SAKAMOTO Kensaku 坂本健作

… Alternative Names

Researcher Number	50240685
Other IDs
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Affiliation (Current)	2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人理化学研究所, その他部局等, その他 2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2017: 独立行政法人理化学研究所, 生命機能科学研究センター・非天然アミノ酸技術研究チーム, チームリーダー 2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, グループディレクター 2016: 独立行政法人理化学研究所, 拡張型遺伝暗号システム研究, チームリーダー … More
Review Section/Research Field	Principal Investigator Basic Section 43040:Biophysics-related / Biophysics / Biological Sciences / Applied molecular and cellular biology / Biophysics / Intelligent informatics Except Principal Investigator Science and Engineering / Sensitivity informatics/Soft computing / General pharmacology / Bioinformatics/Life informatics / Surgical dentistry / Soft computing
Keywords	Principal Investigator アミノアシルtRNA合成酵素 / タンパク質工学 / 非天然型アミノ酸 / 遺伝暗号 / 翻訳後修飾 / 拡張遺伝暗号 / 合成生物学 / 基質特異性 / 転移リボ核酸 / 遺伝学 … More Except Principal Investigator 最適化 / 進化計算 / ウェットGA / DNAコンピューティング / 分子進化 / 進化 / タンパク質工学 / 高度並列GA / リボザイム / tRNA / RNA / DNA computing / Whiplash PCR / PWPCR / Tag-Antitag system / back-hybridization / mis-hybridization / Displacement WPCR / thermodynamics / 遺伝的アルゴリズム / 統計物理 / シミュレーション / 試験管ウィルス / アミノアシル化tRNA合成酵素 / ナチュラルコンピューティング / モンテカルロ法 / 統計力学 / タンパク工学 / 適応度地形 / 生体分子 / ワンポット反応系 / ウェットＧＡ / 高度並列ＧＡ / リアノジン受容体 / 筋小胞体 / カルシウムチャネル / 相互作用 / 人工アミノ酸 / 興奮収縮連関 / 不整脈 / S4-S5リンカー / RNAワールド / アミノアシルtRNA合成酵素 / tRNAアイデンティティー / 古細菌 / 真核生物 / 真正細菌 / レトロポゾン / アミノアシル合成酵素 / アイデンティティ / 微量塩基成分 / RNA世界 / リジンtRNA / プライマー / 逆転写 / RNaseP / RNA World / ribosome / aminoacyl-tRNA synthetase / tRNA identity / archaea / eukaryotes / bacteria / グループIイントロン / 分子デザイン / ハンマーヘッド型リボザイム / snRNP / リボソーム / スプライソソーム / ヘアピン型リボザイム / ンマーヘッド型リボザイム / G167 / GNRA-receptor 4 / マキシザイム / U6snRNA / RNase P / 23SリボソームRNA / 酵素 / 分子設計 / 反応機構 / スプライシング / catalyticRNA / ribozyme / catakytic RNA / snRNA / RNP / group I introns / hammerhead ribozyme / splicing / DNA Computing / Biomolecular Computing / efficiency / strand displacement / statistical thermodynamics / 統計熱力学 / ヘリックス-コイル転移 / 融解 / DNAチップ / タグ-アンチタグ系 / ハイブリダイゼーション・エラー / Statistical Thermodynamics / Helix-Coil Transition / DNA Melting / DNA-based Computing / Tag-Antitag System / PNA-mediated Whiplash PCR / Hybridization Error / リソソーム / LAMP-1 / LAMP-2 / アセンブリ / LAMP / 細胞内輸送 / ミトコンドリア / 骨芽細胞 / 骨細胞 / 超並列進化計算 / WetTDGA / NK地形 / 疑似適応度 / パラメータ最適化 / 細胞シミュレーション / パラメーター最適化 / tyrRS / ウェッジGA / たんぱく質工学 / TyrRS Less

非天然アミノ酸レパートリーに基づく新しいタンパク質機能・構造の進化的探索Principal Investigator
- Principal Investigator
  
  坂本健作
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Institute of Physical and Chemical Research
Engineering of translation molecules for synthetic biology approach on the genetic codePrincipal Investigator
- Principal Investigator
  
