WADA Yoh 和田洋

Researcher Number	50212329
Other IDs	https://orcid.org/0000-0002-7783-7680
External Links
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2009 – 2024: 大阪大学, 産業科学研究所, 准教授 2007: Osaka University, 産業科学研究所, 准教授 1998 – 2006: 大阪大学, 産業科学研究所, 助教授 2004: 国立大学法人大阪大学, 産業科学研究所, 助教授 1996 – 1997: 東京大学, 大学院・総合文化研究科, 助手 1993 – 1995: 東京大学, 教養学部, 助手
Review Section/Research Field	Principal Investigator Cell biology / Biological Sciences / Biological Sciences / Cell biology / Basic Section 44010:Cell biology-related / Basic Section 38060:Applied molecular and cellular biology-related / Molecular biology / 植物生理 Except Principal Investigator Biological Sciences / Cell biology / Biological pharmacy / Functional biochemistry / Biological Sciences
Keywords	Principal Investigator オルガネラ / 液胞 / リソソーム / エンドソーム / エンドサイトーシス / ミクロオートファジー / シグナル伝達 / シンタクシン / 膜融合 / オートファジー … More / 原腸陥入 / 細胞極性 / vacuole / endosome / 初期発生 / 上皮細胞 / 酸性コンパートメント / 小胞輸送 / 低分子量GTPase / シロイヌナズナ / 出芽酵母 / microautophagy / V-ATPase / 初期胚 / lysosome / 臓側内胚葉 / rab7 / 酸性オルガネラ / 遺伝子改変動物 / 細胞内輸送 / VAM / 細胞内局在 / t-SNARE / VAM3遺伝子 / 液胞形成 / オルガネラ酸性化 / HOPS complex / endocytosis / enterocyte / 小腸上皮細胞 / 転写因子 / 栄養吸収 / 小腸上皮 / CORVET複合体 / mVam8 / CORVET / 上皮組織 / HOPS/CORVET複合体 / mTOR / 細胞・組織 / vesicle transport / organelle / vesicle fusion / オルガネラ構築 / プロトン / マウス / syntaxin / Bmp / Wnt / Wntシグナル / 液胞型プロトンポンプ / 空腸 / 大腸菌人工染色体 / ターゲティングベクター / トランスジェニックマウス / ES細胞 / 相同組換え / ノックアウトマウス / 形質転換 / 液胞型ATPase / 破骨細胞 / 生体膜 / 分泌型リソソーム / 遺伝子改変マウス / 神経誘導 / 発生 / イオン環境 / 酸性化 / 伸長成長 / Pep12 / Vam3 / シンタクジン / 膜小胞 / PEP12 / VAM3 / Rab7 / 低分子量 GTPase / 液胞膜 / VAM7遺伝子 … More Except Principal Investigator V-ATPase / ATP / リソソーム / 小胞輸送 / プロトンポンプ / Rab7 / 破骨細胞 / F型ATPase / ATP合成酵素 / V型ATPase / F-ATPase / 細胞生物学 / 蛋白質 / 栄養飢餓 / 酵母 / 自食作用 / Ｖ－ＡＴＰａｓｅ / Rab / 液胞型プロトンポンプ / 骨吸収 / Rab27 / 分泌リソソーム / ATPase / オルガネラ輸送 / 酸性環境 / lysosomes / V-type ATPase / F-type ATPase / Rotation / ATP sypthase / F_0F_1 / ATPase合成酵素 / 膜輸送 / 分子モーター / エネルギー共益 / 回転触媒 / H^+-ATPase / 回転反応 / nano motors / nano machine / Lisosom / F-TPase / ランゲルハンス島 / 分泌顆粒 / 細胞組織 / 酵素 / 生体分子 / インスリン / ナノモーター / ナノマシーン / ダウンレギュレーション / 細胞シグナル / オルガネラ酸性化 / Wntシグナル / エンドサイトーシス / 多能性幹細胞 / 原腸胚形成 / 左右軸形成 / 細胞外シグナル / 細胞内輸送 / 細胞・組織 / ポストゴルジ / 分泌系 / オルガネラ / 調節性分泌 / オートファジー / 細胞内膜系 / メンブレントラフィック / シグナル伝達 / キナーゼ / 変異株 / ストレスタンパク質 / タンパクキナーゼ / APG変異 Less

オルガネラ酸性化が担う細胞極性の確立と維持のメカニズムPrincipal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Osaka University
小腸上皮におけるミクロオートファジーの分子機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
小腸上皮におけるミクロオートファジーの分子機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Endolysosomal dynamics involving microautophagyPrincipal Investigator
- Principal Investigator
  
  Wada Yoh
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Osaka University
Roles of microautophagy in the mouse early embryogenesisPrincipal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Mechanism of V-ATPase-mediated positioning of lysosomes and microtubules
- Principal Investigator
  
  Goto-Matsumoto Naomi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Iwate Medical University
Mechanism for ionic environment formation and organelle trafficking by proton-pumping V-ATPase
- Principal Investigator
  
  Nakanishi Mayumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
Microautophagy in the mouse early embryogenesisPrincipal Investigator
- Principal Investigator
  
  Wada Yoh
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Endocytic pathway involving microautophagy in animalsPrincipal Investigator
- Principal Investigator
  
  Wada Yoh
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Analysis of exracellular signal in cell community of early embryos
- Principal Investigator
  
  MENO Chikara
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
「メンブレントラフィック-分子機構から高次機能への展開」の取りまとめ
- Principal Investigator
  
  大野博司
- Project Period (FY)
  2003 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
  Kanazawa University
発生・分化を担うエンドソーム・リソソームのメンブレンダイナミクスPrincipal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
マウス遺伝子改変の高効率化:ターゲティングベクターの正確かつ迅速な構築法Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
Proton pump ATPase as nano motors
- Principal Investigator
  
