HIROSE Hiroshi 広瀬寛

… Alternative Names

広瀬寛ヒロセヒロシ

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Researcher Number	50208881
Other IDs
External Links
Affiliation (Current)	2025: 慶應義塾大学, 保健管理センター(日吉), 教授
Affiliation (based on the past Project Information) *help	2011 – 2014: 慶應義塾大学, 保健管理センター, 准教授 2007 – 2009: Keio University, 保健管理センター, 准教授 2006: KEIO University, Associate Professor, 保健管理センター, 助教授 2006: 慶應義塾大学, 保健管理センター, 講師 2005: 慶應義塾大学, 保健管理センター, 専任講師 … More 1998: 慶應義塾大学, 保健管理センター, 助手 1997: 慶應義塾大学, 医学部・内科, 助手 1993: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied health science / 内分泌・代謝学
Keywords	Principal Investigator メタボリックシンドローム / アディポネクチン / Single-nucleotide polymorphisms / Insulin resistance / High molecular weight adiponectin / Metabolic syndrome / 遺伝子多型(SNPs) / インスリン抵抗性 / 高分子量アディポネクチン / 人工知能システム … More / 遺伝子多型 / 生活習慣病 / 脂肪細胞 / レプチン / β3-受容体 / 肥満 / HIT細胞 / イミダゾリン化合物 / 糖尿病 Less

Longitudinal study for the prevention of lifestyle-related diseasesPrincipal Investigator
- Principal Investigator
  
  HIROSE Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Keio University
Longitudinal study concerning effects of high-molecular-weight adiponectin and SNPs on incidence of metabolic syndromePrincipal Investigator
- Principal Investigator
  
  HIROSE Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Keio University
Adipokines, SNPs and longitudinal study of Metabolic syndrome.Principal Investigator
- Principal Investigator
  
  HIROSE Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Keio University
肥満ラット脂肪細胞のβ3-受容体,レプチン,PPARγの発現調節機構の検討Principal Investigator
- Principal Investigator
  
  広瀬寛
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Keio University
膵ホルモン分泌におよぼすイミダゾリン化合物およびGi蛋白の影響Principal Investigator
- Principal Investigator
  
  広瀬寛
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Keio University

All 2014 2013 2012 2011 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] アディポネクチンとその受容体 (門脇孝編)2008
- Author(s)
  広瀬寛
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-19500611
[Book] アディポネクチンとその受容体、アディポネクチン濃度の規定因子2008
- Author(s)
  広瀬
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] ロスバスタチン5mg/日投与時の各種代謝指標に及ぼす影響2014
- Author(s)
  広瀬寛、神田武志、河邊博史、齊藤郁夫
- Journal Title
  
  慶應保健研究
  
  Volume: 32 Pages: 43-47
- NAID
  40020216964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500855
[Journal Article] High-molecular-weight adiponectin and Ningen Dock: useful biomarker of metabolic syndrome and related disorders (Review)2014
- Author(s)
  Hirose H
- Journal Title
  
  Ningen Dock International
  
  Volume: 1 Pages: 7-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500855
[Journal Article] 非糖尿病男性における6年間の縦断研究で血清高分子量アディポネクチン濃度低値は耐糖能悪化の予知因子となりうる2012
- Author(s)
  広瀬寛，河邊博史，齊藤郁夫
- Journal Title
  
  人間ドック
  
  Volume: 27 Pages: 585-590
- NAID
  10031145861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500855
[Journal Article] Usefulness of measuring serum high-molecular-weight adiponectin level by recently-developed chemiluminescence enzyme immunoassay at health check-up.2012
- Author(s)
  Hirose H, Saito I, et al.
- Journal Title
  
  Ningen Dock
  
  Volume: 26 Pages: 951-957
- NAID
  10031145834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500855
[Journal Article] Prediction of metabolic syndrome using artificial neural network system based on clinical data including insulin resistance index and serum adiponectin.2011
- Author(s)
  Hirose H, Hozawa S, Saito I, et al.
- Journal Title
  
  Comput. Biol. Med.
  
