HONMA Sadamu 本間定

Researcher Number	50192323
External Links
Affiliation (based on the past Project Information) *help	2012 – 2018: 東京慈恵会医科大学, 医学部, 教授 2007 – 2011: Jikei University School of Medicine, 医学部, 准教授 2004 – 2006: 東京慈恵会医科大学, 医学部, 助教授 2001 – 2003: 東京慈恵会医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Tumor immunology / Hygiene / Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Tumor immunology / Tumor therapeutics
Keywords	Principal Investigator 樹状細胞 / Colorectal cancer / 家族性大腸腺腫症 / モデルマウス / APC遺伝子 / 大腸癌 / がんワクチン / 膵癌 / 質量解析 / プロテオーム … More / ペプチドワクチン / Model mice / LOH mutation / Risk of carcinogenesis / Familial Adenomatous Polyposis / APC gene / マウス / LOH変異 / 発癌リスク / Gene transfection / Beta-catenine / Immunotherapy / APC gene mutation / Dendritic cell / 細胞融合 / 細胞障害性T細胞 / 抗腫瘍免疫 / 遺伝子導入 / β-カテニン / 免疫療法 / APC遺伝子異常 / がん免疫療法 / 腫瘍組織標本 / 腫瘍抗原 / 抗原性ペプチド / Mass imaging / LC/MS/MS / WT1 / 癌免疫療法 / 抗腫瘍効果 / 血管周細胞 / 血管内皮細胞 / 血管新生 / 腫瘍血管 / 血管前駆細胞 / iPS細胞 / 癌幹細胞 / 免疫学 / バイオマス / 生体分子 / 癌 / MS / LC / 中皮腫 … More Except Principal Investigator 樹状細胞 / WT1 / 細胞障害性T細胞 / がんワクチン / 免疫療法 / 樹状細胞ワクチン / 膵癌 / OVA / 細胞性免疫 / MolCraft / 人工タンパク質 / 融合細胞 / PD-1 / NK細胞 / PD-L1 / 免疫チェックポイント / 抗腫瘍免疫 / 腫瘍浸潤単核球 / 初代培養 / 免疫チェックポイント阻害剤 / CD8+T cell / NK cell / Imatinib / Galectin-9 / Tim-3 / GIST / 免疫抑制細胞 / 癌局所 / 膵臓癌 / サイトカイン / 予後バイオマーカー / 集学的免疫化学療法 / 免疫誘導 / 免疫化学療法 / ペプチドワクチン / OVA　(ovalbumin) / 人工タンパク質抗原 / マクロファージ / OVA (Ovalubumin) / TLR-4 / 人工抗原 / OVA(Ovalbumin) / Molcraft / 抗原提示細胞 / TLR4 / エタノール / ワクチン / 免疫原性 / 抑制性Ｔ細胞 / 細胞傷害性Ｔ細胞 / 癌 / 細胞融合 / TGF-beta / 癌細胞 / 高免疫原性 / トール様受容体 / 細胞障害性Ｔ細胞 / がん免疫 / がん細胞 / 免疫 / 人工蛋白質 / 腫瘍免疫療法 / がん / 液性免疫 / 腫瘍免疫 / 癌幹細胞 / 癌ワクチン / 膵がん Less

anti tumor immunology against GIST through immunecheckpoint mechnism
- Principal Investigator
  
  KOMITA HIDEO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
Selection of immunochemotherapy for patients with advanced pancreatic cancer
- Principal Investigator
  
  Koido Shigeo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
Development of cancer vaccine using adjuvant function encrypted artificial antigens
- Principal Investigator
  
  Masaki Ito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Jikei University School of Medicine
Quantitative anlysis on antigenic peptides from the tumor antigen and its application to a biomarker for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  HOMMA SADAMU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor immunology
- Research Institution
  Jikei University School of Medicine
Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation
- Principal Investigator
  
  KOIDO Shigeo
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor immunology
- Research Institution
  Jikei University School of Medicine
Development of a novel cancer immunotherapy using the artificial proteins consisted in the functional peptide motifs.
- Principal Investigator
  
  ITO Masaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor immunology
- Research Institution
  Jikei University School of Medicine
Immunotherapy targeting tumor vascular cells using iPS cell-derived vaccinePrincipal Investigator
- Principal Investigator
  
  HOMMA Sadamu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor immunology
- Research Institution
  Jikei University School of Medicine
Studies on generation of peptide vaccine against cancer stem cells of pancreatic cancer using proteomic analysisPrincipal Investigator
- Principal Investigator
  
  HOMMA Sadamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
Induction of antitumor immunity by fusions of dendritic cells and pancreatic cancer stem cells
- Principal Investigator
  
  KOIDO Shigeo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
プロテオーム解析を用いた中皮腫発生予防のためのペプチドワクチンの開発Principal Investigator
- Principal Investigator
  
  本間定
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Jikei University School of Medicine
Establishment of the method for estimation of carcinogenetic risk in gastrointestinal adenomas using double transgenic micePrincipal Investigator
- Principal Investigator
  
  HOMMA Sadamu, 伊藤正紀
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  The Jikei University School of Medicine
Prevention of gastrointestinal tumors by vaccination with clendritic cells transfected with beta-catenine gene.Principal Investigator
- Principal Investigator
  
  HOMMA Sadamu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine

[Book] Immunotherapy for Pancreatic Cancer2012
- Author(s)
  Koido S, Homma S, Takahara A, Namiki Y, Komita H, Uchiyama K, Ohkusa T, Tajiri H
- Total Pages
  26
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-23501289
[Book] Pancreatic Cancer - Molecular Mechanism and Targets2012
- Author(s)
  Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Hideo Komita, Kan Uchiyama1,　Toshifumi Ohkusa, Hisao Tajiri
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-24501334
[Book] Immunotherapy for Pancreatic Cancer. Pancreatic Cancer - Molecular Mechanism and Targets2012
- Author(s)
  Koido S, Homma S, Takahara A, Namiki Y, Komita H, Uchiyama K, Ohkusa T, Tajiri H
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23501289
[Book] 先端医療シリーズ、肝・胆・膵疾患の最新医療
- Author(s)
  本間定
- Publisher
  先端医療技術研究所(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Book] BIO Clinica
- Author(s)
  本間定
- Publisher
  北隆館(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Book] 先端医療シリーズ、肝・胆・膵疾患、肝・胆・膵疾患の最新医療
- Author(s)
  本間定
- Publisher
  先端医療技術研究所(印刷中)
- Data Source
  KAKENHI-PROJECT-16590487
[Book] BIO Clinica
- Author(s)
  本間定
- Publisher
  北隆館(印刷中)
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.2018
- Author(s)
  Nishida S, Ishikawa T, Egawa S, Koido S, Yanagimoto H, Ishii J, Kanno Y, Kokura S, Yasuda H, Oba MS, Sato M, Morimoto S, Fujiki F, Eguchi H, Nagano H, Kumanogoh A, Unno M, Kon M, Shimada H, Ito K, Homma S, Oka Y, Morita S, Sugiyama H.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 6 Issue: 3 Pages: 320-331
- DOI
  10.1158/2326-6066.cir-17-0386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216, KAKENHI-PROJECT-15K09050, KAKENHI-PROJECT-15K09173
[Journal Article] Encryption of agonistic motifs for TLR4 into artificial antigens augmented the maturation of antigen-presenting cells.2017
- Author(s)
  Ito M, Hayashi K, Minamisawa T, Homma S, Koido S, Shiba K.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 11 Pages: e0188934-e0188934
- DOI
  10.1371/journal.pone.0188934
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09050, KAKENHI-PROJECT-26430172, KAKENHI-PROJECT-17H06255
[Journal Article] Dendritic cell-based vaccine for pancreatic cancer in Japan.2016
- Author(s)
  Okamoto M, Kobayashi M, Yonemitsu Y, Koido S, Homma S
- Journal Title
  