  FUTAI Masamistu
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Microbial Chemistry Research Center
  Osaka University
ATP symthase : Mechanism of subunit Rotation and Catalytic Mechanism
- Principal Investigator
  
  FUTAI Masamitu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
マラリア原虫における細胞内小胞輸送の分子機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
高等植物における液胞形成の制御と組織構築Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Vesicle Transport in Endosomal and Lysosomal SystemsPrincipal Investigator
- Principal Investigator
  
  WADA Yoh
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Scientific and Industrial Research, Osaka University
液胞構築のダイナミズムによる高等植物の形態形成機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
酵母液胞形成における小胞輸送:Vam3p依存とPep12p依存の二つの経路Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
  The University of Tokyo
液胞構築のダイナミズムによる高等植物の形態形成機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
液胞形成における二つのシンタクシン分子Vam3pとPep12pの機能Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
液胞構築のダイナミズムによる高等植物の形態形成機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
液胞膜シンタクシン、Vam3pの局在化機構Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
飢餓ストレスによって誘導される自食作用のシグナル伝達系とその生理的役割
- Principal Investigator
  
  大隅良典
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
液胞構築における酵母VAM3遺伝子産物の機能Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  植物生理
- Research Institution
  The University of Tokyo
自食作用に関与する遺伝子群の分子生物学的解析
- Principal Investigator
  
  大隅良典
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
酵母液胞膜アニオン輸送の分子機構と液胞酸性化の遺伝生化学的解析Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
液胞形態形成におけるVAM7遺伝子産物の機能Principal Investigator
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo

[Book] Role of Autophagy in Mammalian Embryogenesis: Response to Developmental Programs in Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Ed Hayat MA2017
- Author(s)
  Wada, Y. Sun-Wada, G. H.
- Publisher
  Elsevier, Oxford UK
- Data Source
  KAKENHI-PROJECT-26291041
[Book] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging,2016
- Author(s)
  Wada, Y. Sun-Wada, G. H.
- Publisher
  Elsevier
- ISBN
  9780128054215
- Data Source
  KAKENHI-PUBLICLY-16H01201
[Book] Handbook of ATPase : Biochemistry, Cell Biology Pathophysiology2004
- Author(s)
  M.Futai, Y.Wada, J.Kaplan
- Publisher
  WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Book] Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology2004
- Author(s)
  M.Futai, Y.Wada, J.Kaplan
- Total Pages
  469
- Publisher
  WILEY-VCH Verlag GmbH & Co.KgaA, Weinheim, Germany
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology"2004
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Total Pages
  16
- Publisher
  (Ed. by M. Futai, Y. Wada and J. Kaplan) Wiley-VCH Verlag GmbH ＆ Co. KgaA, Weinheim, Germany
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Book] Handbook of ATPase : Biochemistry, Cell Biology, Pathophysiology2004
- Author(s)
  二井將光, 和田洋, Jack Kaplan
- Total Pages
  469
- Publisher
  Wiley-VCH Verlag GmbH & Co.KgaA, Weinheim, Germany(in press)
- Data Source
  KAKENHI-PROJECT-13142204
[Book] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function. In "Handbook of ATPases Biochemistry, Cell Biology, Pathophysiology"2004
- Author(s)
  Masamistu Futai., Yo Wada
- Total Pages
  24
- Publisher
  (Ed. by M. Futai, Y. Wada and J. Kaplan) Wiley-VCH Verlag GmbH ＆ Co. KgaA, Weinheim, Germany
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the Interaction with Rab7 and Secretory Lysosome Trafficking in Osteoclasts2024
- Author(s)
  M.Nakanishi-Matsuia , N. Matsumoto , G-H Sun-Wada , Y. Wada
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 1 Pages: 339-344
- DOI
  10.1248/bpb.b23-00833
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-01-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-23K05754, KAKENHI-PUBLICLY-22H04645, KAKENHI-PROJECT-23K21360
[Journal Article] Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells.2023
- Author(s)
  Takahashi,K , H. Mashima , M.Sekine , T. Uehara , T. Asano , G-H Sun-Wada , Y. Wada , H. Ohnishi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22084-22084
- DOI
  10.1038/s41598-023-49520-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PUBLICLY-22H04645
[Journal Article] Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts2023
- Author(s)
  K. Tokuda, S.-L. Lu, Z. Zidi, Y. Kato, S. Chen, K. Noda, K.i Hirose, Y. Usami, N. Uzawa, S. Murakami S. Murakami S. Toyosawa M.Fukuda G-H Sun-Wada Y. Wada T. Noda
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 48 Issue: 2 Pages: 223-239
- DOI
  10.1247/csf.23061
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-20K15789, KAKENHI-PUBLICLY-22H04645
[Journal Article] Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages.2023
- Author(s)
  1.Noda, K., Tokuda K., Hao F., Wada Y., Sun-Wada, GH. Murakami S., Fukuda M., Ito T., and Noda T.
- Journal Title
  
