Okamoto Hirotsugu 岡本浩嗣

… Alternative Names

OKAMOTO Hirotsugu 岡本浩嗣

岡本浩嗣オカモトヒロツグ

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Researcher Number	50224077
Other IDs
Affiliation (Current)	2025: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2008: Kitasato University, 医学部, 教授 2007: Kitasato University, 医学部, 准教授 2001 – 2005: Kitasato Univ., School of Medicine, Associate Professor, 医学部, 助教授 1999: 九大, 医学(系)研究科, 助手 1997 – 1998: 九州大学, 医学部, 助手 1991 – 1994: 九州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / 麻酔学
Keywords	Principal Investigator 脳血流 / 脳血管スパズム / HETE / EET / 脳梗塞 / 脳虚血 / α-receptor / cerebral infarction / cerebral blood flow / Sympathetic nerve … More / central nervous system / α受容体 / 交感神経 / 脳神経 / Cerebral hemorrhage / Cerebral blood flow / Subarachnoid hemorrhage / Cerebral vasospasm / Aradiclonic acid / Cytochrome P450 / 20HETE / 脳出血 / くも膜下出血 / アラキドン酸 / チトクロームP450 / 酸素運搬 / 虚血再灌流障害 / 亜硝酸 / ヘモグロビン / 一酸化窒素 / 脳保護 / 蛋白発現 / エンドトキシン / (ラ) / 揮発性麻酔薬 / 交感神経活動 / イソフルレン / 心拍出量 / 炭酸ガス … More Except Principal Investigator Ees / Ea / pain control / adhesion / migration / leukocyte / inflammation / microcirculation / nociception / cannabinoid / 白血球 / エンドトキシンショック / マリファナ / 血管外遊走 / ロイコトリエンB_4 / CB2受容体 / CB1受容体 / 好中球 / 神経因性疼痛 / 炎症 / 白血球遊走 / 白血球粘着 / 微小循環 / 疼痛制御 / 循環制御 / カンナビノイド / stroke / air embolism / cardis pulmonary bypass / athers sclerosis / Brain damage / Brain function / Cardiac Surgery / 高次脳機能 / 脳合併症 / 空気寒栓 / 麻酔 / 脳機能 / 脳卒中 / 経食道心エコー / 空気塞栓 / 人工心肺 / 塞栓 / 冠動脈バイパス術 / 脳障害 / 心臓手術 / ventriculo-arterial coupling / myocardial contractility / halothane / isoflurane / 仕事効率 / 後負荷 / alpha作用 / 血管抵抗 / α作用 / ハロセン / イソフルレン / 心室圧容量関係 / 心収縮性 / 麻酔薬 / セボフルラン / イソフルラン / ハロタン / 吸入麻酔薬 / 揮発性麻酔薬 / 麻酔管理 / プレコンディショニング / カルミトニン遺伝子関連ペプチド / 交感神経活動 / 動脈圧受容器反射 / 腎交感神経 / カルシトニン遺伝子関連ペプチド / 内臓血流 / 高炭酸ガス血症 / 低酸素血症 / 容量血管 / プロスタグランディンE_1 Less

Neuroprotective effects of nitric oxide derived from hemoglobin-nitrite reaction against cerebral ischemia-reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hirotsugu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kitasato University
プレコンディショニングと麻酔管理
- Principal Investigator
  
  林行雄
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka University
Contribution α2B adrenoceptor activation to cerebral vasospasm and cerebral infarctionPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hirotsugu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kitasato University
Role of endocannabinoid in circulatory and nociceptive regulation systems
- Principal Investigator
  
  HOKA Sumio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kitasato University
Contribution of cytochrome P450 products, EETs & 20HETE, on cerebral vasospasmPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hirotsugu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kitasato University
Etiology and Prevention of brain function disorder often cordiovascular surgery
- Principal Investigator
  
  HOKA Sumio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KITASATO UNIVERSITY
脳虚血に対する内因性脳保護作用（虚血耐性）の機序と麻酔薬が及ぼす影響の探究Principal Investigator
- Principal Investigator
  
  岡本浩嗣
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
脳内エンドトキシン誘導型酵素発現時の脳循環制御と麻酔薬応答Principal Investigator
- Principal Investigator
  
