Kobayashi Wataru 小林恒

… Alternative Names

WATARU Kobayashi 小林恒

KOBAYASHI Wataru 小林恒

KOBAYASI Wataru 小林恒

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Researcher Number	50234860
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 弘前大学, 医学研究科, 教授 2016 – 2018: 弘前大学, 医学研究科, 教授 2013: 弘前大学, 医学研究科, 准教授 2011 – 2013: 弘前大学, 医学(系)研究科(研究院), 准教授 2000 – 2001: 弘前大学, 医学部, 助教授 … More 1999: Hirosaki University Hospital, Dentistry and Oral Surgery, Assistant Professor, 医学部・付属病院, 講師 1998 – 1999: 弘前大学, 医学部・附属病院, 講師 1994: Hirosaki University Hospital, Oral Surgery, Assistant professor, 医学部・附属病院, 講師 1993: 弘前大学, 医学部附属病院, 講師 1991: Hirosaki University, Sch. of Med., Instructor, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 57080:Social dentistry-related / Social dentistry / Surgical dentistry Except Principal Investigator Surgical dentistry / 外科・放射線系歯学 / Surgical dentistry
Keywords	Principal Investigator 口腔内環境 / 生活習慣病 / 口腔内細菌 / 歯周病 / 社会医学 / 歯周病菌 / 相互調整機構 / 腸内細菌 / 非アルコール性脂肪性肝疾患 / PERMANOVA … More / β多様性 / 口腔内細菌叢 / 糖尿病 / 動脈硬化 / 脂質異常症 / β多様性解析 / 歯学 / オーラルディアドコキネシス： / Red complex / オーラルディアドコキネシス / 舌圧 / レッドコンプレックス / フレイル / オーラルフレイル / ロイコトリエン / 口腔癌 / NPe6 / 光線力学療法 … More Except Principal Investigator 骨吸収 / メカニカルストレス / Osteoprotegerin / sRANKL / MAP kinase / PCR / jaw cyst / Free Radical / 過酸化脂質 / 顎嚢胞 / Nitric oxide / Quantitative RT-PCR / Cyclic tensile strain / Mechanical stress / Osteoblast / インターロイキン6 / 機械的刺激 / TAクローニング / 定量PCR法 / Osteoprotegein / 一酸化窒素 / 定量RT-PCR / 周期的細胞伸展 / 骨芽細胞 / nitricoxide radical / messenger RNA / immunohistolocal stainin / cyst wall fibroblast / inflanunatory cytokine / bone resortion / 嚢胞壁細胞 / 一酸化窒素ラジカル / メッセンジャーRNA / 免疫組織染色 / 嚢胞壁線維芽細胞 / 炎症性サイトカイン / 顎骨嚢胞 / cytokine / antioxidant enzyme / lipid peroxide / microcirculation / intracystic pressure / mechanical stress / bone absorption / シッフ塩基染色法 / レーザードップラー血流計 / 骨吸収因子 / 微小循環障害 / 微小循環 / サイトカイン / 抗酸化酵素 / 嚢胞腔内圧 / Bone remodeling / Microcirculation of the cyst wall / Irrigational method of the jaw cyst / Lipidperoxides / Inhibitory mechanism / Growth mechanism / Jaw cysts / 嚢胞壁生成PG / 増大抑制機序 / 骨再生 / 嚢胞壁微小循環 / フリ-ラジカル / 嚢胞腔洗浄法 / 抑制機序 / 増大機序 / 骨増生法 / 臨床 / 細胞・組織 / 移植・再生医療 / 歯学 / 骨リモデリング / BMP signaling / Wnt signaling / BMP pathway / Wnt pathway / 骨代謝 / メカノセンサー / 骨膜 Less

口腔内細菌と腸内細菌の相互調整機構解明および生活習慣病発症予測と予防法の開発Principal Investigator
- Principal Investigator
  
  小林恒
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Hirosaki University
Study of the relationship over time between oral microbiome and lifestyle diseases with the aim of establishing preventive methods for lifestyle diseasesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Wataru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Hirosaki University
An epidemiological research to elucidate the effects of periodontal disease bacteria to frailty and development of frailty prophylaxisPrincipal Investigator
- Principal Investigator
  
  Kobayashi Wataru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Hirosaki University
Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
口腔癌に対する新規光感受性物質NPe6を用いた光線力学療法の応用に関する研究Principal Investigator
- Principal Investigator
  
  小林恒
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
The influence of mechanical stress on the gene expression related to the differentiation and the growth of bone cell
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
Molecular biological study on the pathophysiological substances and their interactions concerned with the enlargement of jaw cyst
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSAKI UNIVERSITY
Study on the pathological absorption of maxillary bone induced by mechanical stress
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSAKI UNIVERSITY
A Biochemical Study on the Growth Pathogenic Factor and Inhibitory Mechanism of Jaw Cysts
- Principal Investigator
  