  J. Biol Chem.
  
  Volume: 299 Issue: 10 Pages: 105191-105191
- DOI
  10.1016/j.jbc.2023.105191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-20K15789, KAKENHI-PUBLICLY-22H04645
[Journal Article] The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos2022
- Author(s)
  Ge-Hong Sun-Wada, Yoh Wada
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 13590-13590
- DOI
  10.1038/s41598-022-18002-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-19K05950, KAKENHI-PUBLICLY-22H04645, KAKENHI-PUBLICLY-20H05323
[Journal Article] Exploring the Link between Vacuolar-Type Proton ATPase and Epithelial Cell Polarity2022
- Author(s)
  Ge-Hong Sun-Wada, Yoh Wada
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 10 Pages: 1419-1425
- DOI
  10.1248/bpb.b22-00205
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-19K05950, KAKENHI-PUBLICLY-22H04645, KAKENHI-PUBLICLY-20H05323
[Journal Article] The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts2022
- Author(s)
  Matsumoto Naomi、Sekiya Mizuki、Sun-Wada Ge-Hong、Wada Yoh、Nakanishi-Matsui Mayumi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 8455-8455
- DOI
  10.1038/s41598-022-12397-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06546, KAKENHI-PROJECT-21K06553, KAKENHI-PROJECT-19K05950, KAKENHI-PUBLICLY-22H04645, KAKENHI-PUBLICLY-20H05323, KAKENHI-PROJECT-23K21360
[Journal Article] Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm2021
- Author(s)
  Sun-Wada Ge-Hong、Tabata Hiroyuki、Wada Yoh
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 19355-19355
- DOI
  10.1038/s41598-021-98952-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05950, KAKENHI-PROJECT-21K06553, KAKENHI-PUBLICLY-20H05323
[Journal Article] Functional complementation of V-ATPase a subunit isoforms in osteoclasts2020
- Author(s)
  Matsumoto Naomi、Sekiya Mizuki、Fujimoto Yasuyuki、Haga Satoshi、Sun-Wada Ge-Hong、Wada Yoh、Nakanishi-Matsui Mayumi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 4 Pages: 459-466
- DOI
  10.1093/jb/mvaa118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05950, KAKENHI-PROJECT-19K06646, KAKENHI-PROJECT-18K06629, KAKENHI-PROJECT-18K06661, KAKENHI-PROJECT-21K06553, KAKENHI-PUBLICLY-20H05323
[Journal Article] V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.2020
- Author(s)
  Matsumoto N, Matsukawa R, Takahashi S, Kudo K, Sun-Wada GH, Wada Y, Nakanishi-Matsui M.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 389 Issue: 2 Pages: 111901-111901
- DOI
  10.1016/j.yexcr.2020.111901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06661, KAKENHI-PROJECT-19K06646, KAKENHI-PROJECT-19K05950
[Journal Article] Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism2020
- Author(s)
  Kawamura Nobuyuki、Takaoka Katsuyoshi、Hamada Hiroshi、Hadjantonakis Anna-Katerina、Sun-Wada Ge-Hong、Wada Yoh
- Journal Title
  
  Cell Reports
  
  Volume: 31 Issue: 10 Pages: 107733-107733
- DOI
  10.1016/j.celrep.2020.107733
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950, KAKENHI-PUBLICLY-20H05323, KAKENHI-PUBLICLY-20H05369, KAKENHI-PROJECT-19K23756
[Journal Article] Observations From a Mouse Model of Forebrain Voa1 Knockout: Focus on Hippocampal Structure and Function2019
- Author(s)
  Ma Ke、Bin Na-Ryum、Shi Shan、Harada Hidekiyo、Wada Yoh、Wada Ge-Hong-Sun、Monnier Philippe P.、Sugita Shuzo、Zhang Liang
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13
- DOI
  10.3389/fncel.2019.00484
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950
[Journal Article] Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells2019
- Author(s)
  McGuire Christina M.、Collins Michael P.、Sun-Wada GeHong、Wada Yoh、Forgac Michael
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 29 Pages: 11248-11258
- DOI
  10.1074/jbc.ra119.007713
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950
[Journal Article] Vacuolar-type ATPase: A Proton Pump to Lysosomal Trafficking2019
- Author(s)
  Masamitsu Futai, Ge-Hong Sun-Wada, Yoh Wada, Naomi Matsumoto, Mayumi Nakanishi-Matsui
- Journal Title
  
  Proceedings of the Japan Academy, Ser. B
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07357
[Journal Article] Vacuolar-type ATPase: A proton pump to lysosomal trafficking2019
- Author(s)
  FUTAI Masamitsu、SUN-WADA Ge-Hong、WADA Yoh、MATSUMOTO Naomi、NAKANISHI-MATSUI Mayumi
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 6 Pages: 261-277
- DOI
  10.2183/pjab.95.018
- NAID
  130007662351
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-06-11
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05950
[Journal Article] Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment2018
- Author(s)
  Matsumoto N, Sekiya M, Tohyama K, Ishiyama-Matsuura E, Sun-Wada GH, Wada Y, Futai M, Nakanishi-Matsui M.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 6701-6701
- DOI
  10.1038/s41598-018-24918-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07357, KAKENHI-PROJECT-15K07939, KAKENHI-PROJECT-16K18877, KAKENHI-PROJECT-18K06629, KAKENHI-PROJECT-18K06661, KAKENHI-PUBLICLY-16H01201
[Journal Article] Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.2017
- Author(s)
  Mouse Models. Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 2817-2817
- DOI
  10.1038/s41598-017-02988-3
- NAID
  120007089052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08646, KAKENHI-PROJECT-16K09337, KAKENHI-PROJECT-16K09401, KAKENHI-PUBLICLY-16H01201
[Journal Article] Membrane Dynamics in Mammalian Embryogenesis: Implication in Signal Regulation.2016
- Author(s)
  Yoh Wada, Ge-Hong Sun-Wada, Nobuyuki Kawamura, and Jyunichiro Yasukawa.
- Journal Title
  
  Birth Defects Res C Embryo Today.
  
