DOI
  10.1016/j.neuroscience.2012.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500465
[Journal Article] Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H b-synuclein2012
- Author(s)
  S ekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Waragai M, Takenouchi T, Sugama S, Hashimoto M
- Journal Title
  
  Neurosci Lett
  
  Volume: 515(1) Issue: 1 Pages: 97-101
- DOI
  10.1016/j.neulet.2012.03.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21700399, KAKENHI-PROJECT-24500465, KAKENHI-PUBLICLY-24111555
[Journal Article] Synuclein in the pathogenesis of Parkinson's disease and related・-synucleinopathies : Emerging roles and new directions2012
- Author(s)
  Hashimoto M. La Spada AR
- Journal Title
  
  Future Neurol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a Cells: Involvement of PI3 kinase/Akt signaling pathway.2012
- Author(s)
  Takenouchi T. et al.
- Journal Title
  
  Cell Biol. Int.
  
  Volume: 36 Issue: 12 Pages: 1223-1231
- DOI
  10.1042/cbi20120329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-22580389, KAKENHI-PROJECT-24500465, KAKENHI-PLANNED-22113009
[Journal Article] Neuroinflammation in Parkinson's disease and related disorders : lesson from genetically manipulated mouse model of a-synucleinopathy2012
- Author(s)
  Sekiyama K, Sugama S, Fujita M, Sekigawa A, Takamatsu Y, Takenouchi T, Waragai M, Hashimoto M
- Journal Title
  
  Parkinson's Disease
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] β-Synuclein in the pathogenesis of Parkinson’s disease and related α-synucleinopathies: Emerging roles and new directions.2012
- Author(s)
  Hashimoto, M., La Spada, AR.
- Journal Title
  
  Future Neurol.
  
  Volume: 7(2) Issue: 2 Pages: 155-163
- DOI
  10.2217/fnl.12.5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462
[Journal Article] Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein2012
- Author(s)
  Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Hatano T, Rockenstein E, La Spada AR, Masliah E, Hashimoto M
- Journal Title
  
  Mol Brain
  
  Volume: 5 Pages: 34-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659462
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1βunder acidic extracellular pH in LPS-primed microglial cells2011
- Author(s)
  Takenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
- Journal Title
  
  J Neurochem
  
  Volume: 117(4) Pages: 712-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Immunological responses of astroglia in the rat brain under acute stress : interleukin 1 beta co-localized in astroglia2011
- Author(s)
  Sugama S, Takenouchi T, Sekiyama K, Kitani H, Hashimoto M
- Journal Title
  
  Neuroscience
  
  Volume: 192 Pages: 429-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques2011
- Author(s)
  Umahara T, Uchihara T, Yamada S, Hashimoto T, Akimoto J, Haraoka J, Iwamoto T
- Journal Title
  
  Atherosclerosis
  
  Volume: 215 Pages: 392-398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500325
[Journal Article] Cold stress induced morphological microglial activation and increased IL-1βexpression in astroglial cells in rat brain2011
- Author(s)
  Sugama S, Takenouchi T, Fujita M, Kitani H, Hashimoto M
- Journal Title
  
  J Neuroimmunol
  
  Volume: 233(1-2) Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Bridging molecular genetics and biomarkers in lewy body and related disorders2011
- Author(s)
  Ho GJ, Liang W, Waragai M, Sekiyama K, Masliah E, Hashimoto M
- Journal Title
  
  Int J Alzheimers Dis
  
  Pages: 842475-842475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson's Disease2010
- Author(s)
  Waragai M, Sekiyama K, Sekigawa A, Takamatsu Y, Fujita M, Hashimoto M
- Journal Title
  
  Int. J Med. Sci
  
  Volume: 11(11) Pages: 4257-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases2010
- Author(s)
  Takenouchi, T.; Sekiyama, K.; Sekigawa, A.; Fujita, M.; Waragai, M.; Sugama, S.; Iwamaru, Y.; Kitani, H.; Hashimoto, M
- Journal Title
  
  Arch Immunol Ther Exp(Warsz)
  
  Volume: 58(2) Pages: 91-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Aβ-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain2010
- Author(s)
  Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rochenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M
- Journal Title
  
  Nat Commun
  
  Volume: 1 Issue: 1 Pages: 110-110
- DOI
  10.1038/ncomms1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500359, KAKENHI-PROJECT-21300135, KAKENHI-PROJECT-21700399
[Journal Article] Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells2009
- Author(s)
  Parihar MS, Parihar A, Fujita M, Hashimoto M, Ghafourifar P
- Journal Title
  
