HOMMA Hiroshi 本間浩

… Alternative Names

本間浩ホンマヒロシ

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Researcher Number	50190278
Other IDs
External Links
Affiliation (Current)	2025: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2014: Kitasato University, 薬学部, 教授 2004: Kitasato University, School of Pharmaceutical Sciences, Professor 2000 – 2004: Kitasato University, School of Pharmaceutical Science Professor, 薬学部, 教授 1997 – 1999: 東京大学, 大学院・薬学系研究科, 助教授 1997: The Univ.of Tokyo, Grad.School of Pharm.Sci., Associate Professor, 薬学系研究科, 助教授 1995 – 1996: 東京大学, 薬学部, 助教授 1993 – 1994: 共立薬科大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator D-アスパラギン酸 / D-Aspartate / D-アミノ酸 / Steroidogenic acute regulatory protein / ラット / PC 12 cells / hyposmolarity / release / enantioseparation / fluorescent derivatization … More / HPLC / aspartate racemase / glutamate transporter / steroidogenesis / Leydig cells / testosterone / ヒト絨毛性性腺刺激ホルモン / グルタミン酸トランスポーター / ステロイド合成 / Leydig細胞 / Steroidogenic Acute Regulatory protein / テストステロン / 精巣 / sulfotransferase / homeostasis / PC12 cells / hyposmollarity / D-aspartate / mLTC-1 cells / 8-Br-cAMP / mLTC-1細胞 / human chorionic gonadotropin / テストテロン / elongate spermatid / central nervous system / neuroblastic cell / testis / adrenal gland / pineal gland / immunohistochemistry / アドレナリン / 後期精子細胞 / 中枢神経系 / 神経芽細胞 / 副腎 / 松果体 / 免疫組織染色 / siRNA / 組換えタンパク質 / D－アミノ酸 / ラセマーゼ / D-アスパーギン酸 / 線虫 / 欠損変異株 / D-アミノ酸酸化酵素 / D-アスパラギン酸酸化酵素 / 生化学 / Methoxyacetic acid / 精子細胞 / 肝臓 / PAPS / 活性硫酸 / 部位特異的変異誘発 / スルホトランスフェラーゼ / dual-digitonin-pulse-perfusion / liver lobule / zonation / isoform / rat liver / N-terminal sequence / development / subunits / isoelectric variants … More Except Principal Investigator HPLC / NBD-F / benzofurazan / optical resolution / fluorimetric HPLC / fluorescent Edman reagent / Edman degradation / sequensor / PITC / ペプチドシークエンサー / 蛍光エドマン試薬 / ベンゾフラザン / 光学分割 / 蛍光-HPLC法 / エドマン分解 / シークエンサー / anti D-aspartate antibody / chiral stationary phase / pineal gland / D-aspartic acid / HPLCキラル固定相 / マイクロダイアリシス / 抗D-アスパラギン酸抗体 / 光学活性固定相 / 松果体 / D-アスパラギン酸 Less

Identification of mammalian aspartate racemasePrincipal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Study of spatiotemporal expression of D-amino acid oxidases and D-amino acid contents in Caenorhabditis elegansPrincipal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
D-Amino acid synthetic enzyme of the mammalian originPrincipal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Regulation of gene expression by D-amino acidsPrincipal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Stimulation of testosterone synthesis by D-amino acid in testis Leydig cellsPrincipal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
  The University of Tokyo
Development of high-performance amino acid sequensor of peptides
- Principal Investigator
  
  IMAI Kazuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
D-アミノ酸の組織内分布Principal Investigator
- Principal Investigator
  
  HOMMA Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  THE UNVERSITY OF TOKYO
精巣におけるD-アミノ酸の動態Principal Investigator
- Principal Investigator
  
  本間浩
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Studies on the establishment of the analytical method for, and the distribution and change of the total D-amino acids in mammalian body
- Principal Investigator
  
  IMAI Kazuhiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
ステロイドスルホトランスフェラーゼの部位特異的変異誘発Principal Investigator
- Principal Investigator
  
  本間浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
スルホトランスフェラーゼの肝臓内局在性Principal Investigator
- Principal Investigator
  