  Volume: 108 Issue: 1 Pages: 33-34
- DOI
  10.1002/bdrc.21124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21494, KAKENHI-PROJECT-25650066, KAKENHI-PROJECT-26291041, KAKENHI-PROJECT-26440068, KAKENHI-PUBLICLY-16H01201
[Journal Article] The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer2016
- Author(s)
  Cotter, K. Liberman, R. Sun-Wada, G. Wada, Y. Sgroi, D. Naber, S. Brown, D. Breton, S. Forgac, M.
- Journal Title
  
  Oncotarget
  
  Volume: 29 Issue: 29 Pages: 46142-46157
- DOI
  10.18632/oncotarget.10063
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291041, KAKENHI-PROJECT-26440068, KAKENHI-PUBLICLY-16H01201
[Journal Article] Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain.2015
- Author(s)
  Kawamura, N., Sun-Wada, G.H., and Wada, Y.
- Journal Title
  
  Scientific reports
  
  Volume: 5 Issue: 1 Pages: 14027-14027
- DOI
  10.1038/srep14027
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25650066, KAKENHI-PROJECT-26291041, KAKENHI-PROJECT-26440068
[Journal Article] Role of vacuolar-type proton ATPase in signal transduction.2015
- Author(s)
  Sun-Wada, G.H., and Wada, Y.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1847 Issue: 10 Pages: 1166-1172
- DOI
  10.1016/j.bbabio.2015.06.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25650066, KAKENHI-PROJECT-26291041
[Journal Article] Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells.2014
- Author(s)
  Kurauchi-Mito, A., Ichihara, A., Bokuda, K., Sakoda, M., Kinouchi, K., Yaguchi, T., Yamada, T., Sun-Wada, G.H., Wada, Y., and Itoh, H.
- Journal Title
  
  Hypertens Res
  
  Volume: 37 Issue: 9 Pages: 830-835
- DOI
  10.1038/hr.2014.92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650066, KAKENHI-PROJECT-25860696, KAKENHI-PROJECT-26440068
[Journal Article] Role of autophagy in embryogenesis2014
- Author(s)
  Wada, Y., Sun-Wada, G.H., Kawamura, N. & Aoyama, M
- Journal Title
  
  Curr Opin Genet Dev
  
  Volume: 27C Pages: 60-66
- DOI
  10.1016/j.gde.2014.03.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25650066, KAKENHI-PROJECT-26291041
[Journal Article] Role of microautophagy in embryogenesis2014
- Author(s)
  Wada, Sun-Wada, Kawamura, Aoyama
- Journal Title
  
  Curr Opin Genet Dev
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Diversity of proton pumps in osteoclasts: V-ATPase with a3 and d2 isoforms is a major form in osteoclasts2014
- Author(s)
  Matsumoto et al.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1837 Issue: 6 Pages: 744-749
- DOI
  10.1016/j.bbabio.2014.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-24590086, KAKENHI-PROJECT-25650066
[Journal Article] Dynamic visualization of RANKL and Thl7-mediated osteoclast function.2013
- Author(s)
  菊田順一
- Journal Title
  
  The journal of Clinical Investigation
  
  Volume: vol.123 Pages: 866-873
- DOI
  10.1172/jci65054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10335, KAKENHI-PLANNED-22113007, KAKENHI-PROJECT-22689030, KAKENHI-PROJECT-24750160, KAKENHI-PROJECT-25253070, KAKENHI-PROJECT-25650066, KAKENHI-PLANNED-21116002
[Journal Article] Vacuoles in mammals : A subcellular structure indispensable for early embryogenesis2013
- Author(s)
  Wada
- Journal Title
  
  BioArchitecture
  
  Volume: 3 Issue: 1 Pages: 13-19
- DOI
  10.4161/bioa.24126
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-25650066
[Journal Article] The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H+-ATPase biogenesis2013
- Author(s)
  Kinouchi et al
- Journal Title
  
  Plos One
  
  Volume: 8 Issue: 11 Pages: e78603-e78603
- DOI
  10.1371/journal.pone.0078603
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25293198, KAKENHI-PROJECT-25650066
[Journal Article] Vacuolar-type proton pump ATPases: Acidification and pathological relationships2013
- Author(s)
  Sun-Wada and Wada
- Journal Title
  
  Histol Histopathol
  
  Volume: 28 Pages: 805-815
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Positive and negative regulation of developmental signaling by the endocytic pathway2013
- Author(s)
  Wada et al.
- Journal Title
  
  Curr Opin Genet Dev
  
  Volume: 23 Issue: 4 Pages: 391-398
- DOI
  10.1016/j.gde.2013.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-25650066
[Journal Article] Vacuolar-type proton pump ATPases : Acidification and pathological relationships2013
- Author(s)
  Sun-Wada and Wada
- Journal Title
  
  Histol Histopathol
  
  Volume: 28 Pages: 805-815
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Vacuolar-type proton pump ATPases: Acidification and pathological relationships2013
- Author(s)
  Sun-Wada GH, Wada Y
- Journal Title
  
  Histol Histopathol
  
  Volume: 28 Pages: 805-815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650066
[Journal Article] Microautophagy in the visceral endoderm is essential for mouse early development2013
- Author(s)
  Wada et al.
- Journal Title
  
  Autophagy
  
  Volume: 9 Issue: 2 Pages: 252-254
- DOI
  10.4161/auto.22585
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-25650066
[Journal Article] Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos2012
- Author(s)
  Kawamura, Wada et al.
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1071-1071
- DOI
  10.1038/ncomms2069
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-21390050, KAKENHI-PROJECT-23570178, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24659124, KAKENHI-PUBLICLY-23113716
[Journal Article] Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway2012
- Author(s)
  Aoyama, Wada et al.
- Journal Title
  
  Developmental Cell
  
  Volume: 22 Issue: 6 Pages: 1163-1175
- DOI
  10.1016/j.devcel.2012.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-24227010, KAKENHI-PROJECT-24247039, KAKENHI-PROJECT-24390069, KAKENHI-PROJECT-24657144, KAKENHI-PUBLICLY-24116703
[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine2012
- Author(s)
  Takasuga , Wada et al.
- Journal Title
  