  World J Gastrointest Pharmacol Ther
  
  Volume: 7 Issue: 1 Pages: 133-8
- DOI
  10.4292/wjgpt.v7.i1.133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09050, KAKENHI-PROJECT-15K10190, KAKENHI-PROJECT-25463119
[Journal Article] PhaseI/II trial of combination of temozolomide chemotherapy and immunotherapy with fusions of dendritic and glioma cells inpatients with glioblastoma.2016
- Author(s)
  Akasaki Y, Kikuchi T, Homma S, Koido S, Ohkusa T, Tasaki T, Hayashi K, Komita H, Watanabe N, Suzuki Y, Yamamoto Y, Mori R, Arai T, Tanaka T, Joki T, Yanagisawa T, Murayama Y.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 65 Pages: 1499-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09292
[Journal Article] Prognostic Markers for Patient Outcome Following Vaccination with Multiple MHC Class I/II-restricted WT1 Peptide-pulsed Dendritic Cells Plus Chemotherapy for Pancreatic Cancer.2015
- Author(s)
  2.Takakura K, Koido S, Kan S, Yoshida K, Mori M, Hirano Y, Ito Z, Kobayashi H, Takami S, Matsumoto Y, Kajihara M, Misawa T, Okamoto M, Sugiyama H, Homma S, Ohkusa T, Tajiri H.
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 555-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Vaccination with vascular progenitor cells derived from induced pluripotent stem cells elicits antitumor immunity targeting vascular and tumor cells.2014
- Author(s)
  1.Koido S, Ito M, Sagawa Y, Okamoto M, Hayashi K, Nagasaki E, Kan S, Komita H, Kamata Y, Homma S.
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: 63 Issue: 5 Pages: 459-468
- DOI
  10.1007/s00262-014-1531-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334, KAKENHI-PROJECT-25460936, KAKENHI-PROJECT-25463119
[Journal Article] Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer.2014
- Author(s)
  Nishida S, Koido S et al
- Journal Title
  
  J Immunother
  
  Volume: 37 Issue: 2 Pages: 105-114
- DOI
  10.1097/cji.0000000000000020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501289, KAKENHI-PROJECT-24501334, KAKENHI-PROJECT-24591164, KAKENHI-PROJECT-25830116
[Journal Article] Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells.2014
- Author(s)
  Koido S, Homma S et al.
- Journal Title
  
  Int J Oncol
  
  Volume: 45 Issue: 1 Pages: 470-478
- DOI
  10.3892/ijo.2014.2433
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501289, KAKENHI-PROJECT-25463119
[Journal Article] Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity2014
- Author(s)
  Ito M, Hayashi K, Adachi E, Minamisawa T, Homma S, Koido S, Shiba K
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 10 Pages: e110425-e110425
- DOI
  10.1371/journal.pone.0110425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240135, KAKENHI-PROJECT-24501334, KAKENHI-PROJECT-26430172
[Journal Article] Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity.2014
- Author(s)
  Ito M, Hayashi K, Adachi E, Minamisawa T, Homma S, Koido S, Shiba K.
- Journal Title
  
  PLOS ONE
  
  Volume: 9 (10)
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430172
[Journal Article] Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes.2013
- Author(s)
  Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, et al.
- Journal Title
  
  PLoS One.
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augmentation of OK-432-induced helper T cell 1 response by 5-FU and X-ray irradiation2013
- Author(s)
  Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Koido S, Homma S, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y
- Journal Title
  
  Neoplasia
  
  Volume: 15 Pages: 805-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Prognostic impact of expression of bcl-2 and bax genes in circulating immune cells derived from patients with head and neck carcinoma.2013
- Author(s)
  Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, et al.
- Journal Title
  
  Neoplasia
  
  Volume: 15 Pages: 305-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Immunotherapy for colorectal cancer2013
- Author(s)
  Koido S, Ohkusa T, Homma S, Namiki Y, Takakura K, Saito K, Ito Z, Kobayashi H, Kajihara M, Uchiyama K, Arihiro S, Arakawa H, Okamoto M, Gong J, Tajiri H
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 19 Issue: 46 Pages: 8531-8542
- DOI
  10.3748/wjg.v19.i46.8531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Photodynamic diagnosis of colitis-associated dysplasia in a mouse model after oral administration of 5-aminolevulinic acid2013
- Author(s)
  Komoike N, Kato T, Saijo H, Arihiro S, Hashimoto H, Okabe M, Ito M, Koido S, Homma S, Tajiri H
- Journal Title
  
  In Vivo
  
  Volume: 27 Pages: 747-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Identification of HLA class I-binding peptides derived from unique cancer-associated proteins by mass spectrometric analysis2013
- Author(s)
  Kamata Y, Kuhara A, Iwamoto T, Hayashi K, Koido S, Kimura T, Egawa S, Homma S
- Journal Title
  
  Anticancer Research
  
  Volume: 33 Pages: 1853-1859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Suppressive effects on regulatory T cell induction by cyclophosphamide and gemcitabine in vitro.2012
- Author(s)
  Kan S, Hazama S, Maeda K, Inoue Y, Homma S, Koido S, Okamoto M, Oka M.
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 5363-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501289
[Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma2012
- Author(s)
  Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M
- Journal Title
  
  Pancreas
  
  Volume: 41 Pages: 195-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Intrahepatic activated NKT cell has a significant role to exacerbate the hepatitis in experimental autoimmune hepatitis model2012
- Author(s)
  Nakano M Takahashi Het al.(他6名)
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: 170 Issue: 3 Pages: 274-282
- DOI
  10.1111/j.1365-2249.2012.04664.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590748, KAKENHI-PROJECT-24501334
[Journal Article] Gemcitabine enhances Wilms' tumor gene Immunotherapy synergizes with chemotherapy targeting pancreatic cancer2012
- Author(s)
  Koido S., Homma S., Ito M., et al.
- Journal Title
  
  Immunotherpy
  
  Volume: 4 Issue: 1 Pages: 5-7
- DOI
  10.2217/imt.11.150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231, KAKENHI-PROJECT-22650232, KAKENHI-PROJECT-22700898, KAKENHI-PROJECT-23501289
[Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in the patients with advanced pancreatic carcinoma2012
- Author(s)
  Kimura Y, et al
- Journal Title
  
  Pancreas
  
  Volume: 41 Issue: 2 Pages: 195-205
- DOI
  10.1097/mpa.0b013e31822398c6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390364, KAKENHI-PROJECT-22591512, KAKENHI-PROJECT-22592247, KAKENHI-PROJECT-23501289, KAKENHI-PROJECT-24501330
[Journal Article] Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro.2012
- Author(s)
  Kan S, Hazama S, Maeda K, Inoue Y, Homma S, Koido S, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 32 Pages: 5363-5369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501334
[Journal Article] Current immunotherapeutic approaches in pancreatic cancer2011
- Author(s)
  Koido S, Homma S, Takahara A, Namiki Y, Tsukinaga S, Mitobe J, Odahara S, Yukawa T, Matsudaira H, Nagatsuma K, Uchiyama K, Satoh K, Ito M, Komita H, Arakawa H, Ohkusa T, Gong J, Tajiri H
- Journal Title
  
  Clin Dev Immunol
  
  Volume: 2011 Pages: 267539-267539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] 進行膵癌に対するGemcitabine併用WT1標的免疫療法の意義2011
- Author(s)
  小井戸薫雄、本間定、高原映崇、込田英夫、大草敏史、田尻久雄
- Journal Title
  