  本間浩
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoritsu University of Pharmacy
ステロイドスルホトランスフェラーゼのisoelectric variantsPrincipal Investigator
- Principal Investigator
  
  本間浩
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoritsu University of Pharmacy

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent Other

[Book] D-Amino Acids in Chemistry, Life Sciences, and Biotechnology2010
- Author(s)
  H.Homma, et al.
- Total Pages
  377
- Publisher
  Verlag Helvetica Chimica Acta, Zurich, Switzerland.
- Data Source
  KAKENHI-PROJECT-21590071
[Book] Verlag Helvetica Chimica Acta, Zurich, Switzerland, D-Amino Acids in Chemistry, Life Sciences, and Biotechnology2010
- Author(s)
  H. Homma, et al
- Total Pages
  377
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate2015
- Author(s)
  Matsuda S, Katane M, Maeda K, Kaneko Y, Saitoh Y, Miyamoto T, Sekine M, Homma H
- Journal Title
  
  Amino Acids
  
  Volume: 47 Issue: 5 Pages: 975-985
- DOI
  10.1007/s00726-015-1926-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590090
[Journal Article] Characterization of the Enzymatic and Structural Properties of Human D-Aspartate Oxidase and Comparison with Those of the Rat and Mouse Enzymes2015
- Author(s)
  M. Katane, T. Kawata, K. Nakayama, Y. Saitoh, Y. Kaneko, S. Matsuda, Y. Saitoh, T. Miyamoto, M. Sekine, and H. Homma:
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 2 Pages: 298-305
- DOI
  10.1248/bpb.b14-00690
- NAID
  130004872265
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590090
[Journal Article] Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives2015
- Author(s)
  D. Yamamuro, R. Uchida, M. Ohtawa, S. Arima, Y. Futamura, M. Katane, H. Homma, T. Nagamitsu, H. Osada, H. Tomoda
- Journal Title
  
  Bioorg. Medic. Chem. Lett.
  
  Volume: 25 Issue: 2 Pages: 313-316
- DOI
  10.1016/j.bmcl.2014.11.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013
[Journal Article] ビタミンB2誘導体を補酵素とする脳内活性D-アミノ酸代謝酵素の新規阻害剤2014
- Author(s)
  片根真澄、本間　浩
- Journal Title
  
  ビタミン
  
  Volume: 88 Pages: 469-477
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590090
[Journal Article] Simultaneous determination of NG-monomethyl-L-arginine, NG,NG-dimethyl- L-arginine, and NG,NG’-dimethyl- L-arginine , and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column2014
- Author(s)
  S. Nonaka, M. Sekine, M. Tsunoda, Y. Ozeki, K. Fujii, K. Akiyama, K. Shimoda, T. Furuchi, M. Katane, Y. Saitoh, and H. Homma:
- Journal Title
  
  J. Sep. Sci.
  
  Volume: 37 Issue: 16 Pages: 2087-2094
- DOI
  10.1002/jssc.201400240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-24591688
[Journal Article] The antiviral drug acyclovir is a slow-binding inhibitor of D-amino acid oxidase2013
- Author(s)
  M. Katane, S. Matsuda, Y. Saitoh, M. Sekine, T. Furuchi, N. Koyama, I. Nakagome, H. Tomoda, S. Hirono, and H. Homma
- Journal Title
  
  Biochemistry
  
  Volume: 52, (33) Issue: 33 Pages: 5665-5674
- DOI
  10.1021/bi400478a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-24790086
[Journal Article] Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro2013
- Author(s)
  M. Katane, N. Osaka, S. Matsuda, K. Maeda, T. Kawata, Y. Saitoh, M. Sekine, T. Furuchi, I. Doi, S. Hirono, H. Homma
- Journal Title
  
  J. Med. Chem.
  
  Volume: 56, (5) Issue: 5 Pages: 1894-1907
- DOI
  10.1021/jm3017865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-24790086
[Journal Article] Assay of amino acid racemases2012
- Author(s)
  M. Katane, M. Sekine and H. Homma
- Journal Title
  
