Futagami Seiji 二神生爾

… Alternative Names

FUTAGAMI Seiji 二神生爾

二神生爾フタガミセイジ

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Researcher Number	50247011
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2018: 日本医科大学, 医学部, 教授 2016: 日本医科大学, 医学部, 准教授 2013 – 2014: 日本医科大学, 医学部, 准教授 2012: 日本医科大学, 医学部, 講師 2009 – 2011: Nippon Medical School, 医学部, 助教 … More 2007: Nippon Medical School, Internal Medicine, Division of Gastroenterology, Assistant Professor 2005 – 2006: 日本医科大学, 医学部, 助手 2001 – 2002: 日本医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator MCP-1 / COX-2 / CD40 / APE-1 / 胃癌 / 癌幹細胞 / CCR2 / CD133陽性細胞 / ホーミング / CD133 … More / CD44 / H.pylori / 感染後機能性ディスペプシア / acotiamide / urocortin / 十二指腸 / CB68 / GLP-1 / CD68 / 胃排出能 / 十二指腸粘膜 / 膵酵素異常 / 早期慢性膵炎 / 慢性膵炎 / 機能性ディスペプシア / CD4OL / Cdx2 / intestinal metaplasia / V delta2 T cell / V deltal T cell / cyclooxygenase-2 / mucosal defense / COX-2(cyclooxygenase-2) / prostaglandinsE2 / gamma delta T cell / CD40L / cdx2 / 腸上皮化生 / 間葉系幹細胞 / ips gene / CD44陽性細胞 / 腹膜播種 / CD 44陽性細胞 / CD 133陽性細胞 / 胃癌幹細胞 / stem cell / gastric cancer / CD133-/CD44-positive cell / migration / Bone marrow derived cells / NSAID / T cell / cytokine Less

CCR2/CD68 double positive cells were increased the expression levels of MBP protein in the duodenal mucosa of the FD patientsPrincipal Investigator
- Principal Investigator
  
  Futagami Seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School
Analysis of molecular mechanisms and ips genes in mesenchymal stem cells of the patients with advanced gastric cancer.Principal Investigator
- Principal Investigator
  
  FUTAGAMI Seiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School
Analysis of homing system for bone marrow derived cells into gastric cancer tissues through MCP-1 stimulationPrincipal Investigator
- Principal Investigator
  
  FUTAGAMI Seiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School
Investigation of APE-1 regulation induced by gamma/delta T cells in intestinal cellsPrincipal Investigator
- Principal Investigator
  
  FUTAGAMI Seiji
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School
消化管上皮細胞を介した粘膜内T細胞への刺激伝達の解析Principal Investigator
- Principal Investigator
  
  二神生爾
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School

[Book] 症候群ハンドブック2011
- Author(s)
  二神生爾
- Total Pages
  757
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-21590796
[Book] FD診察Q & A2011
- Author(s)
  新福摩弓、二神生爾、坂本長逸
- Total Pages
  160
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-21590796
[Book] FD診察Q&A2011
- Author(s)
  新福摩弓, 二神生爾, 坂本長逸
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-21590796
[Book] Helicobacter pylori感染の最近の知見-Helicobacter感染動物モデルの有用性2008
- Author(s)
  二神生爾, ほか
- Publisher
  北隆社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Book] Helicobacter pylori感染の最近の知見-Helicobacter感染動物モデルの有用性2008
- Author(s)
  二神生爾、ほか
- Publisher
  北隆社
- Data Source
  KAKENHI-PROJECT-17590686
[Book] H.pylori除菌と消化性潰瘍・関連疾患-基礎と臨床研究のアップデート-胃粘膜中IL-7, IL-1beta発現とgamma delta T cell浸潤の検討2005
- Author(s)
  二神生爾, 坂本長逸
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Camostat mesilate, pancrelipase and rabeprazole combination therapy improves epigastric pain in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme2018
- Author(s)
  Yamawaki H, Futagami S, et al.
- Journal Title
  