  坂本健作
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Institute of Physical and Chemical Research
Novel protein-synthesis technology achieving the installation of posttranslational modifications and other chemical modifications through genetic code expansionPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO KENSAKU
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Institute of Physical and Chemical Research
Implementation of massive parallel Evolutionaly Computation from Biological experiment data analysis obtained by wetGA
- Principal Investigator
  
  Yamamura Masayuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Soft computing
- Research Institution
  Tokyo Institute of Technology
Structural basis of LAMP2 aimed to modulate intracellular trafficking of lysosome
- Principal Investigator
  
  Miki Yokoyama
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical and Dental University
Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acids
- Principal Investigator
  
  MURAYAMA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Massive Parallel Evolutionary Computation Theory based on a Molecular Realization of WetGA
- Principal Investigator
  
  YAMAMURA Masayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Sensitivity informatics/Soft computing
- Research Institution
  Tokyo Institute of Technology
Site-specific incorporation of non-natural amino acids into proteins in living cellsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Kensaku
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  The Institute of Physical and Chemical Research
n vitro Genetic Programmin
- Principal Investigator
  
  ROSE John Anthony
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
ナチュラルコンピューティングの分子実現とその設計論
- Principal Investigator
  
  YAMAMURA Masayuki
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Institute of Technology
Application of Molecular Computing to the Design of Useful ProteinsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Kensaku
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Intelligent informatics
- Research Institution
  The University of Tokyo
タンパク質の適応地形の探索Principal Investigator
- Principal Investigator
  
  坂本健作
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アミノアシルtRNA合成酵素のtRNA特異性の改変Principal Investigator
- Principal Investigator
  
  坂本健作
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Researches on ribozymes at molecular and atomic level
- Principal Investigator
  
  INOUE Tan
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Origin and Evolution of RNA
- Principal Investigator
  
  OKADA Norihiro
- Project Period (FY)
  1992 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology

[Journal Article] An expanded genetic code facilitates antibody chemical conjugation involving the lambda light chain2021
- Author(s)
  Kato Akifumi、Ohtake Kazumasa、Tanaka Yoshitaka、Yokoyama Shigeyuki、Sakamoto Kensaku、Shiraishi Yasuhisa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 546 Pages: 35-39
- DOI
  10.1016/j.bbrc.2021.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05821, KAKENHI-PROJECT-18H02416
[Journal Article] Direct homophilic interaction of LAMP-2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells2021
- Author(s)
  Terasawa Kazue、Kato Yuji、Ikami Yuta、Sakamoto Kensaku、Ohtake Kazumasa、Kusano Seisuke、Tomabechi Yuri、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Guan Jun-Lin、Kobayashi Toshihide、Iwata Takanori、Watabe Tetsuro、Yokoyama Shigeyuki、Hara-Yokoyama Miki
- Journal Title
  
  Autophagy
  
  Volume: 17 Pages: 1-19
- DOI
  10.1080/15548627.2021.1911017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05821, KAKENHI-PROJECT-18H02416, KAKENHI-PROJECT-17K12005
[Journal Article] Incorporation of Halogenated Amino Acids into Antibody Fragments at Multiple Specific Sites Enhances Antigen Binding2021
- Author(s)
  Akiko Hayashi, Ken‐ichi Haruna, Haruna Sato, Kenichiro Ito, Chisato Makino, Takuhiro Ito, Kensaku Sakamoto
- Journal Title
  
  ChemBioChem.
  
  Volume: 22 Pages: 120-123
- DOI
  10.1002/cbic.202000429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02416
[Journal Article] Structural basis for genetic-code expansion with bulky lysine derivatives by an engineered pyrrolysyl-tRNA synthetase2019
- Author(s)
  Tatsuo Yanagisawa, Mitsuo Kuratani, Eiko Seki, Nobumasa Hino, Kensaku Sakamoto, Shigeyuki Yokoyama
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 26 Pages: 936-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02416
[Journal Article] Synthetic tyrosine tRNA molecules with noncanonical secondary structures2019
- Author(s)
  K. Sakamoto, A. Hayashi
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Pages: 92-92
- DOI
  10.3390/ijms20010092
- Data Source
  KAKENHI-PROJECT-18H02416
[Journal Article] Cell-free protein synthesis using S30 extracts from Escherichia coli RFzero strains for efficient incorporation of non-natural amino acids into proteins2019
- Author(s)
  J. Adachi, K. Katsura, E. Seki, C. Takemoto, M. Shirouzu, T. Terada, T. Mukai, K. Sakamoto, S. Yokoyama
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20 Pages: 492-492
- DOI
  10.3390/ijms20030492
- Data Source
  KAKENHI-PROJECT-18H02416
[Journal Article] Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes2018
- Author(s)
  A. Yamaguchi, F. Iraha, K. Ohtake, K. Sakamoto
- Journal Title
  
