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Kitoh Toshiyuki  鬼頭 敏幸

Researcher Number 50243027
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-5519-8320
Affiliation (based on the past Project Information) *help 2016 – 2019: 愛知学院大学, 薬学部, 教授
2012 – 2015: 愛知医科大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Medical pharmacy / Laboratory medicine
Keywords
Principal Investigator
臨床 / 薬学 / 蛋白質 / バイオテクノロジー / 生体分子 / 炎症マーカー / 血管内皮 / ガンマグロブリン療法 / 血管炎 / 冠動脈瘤 … More / NT-proBNP / presepsin / ガンマグロブリン / ショットガンプロテオミクス / パターン認識受容体 / バイオマーカー / 冠動脈病変 / pentraxin 3 / Toxic shock 川崎病 / ガンマグロブリン抵抗性 / 川崎病 / 選択的毒性 / 国際情報交換 / アミノ酸代謝 / 感受性予測 / 酵素製剤 / 細胞死 / 抗がん剤 / 選択毒性 / アミノ酸要求性 / 分子標的療法 Less
  • Research Projects

    (2 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (14 People)
  •  A novel therapy by targeting a key molecules pentraxin 3 involved in Kawasaki DiseasePrincipal Investigator

    • Principal Investigator
      KITOH TOSHIYUKI
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Aichi Gakuin University
  •  Development of a predictive system of the sensitivity for L-asparaginase in tumor by monoclonal antibodyPrincipal Investigator

    • Principal Investigator
      Kitoh Toshiyuki
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Aichi Medical University

All 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book Patent

  • [Book] 「小児血液・腫瘍学テキスト」 「化学療法薬(ステロイド等)アスパラギナーゼ」2015

    • Author(s)
      鬼頭敏幸
    • Total Pages
      300
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Journal Article] アスパラギン合成酵素をめぐる研究の現状 - L-アスパラギナーゼ発見から65年間の歩み -2019

    • Author(s)
      鬼頭敏幸
    • Journal Title

      愛知学院大学薬学会誌

      Volume: 11 Pages: 1-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] PENTRAXIN 3 IS THE BEST BIOMARKER OF KAWASAKI DISEASE; PREDICTOR OF IVIG NON-RESPONDER AND CORONARY ARTERY LESION AND SEQUELLAE.2019

    • Author(s)
      Toshiyuki Kitoh, Tsuyoshi Ohara, Taichiro Muto, Akihisa Okumura, Yusuke Koizumi, Yuka Yamagishi Hiroshige Mikamo, Reizo Baba, Kenji Daigo, Takao Hamakubo
    • Journal Title

      European Journal of Pediatrics

      Volume: 178 Pages: 1699-1699

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study2018

    • Author(s)
      Morimoto Akira、On behalf of the Japan LCH Study Group、Shioda Yoko、Imamura Toshihiko、Kudo Kazuko、Kitoh Toshiyuki、Kawaguchi Hiroshi、Goto Hiroaki、Kosaka Yoshiyuki、Tsunematsu Yukiko、Imashuku Shinsaku
    • Journal Title

      International Journal of Hematology

      Volume: 108 Issue: 2 Pages: 192-198

    • DOI

      10.1007/s12185-018-2444-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome2017

    • Author(s)
      Minoia Francesca、Bovis Francesca、Kitoh Toshiyuki、Cron Randy Q.、Cuttica Ruben、Minoia Francesca、Mulaosmanovic Velma、Nichols Kim E.、Imashuku Shinsaku、
    • Journal Title

      The Journal of Pediatrics

      Volume: 189 Pages: 72-78.e3

    • DOI

      10.1016/j.jpeds.2017.06.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.2016

    • Author(s)
      Ravelli A, Minoia F, Kitoh T, Lehmberg K, Lovell D, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron RQ.
    • Journal Title

      RMD Open.

      Volume: 2 Issue: 1 Pages: e000161-e000161

    • DOI

      10.1136/rmdopen-2015-000161

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] 冠動脈病変マーカー(PTX3,sLOX-1,MMP)2016

    • Author(s)
      鬼頭敏幸
    • Journal Title

      日本臨牀増刊号

      Volume: 74 Pages: 513-517

    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] 016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.2016

    • Author(s)
      Ravelli A, Minoia F, Kitoh T, Lehmberg K, Lovell DJ, Miettunen P, Nichols KE, Ozen S, Pachlopnik Schmid J, Ramanan AV, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron RQ
    • Journal Title

      Ann Rheum Dis.