  Int J Biochem Cell Biol
  
  Volume: 41(10) Pages: 2015-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Differential microglial activation between acute stress and lipopolysaccharide treatment2009
- Author(s)
  Sugama, S Takenouchi T, Fujita M, Conti B, Hashimoto M.
- Journal Title
  
  J Neuroimmunol 207
  
  Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Journal Article] The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells2009
- Author(s)
  Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto, M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima, S, Kitani H, Hashimoto M
- Journal Title
  
  J Immunol
  
  Volume: 182(4) Pages: 2051-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies2009
- Author(s)
  Wei J, Fujita M, Nakai M, Waragai M, Sugama S, Takenouchi T, Masliah E, Hashimoto M
- Journal Title
  
  Am. J Pathol
  
  Volume: 174(5) Pages: 1891-909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Differential microglial activation between acute stress and lipopolysaccharide treatment2009
- Author(s)
  Sugama, S Takenouchi T, Fujita M, Conti B, Hashimoto M
- Journal Title
  
  J Neuroimmunol
  
  Volume: 207(1-2) Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells2009
- Author(s)
  Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto, M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima, S, Kitani H, Hashimoto M.
- Journal Title
  
  J Immunol 182
  
  Pages: 2051-2062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Journal Article] Role of Synucleins in Alzheimer's Disease2009
- Author(s)
  Crews L, Tsigelny I, Hashimoto M, Masliah E
- Journal Title
  
  Neurotox Res
  
  Volume: 16(3) Pages: 306-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neuro degeneration2009
- Author(s)
  Sugama, S Takenouchi T, Kitani H, Fujita, M, Hashimoto M.
- Journal Title
  
  J Neuroimmunol 208
  
  Pages: 104-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Journal Article] Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration2009
- Author(s)
  Sugama, S Takenouchi T, Kitani H, Fujita, M, Hashimoto M
- Journal Title
  
  J Neuroimmunol
  
  Volume: 208(1-2) Pages: 104-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Neurotoxic conversion of b-synuclein : a novel approach to generate a transgenic mouse model of synucleinopathies?2009
- Author(s)
  Fujita M, Sekigawa A, Sekiyama K, Sugama S, Hashimoto M
- Journal Title
  
  J Neurol
  
  Volume: 256 Suppl 3 Pages: 286-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300135
[Journal Article] Mitochondrial association of alpha-synuclein causes oxidative stress2008
- Author(s)
  Parihar MS, Parihar A, Fujita M, Hashimoto M. Ghafourifar P
- Journal Title
  
  Cell Mol Life Sci. 65
  
  Pages: 1272-1284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Journal Article] alpha-Synuclein aggregates interfere with Parkin solubility and distribution : role in the pathogenesis of Parkinson's disease2008
- Author(s)
  Kawahara K, Hashimoto M. Baron P, Ho GJ, Crews L, Mizuno H, Rockenstien E, Imam SZ, Masliah E.
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 6979-6987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Journal Article] Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway2008
- Author(s)
  Takenouchi T, Iwamaru Y, Sugama S, Sato M, Hashimoto M. Kitani H.
- Journal Title
  