  Digestion
  
  Volume: 99 Issue: 4 Pages: 283-292
- DOI
  10.1159/000492813
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09294, KAKENHI-PROJECT-19K17444
[Journal Article] New classification Rome IV functional dyspepsia and subtypes2018
- Author(s)
  Futagami S, Yamawaki H, Agawa S, et al.
- Journal Title
  
  Transl Gastroenterol Hepatol
  
  Volume: 3 Pages: 70-70
- DOI
  10.21037/tgh.2018.09.12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients2018
- Author(s)
  Wakabayashi M, Futagami S, Yamawaki H, et al.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 11 Pages: e0205165-e0205165
- DOI
  10.1371/journal.pone.0205165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Management of functional dyspepsia: state of the art and emerging therapies2018
- Author(s)
  Yamawaki H, Futagami S, Wakabayashi M, et al.
- Journal Title
  
  Ther Adv Chronic Dis
  
  Volume: 9 Issue: 1 Pages: 23-32
- DOI
  10.1177/2040622317725479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Impact of cyclooxygenase-2 1195 G-carrier genotype associated with intestinal metaplasia and endoscopic findings based on Kyoto classification.2017
- Author(s)
  Kodaka Y, Futagami S, Tatsuguchi A, et al.
- Journal Title
  
  Digestion
  
  Volume: 96 Issue: 3 Pages: 173-183
- DOI
  10.1159/000479864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.2017
- Author(s)
  Hashimoto S, Futagami S, Yamawaki H, et al.
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: 61 Pages: 140-145
- NAID
  130006038740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Improvement of meal-related symptoms and epigasstric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan2016
- Author(s)
  Yamawaki H, Futagami S, et al.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 28 Issue: 7 Pages: 1037-1047
- DOI
  10.1111/nmo.12805
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Sleep disturbances in functional gastrointestinal disorders2016
- Author(s)
  Futagami S, Yamawaki H, et al.
- Journal Title
  
  Internal Medicine
  
  Volume: 55 Pages: 1509-1510
- NAID
  130005157645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09294
[Journal Article] Systematic review with meta-analysis:post-infectious functional dyspepsia2015
- Author(s)
  Futagami S, Itoh T, Sakamoto C.
- Journal Title
  
  Aliment Pharmacol Ther
  
  Volume: 41 Issue: 2 Pages: 177-188
- DOI
  10.1111/apt.13006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Leu72Met408 polymorphism of the ghrelin gene is associated with early phase of gastric emptying in the patients with functional dyspepsia in Japan2015
- Author(s)
  Yamawaki H, Futagami S, Shimpuku M, Shindo T, Maruki Y, et al
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 21 Issue: 1 Pages: 93-102
- DOI
  10.5056/jnm14086
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.2014
- Author(s)
  Nagoya H, Futagami S, Shimpuku M, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 306
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Impact of sleep disorders, quality of life and gastric emptying in distinct subtypes of functional dyspepsia in Japan2014
- Author(s)
  Yamawaki H, Futagami S, Shimpuku M, et al. (計11名)
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: Vol. 20 No. 1 Issue: 1 Pages: 104-12
- DOI
  10.5056/jnm.2014.20.1.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590927, KAKENHI-PROJECT-24590928
[Journal Article] Impact of sleep disorders, quality of life and gastric emptying in distinct subtypes of functional dyspepsia in Japan2014
- Author(s)
  Yamawaki H, Futagami S, Shimpuku M, et al.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 20 Pages: 104-112
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues.2014
- Author(s)
  Nagoya H, Futagami S, Shimpuku M, Tatsuguchi A, Wakabayashi T, Yamawaki H, Kodaka Y, Kawagoe T, Watarai Y, Makino H, Miyashita M, Tsuchiya S, Crowe SE, Sakamoto C.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 306 Issue: 3 Pages: G183-G190
- DOI
  10.1152/ajpgi.00057.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590927, KAKENHI-PROJECT-24590928
[Journal Article] Impact of eating attitude and impairment of physical quality of life between tertiary clinic and primary clinic functional dyspepsia outpatients in Japan2014
- Author(s)
  Shimpuku M, Futagami S, Tajima N, et al.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 20 Issue: 4 Pages: 506-515
- DOI
  10.5056/jnm14015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Sleep disorders in functional dyspepsia and future therapy.2013
- Author(s)
  Futagami S, Shimpuku M, Yamawaki H, Izumi N, Kodaka Y, Nagoya H, Wakabayashi T, Shindo T, Kawagoe T, Sakamoto C
- Journal Title
  