  Molecules
  
  Volume: 23 Pages: 2460-2460
- DOI
  10.3390/molecules23102460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02416, KAKENHI-PROJECT-16K21631
[Journal Article] Genetic Code Expansion of the Silkworm Bombyx mori to Functionalize Silk Fiber2018
- Author(s)
  Teramoto H, Amano Y, Iraha F, Kojima K, Ito T, Sakamoto K
- Journal Title
  
  ACS Synthetic Biology
  
  Volume: 7 Pages: 801-806
- DOI
  10.1021/acssynbio.7b00437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-15K07800
[Journal Article] Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines2016
- Author(s)
  Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 36946-36946
- DOI
  10.1038/srep36946
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] Crystal structure of eukaryotic translation initiation factor 2B2016
- Author(s)
  Kazuhiro Kashiwagi, Mari Takahashi, Madoka Nishimoto, Takuya B. Hiyama, Toshiaki Higo, Takashi Umehara, Kensaku Sakamoto, Takuhiro Ito, Shigeyuki Yokoyama
- Journal Title
  
  Nature
  
  Volume: 531 Pages: 122-125
- DOI
  10.1038/nature16991
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01548, KAKENHI-PROJECT-26291035
[Journal Article] 大腸菌の遺伝暗号の改変がもたらす組換えタンパク質生産技術の革新2016
- Author(s)
  坂本健作
- Journal Title
  
  化学と生物（日本農芸化学会）
  
  Volume: 54(5) Pages: 343-350
- NAID
  130006772546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291035
[Journal Article] Incorporation of a doubly functionalized synthetic amino acid into proteins for creating chemical and light-induced conjugates2016
- Author(s)
  Atsushi Yamaguchi, Takayoshi Matsuda, Kazumasa Ohtake, Tatsuo Yanagisawa, Shigeyuki Yokoyama, Yoshihisa Fujiwara, Takayoshi Watanabe, Takahiro Hohsaka, Kensaku Sakamoto
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 27 Pages: 198-206
- DOI
  10.1021/acs.bioconjchem.5b00602
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K16561, KAKENHI-ORGANIZER-25102001, KAKENHI-PLANNED-25102006, KAKENHI-PROJECT-26870853, KAKENHI-PROJECT-26291035
[Journal Article] 非天然型アミノ酸アミノ酸の導入によるタンパク質の安定化技術2016
- Author(s)
  大竹和正、坂本健作
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 74 Pages: 34-36
- Data Source
  KAKENHI-PROJECT-26291035
[Journal Article] Protein stabilization utilizing a redefined codon2015
- Author(s)
  Ohtake, K., Yamaguchi, A., Mukai, T., Kashimura, H., Hirano, N., Haruki, M., Kohashi, S., Yamagishi, K., Murayama. K., Tomabechi, Y., Itagaki, T., Akasaka, R., Kawazoe, M., Takemoto, C., Shirouzu, M., Yokoyama, S. & Sakamoto, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 9762-9762
- DOI
  10.1038/srep09762
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870853, KAKENHI-PROJECT-26291035
[Journal Article] Ubiquitn acetylation inhibits polyubiquitin chain elongation2015
- Author(s)
  Ohtake, F., Saeki, Y., Sakamoto, K., Ohtake, K., Nishikawa, H., Tsuchiya, H., Ohta, T., Tanaka, K., and Kanno, J.
- Journal Title
  
  EMBO Rep.
  