      Volume: 75 Issue: 3 Pages: 781-789

    • DOI

      10.1136/annrheumdis-2015-208982

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Journal Article] Childhood-onset psoriatic arthritis in Down syndrome with psoriasis susceptibility variant CARD14 rs116520752015

    • Author(s)
      Sugiura K, Kitoh T, Watanabe D, Muto M, Akiyama M
    • Journal Title

      Rheumatology (Oxford)

      Volume: 54 Issue: 1 Pages: 197-199

    • DOI

      10.1093/rheumatology/keu419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591617, KAKENHI-PROJECT-24590713, KAKENHI-PROJECT-26670526
  • [Journal Article] Hematopoietic stem cell transplantation for patients with acute lymphoblastic leukemia and Down syndrome2015

    • Author(s)
      Goto, H. Kaneko, T. Shioda, Y. Kajiwara, M. Sakashita, K. Kitoh, T. Hayakawa, A. Miki, M. Kato, K. Ogawa, A. Hashii, Y. Inukai, T. Kato, C. Sakamaki, H. Yabe, H. Suzuki, R. Kato, K.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 62 Issue: 1 Pages: 148-152

    • DOI

      10.1002/pbc.25245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Journal Article] Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism.2015

    • Author(s)
      Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, Wada T, Gunji M, Toma T, Kato T, Shiraishi Y, Iwata A, Hori T, Kitoh T, Chiba K, Tanaka H, Sanada M, Takahashi Y, Nonoyama S, Ito M, Miyano S, Ogawa S, Kojima S, Kanegane H.
    • Journal Title

      J Clin Immunol

      Volume: 35 Issue: 7 Pages: 610-614

    • DOI

      10.1007/s10875-015-0202-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09642, KAKENHI-PROJECT-26461570, KAKENHI-PROJECT-24590713
  • [Journal Article] Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients.2014

    • Author(s)
      Minoia, F. Davi, S. Horne, A. Gao, Y. J. Huasong, Z. Kitoh, T. et. al
    • Journal Title

      Arthritis & rheumatology

      Volume: 66 Issue: 11 Pages: 3160-3169

    • DOI

      10.1002/art.38802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome.2014

    • Author(s)
      Muramatsu H, Sakaguchi H, Taga T, Tabuchi K, Adachi S, Inoue M, Kitoh T, Suminoe A, Yabe H, Azuma E, Shioda Y, Ogawa A, Kinoshita A, Kigasawa H, Osugi Y, Koike K, Kawa K, Kato K, Atsuta Y, Kudo K.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 61 Issue: 5 Pages: 925-927

    • DOI

      10.1002/pbc.24883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390273, KAKENHI-PROJECT-24590713, KAKENHI-PROJECT-24791054
  • [Journal Article] Clinical characteristics and outcomes of Chédiak-Higashi syndrome: a nationwide survey of Japan.2013

    • Author(s)
      Nagai K, Yasukawa M, et al.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 60 Issue: 10 Pages: 1582-1586

    • DOI

      10.1002/pbc.24637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390245, KAKENHI-PROJECT-24590713, KAKENHI-PROJECT-24591577
  • [Journal Article] Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease.2013

    • Author(s)
      Wada T
    • Journal Title

      J Clin Immunol.

      Volume: 33 Issue: 4 Pages: 857-864

    • DOI

      10.1007/s10875-012-9859-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591155, KAKENHI-PROJECT-23390270, KAKENHI-PROJECT-24590713, KAKENHI-PROJECT-24591542, KAKENHI-PROJECT-25670472
  • [Journal Article] PBSCT is associated with poorer survival and increased chronic GvHD than BMT in Japanese paediatric patients with acute leukaemia and an HLA-matched sibling donor.2013

    • Author(s)
      Shinzato A, Adachi S, et al.
    • Journal Title

      Pediatric Blood and Cancer

      Volume: in press Issue: 9 Pages: 1513-1519

    • DOI

      10.1002/pbc.24524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390273, KAKENHI-PROJECT-23591536, KAKENHI-PROJECT-24590713
  • [Journal Article] THE THERAPEUTIC VALUE OF ASPARAGINE SYNTHETASE DEFICIENCY IN LANGERHANS CELL HISTIOCYTOSIS.2013