  SUZUKI Mitsugu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Hirosaki University

All 2023 2022 2018 2017 2016 2014

All Journal Article Presentation

[Journal Article] 一般地域住民における口腔環境と口臭についての研究2018
- Author(s)
  田村好拡,　小山俊朗,　長内俊之,　佐竹杏奈,　石崎　博,　野口貴雄,　福田はるか,　沢田かほり,　徳田糸代,　和田啓二,　村上晃満,　西永英司,　中路重之,　井原一成,　小林　恒
- Journal Title
  
  体力栄養免疫学会雑誌
  
  Volume: 28 Pages: 64-67
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] 一般地域住民における口腔内環境と口腔細菌叢に関する研究2018
- Author(s)
  野口貴雄、田村好拡、小山俊朗、長内俊之、佐竹杏奈、石崎博、福田はるか、徳田糸代、沢田かおり、和田啓二、中路重之、井原一成、村下公一、小林恒
- Journal Title
  
  体力栄養免疫学会雑誌
  
  Volume: 28 Pages: 68-71
- NAID
  130007938993
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] 高齢者の口腔機能とフレイルの関係2017
- Author(s)
  佐竹杏奈、小山俊朗、田村好拡、長内俊之、野口貴雄、石橋博、福田はるか、倉内静香、徳田糸代、相馬優樹、村下公一、中路重之、小林恒
- Journal Title
  
  体力栄養免疫学会雑誌
  
  Volume: 27 Pages: 79-82
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] Oral conditions and dysphagia in Japanese, community-dwelling middle-and older-aged adults, independent in daily living2017
- Author(s)
  Inui A.,Takahashi I, Kurauchi S, Soma Y, Oyama T, Tamura Y, Noguchi T, Murashita K, Nakaji S, and Kobayashi. W
- Journal Title
  
  Clinical Interventions in Aging
  
  Volume: 12 Pages: 515-521
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] 口腔環境や生活習慣が唾液の性状に及ぼす影響2017
- Author(s)
  田村好拡、、小林恒、内山千代子、小山俊朗、長内俊之、佐竹杏奈、福田はるか、對馬詩音、倉内静香、相馬優樹、翠川辰之
- Journal Title
  
  体力栄養免疫学会雑誌
  
  Volume: 27 Pages: 76-78
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] 地域住民高齢者の口腔機能検査―特に舌圧とオーラルディアドコキネシスに関してー2017
- Author(s)
  佐竹杏奈、乾明成、小山俊朗、田村好拡、長内俊之、野口貴雄、石崎博、倉内静香、徳田糸代、相馬優樹、村下公一、高橋一平、中路重之、小林恒
- Journal Title
  
  体力栄養免疫学会誌
  
  Volume: 27
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] 非アルコール性脂肪肝疾患と口腔内細菌との関連性2017
- Author(s)
  福田はるか、佐竹杏奈、小山俊朗、田村好拡、長内俊之、野口貴雄、石橋博、倉内静香、徳田糸代、相馬優樹、村下公一、中路重之、小林恒
- Journal Title
  
  体力栄養免疫学会雑誌
  
  Volume: 27 Pages: 73-75
- Data Source
  KAKENHI-PROJECT-16K11879
[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt andBMP signaling pathways2014
- Author(s)
  Ito R, Matsumiya T, Kon T, Narita N, Kubota K, Sakaki H, Ozaki T, Imaizumi T, Kobayashi W, Kimura H
- Journal Title
  
  Biomed. Res.
  
  Volume: 35 Issue: 1 Pages: 69-79
- DOI
  10.2220/biomedres.35.69
- NAID
  130004903861
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592979
[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways2014
- Author(s)
  Ryohei Ito, Tomoh Matsumiya, Takao Kon, Norihiko Narita, Kosei Kubota, Hirotaka Sakaki, Hidemi Yoshida, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura
- Journal Title
  