  Volume: 16 Pages: 192-201
- DOI
  10.15252/embr.201439152
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26870853, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-26000014
[Journal Article] Reassignment of a rare sense codon to a non-canonical amino acid in Escherichia coli2015
- Author(s)
  Mukai, T., Yamaguchi, A., Ohtake, K., Takahashi, M., Hayashi, A., Iraha, F., Kira, S., Yanagisawa, T., Yokoyama, S., Hoshi, H., Kobayashi, T., Sakamoto, K.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 43(16) Pages: 8111-8122
- DOI
  10.1093/nar/gkv787
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870853, KAKENHI-PROJECT-26291035
[Journal Article] Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation2015
- Author(s)
  Masatoshi Wakamori, Yoshifumi Fujii, Noriyuki Suka, Mikako Shirouzu, Kensaku Sakamoto, Takashi Umehara, Shigeyuki Yokoyama
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 17204-17204
- DOI
  10.1038/srep17204
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23114005, KAKENHI-PROJECT-26291035
[Journal Article] Highly reproductive Escherichia coli cells with no specific assignment to the UAG codon2015
- Author(s)
  Mukai, T., Hoshi, H.; Ohtake, K., Takahashi, M., Yamaguchi, A., Hayashi, A., Yokoyama, S. & Sakamoto, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 9699-9699
- DOI
  10.1038/srep09699
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870853, KAKENHI-PROJECT-26291035
[Journal Article] Multiple site-specific installations of Nε-monomethyl-L-lysine into histone proteins by cell-based and cell-free protein synthesis2014
- Author(s)
  Yanagisawa, T., Takahashi, M., Mukai, T., Sato, S., Wakamori, M., Shirouzu, M., Sakamoto, K., and Umehara, T. and Yokoyama, S.
- Journal Title
  
  Chembiochem
  
  Volume: 15 Pages: 1830-1838
- DOI
  10.1002/cbic.201402291
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
[Journal Article] Expanded genetic code technologies for incorporating modified lysine at multiple sites2014
- Author(s)
  Yanagisawa, T., Umehara, T., Sakamoto, K., and Yokoyama, S.
- Journal Title
  
  Chembiochem
  
  Volume: 15 Pages: 2181-2187
- DOI
  10.1002/cbic.201402266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24550203, KAKENHI-PROJECT-24613007, KAKENHI-PROJECT-26291035
[Journal Article] Structural Stability of Halogenated Protein: Fragment Molecular Orbital Study2014
- Author(s)
  Jumpei Takanohashi, Sousuke Kohashi, Takeshi Ishikawa, Kensaku Sakamoto, Kenji Yamagishi
- Journal Title
  
  J. Comput. Chem. Jpn
  
  Volume: 13 Pages: 308-309
- NAID
  130004933669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26291035
[Journal Article] 人為的なコドン再定義から考える遺伝暗号の進化2013
- Author(s)
  坂本健作
- Journal Title
  
  第15回日本RNA学会講演論文集
  
  Volume: S-8
- Data Source
  KAKENHI-PROJECT-23300084
[Journal Article] Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNATyr pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion2010
- Author(s)
  Iraha, F., Oki, K., Kobayashi, T., Ohno. S., Yokogawa, T., Nishikawa, K., Yokoyama, S., Sakamoto, K.
- Journal Title
  
  Nucleic Acids Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Functional replacement of the endogenous tyrosyl-tRNA synthetase-tRNA^<Tyr> pair by the archaeal tyrosine pair in Escherichia coil for genetic code expansion2010
- Author(s)
  Iraha, F., Oki, K., Kobayashi, T., Ohno, S., Yokogawa, T., Nishikawa, K., Yokoyama, S., Sakamoto, K.
- Journal Title
  
  Nucleic Acids Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Genetic encoding of non-natural amino acids in Drosophila melanogaster Schneider 2 cells2010
- Author(s)
  Mukai, T., Wakiyama, M., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Protein Sci 19
  
  Pages: 440-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Genetic encoding of non-natural amino acids in Drosophila melanogaster Schneider 2 cells2010
- Author(s)
  Mukai, T., Wakiyama, M., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Protein Science (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] ヨードチロシンの部位特異的導入と長波長X線を用いた単波長異常分散法による結晶構造解析2009
- Author(s)
  村山和隆、坂本健作
- Journal Title
  