  PNAS 110
  
  Volume: 1726-1731 Issue: 5 Pages: 1726-31
- DOI
  10.1073/pnas.1213212110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-21390050, KAKENHI-PROJECT-23229001, KAKENHI-PROJECT-23701036, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24590930, KAKENHI-PROJECT-24657081, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24659124, KAKENHI-PROJECT-24770115, KAKENHI-PROJECT-24790734, KAKENHI-PUBLICLY-25113517, KAKENHI-PROJECT-25650066, KAKENHI-PUBLICLY-23113706, KAKENHI-PUBLICLY-23113716, KAKENHI-PUBLICLY-23121505, KAKENHI-PUBLICLY-24112515
[Journal Article] Generation of chicken monoclonal antibodies against the a1, a2, and a3 subunit isoforms of vacuolar-type proton ATPase2011
- Author(s)
  Sun-Wada, Wada et al.
- Journal Title
  
  Hybridoma
  
  Volume: 30 Issue: 2 Pages: 199-203
- DOI
  10.1089/hyb.2010.0087
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-23570178
[Journal Article] The (pro)renin Receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes2010
- Author(s)
  Kinouchi, Wada et al.
- Journal Title
  
  Circulation Research
  
  Volume: 107 Issue: 1 Pages: 30-34
- DOI
  10.1161/circresaha.110.224667
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Vacuolar-type proton pump ATPases : roles of subunit isoforms in physiology and pathology2010
- Author(s)
  Sun-Wada, Wada
- Journal Title
  
  Histology and Histopathology
  
  Volume: 25 Pages: 1611-1620
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Vacuolar-type proton pump ATPases : roles of subunit isoforms in physiology and pathology.2010
- Author(s)
  Sun-Wada, et al.
- Journal Title
  
  Histology and Histopathology
  
  Volume: 25 Pages: 1611-1620
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Direct recruitment of H^+ATPase from lysosomes for phagosomal2009
- Author(s)
  Sun-Wada, et al.
- Journal Title
  
  Journal of Cell Science 122
  
  Pages: 2504-2513
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002
[Journal Article] Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms2008
- Author(s)
  Wada, Y., et. al.
- Journal Title
  
  J. Bionenerg. Biomembr. 40
  
  Pages: 53-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Differtial expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues2007
- Author(s)
  Sun-Wada, et. al.
- Journal Title
  
  Cell Tissue Res. 329
  
  Pages: 239-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Selective assembly of subunit isoforms in mouse kidney.2006
- Author(s)
  Ge-Hong., Sun-Wada
- Journal Title
  
  J. Bioenerg. Biomemb. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] The a3 isoform of V-ATPase regulates insulin secretion from pancreatic β-cells.2006
- Author(s)
  Sun-Wada, G.-H. 他
- Journal Title
  
  J. Cell Sci. 119(21)
  
  Pages: 4531-4540
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Simple and straight forward construction of a mouse gene targeting vector using in vitro transposition reaction2005
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  Nucleic Acid Res. 33,No5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Diverse and essential roles pf mammalian vacuolar-type proton ATPase : toward the physiological understanding of inside acidic compartments2004
- Author(s)
  G.-H.Sunwada et al.
- Journal Title
  
  Biochim Biophys Acta 1658
  
  Pages: 106-114
- Data Source
  KAKENHI-PROJECT-15657041
[Journal Article] Regulatory elements, directing gut-specific expression of GATA6 gene during mouse early development.2004
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  J. Biochem. 135
  
  Pages: 165-169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Vacuolar-type proton ATPases : subunit isoforms and tissue-specific function2004
- Author(s)
  G.-H.Sun-wada et al.
- Journal Title
  
  Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology
  
  Pages: 379-392
- Data Source
  KAKENHI-PROJECT-15657041
[Journal Article] Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) specifically expressed in kidney and lung.2004
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 44843-44851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Regulatory elements directing gut expression of the GATA6 gene during mouse early development2004
- Author(s)
  G.-H.Sunwada et al.
- Journal Title
  
  J Biochem 135
  
  Pages: 165-169
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Regulatory elements directing gut expression of the GATA6 gene during mouse early development2004
- Author(s)
  G.-H.Sunwada et al.
- Journal Title
  
  J Biochem 135
  
  Pages: 165-169
- Data Source
  KAKENHI-PROJECT-15657041
[Journal Article] Regulatory elements direting gut ezpression of the GATA46 gene during mouse early development2004
- Author(s)
  Sun-Wada et al.
- Journal Title
  
  J.Biochem. 135
  
  Pages: 165-169
- Data Source
  KAKENHI-PROJECT-15079101
[Journal Article] Diverse and essential roles of mammalian vacuolar-type proton pump ATPase : toward the physiological understanding of inside acidic compartments2004
- Author(s)
  G.-H.Sunwada et al.
- Journal Title
  
  Biochim Biophys Acta 1658
  
  Pages: 106-114
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Vacuolar-type proton ATPases : subuint isoforms and tissue-specific function2004
- Author(s)
  G.H-.Sun-wada et al.
- Journal Title
  
  Handbook of ATPases : Biochemistry, Cell Biology, Pathophysiology
  
  Pages: 379-392
- Data Source
  KAKENHI-PROJECT-15079205
[Journal Article] Diverse and essential roles of mammalian vacuolar-type proton pump ATPase : Toward physiological understanding of inside acidic compartments.2004
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  Biochim. Biophys. Acta. 1658
  
