HATA Masayuki 畑晶之

… Alternative Names

畑晶之ハタマサユキ

畑昌之ハタマサユキ

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Researcher Number	50241972
Other IDs
Affiliation (Current)	2025: 松山大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2007 – 2012: Matsuyama University, 薬学部, 准教授 2002 – 2004: 千葉大学, 大学院・薬学研究院, 助手 1997 – 2000: 千葉大学, 薬学部, 助手 1995: 千葉大学, 医学部, 助手 1993 – 1995: 千葉大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Physical pharmacy / Medical pharmacy Except Principal Investigator Biophysics / Orthopaedic surgery / Virology / Physical pharmacy
Keywords	Principal Investigator 密度汎関数法 / 量子化学計算 / 抗生物質 / 分子動力学計算 / β-ラクタマーゼ / ONIOM法 / 活性化エネルギー / 分子力場計算 / 加水分解機構 / セリンプロテアーゼ … More / ＯＮＩＯＭ法 / 酵素―薬物複合体 / シトクロムＰ４５０ / 酸化反応 / 密度汎関数法 / 酵素-薬物複合体 / ドッキングスタディ / 薬物代謝 / シトクロムP450 / カルバマセピン / 活性部位 / 水酸化反応 / エポキシ化反応 / カルバマゼピン / CYP3A4 / 脱アシル化反応 / 薬剤耐性 / 四面体中間体 / アシル化反応 / クラスC / 半経験的分子軌道法 / 発がん機構 / GTP-GDP変換機構 / 非経験的分子軌道法 / G蛋白 / 情報伝達制御 / Ras蛋白p21 / プロトンリレー / 脱アシル化 / アシル化 / 基質加水分解機構 / クラブラン酸 / コンピュータグラフィックス / ペニシリンG … More Except Principal Investigator 分子動力学計算 / Catalytic Triad / Molecular Dynamics / Molecular Orbital Calculation / Proton-relay Mechanism / Hydrolysis / Serine Protease / Choline Esterase / Acetylcholine / 活性中心 / セリンオキソニウムイオン / 加水分解反応機構 / 抗痴呆薬 / アニオニックサイト / 局所密度汎関数法 / 量子化学計算 / 活性三残基 / 分子動力学 / 分子軌道法計算 / プロトンリレー機構 / 加水分解 / セリンプロテアーゼ / コリンエステラーゼ / アセチルコリン / 化合物ライブラリー / in silico薬物設計 / ニューロトロフィン受容体 / ニューロトロフィン / ソーチリン / RAP(receptor-associated protein) / p75受容体 / アポトーシス / ニューロトロフィン前駆体 / 脊髄損傷修復 / 合成経路 / シミュレーション / 有機合成 / 薬物設計 / プロテアーゼ阻害剤 / 薬剤耐性 / 変異体ウイルス / 結晶工学 / 非破壊 / 固体分散体 / cocrystal / 複合体 / 計算科学 / テラヘルツ / トンネル顕微鏡 / 表面拡散 / (001)面 / ダイヤモンド / エピタキシャル成長 / 結晶成長 / 分子軌道法 / 化学反応理論 Less

A study on the method of prediction of metabolites produced by cytochrome P450Principal Investigator
- Principal Investigator
  
  HATA Masayuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Matsuyama University
脊髄損傷修復への応用をめざした新たな神経保護薬の創生
- Principal Investigator
  
  古川美子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Matsuyama University
Evaluation of molecular states of drug in solid dispersion by terahertz spectroscopy and computational calculation
- Principal Investigator
  
  MORIBE Kunikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Research of Site Selectivity for Substrate Oxidation Catalyzed by CYP3A4Principal Investigator
- Principal Investigator
  
  HATA Masayuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Matsuyama University
Development of anti-HIV chemicals effective for the virus conferring drug resistance
- Principal Investigator
  
  HOSHINO Tyuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Chiba University
クラスCβ-ラクタマーゼによる抗生物質不活化機構に関する研究Principal Investigator
- Principal Investigator
  
  畑晶之
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
Ras蛋白p21の情報伝達制御の分子機構に関する研究Principal Investigator
- Principal Investigator
  
  畑晶之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
β-ラクタマーゼの作用機構-阻害薬開発のための基礎的研究-Principal Investigator
- Principal Investigator
  
  畑晶之
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
β-ラクタマーゼの作用機構-阻害薬開発のための基礎的研究-Principal Investigator
- Principal Investigator
  
  畑晶之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
ENZYMATIC REACTION MECHANISM OF ACETYL CHOLINE ESTERASE---THEORETICAL RESEARCH FOR DEVELOPMENT OF ANTIDEMENTIA AGENT
- Principal Investigator
  
  TSUDA Minoru, 笈川節子
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  CHIBA UNIVERSITY
共有結合性結晶の気相エピタキシャル成長に関する量子化学的研究
- Principal Investigator
  
  OIKAWA Setsuko
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University

All 2013 2012 2011 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Prediction of sites of metabolism in a substrate molecule2012
- Author(s)
  Hitomi Yuki, Teruki Honma, Masayuki Hata, Tyuji Hoshino
- Journal Title
  
  instanced by carbamazepine oxidation by CYP3A4, Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 2 Pages: 775-783
- DOI
  10.1016/j.bmc.2011.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590050
[Journal Article] An epoxidation mechanism of carbamazepine by CYP3A42008
- Author(s)
  Masayuki Hata, Yoshikazu Tanaka, Naoko Kyoda, Taisuke Osakabe, Hitomi Yuki, 他4名
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 5134-5148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590137
[Journal Article] An epoxidation mechanism of carbamazepine by CYP3A42008
- Author(s)
  Masayuki Hata
- Journal Title
  