  日本結晶学会誌 Vo.51
  
  Pages: 251-257
- NAID
  10025158410
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Recognition of non-α-amino substrates by pyrrolysyl-tRNA synthetase2009
- Author(s)
  Kobayashi, T., Yanagisawa, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Journal of Molecular Biology 385
  
  Pages: 1352-1360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography2009
- Author(s)
  Sakamoto, K., Murayama, K., Oki, K., Iraha, F., Kato-Murayama, M., Takahashi, M., Ohtake, K., Kobayashi, T., Kuramitsu, S., Shirouzu, M., Yokoyama S.
- Journal Title
  
  Structure 17
  
  Pages: 335-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography2009
- Author(s)
  Sakamoto, K., Murayama, K., Oki, K., Iraha, F., Kato-Murayama, M., Takahashi, M., Ohtake, K., Kobayashi, T., Kuramitsu, S., Shirouzu, M., Yokoyama, S.
- Journal Title
  
  Structure 17
  
  Pages: 335-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Recognition of non-α-amino substrates by pyrrolysyl-tRNA synthetase2009
- Author(s)
  Kobayashi, T., Yanagisawa, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  J. Mol. Biol 385
  
  Pages: 1352-1360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Multi-step engineering of pyrrolysyl-tRNA synthetase to genetically encode Nε-(o-azidobenzyloxycarbonyl)lysine for site-specific protein modification2008
- Author(s)
  Yanagisawa, T., Ishii, R., Fukunaga, R., Kobayashi, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Chemistry & Biology 15
  
  Pages: 1187-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Adding L-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases2008
- Author(s)
  Mukai, T., Kobayashi, T., Hino, N., Yanagisawa, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Biochemical and Biophysical Research Communications 371
  
  Pages: 818-822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Crystallographic studies on multiple conformational states of active-site loops in pyrrolysyl-tRNA synthetase2008
- Author(s)
  Yanagisawa, T., Ishii, R., Fukunaga, R., Kobayashi, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  J. Mol. Biol 378
  
  Pages: 634-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Transplantation of a tyrosine editing domain into a tyrosyl-tRNA synthetase variant enhances its specificity for a tyrosine analog2008
- Author(s)
  Oki, K., Sakamoto, K., Kobayashi, T., Sasaki, H. M., Yokoyama, S.
- Journal Title
  
  Proceedings of the National Academy of Sciences U. S. A. 105
  
  Pages: 13298-13303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Multi-step engineering of pyrrolysyl-tRNA synthetase to genetically encode N-(o-azidobenzyl oxycarbonyl)lysine for site-specific protein modification2008
- Author(s)
  Yanagisawa, T., Ishii, R., Fukunaga, R., Kobayashi, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Chem. Biol 15
  
  Pages: 1187-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Crystallographic studies on multiple conformational states of active-site loops in pyrrolysyl-tRNA synthetase2008
- Author(s)
  Yanagisawa, T., Ishii, R., Fukunaga, R., Kobayashi, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Journal of Molecular Biology 378
  
  Pages: 634-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Adding L-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases2008
- Author(s)
  Mukai, T., Kobayashi, T., Hino, N., Yanagisawa, T., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Biochem. Biophys. Res. Commun 371
  
  Pages: 818-822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Transplantation of a tyrosine editing domain into a tyrosyl-tRNA synthetase variant enhances its specificity for a tyrosine analog2008
- Author(s)
  Oki, K., Sakamoto, K., Kobayashi, T., Sasaki, H.M., Yokoyama, S.
- Journal Title
  
  Proc. Natl Acad. Sci. USA 105
  
  Pages: 13298-13303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] Site-specific incorporation of non-natural amino acids into proteins in the mammalian cells with an expanded genetic code2007
- Author(s)
  Hino, N., Hayashi, A., Sakamoto, K., Yokoyama, S.
- Journal Title
  
  Nature protocol 1
  
  Pages: 2957-2962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] 分子計算のための一点から開始される探索法2007
- Author(s)
  染谷博司, 山村雅幸, 坂本健作
- Journal Title
  