    • Author(s)
      Kitoh Toshiyuki, Shimomura Yasuto, Hori Toshinari, Terashima Tsuyoshi, Yokoi Toyoharu, Tsurusawa Masahito.
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Journal Article] Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies.2012

    • Author(s)
      Kusano-Arai O
    • Journal Title

      ybridoma (Larchmt)

      Volume: Oct;31(5) Issue: 5 Pages: 325-332

    • DOI

      10.1089/hyb.2012.0014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-24590713
  • [Patent] アスパラギン合成酵素を特異的に認識するモノクローナル抗体2013

    • Inventor(s)
      浜窪隆雄、望月康弘、岩成宏子、新井 修、鬼頭敏幸、鶴澤正仁
    • Industrial Property Rights Holder
      浜窪隆雄、望月康弘、岩成宏子、新井 修、鬼頭敏幸、鶴澤正仁
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-218966
    • Filing Date
      2013-04-09
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] PENTRAXIN 3 IS THE BEST BIOMARKER OF KAWASAKI DISEASE; PREDICTOR OF IVIG NON-RESPONDER AND CORONARY ARTERY LESION AND SEQUELLAE.2019

    • Author(s)
      Toshiyuki Kitoh, Tsuyoshi Ohara, Taichiro Muto, Akihisa Okumura, Yusuke Koizumi, Yuka Yamagishi Hiroshige Mikamo, Reizo Baba, Kenji Daigo, Takao Hamakubo
    • Organizer
      European Academy of Peadiatric Cngress and MasterCourse
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] THE FIRST NATIONWIDE CLINICAL STUDY FOR THE FIRST RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA IN JAPANESE CHILDREN: THE JPLSG-ALL-R08.2018

    • Author(s)
      C. Ogawa, H. U., M. Nishi, J. Yamanaka, S. Mochizuki, T. Nishikawa, H. Toyoda, A. Iguchi, K. Koh, S. Ota, T. Kitoh, K. Okada, T. Asano, T. Deguchi, N. Kiyokawa, T. Hori, Y. Komada, A. Moriya Saito, T. Watanabe, H. Goto.
    • Organizer
      The 50th Congress of the International Society of Paediatric Oncology (SIOP), Kyoto
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] Change in codeine prescription rate after Japanese Ministry of Health and Labor to request usage limitation to under twelve years old children in July 20172018

    • Author(s)
      Tsukada, K., Inui, D., Kato, H., Maki, D., and Kitoh, T
    • Organizer
      27th Federation of Asian Pharmaceutical Associations Congress, Philippine International Convention Center, Manila, Philippines
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] 川崎病の検査値としてのPTX3、Presepsin、NT-proBNPの有用性について2018

    • Author(s)
      大原毅士, 鬼頭敏幸, 武藤太一朗, 奥村彰久, 小泉祐介, 山岸由佳, 三鴨廣繁, 馬場礼三, 太期健二, 浜窪隆雄
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2018
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] Increased levels of plasma pentraxin 3 predict IVIG resistance and coronary artery lesion formation in patients with Kawasaki disease2017

    • Author(s)
      Toshiyuki Kitoh, Yoshiro Kitagawa, Reizo Baba,Atsushi Kaneko, Tomohito Hayakawa, Taichiro Muto,Akihisa Okumura, Kenta Murotani, Noriaki Kume and Takao Hamakubo
    • Organizer
      the 18th International Vasculitis and ANCA Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] Increased levels of plasma pentraxin 3 predict IVIG resistance and coronary artery lesion formation in patients with Kawasaki disease2017

    • Author(s)
      Toshiyuki Kitoh, Reizo Baba, Yoshiro Kitagawa, Taichiro Muto, Akihisa Okumura, Noriaki Kume, Takao Hamakubo
    • Organizer
      EAP 2017 Congress and Master Course
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] Henoch-Schoenlein紫斑病合併後に皮膚症状が劇的に改善した乾癬性関節炎2016

    • Author(s)
      鬼頭 敏幸, 北川 好郎, 佐々木 彩恵子, 楠 隆, 藤井 達哉
    • Organizer
      第119回日本小児科学会総会・学術集会
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] CHANGE IN EXPERT CONSENSUS BASED ON AVAILABILITY OF ADDITIONAL LABORATORY DATA OVER THE COURSE OF MAS:2016