  Biomedical Reserch
  
  Volume: vol.35 Pages: 69-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592979
[Presentation] 口腔内細菌と脂質異常症との関係に関する研究2023
- Author(s)
  高木康貴，小林恒
- Organizer
  第69回日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] 口腔内細菌と脂質異常症との関係に関する研究2023
- Author(s)
  小林　恒
- Organizer
  第36回口腔診断学会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] 一般地域住民における口臭と口腔内細菌の関連について2023
- Author(s)
  小松正太朗,小林恒
- Organizer
  第69回日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] 非アルコール性脂肪性肝疾患と口腔内細菌叢の関連性について2022
- Author(s)
  高木康貴、小林恒
- Organizer
  第76回日本口腔科学会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] 非アルコール性脂肪性肝疾患と口腔内細菌叢の関連性について2022
- Author(s)
  高木康貴、古館健、福田はるか、田村好拡、秋山なつみ、荘豪智、小松正太郎、小林　恒
- Organizer
  第76回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] 一般地域住民における口臭と口腔内細菌の関連について2022
- Author(s)
  小松正太郎、小林恒
- Organizer
  第76回日本口腔科学会
- Data Source
  KAKENHI-PROJECT-21K10202
[Presentation] A study of Relationship between Oral Hypofunction and Oral Microbiota2018
- Author(s)
  小林　恒,　佐竹杏奈,　福田はるか,　鄭　明源,　今　敬生,　久保田耕世,　古舘　健
- Organizer
  13th Asian Congress on Oral & Maxillogasial Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11879
[Presentation] 高齢者の口腔機能とフレイルの関係2017
- Author(s)
  佐竹杏奈、小山俊朗、田村好拡、長内俊之、野口貴雄、石橋博、福田はるか、倉内静香、徳田糸代、相馬優樹、村下公一、中路重之、小林恒
- Organizer
  第27回体力栄養免疫学会
- Data Source
  KAKENHI-PROJECT-16K11879
[Presentation] 地域住民高齢者の口腔機能検査―特に舌圧とオーラルディアドコキネシスに関してー2016
- Author(s)
  佐竹杏奈、乾明成、小山俊朗、田村好拡、長内俊之、野口貴雄、石崎博、倉内静香、徳田糸代、相馬優樹、村下公一、高橋一平、中路重之、小林恒
- Organizer
  第26回体力栄養免疫学会
- Place of Presentation
  長崎大学(長崎県、長崎市）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-16K11879
[Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayとBMP signaling pathwayが活性化される2014
- Author(s)
  伊藤良平、中川祥、小林恒、木村博人、他
- Organizer
  日本口腔科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-05-09
- Data Source
  KAKENHI-PROJECT-23592979
[Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayと BMP signaling pathwayが活性化される2014
- Author(s)
  伊藤　良平、佐藤　寿、榊　宏剛、久保田　耕世、今　敬生、小林　恒、木村　博人
- Organizer
  日本口腔科学会
- Place of Presentation
  東京都新宿区
- Data Source
  KAKENHI-PROJECT-23592979

1. KIMURA Hiroto (90142851)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. FUKUI Roh (70241479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KUSUMI Akinori (90332494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAGAWA Hiroshi (00529688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MATSUMIYA Tomoh (30344592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KUBOTA Kousei (10529689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SAKAKI Hirotaka (90374850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. ITO Ryohei (20638902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SUZUKI Mitsugu (90003368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIROTO Mami (50206306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOMATSU Ken-ichi (30162043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TANAKA Junichi (90197434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SATOH Hisashi (90311539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中路重之 (10192220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 乾明成 (20746391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 沢田かほり (50624889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 高橋一平 (70400132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 佐竹杏奈 (40791124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
19. 福田はるか (60816594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 秋山なつみ (80867375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 小松正太朗 (20992473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高木康貴 (30992474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 成田明子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Wataru 小林 恒

WATARU Kobayashi 小林 恒

KOBAYASHI Wataru 小林 恒

KOBAYASI Wataru 小林 恒

Research Projects

Research Products

Co-Researchers

口腔内細菌と腸内細菌の相互調整機構解明および生活習慣病発症予測と予防法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the relationship over time between oral microbiome and lifestyle diseases with the aim of establishing preventive methods for lifestyle diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An epidemiological research to elucidate the effects of periodontal disease bacteria to frailty and development of frailty prophylaxisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔癌に対する新規光感受性物質NPe6を用いた光線力学療法の応用に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The influence of mechanical stress on the gene expression related to the differentiation and the growth of bone cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological study on the pathophysiological substances and their interactions concerned with the enlargement of jaw cyst

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the pathological absorption of maxillary bone induced by mechanical stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Biochemical Study on the Growth Pathogenic Factor and Inhibitory Mechanism of Jaw Cysts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 一般地域住民における口腔環境と口臭についての研究2018

Author(s)

Journal Title

Data Source

[Journal Article] 一般地域住民における口腔内環境と口腔細菌叢に関する研究2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 高齢者の口腔機能とフレイルの関係2017

Author(s)

Journal Title

Data Source

[Journal Article] Oral conditions and dysphagia in Japanese, community-dwelling middle-and older-aged adults, independent in daily living2017

Author(s)

Journal Title

Data Source

[Journal Article] 口腔環境や生活習慣が唾液の性状に及ぼす影響2017

Author(s)

Kobayashi Wataru 小林恒

WATARU Kobayashi 小林恒

KOBAYASHI Wataru 小林恒

KOBAYASI Wataru 小林恒