  人工知能学会論文誌 22
  
  Pages: 405-415
- NAID
  10022007810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] 分子計算のための一点から開始される探索法2007
- Author(s)
  染谷博司, 山村雅幸, 坂本健作
- Journal Title
  
  人工知能学会誌(J-STAGE) 22・4(採録)
- NAID
  10022007810
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] 非天然型アミノ酸をタンパク質へ部位特異的に導入する技術の開発とその応用2007
- Author(s)
  坂本健作、横山茂之
- Journal Title
  
  蛋白核酸酵素(共立出版) Vol.54,No.12
  
  Pages: 65-71
- Data Source
  KAKENHI-PROJECT-19380195
[Journal Article] DNA polymerase programmed with a hairpin DNA incorporates a multiple-instruction architecture into molecular computing2006
- Author(s)
  K.Komiya, K.Sakamoto, A.Kameda, M.Yamamoto, A.Ohuchi, D.Kiga, S.Yokoyama, M.Hagiya
- Journal Title
  
  Bio Systems Vol.83
  
  Pages: 18-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300100
[Journal Article] DNA polymerase programmed with a hairpin DNA incorporates a multiple-instruction architecture into molecular computing2006
- Author(s)
  K.Komiya, K.Sakamoto, A.Kameda, M.Yamamoto, A.Ohuchi, D.Kiga, S.Yokoyama, M.Hagiva
- Journal Title
  
  BioSystems Vo.83
  
  Pages: 18-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300100
[Journal Article] DNA polymerase programmed with a hairpin DNA incorporates a multiple-instruction architecture into molecular computing2006
- Author(s)
  K.Komiya, K.Sakamoto, A.Kameda, M.Yamamoto, A.Ohuchi, D.Kiga, S.Yokoyama, M.Hagiya
- Journal Title
  
  BioSystems 83
  
  Pages: 18-25
- Data Source
  KAKENHI-PROJECT-15300100
[Journal Article] マルコフ連鎖モンテカルロ法の分子計算による実現の一検討2005
- Author(s)
  染谷博司, 山村雅幸, 坂本健作
- Journal Title
  
  電気学会電子・情報・システム部門大会2005 講演論文集
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] Toward "Wet" Implementation of Genetic Algorithm for Protein Engineering.2004
- Author(s)
  K.Sakamoto, M.Yamamura, H.Someya
- Journal Title
  
  In Preliminary Proceedings of 10th international Workshop on DNA-Based Computers, Milan, Italy,7-10 June 2004
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] タンパク質工学のための遺伝的アルゴリズムの設計2004
- Author(s)
  坂本健作, 山村雅幸, 染谷博司
- Journal Title
  
  電気学会電子・情報・システム部門大会2004講演論文集
- Data Source
  KAKENHI-PROJECT-14085203
[Journal Article] The Escherichia coli argU10(Ts) Phenotype Is Caused by a Reduction in the Cellular Level of the argU tRNA for the Rare Codons AGA and AGG.2004
- Author(s)
  Sakamoto, K., Ishimaru, S., Kobayashi, T., Walker, J.R., Yokoyama
- Journal Title
  