  Pages: 106-114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Subunit rotation in vacuolar-type proton pumping ATPase : relative rotation of G as to c subunit.2003
- Author(s)
  M.Futai, Y.Wada, 他3名
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 23714-23719
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Subunit rotation in vacuolar-type proton pumping ATPase : relative rotation of G as to c subunit.2003
- Author(s)
  M.Futai, Y.Wada
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 23714-23719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.2003
- Author(s)
  M.Futai, Y.Wada, 他9名
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 25585-25590
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.2003
- Author(s)
  M.Futai, Y.Wada
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 25585-25590
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) specifically expressed in kidney and lung.2003
- Author(s)
  M.Futai, Y.Wada
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 44843-44851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] From lysosomes to plasma membrane : Localization of vacuolar type H^+-ATPase with the α3 isoform during osteoclast differentiation.2003
- Author(s)
  M.Futai, Y.Wada, 他5名
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 22023-22030
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Vacuolar H+ pumping ATPase in luminal acidic organelles and extracellular compartments : Common rotational mechanism and diverse physiological roles2003
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  J. Bioenerg. Biomemb. 35
  
  Pages: 347-358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] From lysosomes to plasma membrane : Localization of vacuolar type H^+ATPase with the a3 isoform during osteoclast differentiation.2003
- Author(s)
  M.Futai, Y.Wada
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 22023-22030
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms.2003
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  Cell Struct. Func. 28
  
  Pages: 455-463
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Mouse proton pump ATPase C subunit Isoforms (C2-a and C2-b) specifically expressed in kidney and lung.2003
- Author(s)
  M.Futai, Y.Wada, 他4名
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 44843-44851
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Subunit rotation of ATP synthase embedded in membrances ; α or β subunit rotation relative to the c subunit ring.2002
- Author(s)
  M.Futai, Y.Wada, 他3名
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 99
  
  Pages: 13448-13452
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Subunit rotation of ATP synthase embedded in membranes : α or β subunit rotation relative to the c subunit ring.2002
- Author(s)
  M.Futai, Y.Wada, et al.
- Journal Title
  
  Proc.Natl.acad.Sci.USA 99
  
  Pages: 13448-13452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Sodium and sulfate ion transport in yeast vacuole,2002
- Author(s)
  Masamistu Futai., Yo Wada
- Journal Title
  
  J. Biochem. 131
  
  Pages: 261-265
- NAID
  130003534348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] ATP synthase F_1 sector rotation ; defective torque generation in the β subunit Ser-174 to Phe mutant and its suppression by second mutations.2001
- Author(s)
  M.Futai, Y.Wada, 他6名
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 47508-47511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] A proton pump ATPase with testis-specific El subunit isoform required for acrosome acidification,2001
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  J. Biol. Chem. 277
  
  Pages: 18098-18105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] ATP synthase F, sector rotation ; defective torque generation in the β subunit Ser-174 to Phe mutant and its suppression by second mutations.2001
- Author(s)
  M.Futai, Y.Wada et al.
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 47508-47511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13308037
[Journal Article] Mouse Atp6f, the gene encoding the 23-kDa proteolipid of vacuolar proton translocating ATPase.2001
- Author(s)
  Masamistu Futai., Ge-Hong Sun-Wada
- Journal Title
  
  Gene 274
  
  Pages: 93-99
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] a4, a unique kidney-specific isoform of mouse vacuolar H^+-ATPase subunit a,2001
- Author(s)
  Masamistu Futai Ge-Hong Sun-Wada
- Journal Title
  
  J. Biol. Chem. 276
  
  Pages: 40050-40054
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] The murine genome contain one functional gene and two pseudomonas coding for the 16kDa proteolipid subunit of vacuolar H+-ATPase,2001
- Author(s)
  Ge-Hong Sun-Wada
- Journal Title
  
  Gene 273
  
  Pages: 199-206
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Journal Article] Association of mouse sorting nexin 1 oligomer with early endosome2001
- Author(s)
  Masamistu Futai Ge-Hong Sun-Wada
- Journal Title
  