  J Nippon Med Sch
  
  Volume: 80 Pages: 104-109
- NAID
  130004147211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] The preproghrelin 3056TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with H. pylori-negative functional dyspepsia.2013
- Author(s)
  Futagami S, Shimpuku M, Kawagoe T, Izumi N, et al.
- Journal Title
  
  Internal Medicine
  
  Volume: 52 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Impact of sleep disorders in Japanese patients with functional dyspepsia (FD):nizatidine improves clinical symptoms, gastric emptying and sleep disorders in FD patients.2013
- Author(s)
  Futagami S, Yamawaki H, Izumi N, Shimpuku M, Kodaka Y, Wakabayashi T, Nagoya H, Shindo T, Kawagoe T, Gudis K, Itoh T, Sakamoto C.
- Journal Title
  
  J Gastroenterol Heapatol
  
  Volume: 53 Issue: 8 Pages: 53-60
- DOI
  10.1111/jgh.12236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Water-soluble vitamin deficiencies in complicated peptic ulcer patients soon after ulcer onset in Japan.2013
- Author(s)
  Miyake K, Akimoto T, Kusakabe M, Sato W, Yamada A, Yamawaki H, Kodaka Y, Shimpuku M, Nagoya H, Shindo T, Ueki N, Kusunoki M, Kawagoe T, Futagami S, Tsukui T, Sakamoto C.
- Journal Title
  
  J Nutr Sci Vitaminol
  
  Volume: 59 Pages: 503-508
- NAID
  130003393746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Apurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-κB-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue2013
- Author(s)
  Song J, Futagami S, Nagoya H, Kawagoe T, Yamawaki H, Kodaka Y, et al.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 52 Issue: 2 Pages: 112-119
- DOI
  10.3164/jcbn.12-95
- NAID
  130004466710
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Impact of coexisting irritable bowel syndrome and non-erosive reflux disease on postprandial abdominal fullness and sleep disorders in functional dyspepsia.2013
- Author(s)
  Futagami S, Yamawaki H, Shimpuku M, Izumi N, Wakabayashi T, Kodaka Y, Nagoya H, Shindo T, Kawagoe T, Sakamoto C.
- Journal Title
  
  J Nippon Med Sch
  
  Volume: 80 Pages: 362-370
- NAID
  130004147250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Classification of patients who experience a higher distress level to transoral esophagogastroduodenoscopy than to transnasal esophagogastroduodenoscopy.2012
- Author(s)
  Miyake K, Kusunoki M, Ueki N, Yamada A, Nagoya H, Kodaka Y, Shindo T, Kawagoe T, Gudis K, Futagami S, Tsukui T, Sakamoto C.
- Journal Title
  
  Dig Endosc
  
  Volume: 53 Issue: 4 Pages: 66-73
- DOI
  10.1111/den.12006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] Nizatidine improves clinical symptoms and gastric emptying in patients with functional dyspepsia accompanied by impaired gastric emptying.2012
- Author(s)
  Futagami S, Shimpuku M, Song JM, Kodaka Y, Yamawaki H, Nagoya H, Shindo T, Kawagoe T, Gudis K, Horie A, Gudis K, Iwakiri K, Sakamoto C.
- Journal Title
  