  胆と膵
  
  Volume: 32 Pages: 887-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Current immunotherapeutic approaches in pancreatic cancer2011
- Author(s)
  Koido S., Homma S., Ito M., et al.
- Journal Title
  
  Clin Dev Immunol
  
  Volume: 267539 Pages: 1-15
- DOI
  10.1155/2011/267539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231, KAKENHI-PROJECT-22650232, KAKENHI-PROJECT-22700898, KAKENHI-PROJECT-23501289
[Journal Article] Immunologic monitoring of cellular responses by Dendritic/Tumor cell fusion vaccines2011
- Author(s)
  Koido S., Homma S., Ito M., et al.
- Journal Title
  
  Journal of Biomedicine and Biotechnology
  
  Volume: 910836 Issue: 1 Pages: 1-14
- DOI
  10.1155/2011/910836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231, KAKENHI-PROJECT-22650232
[Journal Article] Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines2011
- Author(s)
  Koido S, Homma S, Takahara A, Namiki Y, Komita H, Nagasaki E, Ito M, Nagatsuma K, Uchiyama K, Satoh K, Ohkusa T, Gong J, Tajiri H
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Pages: 910836-910836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response2011
- Author(s)
  Takahara A, et al
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 60(9) Issue: 9 Pages: 1289-97
- DOI
  10.1007/s00262-011-1033-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591245, KAKENHI-PROJECT-22650231, KAKENHI-PROJECT-22790913, KAKENHI-PROJECT-23501289, KAKENHI-PROJECT-23659489
[Journal Article] Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response2011
- Author(s)
  Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, Mineno J, Shiku H, Nishida S, Sugiyama H, Tajiri H, Homma S
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 60(9) Pages: 1289-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Regulation of tumor immunity by tumor/dendritic cell fusions2010
- Author(s)
  Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, Tajiri H
- Journal Title
  
  Clin Dev Immnol
  
  Volume: 51678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231
[Journal Article] Antigen. specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells2010
- Author(s)
  Koido S, Homma S, Hara E, Namiki Y, Okusa T, Gong J, Tajiri H
- Journal Title
  
  J Biomed Biotech
  
  Volume: Volume 2010 Pages: 12-12
- DOI
  10.1155/2010/752381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK-cell. mediated antitumor activity via tumor necrosis factor-alpha pathway2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S
- Journal Title
  
  J Immunother
  
  Volume: 33 Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Accumulation of functional regulatory T cells in a actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation.2010
- Author(s)
  Saeki C, Nakano M, Takahashi H, Saito S, Homma S, et al.
- Journal Title
  
  Clin Immunol.
  
  Volume: 135 Pages: 156-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK-cell -mediated antitumor activity via tumor necrosis factor-alpha pathway.2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S.
- Journal Title
  
  J Immunother.
  
  Volume: 33 Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions.2010
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  Clin Dev Immunol. 2010
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Accumulation of functional regulatory T cells in a actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation2010
- Author(s)
  Saeki C, Nakano M, Takahashi H, Saito S, Homma S, Tajiri H, Zeniya M
- Journal Title
  
  Clin Immunol
  
  Volume: 135 Pages: 156-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Accumulation of functional regulatory T cells in a actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation.2010
- Author(s)
  Saeki C, Nakano M, Takahashi H, Saito S, Homma S, et al.
- Journal Title
  
  Clin Immunol
  
  Volume: 135 Pages: 156-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells.2010
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  J Biomed Biotech.
  
  Volume: 2010 Pages: 752381-752381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK-cell -mediated antitumor activity via tumor necrosis factor-alpha pathway.2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S.
- Journal Title
  
  J Immunother. 33
  
  Pages: 467-474
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy- versus patient-derived fusions.2010
- Author(s)
  Koido S, Hara E, Homma S, et al.
- Journal Title
  
  Clin Immunol.
  
  Volume: 135 Pages: 384-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Accumulation of functional regulatory T cells in a actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation.2010
- Author(s)
  Saeki C, Nakano M, Takahashi H, Saito S, Homma S, Tajiri H, Zeniya M.
- Journal Title
  
  Clin Immunol. 135
  
  Pages: 156-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells.2010
- Author(s)
  Koido S, Homma S, Hara E,, et al.
- Journal Title
  
  J Biomed Biotech. 2010
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions2010
- Author(s)
  Koido S, Homma S, Hara E, Namiki Y, Takahara A, Komita H, Nagasaki E, Ito M, Ohkusa T, Gong J, and Tajiri H
- Journal Title
  
  Clin Dev Immunol
  
  Volume: Volume 2010 Pages: 14-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy-versus patient-derived fusions2010
- Author(s)
  Koido S, Hara E, Homma S, Namiki Y, Komita H, Takahara A, Nagasaki E, Ito M, Sagawa Y, Mitsunaga M, Uchiyama K, Satoh K, Arihiro S, Ohkusa T, Gong J, Tajiri H
- Journal Title
  
  Clin Immunol
  
  Volume: 135 Pages: 384-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Accumulation of functional regulatory T cells in actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation2010
- Author(s)
  Saeki C, Homma S, et al.
- Journal Title
  
  Clin Immunol.
  
  Volume: 135 Pages: 156-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy- versus patient-derived fusions.2010
- Author(s)
  Koido S, Hara E, Homma S, et al.
- Journal Title
  
  Clin Immunol. 135
  
  Pages: 384-400
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Antigen-specific polyclonal cytotoxic T lymphocytes induced by fusions of dendritic cells and tumor cells.2010
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  J Biomed Biotech.
  
  Volume: 2010 Pages: 752381-752381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions.2010
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  Clin Dev Immunol.
  
  Volume: 2010 Pages: 516768-516768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] The identification of a novel Paneth cell-associated antigen in a familial adenomatous polyposis mouse model2010
- Author(s)
  Ito M, Suzuki H, Sagawa Y, Homma S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 400 Issue: 3 Pages: 548-553
- DOI
  10.1016/j.bbrc.2010.06.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy- versus patient-derived fusions.2010
- Author(s)
  Koido S, Hara E, Homma S, et al.
- Journal Title
  
  Clin Immunol.
  
  Volume: 135 Pages: 384-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Accumulation of functional regulatory T cells in a actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation.2010
- Author(s)
  Saeki C, Nakano M, Takahashi H, Saito S, Homma S, et al.
- Journal Title
  
  Clin Immunol. 135
  
  Pages: 156-166
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK cell-mediated antitumor activity through the tumor necrosis factor-alpha pathway2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S
- Journal Title
  
  J Immunother.
  
  Volume: 33(5) Pages: 467-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : Comparative functional analysis of helthy-versus patient-derived fusions2010
- Author(s)
  Koido S, Hara E, Homma S, Namiki Y, Komita H
- Journal Title
  
  Clin Immunol.
  
  Volume: 135(3) Pages: 384-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650231
[Journal Article] Dendritic/pancreatic carcinoma fusions for clinical use : comparative functional analysis of healthy- versus patient-derived fusions.2010
- Author(s)
  Koido S, Hara E, Homma S, Namiki Y, Komita H, et al.
- Journal Title
  
  Clin Immunol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] The identification of a novel Paneth cell-associated antigen in a familial adenomatous polyposis mouse model2010
- Author(s)
  Ito M, Suzuki H, Sagawa Y, Homma S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 400 Pages: 548-553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK-cell -mediated antitumor activity via tumor necrosis factor-alphapathway2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S.
- Journal Title
  
  J Immunother. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] The identification of a novel Paneth cell-associated antigen in a familial adenomatous polyposis mouse model.2010
- Author(s)
  Ito M, Suzuki H, Sagawa Y, Homma S.
- Journal Title
  
  Biochem Biophys Res Commun. 400
  
  Pages: 548-553
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Combined treatment with dendritic cells and 5-fluorouracil elicits augmented NK-cell -mediated antitumor activity via tumor necrosis factor-alpha pathway.2010
- Author(s)
  Nagasaki E, Takahara A, Koido S, Sagawa Y, Aiba K, Tajiri H, Yagita H, Homma S
- Journal Title
  
  J Immunother.
  