  Volume: 41 Issue: 11 Pages: 1051-1056
- DOI
  10.1016/j.compbiomed.2011.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500855
[Journal Article] Effects of telmisartan therapy on metabolic profiles and serum high molecular weight (HMW)-adiponectin level in Japanese male hypertensive subjects with abdominal obesity.2009
- Author(s)
  Komiya N, Hirose H, Saito I, et. al
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis Vol.16,No.2
  
  Pages: 137-142
- NAID
  10025765186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] 血清の酸化ストレスマーカー(d-ROMs)と各種代謝指標および炎症マーカー等との関係2009
- Author(s)
  広瀬寛, 小宮直子, 河邊博史, 齊藤郁夫:総説
- Journal Title
  
  慶應保健研究 27巻
  
  Pages: 31-36
- NAID
  40016899179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Characteristics of reference intervals of metabolic factors in healthy Japanese: a proposal to set generation-and gender-specific diagnostic criteria for metabolic syndrome.2009
- Author(s)
  Yokoyama H, Hirose H, Saito I, et. al
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis Vol.16,No.2
  
  Pages: 113-120
- NAID
  10025765079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Relations between serum reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population.2009
- Author(s)
  Hirose H, Saito I, et. al
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis Vol.16,No.2
  
  Pages: 77-82
- NAID
  10025764941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] High molecular weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men.2009
- Author(s)
  Seino Y, Hirose H, Saito I, et. al
- Journal Title
  
  Metabolism Vol.58,No.3
  
  Pages: 355-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Relations between serum reactive oxygen metabolites(ROMs)and various inflammatory and metabolic parameters in a Japanese population2009
- Author(s)
  Hirose H, et al.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis 16
  
  Pages: 77-82
- NAID
  10025764941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] High molecular weight adiponectin is a predictor of progression to metabolic syndrome : a population-based 6-year follow-up study2009
- Author(s)
  Seino Y, Hirose H, et al.
- Journal Title
  
  Metabolism 58
  
  Pages: 355-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] 高分子量型アディポネクチン測定の臨床的意義2009
- Author(s)
  広瀬寛
- Journal Title
  
  ホルモンと臨床 Vol.57,No.2
  
  Pages: 169-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension.2008
- Author(s)
  Komiya N, Hirose H, Saito I, et. al
- Journal Title
  
  International Heart Journal Vol.49,No.6
  
  Pages: 681-689
- NAID
  130000069120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] 専門医からみた健診のとらえ方:肥満2008
- Author(s)
  広瀬寛、伊藤裕
- Journal Title
  
  綜合臨床 Vol.57,No.5
  
  Pages: 1554-1558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] 臨床検査を知っていますか?:肥満者における炎症マーカーの意義2008
- Author(s)
  広瀬寛
- Journal Title
  
  肥満と糖尿病 Vol.7,No.3
  
  Pages: 349-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] 総説:肥満症、メタボリックシンドロームの予防と治療2008
- Author(s)
  広瀬寛、齊藤郁夫
- Journal Title
  
  慶應保健研究 26巻
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Significance of leptin and high molecular weight-adiponectin in the general population of Japanese male adolescents.2008
- Author(s)
  Nakatani H, Hirose H, Saito I, et. al
- Journal Title
  
  Metabolism Vol.57,No.2
  
  Pages: 157-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] メタボリックシンドロームの診断・治療に役立つ血中マーカー : 高分子量アディポネクチン2007
- Author(s)
  広瀬寛, 他
- Journal Title
  
  内分泌・糖尿病科 24・4(印刷中)
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] メタボリックシンドロームの診断・治療に役立つ血中マーカー : 高分子量アディポネクチン2007
- Author(s)
  広瀬寛, 他
- Journal Title
  
  内分泌・糖尿病科 24・5(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men.2007
- Author(s)
  Seino Y, Hirose H, Saito I, et. al
- Journal Title
  
  Metabolism Vol.56,No.11
  
  Pages: 1493-1499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Serum high molecular weight (HMW) adiponectin is a useful marker for diagnosis and treatment of metabolic syndrome2007
- Author(s)
  Hiroshi Hirose, Yoshie Seino, Hiroyuki Yamamoto, Ikuo Saito
- Journal Title
  
  Naibunpi Tounyoubyou-ka 24(5)(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men2007
- Author(s)
  Seino Y, Hirose H, Saito I, et. al.
- Journal Title
  
  Metabolism 56
  
  Pages: 1493-1499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500611
[Journal Article] Metabolic syndrome and high molecular weight adiponectin2006
- Author(s)
  Hiroshi HIROSE
- Journal Title
  
  The Japanese Journal of Constitutional Medicine 68(1-2)
  