  Digestion
  
  Volume: 86 Pages: 114-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590928
[Journal Article] 機能性ディスペプシアの病態生理胃排出能と遺伝子多型2011
- Author(s)
  新福摩弓, 二神生爾, 北村忠弘, 坂本長逸
- Journal Title
  
  日本臨床生理学会雑誌
  
  Volume: 41 Pages: 87-93
- NAID
  10030463313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] G-proteinβ3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese2011
- Author(s)
  S himpuku M, Futagami S, Kawagoe T, Nagoya H, Shindo T, Horie A, Kodaka Y, Itoh T, Sakamoto C
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 23 Issue: 12 Pages: 1073-1080
- DOI
  10.1111/j.1365-2982.2011.01781.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796, KAKENHI-PROJECT-23590927
[Journal Article] The effects of nizatidine on transient lower esophageal sphincter relaxations (TLESRs) and acid reflux in healthy subjects2011
- Author(s)
  Iwakiri K, Kawami N, Sano H, Tanaka Y, Umezawa M, Futagami S, et al
- Journal Title
  
  Journal of Smooth Muscle Research
  
  Volume: 47 Issue: 6 Pages: 157-166
- DOI
  10.1540/jsmr.47.157
- NAID
  10030121548
- ISSN
  0916-8737, 1884-8796
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The incidence of deep vein thrombosis in Japanese patients und ergoing endoscopic submucosal dissection2011
- Author(s)
  Kusunoki M, Miyake K, Shindo T, Ueki N, Kawagoe T, Gudis K, Futagami S, et al
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 74 Pages: 798-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The effects of nizatidine on transient lower esophageal sphincter relaxations (TLESRs) and acid reflux in healthy subjects2011
- Author(s)
  Iwakiri K, Kawami N, Sano H, Tanaka Y, Umzawa M, Futagami S, et al, et al
- Journal Title
  
  J Smooth Muscle Res
  
  Volume: 47 Pages: 157-166
- NAID
  10030121548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Pathophysiology of Functional Dyspepsia2011
- Author(s)
  Futagami S, Shimpuku M, Yin Y, Shindo T, Kodaka Y, Nagoya H, Nakazawa S, Fujimoto M, Izumi N, Ohishi N, Kawagoe T, Horie A, Iwakiri K, Sakamoto C
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 78 Issue: 5 Pages: 280-285
- DOI
  10.1272/jnms.78.280
- NAID
  130004147108
- ISSN
  1345-4676, 1347-3409
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The incidence of deep vein thrombosis in Japanese patients undergoing endoscopic submucosal dissection2011
- Author(s)
  K usunoki M, Miyake K, Shindo T, Ueki N, Kawagoe T, Gudis K, Futagami S, et al
- Journal Title
  
  Gastrointest Endosc
  
  Volume: 74 Issue: 4 Pages: 798-804
- DOI
  10.1016/j.gie.2011.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils2010
- Author(s)
  Futagami S, Hamamoto T, Shimpuku M, Nagoya H, Kawagoe T, Horie A, Shindo T, Gudis K, Sakamoto C
- Journal Title
  
  Digestion
  
  Volume: 81 Issue: 3 Pages: 193-203
- DOI
  10.1159/000252790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils.2010
- Author(s)
  Futagami S, Hamamoto T, Shimpuku M, Nagoya H, Kawagoe T, Horie A, Shindo T, Gudis K, Sakamoto C.
- Journal Title
  
  Digestion 81
  
  Pages: 193-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia2010
- Author(s)
  Futagami S, Shindo T, Kawagoe T, Horie A, Shimpuku M, Gudakamoto C
- Journal Title
  
  Am J Gastroenterol
  
  Volume: 105 Issue: 8 Pages: 1835-1842
- DOI
  10.1038/ajg.2010.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The prokinetic effect of mosapride citrate combined with omeprazole the rapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying.2010
- Author(s)
  Futagami S, et al.
- Journal Title
  