  岡本浩嗣
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
揮発性麻酔薬(イソフルレン,デスフルレン)の交感神経興奮作用の機序と防止法の解明Principal Investigator
- Principal Investigator
  
  岡本浩嗣
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
呼気終末炭酸ガス濃度を用いた新しい心拍出量測定法の開発Principal Investigator
- Principal Investigator
  
  岡本浩嗣
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyushu University
THE EFFECT OF ANESTHETICS ON CARDIO-VASCULAR INTERACTION
- Principal Investigator
  
  HOKA Sumio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYUSHU UNIVERSITY
肝移植時のVeno-Venous Bypass流量を決定する因子に関する研究
- Principal Investigator
  
  HOKA Sumio
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Kyushu University

All 2009 2007 2005 2004 2003 2002

All Journal Article Presentation

[Journal Article] Dexmedetomidine-induced cerebral hypoperfusion aggravates ischemic brain injury in rats2009
- Author(s)
  Nakano T, Okamoto H
- Journal Title
  
  Journal of Anesthesia (in press)
- Data Source
  KAKENHI-PROJECT-19591817
[Journal Article] The effect of dexmedetomidine on tetrodotoxin resistant Na+ currents in small-sized dorsal root ganglion neurons.2005
- Author(s)
  Maruyama M, Okamoto H, Nakano T, et al.
- Journal Title
  
  Circ Cont 26
  
  Pages: 24-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] Dexmedetomidine-induced cerebral hypoperfusion aggravates ischemic brain damage in chronic rat model.2005
- Author(s)
  Nakano T.Okamoto H et al.
- Journal Title
  
  Anesthesiology 103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] Dexmedetomidine-induced cerebral hypoperfusion aggravates ischemic brain damage in chronic rat model2005
- Author(s)
  Nakano T, Okamoto H, et al.
- Journal Title
  
  Anesthesiology 103
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] The effect of dexmedetomidine on tetrodotoxin resistant Na^+ currents in small-sized dorsal root ganglion neurons.2005
- Author(s)
  Maruyama M, Okamoto H, Nakano T et al.
- Journal Title
  
  Circulation Control 26
  
  Pages: 24-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] The effect of dexmedetomidine on transient cerebral ischemia in rats.2004
- Author(s)
  Kimotsuki, H., Okamoto, H., Ozawa, A., Hoka, S.
- Journal Title
  
  Circ Cont 25
  
  Pages: 50-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch2004
- Author(s)
  Ozawa A, Nara Y, Kimotsuki H, Nakahara E, Okamoto H, Hoka S
- Journal Title
  
  Curculation Control 25・3
  
  Pages: 267-271
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Migration of neutrophils elicited by leukotriene B4 is inhibited by fasudil, a Rho-kinase inhibitor, in the microvasculature of hamster cheek pouch.2004
- Author(s)
  Ozawa, A., Nara, Y., Kimotsuki, H., Nakahara, E., Okamoto, H., Hoka, S.
- Journal Title
  
  Circ Cont 25
  
  Pages: 267-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] The effect of dexmedetomidine on transient cerebral ischemia in rats.2004
- Author(s)
  Kinotsuki H, Okamoto H, Ozawa A, Hoka S
- Journal Title
  
  Circulation Control 25
  
  Pages: 50-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] The effect of dexmedetomidine on transient cerebral ischemia in rats.2004
- Author(s)
  Kimotsuki H, Okamoto H, Ozawa A, Hoka S
- Journal Title
  
  Circ Cont 25
  
  Pages: 50-55
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591561
[Journal Article] Faster oscillometric manometry does not sacrifice the accuracy of blood pressure determination.2004
- Author(s)
  Sugimachi, M., Okamoto, H., Hoka, S., Sunagawa, K.
- Journal Title
  
  Blood Press Monit 9
  
  Pages: 135-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats.2003
- Author(s)
  Yamaguchi-Sase, S., Hayashi, I., Okamoto, H., Nara, Y., Matsuzaki, S., Hoka, S., Majima, M.
- Journal Title
  
  Inflamm Res 52
  
  Pages: 164-169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Quantitative analysis of left ventricular regional wall motion with color kinesis during abdominal aortic cross-clampi.2003
- Author(s)
  Yamaura, K., Hoka, S., Okamoto, H., Takahashi, S.
- Journal Title
  