  Methods in Mol Biol
  
  Volume: 794 Pages: 367-379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Immunohistochemical localization of endogenous D-aspartate in the marine brown alga Sargassum fusiforme Biosci2011
- Author(s)
  T. Yokoyama, M. Amano, M. Sekine, H. Homma, M. Tokuda and M. Sato
- Journal Title
  
  Biotech. Biochem
  
  Volume: 75 Pages: 1481-1484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] D-Aspartate-an important bioactive substance in mammals : a review from an analytical and biological point of view2011
- Author(s)
  M. Katane and H. Homma
- Journal Title
  
  J. Chromatogr. B
  
  Volume: 879 Pages: 3108-3121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] D-Aspartate-an important bioactive substance in mammals : a review from an analytical and biological point of view2011
- Author(s)
  M.Katane, H.Homma
- Journal Title
  
  J.Chromatogr.B
  
  Volume: 879 Issue: 29 Pages: 3108-3121
- DOI
  10.1016/j.jchromb.2011.03.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase2011
- Author(s)
  M. Katane, Y. Saitoh, K. Maeda, T. Hanai, M. Sekine, T. Furuchi, and H. Homma
- Journal Title
  
  Amino Acids
  
  Volume: 40 Pages: 467-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Generation of enantiomeric amino acids during acid hydrolysis of peptides detected by the liquid chromatography/tandem mass spectroscopy2010
- Author(s)
  T. Miyamoto, M. Sekine, T. Ogawa, M. Hidaka, H. Homma and H. Masaki
- Journal Title
  
  Chem. Biodivers
  
  Volume: 7 Pages: 1644-1650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Detection of D-amino acids in purified proteins synthesized in Escherichia coli2010
- Author(s)
  T. Miyamoto, M. Sekine, T. Ogawa, M. Hidaka, H. Homma and H. Masaki
- Journal Title
  
  Amino Acids
  
  Volume: 38 Pages: 1377-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans2010
- Author(s)
  M. Katane, Y. Saitoh, Y. Seida, M. Sekine, T. Furuchi, and H. Homma
- Journal Title
  
  Chem. Biodivers
  
  Volume: 7 Pages: 1424-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Thiolactomycin inhibits D-aspartate oxidase : a novel approach to probing the active site environment2010
- Author(s)
  M. Katane, Y. Saitoh, T. Hanai, M. Sekine, T. Furuchi, N. Koyama, I. Nakagome, H. Tomoda, S. Hirono and H. Homma
- Journal Title
  
  Biochimie
  
  Volume: 92 Pages: 1371-1378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] D-Aspartate oxidase : the sole catabolic enzyme acting on free D-aspartate in mammals2010
- Author(s)
  M. Katane, H. Homma
- Journal Title
  
  Chem. Biodivers
  
  Volume: 7 Pages: 1435-1449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Journal Article] Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells2009
- Author(s)
  T. Furuchi, T. Suzuki, M. Sekine, M. Katane and H. Homma
- Journal Title
  