  Volume: 33 Pages: 467-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] The identification of a novel Paneth cell-associated antigen in a familial adenomatous polyposis mouse model.2010
- Author(s)
  Ito M, Suzuki H, Sagawa Y, Homma S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 400 Pages: 548-553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions2010
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  Clin Dev Immunol
  
  Volume: 2010 Pages: 516768-516768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] The identification of a novel Paneth cell-associated antigen in a familial adenomatous polyposis mouse model2010
- Author(s)
  Ito M, Suzuki H, Sagawa Y, Homma S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 400 Pages: 548-553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650232
[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumor immunity2009
- Author(s)
  Homma S, Koido S, Sagawa Y, et al.
- Journal Title
  
  Clinical and Experimental Immunology 156
  
  Pages: 344-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host antitumor immunity2009
- Author(s)
  Homma S. Koido S, et al.
- Journal Title
  
  Clin Exp Immunol 156
  
  Pages: 344-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host antitumor immunity2009
- Author(s)
  Homma S, Koido S, Sagawa Y, Suzuki H, Komita H, Nagasaki E, Takahara A, Horiguchi-Yamada J, Tajiri H, Zeldin D, Obata T.
- Journal Title
  
  Clin Exp Immunol (in press)
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity.2009
- Author(s)
  Homma S, Koido S, Sagawa Y, et al.
- Journal Title
  
  Clin Exp Immunol. 156(2)
  
  Pages: 344-52
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] Cancer immunotherapy by fusions of dendritic cells and tumor cells2009
- Author(s)
  Koido S, Hara E, Homma S, Ohkusa T, Gong J, Tajiri H.
- Journal Title
  
  Immunotherapy 1
  
  Pages: 49-62
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumor immunity2009
- Author(s)
  Homma S, Koido S, Sagawa Y, et al.
- Journal Title
  
  Clinical and Experimental Immunology 156
  
  Pages: 344-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells.2008
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  J Transl Med. 6
  
  Pages: 51-70
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008
- Author(s)
  Koido S, Homma S, Hara E, Mitsunaga M, Namiki Y, Takahara A, Nagasaki E, Komita H, Sagawa Y, Ohkusa T, Fujise K, Gong J, Tajiri H.
- Journal Title
  
  J Transl Med 6
  
  Pages: 51-51
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008
- Author(s)
  Koido S, Homma S, Hara E, et al.
- Journal Title
  
  Journal of Translational Medicine 6
  
  Pages: 51-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390214
[Journal Article] In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells2008
- Author(s)
  Koido S, Homma S, Hara E, etal.
- Journal Title
  
  Journal of Translational Medicine 6
  
  Pages: 51-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells2007
- Author(s)
  Koido S, Hara E, Homma S, Mitsunaga M, Takahara A, Nagasaki E, Kawahara H, Watanabe M, Toyama Y, Yanagisawa S, Kobayashi S, Yanaga K, Fujise K, Gong J, Tajiri H.
- Journal Title
  
  J Immunol 179
  
  Pages: 4874-83
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] Dendritic/tumor fusion cell-based vaccination against cancer2007
- Author(s)
  Koido S, Hara E, Homma S, Fujise K, Gong J, Tajiri H.
- Journal Title
  
  Arch Immunol Ther Exp 55
  
  Pages: 281-287
- Data Source
  KAKENHI-PROJECT-19590793
[Journal Article] Dendritic/tumor fusion cell-based vaccination against cancer2007
- Author(s)
  Koido S, Hara E, Homma S, et. al.
- Journal Title
  
  Arch. Immunol. Ther. Exp. 55
  
  Pages: 281-287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Synergistic induction of antigen-specific CTL by fusions of TRL-stimulated dendritic cells and heat-stressed tumor cells.2007
- Author(s)
  Koido S, Hara E, Homma S, et. al.
- Journal Title
  
  J. Immunol. 179
  
  Pages: 4874-4883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse heaptocellular carcinoma.2006
- Author(s)
  Komita H, Homma S, Saotome H, Zeniya M, Ohno T, Toda G
- Journal Title
  
  Journal of Hepatology 45・5
  
  Pages: 662-672
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] 樹状細胞ワクチン効果増強のための様々な試み.2006
- Author(s)
  本間定
- Journal Title
  
  BIO Clinica 21・2
  
  Pages: 59-64
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Cancer immunotherapy using dendritic/tumor-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses.2006
- Author(s)
  Homma S, Sagawa Y, Ito M, Ohno T, Toda G
- Journal Title
  
  Clinical and Experimental Immunology 144・1
  
  Pages: 41-47
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Dendritic/tumor-fusion vaccine.2006
- Author(s)
  Homma S
- Journal Title
  
  Modern Aspect of Immunobiology 19
  
  Pages: 37-37
- Data Source
  KAKENHI-PROJECT-18659174
[Journal Article] Cancer immunotherapy by fusions of dendritic and tumour cells and rhII-12.2005
- Author(s)
  Sadamu Homma
- Journal Title
  
  European Journal of Clinical Investigation 35(4)
  
  Pages: 279-286
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Cancer immunotherapy by fusions of dendritic and tumour cells and rhIL-12.2005
- Author(s)
  Sadamu Homma
- Journal Title
  
  European Journal of Clinical Investigation 35(4)
  
  Pages: 279-286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Antitumor activity mediated by CD4+ cytotoxic T lymphocytes against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-122005
- Author(s)
  Sadamu Homma
- Journal Title
  
  Immunology 115(4)
  
  Pages: 451-461
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Inhibition of spontaneous development of liver tumors by inoculation with dendritic cells loaded with hepatocellular carcinoma cells in C3H/HeNCrj mice.2004
- Author(s)
  Irie M, Homma S, Komita H, Zeniya M, Kufe D, Ohno T, Toda G.
- Journal Title
  
  Int.J. Cancer 111
  
  Pages: 238-245
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] 消化器癌に対する新たな免疫療法をめざしたヒト樹状細胞/癌細胞融合ワクチンの作製に関する基礎的研究2004
- Author(s)
  榎本康之, 本間定, 幡場良明, 原栄一, 銭谷幹男, 大野典也
- Journal Title
  
  東京慈恵会医科大学雑誌 119
  
  Pages: 99-115
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine.2004
- Author(s)
  Iinuma T, Homma S, Noda T, Kufe D, Ohno T, Toda G.
- Journal Title
  
  J Clin Invest 113
  
  Pages: 1307-1317
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Cancer immunotherapy using dendritic/tumor-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses.
- Author(s)
  Sadamu Homma
- Journal Title
  
  Clinical and Experimental Immunology (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Cancer immunotherapy using dendritic/tumor-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses
- Author(s)
  Homma S
- Journal Title
  
  Clinical and Experimental Immunology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590487
[Journal Article] Cancer immunotherapy using dendritic/tumor-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses.
- Author(s)
  Sadamu Homma
- Journal Title
  