  J Immunol 180
  
  Pages: 7827-7839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650053
[Patent] 変異型βシヌクレイントランスジェニック非ヒト動物2012
- Inventor(s)
  橋本款、藤田雅代、中井雅晶、井上聡、津久井通
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Number
  2006-329803
- Filing Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23659462
[Patent] METHOD FOR TREATING AND/OR PREVENTING NEURODEGENERATIVE DISEASE BY ADIPONECTIN RECEPTOR AGONIST2012
- Inventor(s)
  橋本　款、関山　一成、高松　芳樹、藤田　雅代、関川　明生
- Industrial Property Rights Holder
  橋本　款、関山　一成、高松　芳樹、藤田　雅代、関川　明生
- Industrial Property Rights Type
  特許
- Filing Date
  2012-08-20
- Overseas
- Data Source
  KAKENHI-PUBLICLY-24111555
[Patent] アディポネクチンを含む神経編成疾患の治療及び/又は予防用医薬組成物2011
- Inventor(s)
  橋本, ら
- Industrial Property Rights Holder
  橋本, ら
- Industrial Property Number
  2011-274797
- Filing Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21300135
[Patent] アディポネクチンを含む神経変性疾患の治療及び/又は予防用医薬組成物2011
- Inventor(s)
  橋本款、関山一成
- Industrial Property Rights Holder
  橋本款、関山一成、高松芳樹、藤田雅代、関川明生
- Filing Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21300135
[Patent] アディポネクチンを含む神経編成疾患の治療及び／又は予防用医薬組成物2011
- Inventor(s)
  橋本、その他４名
- Industrial Property Rights Holder
  橋本、その他４名
- Industrial Property Number
  2011-274797
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23659462
[Patent] 変異型βシヌクレインとαシヌクレインとを共発現する形質転換細胞及びトランスジェニック非ヒト動物2007
- Inventor(s)
  橋本款, 藤田雅代, 中井雅晶, 魏建設
- Industrial Property Rights Holder
  財団法人東京都医学機構
- Industrial Property Number
  2007-058272
- Filing Date
  2007-03-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Patent] 変異型βシヌクレインとアルファシヌクレインとを共発現する形質転換細胞及びトランスジェニック非ヒト動物2007
- Inventor(s)
  橋本款, 藤田雅代, 中井雅晶, 魏建設
- Industrial Property Rights Holder
  財団方針東京都医学機構
- Industrial Property Number
  2007-058272
- Filing Date
  2007-03-08
- Data Source
  KAKENHI-PROJECT-17300115
[Patent] 変異型(P123H)βシヌクレイン過剰発現マウス2007
- Inventor(s)
  橋本款, 藤田雅代, 中井雅晶, 井上聡, 津久井通
- Industrial Property Rights Holder
  財団法人東京都医学機構埼玉大学
- Industrial Property Number
  2006-329803
- Filing Date
  2007-03-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] α及びβシヌクレインを共発現させたトランスジェニックフライモデルでの網羅的トランスクリプトーム解析2016
- Author(s)
  高松芳樹、小池和佳子、本多芳子、児玉亨、井上聡、橋本款
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] Possible involvement of adiponectin in the pathogenesis of Alzheimer’s disease2016
- Author(s)
  Hashimoto M. Takamatsu Y, Masliah E, Waragai M
- Organizer
  第51回日本神経科学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] シヌクレイノパチーの病態に対する重力の影響2016
- Author(s)
  橋本款、高松芳樹
- Organizer
  第35回日本認知症学術集会
- Place of Presentation
  東京国際フォ－ラム（東京都千代田区）
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] 抗糖尿病因子；アディポネクチンを用いたパーキンソン病の発症前治療法の可能性2015
- Author(s)
  橋本款
- Organizer
  第12回 RCGM フロンティア国際シンポジウム、サテライトミーティング（招待講演）
- Place of Presentation
  埼玉医科大学ゲノムセンター、埼玉県入間郡
- Year and Date
  2015-02-13
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] αシヌクレインの蓄積がGM2ガングリオシドーシス病に与える影響2015
- Author(s)
  鈴木京子、山口章、川島真人、神崎誠一、幸光範子、勝瀬大海、青木直哉、都甲崇、南澤麿優覧、青木一郎、橋本款、山中正二、平安良雄
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] 抗糖尿病因子；アディポネクチンを用いたパーキンソン病の発症前治療法の可能性2015
- Author(s)
  橋本款
- Organizer
  第12回 RCGM フロンティア国際シンポジウム、サテライトミーティング
- Place of Presentation
  埼玉医科大学ゲノムセンター
- Year and Date
  2015-02-13
- Invited
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] レビー小体型認知症で同定された２種類の変異型βシヌクレイン（P123H、V70M）は、ショウジョウバエ脳において異なるメカニズムで神経変性を引き起こす2015
- Author(s)
  高松芳樹、関山一成、井上聡、本多芳子、児玉亨、橋本款
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] レビー小体型認知症で同定された２種類の変異型βシヌクレイン（P123H、V70M）は、ショウジョウバエ脳において異なるメカニズムで神経変性を引き起こす2015
- Author(s)
  高松芳樹、関山一成、井上聡、本多芳子、児玉亨、橋本款
- Organizer
  BMB2015
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] Disease Modifying Effect of Adiponectin in a Model of α-Synucleinopathies in Vitro and in Vivo.2015
- Author(s)
  Masaaki Waragai, Kazunari Sekiyama, Yoshiki Takamatsu, Masayo Fujita, Akio Sekigawa, Naomichi Iwai, Edward Rockenstein, Satoshi Inoue, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
- Organizer
  Alzheimer's Association International Conference (AAIC2015)
- Place of Presentation
  Washington, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] Disease Modifying Effect of Adiponectin in a Model of α-Synucleinopathies in Vitro and in Vivo.2015
- Author(s)
  Masaaki Waragai, Kazunari Sekiyama, Yoshiki Takamatsu, Masayo Fujita, Akio Sekigawa, Naomichi Iwai, Edward Rockenstein, Satoshi Inoue, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
- Organizer
  Alzheimer's Association International Conference (AAIC2015)
- Place of Presentation
  Washington D.C., USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] レビー小体型認知症で同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析.2013