  Arch. Biochem. Biophys
  
  Volume: 490 Pages: 118-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590071
[Patent] D－アミノ酸オキシダーゼの阻害剤2013
- Inventor(s)
  本間　浩、片根真澄、供田　洋、小山信裕
- Industrial Property Rights Holder
  本間　浩、片根真澄、供田　洋、小山信裕
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-080701
- Filing Date
  2013-04-08
- Data Source
  KAKENHI-PROJECT-24590090
[Patent] D-アスパラギン酸オキシダーゼおよびD-アミノ酸オキシダーゼに対する新規阻害剤2010
- Inventor(s)
  本間浩、片根真澄、供田洋、小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Acquisition Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-21590071
[Patent] D-アスパラギン酸オキシダーゼおよびD-アミノ酸オキシダーゼに対する新規阻害剤2010
- Inventor(s)
  本間浩, 片根真澄, 供田洋, 小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Acquisition Date
  2010-02-26
- Data Source
  KAKENHI-PROJECT-21590071
[Patent] D-アスパラギン酸オキシダーゼおよびD-アミノ酸オキシダーゼに対する新規阻害剤2009
- Inventor(s)
  本間浩, 片根真澄, 供田洋, 小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Industrial Property Number
  2009-105345
- Filing Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] 抗ウイルス薬であるacyclovirのD-アミノ酸代謝酵素に対する新規阻害活性2014
- Author(s)
  片根真澄、松田さつき、宮本哲也、齋藤康昭、関根正恵、古地壯光、小山信裕、中込泉、供田洋、広野修一、本間浩
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学黒髪キャンパス（熊本市）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] D-Amino acid aminotransferase localization in Arabidopsis thaliana.2014
- Author(s)
  Masae Sekine, Sho Sugawara, Masumi Katane, Yasuaki Saitoh, Tetsuya Miyamoto, and Hiroshi Homma
- Organizer
  The 2nd International Conference of D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] NBD-Fを用いたメチルアルギニン類の高感度HPLC-蛍光検出法の開発および統合失調症患者血漿への応用2014
- Author(s)
  野中聖子、関根正恵、角田誠、尾関祐二、藤井久彌子、秋山一文、下田和孝、片根真澄、齋藤康昭、宮本哲也、本間浩
- Organizer
  第４回新アミノ酸分析研究会
- Place of Presentation
  東京大学武田先端知ビル（東京）
- Year and Date
  2014-11-17
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Analysis of D-amino acid residues in proteins treated with alkaline2014
- Author(s)
  Tetsuya Miyamoto, Nobuyuki Takahashi, Masae Sekine, Tetsuhiro Ogawa, Makoto Hidaka, Hiroshi Homma, Haruhiko Masaki
- Organizer
  The 2nd International Conference of D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] HPLC-蛍光検出法を用いたメチルアルギニン類の高感度定量法の開発2014
- Author(s)
  野中聖子、関根正恵、角田誠、片根真澄、齋藤康昭、宮本哲也、本間浩
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本市）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] The role and behavior of D-amino acids in living organisms2014
- Author(s)
  Hiroshi Homma
- Organizer
  The second International Conference on D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-02
- Invited
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] The rat and human homologues of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate2014
- Author(s)
  Satsuki Matsuda, Masumi Katane, Kazuhiro Maeda, Yuusuke Kaneko, Yasuaki Saitoh, Tetsuya Miyamoto, Masae Sekine, Hiroshi Homma
- Organizer
  The 2nd International Conference of D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-03
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] D-Aspartate oxidase deficiency in C. elegans extends lifespan by inhibiting NMDA receptor and TOR2014
- Author(s)
  Yasuaki Saitoh, Mari Okutsu, Syunya Nakano, Masumi Katane, Tetsuya Miyamoto, Masae Sekine, Taro Sakamoto, Hirotaka Imai, Hiroyuki Arai, Hiroshi Homma
- Organizer
  The 2nd International Conference of D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-04
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 哺乳類細胞におけるD-アスパラギン酸の細胞内含量を変化させる微生物由来天然有機化合物の同定と機能解析2014
- Author(s)
  金子雄介、片根真澄、渡邉美咲、土肥祐基、松田さつき、古地壯光、齋藤康昭、宮本哲也、関根正恵、小山信裕、供田　洋、本間　浩
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] シロイヌナズナ植物体におけるD-アミノ酸アミノトランスフェラーゼ発現部位の解析2014
- Author(s)
  関根正恵、菅原　祥、片根真澄、齋藤康昭、宮本哲也、本間　浩
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] A sensitive assay method of aspartate-specific racemase2014
- Author(s)
  Masumi Katane, Kazuki Nakayama, Tomonori Kawata, Satsuki Matsuda, Yuusuke Kaneko, Yasuaki Saitoh, Tetsuya MIyamoto, Masae Sekine, Hiroshi Homma
- Organizer
  The 2nd International Conference of D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-03