  Clinical and Experimental Immunology (in press)
- Data Source
  KAKENHI-PROJECT-16590487
[Presentation] 切除不能進行・再発膵癌に対するgemcitabine+WT1ワクチン併用療法のランダム化第II相試験多施設共同研究2016
- Author(s)
  石川剛、西田純幸、江川新一、小井戸薫雄、森本創世子、石井淳、菅野良秀、柳本泰明、大庭真梨、古倉聡、本間定、島田英昭、森田智視、岡芳弘、杉山治夫
- Organizer
  第29回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] 進行膵癌に対するゲムシタビン併用WT1ペプチドワクチン療法ランダム化第II相臨床試験2016
- Author(s)
  小井戸薫雄、西田純幸、石川剛、江川新一、石井淳、菅野良秀、柳本泰明、古倉聡、森本創世子、大庭真梨、江口英利、島田英昭、本間定、森田智視、杉山治夫
- Organizer
  第54回日本癌治療学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-20
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] 進行膵癌に対するゲムシタビン併用WT1ワクチン療法ランダム化II相臨床試験：臨床効果と抗原特異的免疫反応の評価2016
- Author(s)
  西田純幸、石川剛、江川新一、小井戸薫雄、森本創世子、石井淳、菅野良秀、柳本泰明、大庭真梨、古倉聡、本間定、島田英昭、森田智視、岡芳弘、杉山治夫
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] Randomized, open-label phases II study of WT1 peptide vaccine plus gemcitabine for advanced pancreatic cancer: Clinical efficacy and immune response.2016
- Author(s)
  Sumiyuki Nishida, Takeshi Ishikawa, Satoshi Kokura, Shin-ichi Egawa, Shigeo Koido, Hiroaki Yasuda, Hiroaki Yanagimoto, Jun Ishii, Yoshihide Kanno, Mari S. Ohba, Maho Sato, Soyoko Morimoto, Hidetoshi Eguchi, Hiroaki Nagano, Sadamu Homma, Yoshihiro Oka, Satoshi Morita, Haruo Sugiyama.
- Organizer
  ASCO 2016 meeting 第52回米国癌治療学会議
- Place of Presentation
  Chicago、USA
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] Artificial antigen appended with TLR-4 agonist peptide motif stimulates cytokine production of antigen-presenting cells.2016
- Author(s)
  Ito Masaki, Hayashi Kazumi, Minamisawa Tamiko, Koido Shigeo, Homma Sadamu, Shiba Kiyotaka
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] Antigen-presenting cells recognize the molecular contexts of artificial protein antigen2015
- Author(s)
  Masaki Ito, Kazumi Hayashi, Sadamu Homma, Shigeo Koido, Tamiko Minamisawa & Kiyotaka Shiba
- Organizer
  ICCIM 2015/ 19th JACI 23rd MMCB
- Place of Presentation
  東京大学　伊藤謝恩ホール
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430172
[Presentation] 進行膵癌患者血中の可溶性PDL-12015
- Author(s)
  本間定、小井戸薫雄、佐川由紀子、林和美、込田英夫、鎌田裕子、伊藤正紀
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K09050
[Presentation] Encrypted peptidic ligand for TLR-4 augmented the cellular immunity of artificial proteinous antigens.2015
- Author(s)
  伊藤正紀、林和美、南澤宝美后、小井戸薫雄、本間定、芝清隆
- Organizer
  第７４回　日本癌学会総会
- Place of Presentation
  名古屋　国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430172
[Presentation] クロスプレゼンテーション活性は抗原の分子コンテクスト（モチーフの配置）により影響を受ける2015
- Author(s)
  伊藤正紀、本間定、南澤宝美后、芝清隆
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430172
[Presentation] Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity2014
- Author(s)
  Ito M, Hayashi K, Adachi E, Minamisawa T, Koido S, Homma S, Shiba K.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26430172
[Presentation] 細胞性免疫を誘導する人工抗原の作用メカニズムの解析2014
- Author(s)
  伊藤正紀、林和美、南澤宝美后、小井戸薫雄、本間定、芝清隆
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-26430172
[Presentation] 進行膵癌に対するWT1ペプチドワクチンとゲムシタビンによる集学的治療法の選択基準2013
- Author(s)
  小井戸薫雄, 西田純幸, 本間定, 込田英夫, 高原映崇, 高倉一樹, 内山幹, 今津博雄, 荒川廣志, 大草敏史, 田尻久雄
- Organizer
  第５５回日本消化器病学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] Optimization of mplecular context of antigenic peptides in artificial protein for enhanced cellular immunogenicity2013
- Author(s)
  伊藤正紀、林　和美、本間　定、小井戸薫雄、芝　清隆
- Organizer
  第17回日本がん免疫学会学術総会
- Place of Presentation
  宇部
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 分子標的治療薬Trastuzumab-Emtansineのヒト膵がん細胞に対する抗腫瘍効果2013
- Author(s)
  カン　シン、小井戸薫雄、岡本正人、林　和美、伊藤正紀、鎌田裕子、込田英夫、永崎栄次郎、本間　定
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 前立腺癌細胞におけるHLAクラスI分子結合ペプチドの探索2013
- Author(s)
  鎌田　裕子、久原　映子、岩本　武雄、木村　高弘、林　和美、小井戸　重雄、頴川　晋、本間　定
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] WT1およびMUC1がん抗原ペプチドを用いた進行膵癌に対する樹状細胞ワクチン療法2013
- Author(s)
  辻谷俊一、岡本正人、木村幸乃、本間　定、小井戸薫雄、高橋秀徳、掛地吉弘、前原喜彦
- Organizer
  第67回日本消化器外科学会定期学術総会
- Place of Presentation
  シーガイアコンベンションセンター
- Data Source
  KAKENHI-PROJECT-23501289
[Presentation] 外来抗原エピトープの分子コンテクストを最適化した人工タンパク質は細胞性免疫を誘導する2013
- Author(s)
  伊藤正紀、林　和美、本間　定、小井戸薫雄、芝　清隆
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 膵癌に対するゲムシタビン併用WT1ペプチドワクチン療法の臨床効果と免疫誘導2012
- Author(s)
  西田純幸、小井戸薫雄、原一馬、森本創世子、坪井昭博、本間定、武田裕、込田英夫、永野浩昭、岡芳弘、大草敏史、田尻久雄、杉山治夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-05
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 化学療法剤による癌細胞の免疫感受性の増強2012
- Author(s)
  カンシン、木村幸乃、塚田旬、吉崎慎二、石田尾武文、岡本正人、本間定、小井戸薫雄、恒富亮一、吉村清、硲彰一、岡正朗
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-04
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] iPS細胞から腫瘍血管を標的とした癌ワクチンの開発2012
- Author(s)
  本間定、佐川由紀子、伊藤正紀、永崎栄次郎、高原映崇、込田英夫、小井戸薫雄
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-03
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] Study of photodynamic diagnosis of colon cancer generated in DSS(Dextran sulfate sodium) utilizing Apc(Adenomatous polyposis Coli) knockout mice by visualization following oral 5-aminolevulinic acid sensitization2012
- Author(s)
  Komoike A, Homma S, Ito M, et al
- Organizer
  DDW Digestive Disease Weeks
- Place of Presentation
  San Diego, CA USA
- Year and Date
  2012-05-20
- Data Source
  KAKENHI-PROJECT-22650231
[Presentation] WT1 immune response against pancreatic cancer cells is enhanced by treatment with gemcitabine which up-regulates WT1 expression of the cancer cells2012
- Author(s)
  Sadamu Homma, Akitaka Takahara, Shigeo Koido
- Organizer
  The 6th International Conference on WT1 in Human Neoplasia
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23501289
[Presentation] Activated NKT cells producing interferon-gamma potentiate cytotoxic T cell-mediated autoimmune hepatic inflammation2011
- Author(s)
  Nakano M, Nakagawa R, Saeki C, Oikawa T, Takahashi H, Homma S, Zeniya M
- Organizer
  59^<th> American Association of Liver disease Liver Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-07
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] iPS細胞から腫瘍血管を標的とした癌ワクチンの開発2011
- Author(s)
  本間定、佐川由紀子、伊藤正紀, ほか
- Organizer
  第70日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] iPS細胞から腫瘍血管を標的とした癌ワクチンの作製2011
- Author(s)
  本間定、佐川由紀子、伊藤正紀、永崎栄次郎、高原映崇、込田英夫、小井戸薫雄
- Organizer
  第15回日本がん免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 自己免疫性肝障害を惹起する自己反応性CD8+T細胞の活性化と肝内誘導には肝内活性化NKT細胞が関与する2011
- Author(s)
  中野真範、中川良、佐伯千里、及川恒一、高橋宏樹、本間定、田尻久雄、銭谷幹男
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] iPS細胞から腫瘍血管を標的とした癌ワクチンの開発2011
- Author(s)
  本間定、佐川由紀子、伊藤正紀、永崎栄次郎、高原映崇、込田英夫、小井戸薫雄
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22650231
[Presentation] iPS細胞から腫瘍血管を標的とした癌ワクチンの作製2011
- Author(s)
  本間定、佐川由紀子、伊藤正紀、永崎栄次郎、高原映崇、込田英夫、小井戸薫雄
- Organizer
  第15回日本がん免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2011-07-01
- Data Source
  KAKENHI-PROJECT-22650231
[Presentation] 進行膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビンの併用効果のメカニズム2010
- Author(s)
  本間定、高原映崇、小井戸薫雄
- Organizer
  日本消第96回化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 膵癌に対するWT1ペプチド免疫療法2010