- Author(s)
  高松芳樹，関川明生，堀内純二郎，関山一成，藤田雅代，児玉亨，齋藤実，橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PUBLICLY-24111555
[Presentation] シヌクレイノパチー病態におけるアディポネクチンの治療効果について.2013
- Author(s)
  関山一成, 藤田雅代, 高松芳樹, 橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M.
- Organizer
  Neuroscinence 2013
- Place of Presentation
  San Diego　Convention center USA
- Data Source
  KAKENHI-PUBLICLY-24111555
[Presentation] レビー小体型認知症で同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析.2013
- Author(s)
  高松芳樹，関川明生，堀内純二郎，関山一成，藤田雅代，児玉亨，齋藤実，橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M.
- Organizer
  Neuroscinence 2013
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] シヌクレイノパチー病態におけるアディポネクチンの治療効果について.2013
- Author(s)
  関山一成, 藤田雅代, 高松芳樹, 橋本款.
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PUBLICLY-24111555
[Presentation] シヌクレイノパチー病態におけるアテ?ィホ?ネクチンの治療効果について2013
- Author(s)
  関山一成、藤田雅代、高松芳樹、橋本款
- Organizer
  第３６回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] レビー小体型認知症て同定された変異型β シヌクレイン(P123H, V70M) を導入したショウジョウバエの解析2013
- Author(s)
  高松芳樹、関川明生、堀内純ニ郎、関山一成、藤田雅代、児玉亨、齊藤実、橋本款
- Organizer
  第３６回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] The anti-diabetic hormone, adiponectin, has protective effect on the pathogenesis of in vitro and in vivo models of α-synucleinopathies.2013
- Author(s)
  Sekiyama K, Fujita M, Sekigawa A, Takamatsu Y, Hashimoto M
- Organizer
  Neuroscinence 2013
- Place of Presentation
  San Diego USA
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] エルドバ誘発性ジスキネジアと大脳基底核におけるシヌクレイン病理の関連性2012
- Author(s)
  橋本款
- Organizer
  第54回日本老年医学会学術集会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23659462
[Presentation] エルドバ誘発性ジスキネジアと大脳基底核におけるシヌクレイン病理の関連性2012
- Author(s)
  橋本款
- Organizer
  第54回日本老年医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-06-29
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111555
[Presentation] Mechanism of axonal globule formation in a mouse model of α-synucleinopathy is distinct from thatin a mouse model of β-synucleinopathy2012
- Author(s)
  関川明生関山一成、藤田雅代、高松芳樹、橋本款
- Organizer
  第53回日本神経病理学会総会学術研究会
- Place of Presentation
  新潟
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-23659462
[Presentation] シヌクレインマウスの軸索腫脹病変におけるリソソーム系異常およびミトファジーの組織学的解析2011
- Author(s)
  関川明生、藤田雅代、関山一成、高松芳樹、橋本款
- Organizer
  第52回日本神経病理学会総会
- Place of Presentation
  京都
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] パーキンソン病及び関連疾患の病態におけるアディポネクチンの役割2011
- Author(s)
  関山一成,藤田雅代,関川明生,高松芳樹,橋本款
- Organizer
  第7回東京都福祉保健医療学会
- Place of Presentation
  東京
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] Morphological analysis of synaptic loss and axon degeneration inα-synucleinopathy model mouse2011
- Author(s)
  Akio Sekigawa, Masayo Fujita, Kazunari Sekiyama, Yoshiki Takamatsu, Makoto Hashimoto
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] 新規シヌクレインマウスモデルを用いた神経変性機序の解明、及び治療法開発への応用2011
- Author(s)
  橋本款
- Organizer
  第129回ゲノム医学研究センター学術集会
- Place of Presentation
  埼玉医科大学ゲノム医学研究センター
- Year and Date
  2011-07-04
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] シヌクレインマウスの軸索腫脹病変におけるリソソーム系異常およびミトファジーの組織学的解析2011
- Author(s)
  関川明生、藤田雅代、関山一成、高松芳樹、橋本款
- Organizer
  第52回日本神経病理学会総会(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659462
[Presentation] α-synuclein stimulates aggregation of adiponecin in the pathogenesis of Lewy body disease2011
- Author(s)
  関山一成,藤田雅代,関川明生,高松芳樹,橋本款
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] A b-synuclein mutation linked to familial dementia with Lewy bodies produces neurodegeneration when expressed in mouse brain2011
- Author(s)
  Fujita, M. Sekiyaam, K, Sekigawa, A Yoshiki Takamatsu, Rockenstein, E, Masliah, M, Hashimoto, M
- Organizer
  AD/PD 2011
- Place of Presentation
  バルセロナ
- Year and Date
  2011-03-14
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] MIBG 心筋シンチグラフィによる前頭側頭葉変性症とレビー小体型認知症の鑑別2011
- Author(s)
  稲葉彰, 坂本昌巳, 橋本祐二, 吾妻玲欧, 織茂智之, 服部高明, 三村将, 福井俊哉, 伊藤憲嘉, 内原俊記, 若林孝一, 高橋均, 柿田明美
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22500325
[Presentation] Sandhoff病モデルマウス脳におけるαシヌクレインの病態関与の研究2010
- Author(s)
  鈴木京子、山口章、神崎誠一、都甲崇、勝瀬大海、青木直哉、藤田雅代、橋本款、山中正二、平安良雄
- Organizer
  BMB2010(第33回日本分子生物学会第83回日本生化学会合同大会)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] Neuropathological Characterization of a Novel Mouse Model of Dementia with Lewy Bodies2010
- Author(s)
  Hashimoto, M
- Organizer
  BIT's 2nd International Congress of Antibodies-2010
- Place of Presentation
  北京
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] Non-apoptotic cell death in hippocampus and cerebral cortex of bigenic mice overexpressing both beta-synuclein(P123H) and alpha-synuclein2010