  J. Biochem. 130
  
  Pages: 765-7771
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13142204
[Presentation] Microautophagic Membrane Dynamics is Involved in Assembly of Large Vacuoles in Mammalian Cells.2023
- Author(s)
  Kanae Shirahama-Noda, Ge-Hong Sun-Wada and Yoh Wada
- Organizer
  The 26th SANKEN International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04645
[Presentation] Endolysosomal Integrity Maintains the Extraembryonic Ectoderm Lineage via mTORC1 Signalling2023
- Author(s)
  Yoh Wada, Ge-Hong Sun-Wada
- Organizer
  Keystone Symposium on Molecular and Cellular Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950
[Presentation] Microautophagic Membrane Dynamics is Involved in Assembly of Large Vacuoles in Mammalian Cells2023
- Author(s)
  Kanae SHIRAHAMA-NODA, Ge-Hong SUN-WADA, Yoh WADA
- Organizer
  The 26th SANKEN International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950
[Presentation] Endolysosomal Integrity Maintains the Extraembryonic Ectoderm Lineage via mTORC1 Signalling2023
- Author(s)
  Yoh Wada, Ge-Hong Sun-Wada
- Organizer
  Keystone Symposium on Molecular and Cellular Biology: Stem Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04645
[Presentation] Assembly of large vacuoles in mammalian cells involving microautophagy.2022
- Author(s)
  Kanae SHIRAHAMA-NODA, Ge-Hong SUN-WADA, Yoh WADA
- Organizer
  The 10th International Symposium on Autophagy (ISA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05950
[Presentation] Assembly of large vacuoles in mammalian cells involving microautophagy.2022
- Author(s)
  Yoh Wada, Ge-Hong Sun-Wada
- Organizer
  The 10th International Symposium on Autophagy (ISA)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04645
[Presentation] Vacuolar-type Proton ATPase Is Required for Maintenance of Apicobasal Polarity of Embryonic Visceral Endoderm2021
- Author(s)
  SGe-Hong Sun-Wada, Yoh Wada
- Organizer
  V-ATPase Summit: From structure and mechanism to cell biology, physiology and disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05323
[Presentation] 破骨細胞における分泌リソソームの局在に対する V-ATPase 阻害剤（バフィロマイシン A1）の影響2018
- Author(s)
  松元奈緒美、關谷瑞樹、遠山稿二郎、石山（松浦）絵里、孫（和田）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  日本薬学会　第１３８年会
- Data Source
  KAKENHI-PROJECT-16K07357
[Presentation] V-ATPase a3アイソフォームのリソソーム輸送における機能2018
- Author(s)
  松元奈緒美、關谷瑞樹、遠山稿二郎、石山（松浦）絵里、和田（孫）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  第84回日本生化学会東北支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-16K07357
[Presentation] V-ATPase a3アイソフォームは破骨細胞の分泌リソソームの細胞内輸送に必須である2018
- Author(s)
  松元奈緒美、関谷瑞樹、遠山稿二郎、石山（松浦）絵里、和田（孫）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07357
[Presentation] EURONS WITHOUT G2 SUBUNIT OF VACUOLAR-TYPE PROTON TRANSPORTING ATPASE: A BETTER SOURCE FOR ENZYME STRUCTURE AND FUNCTIONAL STIDIES2016
- Author(s)
  Nobuyuki Kawamura, Ge-Hong Sun-Wada, and Yoh Wada
- Organizer
  #rd NovAlix Conference on Biophysics in Drug Discovery 2016
- Place of Presentation
  Strasbourg, France
- Year and Date
  2016-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291041
[Presentation] 大理石病患者由来V-ATPase a3イソフォーム変異の骨吸収活性への影響2016
- Author(s)
  松元奈緒美、高橋翔平、工藤昴士、和田（孫）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K07939
[Presentation] 破骨細胞に特徴的なリソソームの局在におけるV-ATPase a3イソフォームの関与2016
- Author(s)
  松元奈緒美、關谷瑞樹、遠山稿二郎、孫（和田）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16K07357
[Presentation] 破骨細胞に特徴的なリソソームの局在におけるV-ATPase a3イソフォームの関与2016
- Author(s)
  松元奈緒美、關谷瑞樹、遠山稿二郎、孫（和田）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07939
[Presentation] 破骨細胞におけるV-ATPase a3イソフォームの機能評価2015
- Author(s)
  松元奈緒美、高橋翔平、工藤昴士、和田（孫）戈虹、和田洋、二井將光、中西（松井）真弓
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手県紫波郡矢巾
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K07939
[Presentation] Microautophagic assembly of large vacuoles in mammalian embryonic tissues2013
- Author(s)
  Yoh Wada
- Organizer
  CSH-Asia Conference: Membrane Protein Structure & Function
- Place of Presentation
  蘇州・中国
- Year and Date
  2013-05-14
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Rab7-dependent microautophagy in the visceral endoderm is essential for mouse early development2013
- Author(s)
  Yoh Wada
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Endosome dynamism during early embryogenesis2013
- Author(s)
  Yoh Wada
- Organizer
  Mouse Molecular Genetics
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endosome dynamism during early embryogenesis2013
- Author(s)
  Yoh Wada
- Organizer
  Mouse Molecular Genetics
- Place of Presentation
  Cambridge, United Kingdom
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Microautophagic assembly of large vacuoles in mammalian embryonic tissues2013
- Author(s)
  Yoh Wada
- Organizer
  CSH-Asia Conference: Membrane Protein Structure & Function
- Place of Presentation
  蘇州、中国
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Rab7-dependent microautophagy in the visceral endoderm is essential for mouse early development2013
- Author(s)
  Wada et al.
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, USA
- Year and Date
  2013-04-21
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endosome dynamism during early embryogenesis2012
- Author(s)
  Yoh Wada
- Organizer
  Hong Kong Society for Developmental Biology Symposium: From Embryology to Disease Mechanisms
- Place of Presentation
  HK Academy of Medicine, Hong Kong
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Rab7-dependent microautophagy in gastrulating mouse embryo2012
- Author(s)
  Yoh Wada et al.
- Organizer
  Cold Spring Harbor Asia Meeting on The Small GTPases at Different Scales: Proteins, Membranes, and Cells
- Place of Presentation
  CSHL-ASIA, Suzhou, China
- Year and Date
  2012-09-25
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos2012
- Author(s)
  Yoh Wada
- Organizer
  The 6th International Symposium on Autophagy
- Place of Presentation
  Busena, Nago, Okinawa, Japan
- Year and Date
  2012-10-30
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endocytic regulation of BMP signalling during mouse gastrulation2011
- Author(s)
  Yoh Wada
- Organizer
  EMBO workshop on Lineage Commitments
- Place of Presentation
  Provinciehuis, Lueven, Belgium
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endocytic regulation of BMP signalling during mouse gastrulation2011
- Author(s)
  Yoh Wada
- Organizer
  EMBO workshop on Lineage Commitments
- Place of Presentation
  Provinciehuis, Lueven, Belgium(Invited Presentation)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endocytic organelles in mouse gastrulae : multiple roles in spatiotemporal signalling during early embryogenesis2011
- Author(s)
  Yoh Wada
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  Hokkaido University, Sapporo, Japan
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Endocytic organelles in mouse gastrulae : multiple roles in spatiotemporal signalling during early embryogenesis2011
- Author(s)
  Yoh Wada
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  Hokkaido University, Sapporo, Japan(招待講演)
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Late endocytic pathway in mouse embryos : implication in spatiotemporal signaling during gastrulation.2010
- Author(s)
  Sun-Wada, et al.
- Organizer
  The 16th International Conference of the International Society of Differentiation
- Place of Presentation
  奈良市
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Spatial restriction of BMP signalling in mouse gastrula by the endocytic pathway2010
- Author(s)
  Wada, et al.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Verte brate Organogenesis
- Place of Presentation
  New York, U.S.A
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryo2010
- Author(s)
  Wada et al.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Mouse Genetics
- Place of Presentation
  New York, U.S.A
- Year and Date
  2010-10-27
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] エンドサイトーシスから初期胚発生をみる2010
- Author(s)
  和田洋
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪市
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Spatial restriction of BMP signalling in mouse gastrula by the endocytic pathway2010
- Author(s)
  Wada et al.
- Organizer
  Cold Spring Harbor Laboratory Meeting on Vertebrate Organogenesis
- Place of Presentation
  New York, U.S.A
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Late endocytic pathway in mouse embryos : implication in spatiotemporal signaling during gastrulation2010
- Author(s)
  Sun-Wada et al.
- Organizer
  The 16th International Conference of the International Society of Differentiation
- Place of Presentation
  奈良市
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Direct recruitment of V‐ATPase from lysosomes for phagosome acidification.2009
- Author(s)
  Sun-Wada, et al.
- Organizer
  第82回日本生化学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Vacuolar-type H^+‐ATPase with the a3 isoform is the proton pump on premature melanosomes.2009
- Author(s)
  Sun-Wada, et al.
- Organizer
  JBS Biofrontier Symposium on Proton Homeostasis and Proton Ciruit
- Place of Presentation
  Morioka
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] Direct recruitment of V‐ATPase from lysosomes for phagosome acidification.2009
- Author(s)
  Wada, et al.
- Organizer
  JBS Biofrontier Symposium on Proton Homeostasis and Proton Ciruit
- Place of Presentation
  Morioka
- Data Source
  KAKENHI-PLANNED-21116002
[Presentation] V-ATPase regulation of insulin secretion2007
- Author(s)
  Sun, Wada, et. al.
- Organizer
  FASEB Summer Conference on Transport ATPases
- Place of Presentation
  Vermont, NH, USA
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-15079205
[Presentation] Upregulation of Vacuolar-type ATPase G1 Subunit by a Genetic Loss of Subunit G2 in Neuron
- Author(s)
  Kawamura N, Sun-Wada GH, and Wada Y
- Organizer
  The 15th IUBMB24th FAOBMB-TSBMB Conference
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2014-10-20 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Microautophagy, a unique membrane dynamics, in rodent visceral endoderm is involved in the regulation of canonical Wnt pathway and morphogenesis.
- Author(s)
  Yoh Wada, Minako Aoyama, Nobuyuki Kawamura, and Ge-Hong Sun-Wada
- Organizer
  Endoderm Lineages in Development and Disease Keystone Symposium
- Place of Presentation
  Keystone Resort-Keystone, Colorado, USA
- Year and Date
  2015-02-08 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Embryonic defect in ATP6Voc mutant mice lacking the vacuolar-type H^+-ATPase'c subunit
- Author(s)
  Ge-Hong Sun-Wada, Hiroyuki Tabata, Nobuyuki Kawamura and Yoh Wada
- Organizer
  Endoderm Lineages in Development and Disease Keystone Symposium
- Place of Presentation
  Keystone Resort-Keystone, Colorado, USA
- Year and Date
  2015-02-08 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-25650066
[Presentation] Microautophagy, a unique membrane dynamics, in rodent visceral endoderm is involved in the regulation of canonical Wnt pathway and morphogenesis.
- Author(s)
  Wada Y., Aoyama M. Kawamura N., Sun-Wada GH
- Organizer
  Endoderm lineages in development and disease, Keystone Symposium
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2015-02-08 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-26291041
[Presentation] Upregulation of Vacuolar-type ATPase G1 Subunit by a Genetic Loss of Subunit G2 in Neuron
- Author(s)
  Nobuyuki Kawamura, Ge-Hong Sun-Wada, and Yoh Wada
- Organizer
  15th IUBMB International Conference
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2014-10-21 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25650066