- Author(s)
  本間定、小井戸薫雄、込田英夫、高原映崇、大草敏史、西田純幸、武田裕、岡芳弘、伊藤壽記、坪井昭博、杉山治夫
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 切除不能・再発進行膵臓癌に対するゲムシタビン併用WT1ペプチドワクチン療法第1相臨床試験2010
- Author(s)
  西田純幸、武田裕、小井戸薫雄、岡芳弘、込田英夫、本間定, ほか
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 進行膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビンの併用効果のメカニズム2010
- Author(s)
  本間定、高原映崇、小井戸薫雄
- Organizer
  第19回日本癌病態治療研究会
- Place of Presentation
  東京
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 切除不能・再発進行膵臓癌に対するゲムシタビン併用WT1ペプチドワクチン療法第1相臨床試験2010
- Author(s)
  西田純幸、武田裕、小井戸薫雄、岡芳弘、込田英夫、本間定、大草敏史、森正樹、土岐祐一郎、川瀬一郎、田尻久雄、杉山治夫
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 進行膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビンの併用効果のメカニズム2010
- Author(s)
  本間定、高原映崇、小井戸薫雄
- Organizer
  第19回日本癌病態治療研究会
- Place of Presentation
  東京
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 膵癌に対するWT1ペプチド免疫療法2010
- Author(s)
  本間定、小井戸薫雄、込田英夫、ほか
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 切除不能・再発進行膵臓癌に対するゲムシタビン併用WT1ペプチドワクチン療法第1相臨床試験2010
- Author(s)
  西田純幸、武田裕、小井戸薫雄、岡芳弘、込田英夫、本間定、ほか
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 進行膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビンの併用効果のメカニズム2010
- Author(s)
  本間定、高原映崇、小井戸薫雄
- Organizer
  日本消第96回化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 臨床応用に向けた樹状細胞と膵癌細胞との融合膵癌ワクチン2010
- Author(s)
  小井戸薫雄、本間定、込田英夫、高原映崇、大草敏史、田尻久雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 抗腫瘍免疫反応により産生されるインターフェロンガンマはゲムシタビン活性化酵素の発現を上昇させる2010
- Author(s)
  本間定、佐川由紀子、高原映崇、永崎栄次郎、込田英夫、伊藤正紀、小井戸薫雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22650231
[Presentation] 抗腫瘍免疫反応により産生されるインターフェロンガンマはゲムシタビン活性化酵素の発現を上昇させる2010
- Author(s)
  本間定、佐川由紀子、高原映崇、永崎栄次郎、込田英夫、伊藤正紀、小井戸薫雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22650232
[Presentation] 臨床応用に向けた樹状細胞と膵癌細胞との融合膵癌ワクチン2010
- Author(s)
  小井戸薫雄、本間定、込田英夫、ほか
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 抗腫瘍免疫反応により産生されるインターフェロンガンマはゲムシタビン活性化酵素の発現を上昇させる2010
- Author(s)
  本間定、佐川由紀子、高原映崇、永崎栄次郎、込田英夫、伊藤正紀、小井戸薫雄
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 進行膵臓癌に対するゲムシタビン併用WT1ペプチドワクチン療法2009
- Author(s)
  西田純幸, 武田裕, 岡芳弘, 小井戸薫雄, 込田英夫, 伊藤壽記, 本間定, ほか
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] トール様受容体を刺激した樹状細胞と熱処理した大腸癌細胞の融合細胞は効果的な細胞傷害性T細胞を誘導する2009
- Author(s)
  小井戸薫雄, 込田英夫, 本間定, ほか
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Conditional IL-12 Gene Therapy Promotes Safe amd effective Anti-Tumor Immunity.2009
- Author(s)
  込田英夫, 小井戸薫雄, 本間定, ほか
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 自己免疫性肝炎マウスモデルにおける制御性T細胞の動態と病態との関連の解析2009
- Author(s)
  佐伯千里、中野真範、及川恒一、高橋宏樹、本間定、ほか
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビン併用療法の相乗効果のメカニズム2009
- Author(s)
  高原映崇, 永崎栄二郎, 小井戸薫雄, 佐川由紀子, 伊藤正紀, 田尻久雄, 本間定
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 進行肝細胞癌における樹状細胞ワクチンの免疫回避機構の解明2009
- Author(s)
  小井戸薫雄, 本間定, 込田英夫, ほか
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 肝血管肉腫に対する抗腫瘍免疫の誘導2009
- Author(s)
  込田英夫, 小井戸薫雄, 本間定, ほか
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Accumulation of functional regulatory T cells in actively inflamed liver in mouse dendritic cell-based autoimmune hepatic inflammation.2009
- Author(s)
  Chisato Saeki, Masanori Nakano, Tsunegazu oikawa, Hiroki Takahashi, Sadamu Homma, et al.
- Organizer
  The 60th Annual Meeting of the American Association for the Study of Liver Disease.
- Place of Presentation
  Boston
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 肝細胞癌産生物質はヒト樹状細胞と癌細胞との融合細胞を未成熟化し抑制性T細胞を誘導する2009
- Author(s)
  小井戸薫雄, 本間定, 原栄一, 込田英夫, 佐川由紀子, 高原映崇, 永崎栄二郎, 伊藤正紀, ほか
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] WT1ペプチドワクチンと塩酸ゲムシタビンを併用した進行膵臓癌に対する新たな治療戦略2009
- Author(s)
  西田純幸, 武田裕, 岡芳弘, 小井戸薫雄, 本間定, ほか
- Organizer
  第13回日本がん免疫学会総会
- Place of Presentation
  北九州
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Fusions of human dendritic cells and pancreatic carcinoma cells induce antigen-specific antitumor immune responses.2009
- Author(s)
  Shigeo Koido, Eiichi Hara, Sadamu Homma, et al.
- Organizer
  Digestive Disease Week
- Place of Presentation
  CHICAGO, ILINOIS
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 樹状細胞と5-FUの併用療法はTNF-αを介した抗腫瘍効果.2009
- Author(s)
  永崎栄次郎, 小井戸薫雄, 田尻久雄, 相羽恵介, 本間定
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 肝血管肉腫に対する抗腫瘍免疫の誘導2009
- Author(s)
  込田英夫, 本間定, 小井戸薫雄, ほか
- Organizer
  第45回肝臓病学、会
- Place of Presentation
  神戸
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Fusions of human dendritic cells and hepatocellular carcinoma cells induce cytotoxic and regulatory T cells in vitro.2009
- Author(s)
  Shigeo Koido, Sadamu Homma, Eiichi Hara, et al.
- Organizer
  Keystone Symposia, Dendritic Cells (Z2)
- Place of Presentation
  Banff, Canada.
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 固形腫瘍拒絶抗原としてのHemoglobin-βの効果Short Title : DC-IL12 gene therapy of cancer2009
- Author(s)
  込田英夫、本間定、小井戸薫雄、田尻久雄、Andrew A. Amoscato、Sean M Alber Walter J. Storkus
- Organizer
  第21回日本バイオセラピィ学会
- Place of Presentation
  東京
- Year and Date
  2009-11-19
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] 膵癌に対するWT1ペプチドワクチンと塩酸ゲムシタビン併用療法の相乗効果のメカニズム2009
- Author(s)
  高原映崇, 永崎栄次郎, 小井戸薫雄, 佐川由紀子, 伊藤正紀, 越智俊元, 藤原弘, 安川正貴, 田尻久雄, 本間定
- Organizer
  第22回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  大阪
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 樹状細胞と5-FUの併用療法はTNF-αを介した抗腫瘍相乗効果を示した2009
- Author(s)
  永崎栄次郎、高原映崇、小井戸薫雄、田尻久雄、本間定, ほか
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] On/offシステムによるIL-12遺伝子治療により安全で効率的な抗腫瘍効果の誘導2009
- Author(s)
  込田英夫, Xi Zhao, 小井戸薫雄, 本間定, ほか
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 膵臓癌に対する塩酸ゲムシタビンとWT1ペプチドワクチン併用療法の有効性に関する基礎的検討2009
- Author(s)
  高原映崇、本間定、田尻久雄
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 肝細胞癌産生物質はヒト樹状細胞と癌細胞との癒合細胞を未熟化し抑制性T細胞を誘導する2009
- Author(s)
  小井戸薫雄、本間定、原栄一、込田英夫、並木禎尚, ほか
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 肝癌細胞に発現するチトクロームP450分子の抗腫瘍免疫誘導における意義2009
- Author(s)
  本間定, 込田英夫, 小井戸薫雄, ほか
- Organizer
  第45回日本肝臓学会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 樹状細胞と肝細胞癌との融合細胞ワクチンによる免疫応答の誘導2008
- Author(s)
  小井戸薫雄、本間定、光永真人、ほか
- Organizer
  第50回日本消化器病学会大会JDDW
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 樹状細胞と肝細胞癌との融合細胞ワクチンによる免疫応答の誘導2008
- Author(s)
  小井戸薫雄、本間定、光永眞人、高原映崇、藤瀬清隆、田尻久雄
- Organizer
  第50回日本消化器病学会大会JDDW
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] アロ癌細胞株と自己樹状細胞との融合細胞にて誘導されたMUC1特異的細胞障害性T細胞の特徴2008
- Author(s)
  小井戸薫雄, 本間定, 高原映崇, ほか
- Organizer
  第94会日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-09
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] IL-12遺伝子導入樹状細胞の腫瘍内投与は腫瘍血管を標的とした抗腫瘍抗果を示す2008
- Author(s)
  込田英夫、小井戸薫雄、田尻久雄、本間定、ほか
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Intratumor DC. IL-12 therapy elicits protective immunity against the tumor-associated vasculature2008
- Author(s)
  Hideo Komita、Shigeo Koido、Hisao Tajiri、Sadamu Homma、Andrew A Amoscato、Stean M Alber、Walter J Storkus
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] DCワクチンと5-FU併用のNK細胞を介する抗腫瘍増強効果2008