  Pages: 85-89
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] メタボリックシンドロームと体質改善-高分子量アディポネクチンを指標として-2006
- Author(s)
  広瀬寛
- Journal Title
  
  日本体質医学会雑誌 68巻・1,2合併号
  
  Pages: 85-89
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] メタボリックシンドロームと体質改善-高分子量アディポネクチンを指標として-2006
- Author(s)
  広瀬寛
- Journal Title
  
  日本体質医学会雑誌 68巻 1・2合併号(未定)
- Data Source
  KAKENHI-PROJECT-17500479
[Journal Article] メタボリックシンドロームと体質改善-高分子量アディポネクチンを指標として-2006
- Author(s)
  広瀬寛
- Journal Title
  
  日本体質医学会雑誌 68巻1・2合併号
  
  Pages: 85-89
- Data Source
  KAKENHI-PROJECT-17500479
[Presentation] 臍高部CTスキャンによる内臓脂肪・皮下脂肪面積やHOMA-R・HOMA-βと糖尿病・高血圧・メタボリックシンドロームなどとの関係2014
- Author(s)
  広瀬寛，高山美智代，井上詠，岩男泰，河邊博史、杉野吉則
- Organizer
  第５５回日本人間ドック学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] 生活習慣病とアディポネクチンについて2014
- Author(s)
  広瀬寛
- Organizer
  第52回全国大学保健管理研究集会
- Place of Presentation
  慶應義塾大学三田キャンパス（東京都港区）
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] 欧米人集団ゲノムワイド関連解析で同定された2型糖尿病感受性遺伝子領域の日本人集団における検証2014
- Author(s)
  酒井健輔，今村美菜子，岩田実，広瀬寛，綿田裕孝，前川聡，戸辺一之，柏木厚典，加来浩平，河盛隆造，田中逸，前田士郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-05-25
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] Usefulness of genetic risk score constructed from 49 loci for type 2 diabetes in Japanese individuals2013
- Author(s)
  Imamura M, Hirose H, Maeda S, et al.
- Organizer
  第49回欧州糖尿病学会
- Place of Presentation
  バルセロナコンベンションセンター（スペイン）
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] Replication study for the association of DUSP9 locus and 6 South Asian GWAS derived loci with susceptibility to type 2 diabetes in a Japanese population.2012
- Author(s)
  Imamura M, Iwata M, Maegawa H, Watada H, Tanaka Y, Hirose H, Kashiwagi A, Tobe K, Kaku K, Kawamori R, Nakamura Y, Maeda S
- Organizer
  第72回米国糖尿病学会
- Place of Presentation
  米国、フィラデルフィア
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] Prediction of metabolic syndrome using artificial neural network system and clinical data （シンポジウム）2011
- Author(s)
  広瀬寛、朴沢重成、齊藤郁夫、他
- Organizer
  第43回日本動脈硬化学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] 耐糖能別に見た、化学発光酵素免疫測定法（CLEIA法）による高分子量（HMW）アディポネクチン（ADPN）濃度の違い2011
- Author(s)
  広瀬寛、齊藤郁夫、他
- Organizer
  第54回日本糖尿病学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] 健康診断受診者における, 血清Reactive oxygen metabolites(ROMs)と各種代謝指標および炎症マーカーなどとの関係2009
- Author(s)
  広瀬寛、小宮直子、齊藤郁夫, 他
- Organizer
  第52回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2009-05-24
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] 高分子量アディポネクチン濃度低値はメタボリックシンドローム発症の危険因子である:中高年男性416名における6年間の縦断研究2009
- Author(s)
  広瀬寛
- Organizer
  第82回日本内分泌学会
- Place of Presentation
  群馬県民会館(前橋)
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] 高分子量アディポネクチン濃度低値はメタボリックシンドローム発症の危険因子である:中高年男性416名における6年間の縦断研究(シンポジウム)2009
- Author(s)
  広瀬寛、清野芳江、齊藤郁夫, 他
- Organizer
  第82回日本内分泌学会
- Place of Presentation
  前橋
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] "内臓肥満型"の男性高血圧患者において、テルミサルタンの投与は血清高分子量アディポネクチンを増加させた2008
- Author(s)
  広瀬寛、齊藤郁夫, 他
- Organizer
  第31回日本高血圧学会
- Place of Presentation
  札幌
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] ライフスタイルおよび健康診断結果で算出した指数による、心血管病のリスク評価2008
- Author(s)
  広瀬寛、齊藤郁夫, 他
- Organizer
  第105回日本内科学会
- Place of Presentation
  東京
- Year and Date
  2008-04-12
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] 健診受診者における酸化ストレスマーカーと各種代謝指標、炎症マーカーなどとの関係2008
- Author(s)
  広瀬寛、齊藤郁夫, 他
- Organizer
  第12回日本心血管内分泌代謝学会
- Place of Presentation
  熊本
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] メタボリックシンドロームの予測と高分子量アディポネクチン・MCP-1値との関連2007
- Author(s)
  清野芳江、広瀬寛、齊藤郁夫, 他
- Organizer
  第28回日本肥満学会
- Place of Presentation
  東京
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] 健康診断結果で算出可能な指数による心血管病リスク評価の試み2007
- Author(s)
  広瀬寛、齊藤郁夫, 他
- Organizer
  第11回日本心血管内分泌代謝学会
- Place of Presentation
  東京
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19500611
[Presentation] 血清高分子量アディポネクチン濃度低値は非糖尿病男性において耐糖能悪化の予知因子となり得る
- Author(s)
  広瀬寛，河邊博史，齊藤郁夫
- Organizer
  第55回日本糖尿病学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] ロスバスタチン5mg/日投与時の各種代謝指標に及ぼす影響
- Author(s)
  広瀬寛，他
- Organizer
  第45回日本動脈硬化学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-23500855
[Presentation] Associations of visceral fat area and HOMA-R with both diabetes mellitus and hypertension in a health checkup program
- Author(s)
  Hirose H, Takayama M, Iwao Y, Kawabe H, Sugino Y
- Organizer
  第５０回欧州糖尿病学会
- Place of Presentation
  ウィーンコンベンションセンター（オーストリア）
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-23500855