1. SUN-WADA Ge-hong (00314427)

# of Collaborated Projects: 6 results

# of Collaborated Products: 42 results
2. FUTAI Masamistu (50012646)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
3. GOTO NAOMI (80403971)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. Nakanishi Mayumi (20270506)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. 大隅良典 (30114416)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 岡敏彦 (40263321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 表弘志 (10273707)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 三本木至宏 (10222027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MENO Chikara (20311764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KITAJIMA Keiko (00332784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OKI Shinya (90452713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKAZAWA Shinn (50187944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SEKIYA MIZUKI (70509033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 大野博司 (50233226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中野明彦 (90142140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉森保 (60191649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中山和久 (40192679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 岡本宏 (60025632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐藤雅彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 菊田順一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 川村暢幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 前田大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WADA Yoh 和田 洋

Research Projects

Research Products

Co-Researchers

オルガネラ酸性化が担う細胞極性の確立と維持のメカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

小腸上皮におけるミクロオートファジーの分子機構Principal Investigator

Principal Investigator

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Review Section

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小腸上皮におけるミクロオートファジーの分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endolysosomal dynamics involving microautophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of microautophagy in the mouse early embryogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of V-ATPase-mediated positioning of lysosomes and microtubules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for ionic environment formation and organelle trafficking by proton-pumping V-ATPase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Microautophagy in the mouse early embryogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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Endocytic pathway involving microautophagy in animalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of exracellular signal in cell community of early embryos

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

「メンブレントラフィック-分子機構から高次機能への展開」の取りまとめ

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発生・分化を担うエンドソーム・リソソームのメンブレンダイナミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウス遺伝子改変の高効率化:ターゲティングベクターの正確かつ迅速な構築法Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

WADA Yoh 和田洋