- Author(s)
  Homma S, et al.
- Organizer
  第21回日本バイオセラピー学会総会
- Place of Presentation
  東京
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18659174
[Presentation] 樹状細胞の提示する抗原ペプチドのプロテオーム解析による自己免疫性肝疾患の標的抗原の探索2008
- Author(s)
  本間定, ほか
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18659174
[Presentation] 初代がん細胞株の樹立 : 大腸がん、膵臓がん、メラノーマ、脳転移性腫瘍2008
- Author(s)
  原栄一、坂本裕彦、小川匡市、渡部道章、田中俊英、本間定、小井戸薫雄
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 樹状細胞の提示する抗原ペプチドのプロテオーム解析による自己免疫性肝疾患の標的抗原の探索2008
- Author(s)
  本間定, ほか
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] DCワクチンと5-FU併用のNK細胞を介する抗腫瘍増強効果2008
- Author(s)
  永崎栄次郎、高原映崇、小井戸薫雄、相羽恵介、本間定
- Organizer
  第21回日本バイオセラピィ学会
- Place of Presentation
  東京
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] トール様受容体を刺激した樹状細胞と熱処理した癌細胞との融合細胞による細胞傷害性T細胞の誘導2008
- Author(s)
  小井戸薫雄、原栄一、本間定、ほか
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] DCワクチンと5-FU併用のNK細胞を介する抗腫瘍増強効果2008
- Author(s)
  Homma S, et al.
- Organizer
  第21回日本バイオセラピー学会総会
- Place of Presentation
  東京
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] 固形腫瘍拒絶抗原としてのHemoglobin-βの効果Short Title : DC-IL12 gene therapy of cancer2008
- Author(s)
  込田英夫, 本間定, 小井戸薫雄, ほか
- Organizer
  第21回日本バイオセラピィ学会
- Place of Presentation
  東京
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] アロ癌細胞株と自己樹状細胞との融合細胞にて誘導されたMUC1特異的細胞障害性T細胞の特徴2008
- Author(s)
  小井戸薫雄、本間定、高原映崇、光永眞人、藤瀬清隆、田尻久雄
- Organizer
  第94会日本消化器病学会総会
- Place of Presentation
  福岡
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation]2008
- Author(s)
  込田英夫, 小井戸薫雄, 田尻久雄, 本間定, ほか
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  東京
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-20390214
[Presentation] Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells2008
- Author(s)
  Shigeo Koido, Eiichi Hara, Sadamu Homma, Makoto Mitsunaga, Akitaka Takahara, Eiichiro Nagasaki, Hidejiro kawahara, Yoichi Toyama, Hideo Komita, Susumu Kobayashi, Katsuhiko Yanaga, Toshifumi Ohkusa, Hisao Tajiri
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] Establishment of many types of primary cancer cell lines; Colon、pancreas、melanoma、and metastatic brain tumors2008
- Author(s)
  Eiichi Hara、Hirohiko Sakamoto、Masaichi Ogawa、Michiaki Watanabe、Toshihide Tanaka、Sadamu Homma、Shigeo Koido
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] プロテオーム解析技術(LC/MS/MS)を用いた肝癌のT細胞認識抗原の探索2007
- Author(s)
  本間定, ほか
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18659174
[Presentation] Characterization of hepatoma antigen identified from dendritic/hepatoma fusion cells by mass spectrometric analysis2007
- Author(s)
  Sadamu Homma S、Yukiko Sagawa、Shigeo Koido、Eiichiro Nagasaki、Akitaka Takahara
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] OK-432は樹状細胞と大腸癌細胞の融合細胞の融合効率を増強し、自己大腸癌に対する効果的CTLを誘導する2007
- Author(s)
  小井戸薫雄、本間定、光永眞、鳥居明、柳沢暁、遠山洋一、河原秀次郎、渡部通章、吉田清哉、小林進、矢永勝彦、藤瀬清隆、田尻久雄
- Organizer
  第93会日本消化器病学会総会
- Place of Presentation
  青森
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] Generation of antigen-specific T cells stimulated by fusions of dendritic cells and allogeneic cancer cell line2007
- Author(s)
  Shigeo Koido S、Sadamu Homma S、Akitaka Takahara、Eiichiro Nagasaki E、Makoto Mitsunaga 、Yasuhiro Tanaka Y、Kiyotaka Fujise、Hisao Tajiri
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] プロテオーム解析技術(LC/MS/MS)を用いた肝癌のT細胞認識抗原の探索2007
- Author(s)
  本間定、佐川由紀子、永崎栄次郎、小井戸薫雄、小幡徹
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] Characterization of hepatoma antigen identified from dendritic/hepatoma fusion cells by mass spectrometric analysis2007
- Author(s)
  Homma S, et. al.
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-07
- Data Source
  KAKENHI-PROJECT-18659174
[Presentation] Dendritic cells engineered to secrete interleukin-12 delivered into sarcoma results in the cross-priming of CD8+ T cells response against hemoglobin-beta2007
- Author(s)
  込田英夫、小井戸薫雄、田尻久雄、本間定、Amoscato AA、Storkus WJ
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  東京
- Year and Date
  2007-07-02
- Data Source
  KAKENHI-PROJECT-19590793
[Presentation] 7.CD20 up-regulation in B cell lymphoma by some chemotherapeutic agents enhances antitumor activity of rituximab.
- Author(s)
  林和美, 鎌田裕子, 永崎栄次郎, カンシン, 伊藤正紀, 小井戸薫雄, 相羽惠介, 本間定.
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 9.Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity.
- Author(s)
  伊藤正紀、林和美、南澤宝美宕、小井戸薫雄、本間定、芝清隆
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 進行がん患者に対するMAGE-A4あるいはSurvivinを標的としたH/K-HELPがんワクチン第１相臨床試験
- Author(s)
  北村秀光、大竹淳矢、高橋典彦、大野陽介、中野基一郎、藤堂　省、福田　諭、奥野清隆、戸倉新樹、本間　定、小井戸薫雄、富樫裕二、西村孝司
- Organizer
  第７１回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 化学療法剤によるヒト膵癌細胞に対する免疫的細胞死の誘導
- Author(s)
  寺島理沙、佐川由紀子、鎌田裕子、カンシン、伊藤正紀、小井戸薫雄、本間　定
- Organizer
  第129回成医会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] がんワクチンンを用いたがんの治療の現状
- Author(s)
  本間　定
- Organizer
  第84回獣医麻酔外科学会
- Place of Presentation
  大宮
- Invited
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] iPS 細胞から腫瘍血管を標的としたがんワクチンの作製
- Author(s)
  本間　定、佐川由紀子、伊藤正紀、永崎栄次郎、高原映崇、込田英夫、小井戸薫雄
- Organizer
  第23回日本樹状細胞研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 3.Dendritic cells pulsed with WT1-specific MHC class I/II restricted epitopes for pancreatic cancer
- Author(s)
  小井戸薫雄、本間定、岡本正人、伊藤正紀、杉山治夫、大草敏史、田尻久雄.
- Organizer
  第18回日本がん免疫学会
- Place of Presentation
  松山
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] 1.Gemcitabine pulse WT1 peptide-based cancer vaccine versus gemcitabine alone for advanced pancreatic cancer: Randomized phase II clinical study in multi-center -Interim analysis-
- Author(s)
  Sumiyuki Nishida, Shinichi Egawa, Satoshi Kokura, Takeshi Ishikawa, Shigeo Koido, Sadamu Homma, Soyoko Morimoto, Satoshi Morita, Yoshihiro Oka, Haruo Sugiyama
- Organizer
  International Conference on WT1 in Human Neoplasia.
- Place of Presentation
  Barcelona
- Year and Date
  2014-04-22 – 2014-04-23
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] ウイルムス腫瘍遺伝子産物（WT1）由来のヘルパーとキラーペプチドをマルチプル・パルスした樹状細胞ワクチンと化学療法を併用した新規免疫化学療法
- Author(s)
  小井戸薫雄　本間定　田尻久雄
- Organizer
  Japan Digestive Disease Week 2014
- Place of Presentation
  神戸
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-23501289
[Presentation] 腫瘍血管ペリサイトを標的とした新たながん免疫療法とGIST治療への応用.
- Author(s)
  込田英夫、小井戸薫雄、本間　定.
- Organizer
  第98回日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] Dendritic cells pulsed with WT1-specific MHC class I/II restricted epitopes for pancreatic cancer
- Author(s)
  小井戸薫雄、本間定など
- Organizer
  第18回日本がん免疫学会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-23501289
[Presentation] 11.HER2 up-regulation by gemcitabine augments antitumor effect of trastuzumab emtansine against low HER2 breast cancer cell.
- Author(s)
  かんしん、小井戸薫雄、岡本正人、林和美、伊藤正紀、鎌田裕子、込田英夫、永崎栄次郎、本間定
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501334
[Presentation] がんワクチンの挑戦
- Author(s)
  本間　定
- Organizer
  第１０回がんワクチン療法研究会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24501334
[]
[]
[]