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 生体内に見出されるD－アミノ酸2014
- Author(s)
  本間　浩
- Organizer
  九州大学創薬育薬産学官連携セミナー
- Place of Presentation
  九州大学大学院　薬学研究院（福岡市）
- Year and Date
  2014-08-12
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Establishment of a two-dimensional chiral HPLC-MS/MS system for the determination of trace amounts of D-amino acid residues in proteins2014
- Author(s)
  Shoto Ishigo, Reina Fujita, Yurika Miyoshi, Eiichi Negishi, Hirohisa Onigahara, Masashi Mita, Tetsuya Miyamoto, Haruhiko Masaki, Hiroshi Homma, Tadashi Ueda and Kenji Hamase
- Organizer
  The second International Conference on D-Amino Acid Research (IDAR2014)
- Place of Presentation
  Tochigi prefectural culture center, Utsunomiya, Tochigi
- Year and Date
  2014-09-02
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 線虫の寿命におけるTORシグナルとD-アミノ酸2014
- Author(s)
  齋藤康昭、奥津茉莉、中野俊哉、宮本哲也、関根正恵、片根真澄、坂本太郎、今井浩孝、新井洋由、本間浩
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  パシフィコ横浜　横浜
- Year and Date
  2014-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 統合失調症患者血清におけるアミノ酸の定量2014
- Author(s)
  関根正恵、尾関祐二、藤井久彌子、片根真澄、齋藤康昭、宮本哲也、下田和孝、秋山一文、本間浩
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本市）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] mRNA expression of L-serine synthesis enzyme in the peripheral blood of patients with schizophrenia2013
- Author(s)
  Yuji Ozeki, Masae Sekine, Kumiko Fujii, Takashi Watabnabe, Yumiko Takano, Hiroaki Okayasu, Takahiro Shnozaki, Akiko Aoki, Hideaki Aoki, Mori Harunobu, Kazufumi Akiyama, Hiroshi Homma, Kazutaka Shimoda
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 天然物ライブラリーを用いた細胞内D-Asp濃度に影響を及ぼす化合物のスクリーニング2013
- Author(s)
  金子雄介、古地壯光、奥田麻耶、保母香純、関根正恵、片根真澄、本間　浩
- Organizer
  第9回Ｄ－アミノ酸研究会学術講演会
- Place of Presentation
  関西大学千里山キャンパス（大坂）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] D-アミノ酸代謝酵素に対する新規阻害剤2013
- Author(s)
  片根　真澄、本間　浩
- Organizer
  第86回日本生化学会大会（横浜）　シンポジウム「D-アミノ酸研究の新展開」
- Place of Presentation
  パシフィコ横浜（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] D-Aspartate oxidase is involved in the caloric restriction-induced lifespan extension in C. elegans2013
- Author(s)
  Yasuaki Saitoh, Mari Okutsu, Masumi Katane, Masae Sekine, Takemitsu Furuchi, Taro Sakamoto, Takao Inoue, Hiroyuki Arai, Hiroshi Homma
- Organizer
  第19回 C. elegans 国際会議
- Place of Presentation
  UCLA（Los Angeles、USA）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 哺乳類細胞におけるD-アスパラギン酸の含量とD-アスパラギン酸代謝関連酵素2013
- Author(s)
  松田さつき、片根真澄、前田和洋、齋藤康昭、関根正恵、古地壯光、本間浩
- Organizer
  第9回Ｄ－アミノ酸研究会学術講演会
- Place of Presentation
  関西大学千里山キャンパス（大坂）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Protein L-isoaspartyl/D-aspartylo-methyltransferase(PIMT)の転写調節機構の解析2011
- Author(s)
  古地壯光、本間浩
- Organizer
  第84回日本生化学会大会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] Protein L-isoaspartyl/D-aspartyl-o-methyltransferase (PIMT)の転写調節機構の解析2011
- Author(s)
  古地壯光、本間浩
- Organizer
  第84回日本生化学会大会シンポジウム「D-アミノ酸の生化学-飛躍する新領域-」
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] 新規D-アスパラギン酸オキシダーゼ阻害剤thiolactomycinの同定と機能解析2010
- Author(s)
  片根真澄、齋藤康昭、花井俊彦、関根正恵、古地壯光、小山信裕、中込泉、供田洋、広野修一、本間浩
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] 精製タンパク質におけるD-アミノ酸残基の再現性ある検出と由来2010
- Author(s)
  宮本哲也、関根正恵、小川哲弘、日高真誠、渡邉秀典、本間浩、正木春彦
- Organizer
  日本農芸化学会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] モデル植物シロイヌナズナにおけるD-アミノ酸アミノトランスフェラーゼの解析2010
- Author(s)
  関根正恵、野沢岳史、古地壯光、片根真澄、小林義典、本間浩
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] Molecular characterization and tissue localization of nematode D-amino acid degradative enzymes2009
- Author(s)
  Saitoh, Y., Katane, M., Seida, Y., Furuchi, T., Kobuna, K., Sakamoto, T., Inoue, T., Arai, H., Nakagawa, Y., Homma, H.
- Organizer
  The first international conference of D-amino acidresearch
- Place of Presentation
  Awaji, Hyogo
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] Site-directed mutagenesis study on the active site residues of mouse D-aspartate oxidase2009
- Author(s)
  Masumi Katane, Toshihiko Hanai, Masae Sekine, Takemitsu Furuchi, Hiroshi Homma
- Organizer