- Author(s)
  Fujita, M., Sugama, S., Sekiyama, K., Sekigawa, A., Tsukui, T., Inoue, S., Hashimoto, M
- Organizer
  BMB2010(第33回日本分子生物学会第83回日本生化学会合同大会)
- Place of Presentation
  神戸ポートピアアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] Adiponectin is produced by microglial cellls : a possible role of a negative regulator of inflammation in the brain2010
- Author(s)
  Sekiyama, K., Takenouchi, T., Sugama, S., Kitani, H., Hashimoto, M
- Organizer
  BMB2010(第33回日本分子生物学会第83回日本生化学会合同大会)
- Place of Presentation
  神戸ポートピアアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] シヌクレイノパチーマウス及び細胞モデルにおけるリソゾーム病変と糖脂質の蓄積2010
- Author(s)
  藁谷正明、関川明生、藤田雅代、関山一成、赤津裕康、魏建設、橋本款
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-21300135
[Presentation] Protectiverole of glycoshingolipids for lysosomal pathology in synuclein opathies2008
- Author(s)
  Wei J, Nakai M, Fujita M, Hashimoto M
- Organizer
  第31回日本神・経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20650053
[Presentation] βシヌクレイン(P123H)過剰発現型トランスジェニックマウスの解析2008
- Author(s)
  藤田雅代, 中井雅晶, 魏建設, 藁谷正明, 津久井通, 井上聡, 橋本款
- Organizer
  第49回日本神経病理学会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20650053
[Presentation] Transgenic mice model for Lewy body disease2008
- Author(s)
  Hashimoto M, Fujita M, Nakai, M, Sekigawa A
- Organizer
  第17回パーキンソン病治療学会(ノバルティス_ファーマ主催)
- Place of Presentation
  東京
- Year and Date
  2008-09-27
- Data Source
  KAKENHI-PROJECT-20650053
[Presentation] Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy body.2007
- Author(s)
  Hashimoto, M., et. al.
- Organizer
  Annual meeting of Society for Neuroscience.
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy body.2007
- Author(s)
  Hashimoto M
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy body.2007
- Author(s)
  Hashimoto M, et. al.
- Organizer
  Ammual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego,USA
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Molecular mechanism for the inverse incidence of of Parkinson's disease and cancer : Synuclein as stimulator of tumour differentiation.2006
- Author(s)
  Hashimoto, M.
- Organizer
  The 29th annual meeting of the Japan neuroscience Society
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-07-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Molecular mechanism for the inverse incidence of Parkinson's disease and cancer:Synuclein as stimulator of tumour differentiation,2006
- Author(s)
  Hashimoto M
- Organizer
  The 29th annual meeting of the Japan neuroscience society
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2006-07-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Designing new treatments for dementia.2006
- Author(s)
  Hashimoto, M.
- Organizer
  37th Professor Janez Plecnik Memorial Meeting : Recent Progress in Dementia Research
- Place of Presentation
  Ljubliana, Slovenia
- Year and Date
  2006-12-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] Designing new treatments for dementia.,2006
- Author(s)
  Hashimoto M
- Organizer
  37th Professor Janez Plecnik Memorial Meeting:Recent Progress in Dementia Research
- Place of Presentation
  Ljubliana,Slovenia
- Year and Date
  2006-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300115
[Presentation] エルドバ誘発性ジスキネジアと大脳基底核におけるシヌクレイン病理の関連性
- Author(s)
  橋本款
- Organizer
  第54回日本老年医学会学術集会（招待講演）
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23659462
[Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する
- Author(s)
  関山一成, 高松芳樹, 橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25640030
[Presentation] レビー小体型認知症で見出された変異型βシヌクレインを発現するショウジョウバエは神経変性様表現型を示す
- Author(s)
  高松芳樹, 関山一成, 本多芳子, 児玉亨, 橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-09-11 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] Parkin mutations impair mitochondrial function and enhance neurodegeneration in synucleinopathy associated with dementia with Lewy bodies
- Author(s)
  3.Wei, J., Yi Wang, Y., Wu, J., Wei, N., Li, P., Sekiyama, K., Fujita, M., Hashimoto, M.
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-09-11 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する
- Author(s)
  関山一成, 高松芳樹, 橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2014-09-11 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25290019
[Presentation] Adiponectin, the anti-diabetic adipokine, has a therapeutic effect in models of α-synucleinopathies.
- Author(s)
  Sekiyama, K., Waragai, M., Takamatsu, Y., Hashimoto, M.
- Organizer
  AD/PD 2015
- Place of Presentation
  Nice, France
- Year and Date
  2015-03-19 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25290019