1. KOIDO Shigeo (70266617)

# of Collaborated Projects: 8 results

# of Collaborated Products: 141 results
2. ITO Masaki (80297366)

# of Collaborated Projects: 6 results

# of Collaborated Products: 40 results
3. SHIBA Kiyotaka (40196415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. IWAMOTO Takeo (90568891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TODA Gotaro (40090500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOMITA HIDEO (90534561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 小幡徹 (80119776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NISHIDA Sumiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. Morimoto Soyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高橋宏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HONMA Sadamu 本間 定

Research Projects

Research Products

Co-Researchers

anti tumor immunology against GIST through immunecheckpoint mechnism

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Selection of immunochemotherapy for patients with advanced pancreatic cancer

Principal Investigator

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Development of cancer vaccine using adjuvant function encrypted artificial antigens

Principal Investigator

Project Period (FY)

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Research Institution

Quantitative anlysis on antigenic peptides from the tumor antigen and its application to a biomarker for cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

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Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

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Development of a novel cancer immunotherapy using the artificial proteins consisted in the functional peptide motifs.

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Immunotherapy targeting tumor vascular cells using iPS cell-derived vaccinePrincipal Investigator

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Studies on generation of peptide vaccine against cancer stem cells of pancreatic cancer using proteomic analysisPrincipal Investigator

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Induction of antitumor immunity by fusions of dendritic cells and pancreatic cancer stem cells

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プロテオーム解析を用いた中皮腫発生予防のためのペプチドワクチンの開発Principal Investigator

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Establishment of the method for estimation of carcinogenetic risk in gastrointestinal adenomas using double transgenic micePrincipal Investigator

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Prevention of gastrointestinal tumors by vaccination with clendritic cells transfected with beta-catenine gene.Principal Investigator

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[Book] Immunotherapy for Pancreatic Cancer2012

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HONMA Sadamu 本間定