  The first international conference of D-amino acid research
- Place of Presentation
  Awaji, Hyogo
- Year and Date
  2009-07-02
- Data Source
  KAKENHI-PROJECT-21590071
[Presentation] 植物におけるD-アミノ酸とD-アミノ酸代謝酵素の解析
- Author(s)
  関根正恵、野沢岳史、片根真澄、齋藤康昭、宮本哲也、本間浩
- Organizer
  第31回白金シンポジウム
- Place of Presentation
  北里大学白金キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] バーチャルスクリーニングに基づくD-アミノ酸オキシダーゼ新規阻害剤の同定とin vitroでの性質決定
- Author(s)
  片根真澄、大坂奈央子、松田さつき、前田和洋、川田知紀、齋藤康昭、関根正恵、古地壯光、土井一生、広野修一、本間浩
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 哺乳類細胞におけるD-アスパラギン酸の生合成とD-アスパラギン酸代謝関連酵素
- Author(s)
  松田さつき，片根真澄，前田和洋，齋藤康昭，関根正恵，古地壯光，本間浩
- Organizer
  第26回北里大学バイオサイエンスフォーラム
- Place of Presentation
  北里大学相模原キャンパス（神奈川県、相模原市）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 線虫の生殖におけるD-アミノ酸分解酵素の機能解析
- Author(s)
  齋藤康昭、片根真澄、関根正恵、古地壯光、坂本太郎、井上貴雄、新井洋由、中川靖一、本間浩
- Organizer
  第８回Ｄ－アミノ酸研究会学術講演会
- Place of Presentation
  瀬田、滋賀県
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Protein L-isoaspartyl (D-aspartyl) O-methyltransferase (PIMT) の発現制御因子の探索
- Author(s)
  古地壯光、原田　怜、立石秀樹、清水由香里、伊藤耕平、片根真澄、関根正恵、太田安隆、本間　浩
- Organizer
  第８回Ｄ－アミノ酸研究会学術講演会
- Place of Presentation
  瀬田、滋賀県
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Physiological functions of D-amino acids
- Author(s)
  Homma H
- Organizer
  Molecular Chirality Asia 2012
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] HPLC-蛍光検出法を用いたメチルアルギニン類の高感度定量法の開発
- Author(s)
  野中聖子、関根正恵、角田誠、本間浩
- Organizer
  第10回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 線虫D-アスパラギン酸オキシダーゼの寿命における役割
- Author(s)
  齋藤康昭、宮本哲也、関根正恵、片根真澄、本間浩
- Organizer
  第31回白金シンポジウム
- Place of Presentation
  北里大学白金キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 線虫の寿命におけるD-アスパラギン酸オキシダーゼの機能解析
- Author(s)
  齋藤康昭、片根真澄、関根正恵、古地壯光、坂本太郎、井上貴雄、新井洋由、中川靖一、本間浩
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] Phosphoserine phosphatase activity is elevated and negatively correlated with serum D-serine concentration in schizophrenia patients
- Author(s)
  Yuji Ozeki, Masae Sekine, Kumiko Fujii, Takashi Watanabe, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Akiko Aoki, Hideaki Aoki, Harunobu Mori, Kazufumi Akiyama, Hiroshi Homma, Kazutaka Shimoda
- Organizer
  15th International Congress on Schizophrenia Research
- Place of Presentation
  The Broadmoor, Colorado Springs, Colorado, USA
- Year and Date
  2015-03-28 – 2015-04-01
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 抗ウイルス薬acyclovirのD-アミノ酸オキシダーゼに対する阻害作用
- Author(s)
  片根真澄、宮本哲也、齋藤康昭、関根正恵、本間浩
- Organizer
  第31回白金シンポジウム
- Place of Presentation
  北里大学白金キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 線虫D-アスパラギン酸オキシダーゼの寿命における役割
- Author(s)
  齋藤康昭、片根真澄、関根正恵、古地壯光、坂本太郎、井上貴雄、新井洋由、中川靖一、本間浩
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] HPLC-蛍光検出法を用いたメチルアルギニン類の高感度定量法の開発および統合失調症患者血漿サンプル測定への応用
- Author(s)
  野中聖子、関根正恵、角田誠、尾関祐二、藤井久彌子、秋山一文、下田和孝、片根真澄、齋藤康昭、宮本哲也、本間浩
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  帝京大学薬学部（東京）
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] In silicoスクリーニングで同定したD-アミノ酸オキシダーゼ新規阻害剤のin vitroでの解析
- Author(s)
  片根真澄、大坂奈央子、松田さつき、前田和洋、川田知紀、齋藤康昭、関根正恵、古地壯光、土井一生、広野修一、本間　浩
- Organizer
  第８回Ｄ－アミノ酸研究会学術講演会
- Place of Presentation
  瀬田、滋賀県
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 統合失調症患者の全血を対象としたL-セリン合成酵素のmRNA発現量検討
- Author(s)
  尾関祐二、関根正恵、藤井久彌子、渡邊崇、髙野有美子、岡安寛明、篠崎隆央、青木顕子、青木秀明、森玄房、秋山一文、本間浩、下田和孝
- Organizer
  第八回日本統合失調症学会
- Place of Presentation
  浦河町総合文化会館（浦河町、北海道）
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] 統合失調症患者における血漿中アミノ酸濃度の解析
- Author(s)
  関根正恵、尾関祐二、藤井久彌子、片根真澄、齋藤康昭、宮本哲也、秋山一文、下田和孝、本間　浩
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  帝京大学薬学部（東京）
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] HEK293細胞におけるD-Asp濃度調節機構の解析
- Author(s)
  古地壯光、保母香純、奥田麻耶、金子雄介、関根正恵、片根真澄、太田安隆、本間　浩
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590090
[Presentation] ビタミンB2誘導体を補酵素とする脳内活性D-アミノ酸代謝酵素の新規阻害剤
- Author(s)
  片根　真澄、本間　浩
- Organizer
  シンポジウム「ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究-ビタミン研究が切り拓く疾患生命科学のフロンティア」
- Place of Presentation
  大阪大学中之島センター（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-24590090
[]