    • Author(s)
      Sergio Davi, Francesca Minoia, AnnaCarin Horne, Toshiyuki Kitoh, Raju Khubchandani, Norman T Ilowite, Jan-Inge Henter, Alexei A Grom, Fabrizio De Benedett, Alberto Martini, Nicolino Ruperto, Randy Q Cron, Angelo Ravelli
    • Organizer
      23rd European Paediatric Rheumatology Congress
    • Place of Presentation
      Genova, Italy
    • Year and Date
      2016-09-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08422
  • [Presentation] Flow Cytometric Detection of Asparagine Synthetase Protein in Leukemia Cells; Indication for LAsparaginase Therapy2013

    • Author(s)
      Toshiyuki Kitoh, Kou Suchan Gao Siqiang, Hidefumi Kato, Yasuto Shimomura, Toshinori Hori, Kimiyoshi Sakaguchi, Hiroshi Miwa, Masahito Tsurusawa, Takao Hamakubo
    • Organizer
      EAP 2013-European Academy of Paediatrics Educational Congress & MasterCourse
    • Place of Presentation
      Lyon, France
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] AGGRESSIVE LANGERHANS CELL HISTIOCYTOSIS FOLLOWING T-ALL: CLONALLY RELATED NEOPLASMS WITHOUT BRAF V600E MUTATION AND SUFFICIENT EXPRESSION OF ASPARAGINE SYNTHETASE2013

    • Author(s)
      Kitoh Toshiyuki, Akiyama Masaharu, Taki Tomohiko, Shimomura Yasuto, Hori Toshinari, Terashima Tsuyoshi, Yokoi Toyoharu, Tsurusawa Masahito.
    • Organizer
      29th Histiocyte Society Annual Meeting
    • Place of Presentation
      Washington, DC. USA
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] THE THERAPEUTIC VALUE OF ASPARAGINE SYNTHETASE DEFICIENCY IN LANGERHANS CELL HISTIOCYTOSIS2012

    • Author(s)
      Kitoh T, Shimomura Y, Hori T, Terashima T, Yokoi T, Tsurusawa M
    • Organizer
      the 28th Annual Meeting of the Histiocyte Society
    • Place of Presentation
      London, UK
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] Hematopoietic Cell Transplantation for Patients with Acute Lymphoblastic Leukemia and Down Syndrome.

    • Author(s)
      Hiroaki Goto, Takashi Kaneko, Yoko Shioda, Michiko Kajiwara, Kazuo Sakashita, Toshiyuki Kitoh, Akira Hayakawa, Mizuka Miki, Hisashi Sakamaki, Hiromasa Yabe, Ritsuro Suzuki, Kohji Kato
    • Organizer
      8th SIOP-Asia Congress
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-04-15 – 2014-04-17
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] DEVELOPMENT OF NEW CLASSIFICATION CRITERIA FOR MACROPHAGE ACTIVATION SYNDROME COMPLICATING SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

    • Author(s)
      Minoia F, Davi S, Bovis F, Pistorio A, Arico M, Avcin T, Behrens E, FD, Filipovich L, Grom A,Henter JI, Horne A, Ilowite N,Jordan M, Khubchandani R,Kitoh T, et.al
    • Organizer
      the 21st European Pediatric Rheumatology Congress
    • Place of Presentation
      Belgrade, Serbia
    • Year and Date
      2014-09-17 – 2014-09-21
    • Data Source
      KAKENHI-PROJECT-24590713
  • [Presentation] Flow Cytometric Detection of Asparagine Synthetase Protein in Leukemia Cells; Indication for L- Asparaginase Therapy

    • Author(s)
      Toshiyuki Kitoh, Kou Suchan Gao Siqiang, Hidefumi Kato, Kenji Miyata, Yasuto Shimomura, Toshinori Hori, Kimiyoshi Sakaguchi, Yasuo Horikoshi, Kentarou Ohki, Katsuyoshi Koh, and Takao Hamakubo.
    • Organizer
      56th ASH Annual Meeting and Exposition
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-12-06 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-24590713
  • 1.  YOKOI TOYOHARU (40200886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  TSURUSAWA MASAHITO (90172064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  KATO HIDEFUMI (40298584)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 4.  HAMAKUBO TAKAO (90198797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  北川 好郎 (00440719)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  三鴨 廣繁 (00262775)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  馬場 礼三 (90287029)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 8.  武藤 太一朗 (80613695)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 9.  太期 健二 (20466866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  WADA Taizo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  安川 正貴
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  杉浦 一充
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  足立 壮一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  伊藤 洋志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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