  J Cardiothorac Vasc Anesth 17
  
  Pages: 703-708
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Role of kinin and prostaglandin in cutaneous thermal nociception.2002
- Author(s)
  Matsuzaki, S., Hayashi, I., Nara, Y., Komata, K., Yamanaka, M., Okamoto, H., Hoka, S., Majima, M.
- Journal Title
  
  Int Immunopharmacol 2(13-14)
  
  Pages: 2005-2012
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Intrathecal fentanyl/meperidine combined with low-dose epidural bupivacaine for Cesarean section in a patient with advanced Krukenberg tumors.2002
- Author(s)
  Okutomi, T., Hoshino, Y., Amano, K., Okamoto, H., Hoka, S.
- Journal Title
  
  Acta Anaesthesiol Scand 46
  
  Pages: 1272-1275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Journal Article] Continuous spinal analgesia for labor and delivery in a parturient with hypertrophic obstructive cardiomyopathy.2002
- Author(s)
  Okutomi, T., Kikuchi, S., Amano, K., Okamoto, H., Hoka, S.
- Journal Title
  
  Acta Anaesthesiol Scand 46
  
  Pages: 329-331
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370494
[Presentation] 亜硝酸からのNOによる局所脳虚血再灌流後の脳保護効果2009
- Author(s)
  岡本浩嗣、中野貴明
- Organizer
  第13回神経麻酔集中治療研究会
- Place of Presentation
  大阪
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19591817
[Presentation] 亜硝酸からのNOによる局所脳虚血再灌流後の脳保護効果2009
- Author(s)
  岡本浩嗣, ほか
- Organizer
  第13回神経麻酔集中治療研究会
- Place of Presentation
  大阪市
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19591817
[Presentation] Neuroprotective effects of nitrite against cerebral-reperfusion injury in rat2007
- Author(s)
  岡本浩嗣
- Organizer
  アメリカ麻酔学会
- Place of Presentation
  サンフランシスコ市(USA)
- Year and Date
  2007-10-15
- Data Source
  KAKENHI-PROJECT-19591817
[Presentation] Neuroprotective effects of nitrite against cerebral-reperfusion injury in rat2007
- Author(s)
  Okamoto H, Nakano T, Hoka S
- Organizer
  アメリカ麻酔学会
- Place of Presentation
  サンフランシスコ市
- Year and Date
  2007-10-15
- Data Source
  KAKENHI-PROJECT-19591817

1. HOKA Sumio (60150447)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
2. KAWASAKI Toshihiro (80253433)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAKENAKA Tomoaki (00179657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ARAI Masayasu (50222724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ARAI Tamie (00245408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 林行雄 (60294063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 古家仁 (70183598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 北口勝康 (30183297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 森田潔 (40108171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Okamoto Hirotsugu 岡本 浩嗣

OKAMOTO Hirotsugu 岡本 浩嗣

岡本 浩嗣 オカモト ヒロツグ

Research Projects

Research Products

Co-Researchers

Neuroprotective effects of nitric oxide derived from hemoglobin-nitrite reaction against cerebral ischemia-reperfusion injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プレコンディショニングと麻酔管理

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution α2B adrenoceptor activation to cerebral vasospasm and cerebral infarctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of endocannabinoid in circulatory and nociceptive regulation systems

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of cytochrome P450 products, EETs & 20HETE, on cerebral vasospasmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Etiology and Prevention of brain function disorder often cordiovascular surgery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳虚血に対する内因性脳保護作用（虚血耐性）の機序と麻酔薬が及ぼす影響の探究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳内エンドトキシン誘導型酵素発現時の脳循環制御と麻酔薬応答Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

揮発性麻酔薬(イソフルレン,デスフルレン)の交感神経興奮作用の機序と防止法の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

呼気終末炭酸ガス濃度を用いた新しい心拍出量測定法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE EFFECT OF ANESTHETICS ON CARDIO-VASCULAR INTERACTION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝移植時のVeno-Venous Bypass流量を決定する因子に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dexmedetomidine-induced cerebral hypoperfusion aggravates ischemic brain injury in rats2009

Author(s)

Okamoto Hirotsugu 岡本浩嗣

OKAMOTO Hirotsugu 岡本浩嗣

岡本浩嗣オカモトヒロツグ