  J of Gastroenterology
  
  Volume: 45 Pages: 413-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] An analysis of persistent symptoms in acid-suppressed patients with non-erosive reflux disease undergoing esophageal pH-impedance monitoring.2010
- Author(s)
  Iwakiri K, Sano H, Tanaka Y, Kawami N, Umezawa M, Iizumi T, Futagami S, Hoshihara Y, Nomura T, Miyashita M, Sakamoto C.
- Journal Title
  
  Nippon Shokakibyo Gakkai Zasshi 107
  
  Pages: 538-548
- NAID
  10026416955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying2010
- Author(s)
  Futagami S, Iwakiri K, Shindo T, Kawagoe T, Horie A, Shimpuku M, Tanaka Y, Kawami N, Gudis K, Sakamoto C
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Issue: 4 Pages: 413-421
- DOI
  10.1007/s00535-009-0173-0
- NAID
  10027215633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric PPI-r esistant NERD patients with delayed gastric emptying.2010
- Author(s)
  Futagami S, Iwakiri K, Shindo T, Kawagoe T, Horie A, Shimpuku M, Tanaka Y, Kawami N, Gudis K, Sakamoto C
- Journal Title
  
  J Gastroenterol 45
  
  Pages: 413-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia.2010
- Author(s)
  Futagami S, et al.
- Journal Title
  
  Am J Gastroenterol
  
  Volume: 105 Pages: 1835-1842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Characteristics of symptomatic reflux episodes in patients with non-erosivereflux disease who have a positive symptom index on proton pump inhibitor therapy2010
- Author(s)
  Iwakiri K, Sano H, Tanaka Y, Kawami N, Umezawa M, Futagami S, et al
- Journal Title
  
  Digestion
  
  Volume: 82(3) Issue: 3 Pages: 156-61
- DOI
  10.1159/000309483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils.2010
- Author(s)
  Futagami S, et al.
- Journal Title
  
  Digestion
  
  Volume: 81 Pages: 193-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Duodenogastric reflux induced by endoscopic submucosal dissection.2009
- Author(s)
  Miyake K, Kusunoki M, Shindo T, Ueki N, Kawagoe T, Gudis K, Tatsuguchi A, Futagami S, Tsukui T, Sakamoto C.
- Journal Title
  
  Endoscopy 41
  
  Pages: 934-940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Impact of quadruple regimen of clarithromycin added to metronidazole-containing triple therapy against Helicobacter infection following clarithromycin-containing triple-therapy failure.2009
- Author(s)
  Ueki N, Miyake K, Kusunoki M, Shindo T, Kawagoe T, Futagami S, Tsukui T, Inagaki H, Sakamoto C.
- Journal Title
  
  Helicobacter 14
  
  Pages: 91-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] MCP-1 and CD40 ligation have a synergistic effect on VEGF production through COX-2 upregulation in gastric cancer.2008
- Author(s)
  Futagami, S., Tatsuguchi, A., Hiratsuka, T., et. al.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 31-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids 78
  
  Pages: 137-146
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] MCP-1 and CD40 ligation have a synergistic effect on VEGF production through COX-2 upregulation in gastric cancer.2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 31-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] MCP-1 and CD40 ligation have a synergistic effect on VEGF production through COX-2 upregulation in gastric cancer2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 31-39
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells.2008
- Author(s)
  Futagami, S., et. al.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids 78
  
  Pages: 137-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Expression of apurinic/apyrimidinic endonuclease-1(APE-1)in H. pylori associated gastritis, gastric adenoma, and gastric cancer.2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  Helicobacter (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells.2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  Prostaglandins Leukot Essent Fatty Acids 78
  
  Pages: 137-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Expression of apurinic/apyrimidinic endonuclease-1(APE-1)in H.pylori associated gastritis,gastric adenoma,and gastric cancer2008
- Author(s)
  Futagami S, et. al.
- Journal Title
  