  S.Journal of Bacteriology
- Data Source
  KAKENHI-PROJECT-14085203
[Patent] アミノアシルtRNA合成酵素活性を有するポリペプチド及びその利用2008
- Inventor(s)
  大木健二、坂本健作、横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2008-029236
- Filing Date
  2008-02-08
- Data Source
  KAKENHI-PROJECT-19380195
[Patent] アミノアシルtrna合成酵素活性を有するポリペプチド及びその利用2008
- Inventor(s)
  大木健二、坂本健作、横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2008-029236
- Filing Date
  2008-02-08
- Data Source
  KAKENHI-PROJECT-19380195
[Patent] 変異体ピロリジル-tRNA合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法2007
- Inventor(s)
  小林隆嗣、柳沢達男、坂本健作、横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2007-243574
- Filing Date
  2007-09-20
- Data Source
  KAKENHI-PROJECT-19380195
[Patent] エステル結合を含む非天然タンパク質の製造方法2007
- Inventor(s)
  小林隆嗣、柳沢達男、向井崇人、坂本健作、横山茂之
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2007-302452
- Filing Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19380195
[Patent] 変異体ピロリジル-trna合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法2007
- Inventor(s)
  小林隆嗣, 坂本健作, 横山茂之, 柳沢達男
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2007-243574
- Filing Date
  2007-09-20
- Data Source
  KAKENHI-PROJECT-19380195
[Patent] エステル結合を含む非天然タンパク質の製造方法
- Inventor(s)
  小林隆嗣, 向井崇人, 坂本健作, 横山茂之, 柳沢達男
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2007-302452
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 遺伝暗号改変が拓くタンパク質工学2021
- Author(s)
  坂本健作
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] 改変型抗体の作製のための技術基盤2019
- Author(s)
  坂本健作
- Organizer
  兵庫県立こども病院－理研BDR第4回ジョイントシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] ゼノバイオロジーを目指すタンパク質工学2019
- Author(s)
  坂本健作
- Organizer
  日本薬学会第140年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] Xeno-protein engineeringの抗体開発への応用2019
- Author(s)
  坂本健作、林明子、山口純、柳沢達男、田村浩子、長門石曉、津本浩平、藏地理代、金山洋介、渡辺恭良
- Organizer
  第14回無細胞生命科学研究会
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] 10.非天然型アミノ酸含有抗体発現生産技術と生体直交反応性キレーター修飾の組み合わせによる高均一な64Cu標識トラスツズマブFabの作製2019
- Author(s)
  仁欽、藁科翔太、毛利浩太、高橋麻衣子、金山洋介、高橋美穂子、林明子、林中恵美、和田康弘、渡辺恭良、坂本健作、向井英史
- Organizer
  日本分子イメージング学会第14回学術総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] 人工遺伝暗号技術の抗体医薬への応用2019
- Author(s)
  坂本健作
- Organizer
  理研シンポジウム「理研エンジニアリングネットワーク/精密武装抗体の合成と機能評価」
- Invited
- Data Source
  KAKENHI-PROJECT-18H02416
[Presentation] Expanded genetic codes in mammalian cells, codon reassignments in E. coli, and their applications2016
- Author(s)
  Kensaku Sakamoto
- Organizer
  The 2016 Genetic Code Expansion Conference
- Place of Presentation
  アメリカ　コバリス
- Year and Date
  2016-08-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291035
[Presentation] 人為的なコドン再定義から考える遺伝暗号の進化2013
- Author(s)
  坂本健作, 向井崇人, 大竹和正, 染谷博司
- Organizer
  第15回日本RNA学会
- Place of Presentation
  愛媛県・県民文化会館・ひめぎんホール
- Year and Date
  2013-07-25
- Data Source
  KAKENHI-PROJECT-23300084
[Presentation] タンパク質複合体の光架橋による結晶構造解析技術の開発2009
- Author(s)
  佐藤心、三桝信哉、佐藤文、樋野展正、坂本健作、梅原崇史、横山茂之
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 遺伝暗号拡張のための大腸菌内在性チロシン翻訳系の置換2009
- Author(s)
  伊良波史枝、大野敏、横川隆志、西川一八、横山茂之、坂本健作
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 翻訳後修飾アミノ酸のタンパク質への部位特異的導入2009
- Author(s)
  小林隆嗣、坂本健作、柳沢達男、横山茂之
- Organizer
  第4回無細胞生命科学研究会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] タンパク質の特定のモチーフを介するタンパク質間相互作用の細胞内光クロスリンク法による網羅的解析2008
- Author(s)
  樋野展正, 尾山大明, 佐藤文, 向井崇人, 秦裕子, 山本雅, 坂本健作, 横山茂之
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 光クロスリンク法を用いた特定のモチーフを介するタンパク質間相互作用の網羅的解析2008
- Author(s)
  樋野展正、尾山大明、佐藤文、向井崇人、秦裕子、山本雅、坂本健作、横山茂之
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会合同大会(BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 光クロスリンカーのタンパク質への部位特異的な導入と複合体解析への応用2007
- Author(s)
  佐藤文、樋野展正、林明子、伊良波史枝、向井崇人、梅原崇史、坂本健作、岩崎健一郎、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 非天然型アミノ酸の導入によるタンパク質の部位特異的な蛍光標識技術2007
- Author(s)
  伊良波史枝、向井崇人、佐藤文、林明子、樋野展正、保坂俊彰、山登一郎、大野敏、横川隆志、西川一八、坂本健作、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 光クロスリンク能を有する新規非天然型アミノ酸Tmd-Pheを認識するアミノアシルtRNA合成酵素の探索2007
- Author(s)
  佐藤文、樋野展正、坂本健作、横山茂之
- Organizer
  9th RNA meeting
- Place of Presentation
  名古屋
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] SILAC法を併用したin vivo光クロスリンク法によるタンパク質間相互作用の網羅的解析2007
- Author(s)
  樋野展正、向井崇人、佐藤文、林明子、伊良波史枝、尾山大明、秦裕子、坂本健作、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 動物細胞における非天然型アミノ酸導入技術の拡張2007
- Author(s)
  向井崇人、小林隆嗣、樋野展正、柳沢達男、林明子、坂本健作、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] ヨードチロシンのタンパク質への部位特異的な導入と単波長異常分散法によるタンパク質結晶構造解析への応用2007
- Author(s)
  坂本健作、大木健二、村山和隆、小林隆嗣、白水美香子、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 同一の非天然型アミノ酸を認識する二つの異なった分子機構2007
- Author(s)
  大木健二、坂本健作、小林隆嗣、横山茂之
- Organizer
  9th RNA meeting
- Place of Presentation
  名古屋
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 光クロスリンク能を持つ非天然型アミノ酸をタンパク質に導入することによる細胞内タンパク質間相互作用解析法2007
- Author(s)
  樋野展正、向井崇人、佐藤文、坂本健作、横山茂之
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PROJECT-19380195
[Presentation] 「原始的な」アミノアシルtRNA合成酵素を用いた生体内における非天然型主鎖・側鎖構造のタンパク質への部位特異的導入2007
- Author(s)
  小林隆嗣、柳沢達男、坂本健作、横山茂之
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19380195