  Bioorganic, Medicinal Chemistry 16
  
  Pages: 5134-5148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590137
[Journal Article] Computational Characterization of Structural Role of the Non- active Site Mutation M36I of Human Immunodeficiency Virus Type 1 Protease2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, S. Neya, J. Kakizawa, W. Sugiura, T. Hoshino
- Journal Title
  
  Journal of Molecular Biology 370
  
  Pages: 598-607
- NAID
  120007075168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] Mechanism of Drug Resistance Due to N88S in CRF01_AE HIV-1 Protease Analyzed by Molecular Dynamics Simulations2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, T. Hoshino, J. Kakizawa, W. Sugiura
- Journal Title
  
  Journal of Medicinal Chemistry 50
  
  Pages: 1768-1777
- NAID
  120007075525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] Computational Characterization of Structural Role of the Non-active Site Mutation M36I of Human Immunodeficiency Virus Type 1 Protease2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, S. Neya, J, Kakizawa, W. Sugiura, T. Hoshino
- Journal Title
  
  Journal of Molecular Biology 370
  
  Pages: 598-607
- NAID
  120007075168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] シトクロムP450による一酸素原子添加反応における酸素活性化機構2013
- Author(s)
  畑晶之、友永祥代
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-22590050
[Presentation] CYP3A4が触媒するカルバマゼピン酸化反応について2012
- Author(s)
  畑晶之、石井伊都子
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590050
[Presentation] Monooxygenation Mechanism of Carbamazepine by CYP3A42011
- Author(s)
  畑晶之、石井伊都子
- Organizer
  第21回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2011-05-30
- Data Source
  KAKENHI-PROJECT-22590050
[Presentation] CYP3A4が触媒するカルバマゼピン酸化反応機構2011
- Author(s)
  畑晶之、石井伊都子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590050
[Presentation] CYP3A4によるカルバマゼピン酸化反応機構2009
- Author(s)
  畑晶之
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590137
[Presentation] テラヘルツ・遠赤外吸収スペクトル測定によるエテンザミド-チオ尿素複合体形成の評価2008
- Author(s)
  森部久仁一、Limwikrant Waree、東顕二郎、山本恵司、畑晶之、笹倉大督
- Organizer
  第25回製剤と粒子設計シンポジウム
- Place of Presentation
  琵琶湖ホテル
- Year and Date
  2008-11-13
- Data Source
  KAKENHI-PROJECT-19590035
[Presentation] 医薬品と尿素化合物との複合体形成 : テラヘルツ分光法による評価2007
- Author(s)
  Limwikrant Waree、森部久仁一、安藤茂、東顕二郎、山本恵司、畑晶之
- Organizer
  第24回製剤と粒子設計シンポジウム
- Place of Presentation
  浜松アクトシティー
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-19590035
[Presentation] 医薬品と尿素化合物との複合体形成:テラヘルツ分光法による評価2007
- Author(s)
  Limwikrant Waree, 森部久仁一, 安藤茂, 東顕二郎, 山本恵司, 畑昌之
- Organizer
  第24回製剤と粒子設計シンポジウム
- Place of Presentation
  浜松アクトシティー
- Year and Date
  2007-11-14
- Data Source
  KAKENHI-PROJECT-19590035
[Presentation] テラヘルツ分光法による尿素及びチオ尿素と医薬品との複合体形成の評価2007
- Author(s)
  森部久仁一、安藤茂、畑晶之、戸塚裕一、山本恵司
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮ソニックホール
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19590035
[Presentation] シトクロムP450による一酸素原子添加反応における酸素活性化機構
- Author(s)
  畑　晶之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-22590050

1. TSUDA Minoru (90009506)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. OIKAWA Setsuko (60101359)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. MORIBE Kunikazu (50266350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. YAMAMOTO Keiji (50110341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. HOSHINO Tyuji (90257220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 古川美子 (20219108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中島光業 (70311404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岩村樹憲 (70184900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 波多江典之 (30449912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中西雅之 (00281048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 加来鉄平 (20435077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 東顕二郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. LIMWIKRANT Waree

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. WANAWONGTHAI Chalermphon

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 丸山直

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HATA Masayuki 畑 晶之

畑 晶之 ハタ マサユキ

畑 昌之 ハタ マサユキ

Research Projects

Research Products

Co-Researchers

A study on the method of prediction of metabolites produced by cytochrome P450Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脊髄損傷修復への応用をめざした新たな神経保護薬の創生

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of molecular states of drug in solid dispersion by terahertz spectroscopy and computational calculation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of Site Selectivity for Substrate Oxidation Catalyzed by CYP3A4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-HIV chemicals effective for the virus conferring drug resistance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

クラスCβ-ラクタマーゼによる抗生物質不活化機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ras蛋白p21の情報伝達制御の分子機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

β-ラクタマーゼの作用機構-阻害薬開発のための基礎的研究-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

β-ラクタマーゼの作用機構-阻害薬開発のための基礎的研究-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ENZYMATIC REACTION MECHANISM OF ACETYL CHOLINE ESTERASE---THEORETICAL RESEARCH FOR DEVELOPMENT OF ANTIDEMENTIA AGENT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

共有結合性結晶の気相エピタキシャル成長に関する量子化学的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Prediction of sites of metabolism in a substrate molecule2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An epoxidation mechanism of carbamazepine by CYP3A42008

Author(s)

Journal Title

Data Source

HATA Masayuki 畑晶之

畑晶之ハタマサユキ

畑昌之ハタマサユキ