1. SAITO IKUO (60129442)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. HOZAWA Shigenari (40181482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KAWABE Hiroshi (90129403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

HIROSE Hiroshi 広瀬 寛

広瀬 寛 ヒロセ ヒロシ

Research Projects

Research Products

Co-Researchers

Longitudinal study for the prevention of lifestyle-related diseasesPrincipal Investigator

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Longitudinal study concerning effects of high-molecular-weight adiponectin and SNPs on incidence of metabolic syndromePrincipal Investigator

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Adipokines, SNPs and longitudinal study of Metabolic syndrome.Principal Investigator

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肥満ラット脂肪細胞のβ3-受容体,レプチン,PPARγの発現調節機構の検討Principal Investigator

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膵ホルモン分泌におよぼすイミダゾリン化合物およびGi蛋白の影響Principal Investigator

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[Book] アディポネクチンとその受容体 (門脇 孝編)2008

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[Book] アディポネクチンとその受容体、アディポネクチン濃度の規定因子2008

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[Journal Article] ロスバスタチン5mg/日投与時の各種代謝指標に及ぼす影響2014

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NAID

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[Journal Article] High-molecular-weight adiponectin and Ningen Dock: useful biomarker of metabolic syndrome and related disorders (Review)2014

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[Journal Article] 非糖尿病男性における6年間の縦断研究で血清高分子量アディポネクチン濃度低値は耐糖能悪化の予知因子となりうる2012

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NAID

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[Journal Article] Usefulness of measuring serum high-molecular-weight adiponectin level by recently-developed chemiluminescence enzyme immunoassay at health check-up.2012

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NAID

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[Journal Article] Prediction of metabolic syndrome using artificial neural network system based on clinical data including insulin resistance index and serum adiponectin.2011

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DOI

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[Journal Article] Effects of telmisartan therapy on metabolic profiles and serum high molecular weight (HMW)-adiponectin level in Japanese male hypertensive subjects with abdominal obesity.2009

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NAID

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[Journal Article] 血清の酸化ストレスマーカー(d-ROMs)と各種代謝指標および炎症マーカー等との関係2009

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NAID

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[Journal Article] Characteristics of reference intervals of metabolic factors in healthy Japanese: a proposal to set generation-and gender-specific diagnostic criteria for metabolic syndrome.2009

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HIROSE Hiroshi 広瀬寛

広瀬寛ヒロセヒロシ

[Book] アディポネクチンとその受容体 (門脇孝編)2008