1. YAMAMURA Masayuki (00220442)

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# of Collaborated Products: 4 results
2. SOMEYA Hiroshi (00333518)

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3. KOMIYA Ken (20396790)

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5. KUREBAYASHI Nagomi (50133335)

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7. OKADA Norihiro (60132982)

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12. INOUE Tan (40114855)

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17. ROSE John Anthony (00345125)

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18. HAGIYA Masami (30156252)

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19. SUYAMA Akira (90163063)

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20. Miki Yokoyama (70191533)

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26. 新田克巳 (60293073)

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27. 太田元規 (40290895)

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28. 喜多一 (20195241)

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# of Collaborated Products: 0 results
31. 小松康雄 (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 新田至 (30272404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. KA 井上 (90302877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. MURATA Shigenori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. TERASAWA Kazue

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 村田成範

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. TAKASHIMA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
38. OKADA Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. HINO Nobumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. KITA Ayami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. ITO Takuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. YANAGISAWA Tatsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
43. UMEHARA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
44. SAEKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. OHTAKE Fumiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. TERAMOTO Hidetoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 土井健史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 大竹和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
49. 太田智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 小島桂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 須賀則之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 渡邉貴嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 芳坂貴弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAMOTO Kensaku 坂本 健作

坂本 健作 サカモト ケンサク

Research Projects

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非天然アミノ酸レパートリーに基づく新しいタンパク質機能・構造の進化的探索Principal Investigator

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Engineering of translation molecules for synthetic biology approach on the genetic codePrincipal Investigator

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Novel protein-synthesis technology achieving the installation of posttranslational modifications and other chemical modifications through genetic code expansionPrincipal Investigator

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Site-specific incorporation of non-natural amino acids into proteins in living cellsPrincipal Investigator

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Application of Molecular Computing to the Design of Useful ProteinsPrincipal Investigator

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タンパク質の適応地形の探索Principal Investigator

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アミノアシルtRNA合成酵素のtRNA特異性の改変Principal Investigator

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SAKAMOTO Kensaku 坂本健作

坂本健作サカモトケンサク