1. FUKUSHIMA Takashi (00272485)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. IMAI Kazuhiro (50012620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SANTA Tomofumi (30187306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUJIWAKE Hideshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HOMMA Hiroshi 本間 浩

本間 浩 ホンマ ヒロシ

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Identification of mammalian aspartate racemasePrincipal Investigator

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Study of spatiotemporal expression of D-amino acid oxidases and D-amino acid contents in Caenorhabditis elegansPrincipal Investigator

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D-Amino acid synthetic enzyme of the mammalian originPrincipal Investigator

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Regulation of gene expression by D-amino acidsPrincipal Investigator

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Stimulation of testosterone synthesis by D-amino acid in testis Leydig cellsPrincipal Investigator

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Development of high-performance amino acid sequensor of peptides

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D-アミノ酸の組織内分布Principal Investigator

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精巣におけるD-アミノ酸の動態Principal Investigator

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Studies on the establishment of the analytical method for, and the distribution and change of the total D-amino acids in mammalian body

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ステロイドスルホトランスフェラーゼの部位特異的変異誘発Principal Investigator

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スルホトランスフェラーゼの肝臓内局在性Principal Investigator

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ステロイドスルホトランスフェラーゼのisoelectric variantsPrincipal Investigator

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[Book] D-Amino Acids in Chemistry, Life Sciences, and Biotechnology2010

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Total Pages

HOMMA Hiroshi 本間浩

本間浩ホンマヒロシ