1. SUGAMA Shuei (70302461)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. TAKENOUCHI Takato (20292518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. WAKABAYASHI Koichi (50240768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. UCHIHARA Toshiki (10223570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. ORIMO Satoshi (10392359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. WADA Masaaki (80192821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKADO Haruo (60221842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJITA Masayo (90415539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WEI Jianshe (50399466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAI Masaaki (00217647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAKINUMA Yoshihiko (40233944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 小柳清光 (00134958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 壱岐純子 (60399467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Conti Bruno

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 高松芳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 徳田隆彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 月本光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASHIMOTO Makoto 橋本 款

Research Projects

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Co-Researchers

Investigation of microglia and chronic stress in the onset of Parkinson disease

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Therapeutic potential of the anti-neurodegeneration effect of benign adipokinesPrincipal Investigator

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A nasal injection of adiponectin: a novel therapeutic strategy against neurodegenerative diseasePrincipal Investigator

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新規レビー小体型認知症モデルマウスを用いたワクチン療法の開発Principal Investigator

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Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease

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Mechanism by which the pathogenesis of Parkinson's disease is stimulated by Gaucher's mutation.Principal Investigator

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α-synuclein-positive neurites as an early diagnostic indicator

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Analyses of neuropathogenic effects ofβsynuclein using a novel mouse model of synucleinopathies and post mortem brainsPrincipal Investigator

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ポリフェノールのオートファジー促進作用とシヌクレノパチー治療への可能性Principal Investigator

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INVESTIGATION OF THE SYNERGIC EFFECT OF β-SYNUCLEIN WITH HSP27 ON NEUROPROTECTIONPrincipal Investigator

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Does stress promotes neurodegenerative changes?

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[Book] 脳内環境辞典2017

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[Book] 「遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発」2014

Author(s)

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Data Source

[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014

HASHIMOTO Makoto 橋本款