  Helicobacter (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Chemopreventative effect of celecoxib in gastric cancer.2007
- Author(s)
  Futagami S, Suzuki K, Hiratsuka T, et al.
- Journal Title
  
  Inflammopharmacology 15
  
  Pages: 1-4
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Helicobacter pylori infection induces accumulation of Vdelta 1 T cells via CCR2 upregulation2006
- Author(s)
  Futagami S, Hiratsuka T, Shindo T, et al.
- Journal Title
  
  Aliment Pharmacol Ther 2006 Suppl 4
  
  Pages: 8-15
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolina gerbils.2006
- Author(s)
  Futagami S, Suzuki K, Hiratsuka T, et al.
- Journal Title
  
  Digestion 74
  
  Pages: 187-198
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Gamma delta T cells increase with gastric mucosal interleukin(IL)-7, IL-1β and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis.2006
- Author(s)
  Futagami S, Hiratsuka T, Suzuki K, et al.
- Journal Title
  
  J Gastroenterol Heaptol 21
  
  Pages: 32-40
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma.2006
- Author(s)
  Tanaka S, Tatsuguchi A, Futagami S, et al.
- Journal Title
  
  Gut 55
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Gammadelta T cells increase with gastric mucosal interleukin(IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis.2006
- Author(s)
  Futagami, S., Hiratsuka, T., Suzuki, K., et. al.
- Journal Title
  
  Gastroenterol Hepatol 21
  
  Pages: 32-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation.2006
- Author(s)
  Futagami S, et al.
- Journal Title
  
  Alimentary pharmacology & Therapeutics (In press)
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Gamma delta T cells increase with gastric mucosal interleukin-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis.2006
- Author(s)
  Futagami S, et al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 21
  
  Pages: 32-40
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice.2005
- Author(s)
  Hiratsuka T, Futagami S, et al.
- Journal Title
  
  Scand J Gastroenterol 40
  
  Pages: 903-913
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Heregulin-alpha and heregulin beta expression is linked to a COX-2 PGE2 pathway in human gastric fibroblasts.2005
- Author(s)
  Nagata K, Wada K, Tatsuguchi A, Futagami S, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 15
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Rebamipide reduces indomethacin-induce gastrlc injury in mice via down-regulation of ICAM-1 expression.2005
- Author(s)
  Hiratsuka T, Futagami S, et al.
- Journal Title
  
  Dig Bis Sci 50
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils.
- Author(s)
  Futagami, S., Suzuki, K., Hiratsuka T, et. al.
- Journal Title
  
  Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Journal Article] Nizatidine improves clinical symptoms and gastric emptying in the patients with functional dyspepsia accompanying with impaired gastric emptying
- Author(s)
  Futagami S, et al
- Journal Title
  
  Digestion
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Journal Article] Nizatidine improves clinical symptoms and gastric emptying in the patients with functional dyspepsia accompanying with impaired gastric emptying
- Author(s)
  Futagami S, et al
- Journal Title
  
  Digestion
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] LPS 刺激urocortin 脳槽内投与ラットにおける消化管粘膜内炎症細胞浸潤の検討2018
- Author(s)
  酒瀬川典子、二神生爾
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 早期慢性膵炎および慢性膵炎疑診例に対する治療戦略-cross over試験の試み-2018
- Author(s)
  二神生爾、山脇博士、岩切勝彦
- Organizer
  第104回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 早期慢性膵炎と膵酵素異常を伴うFD 患者群の鑑別診断における早期胃排出能の有用性2018
- Author(s)
  阿川周平、山脇博士、二神生爾
- Organizer
  第104回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 早期慢性膵炎及び慢性膵炎疑診例に対する治療戦略～cross over 試験の試み～2018
- Author(s)
  山脇博士、二神生爾、岩切勝彦
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 早期慢性膵炎患者および機能性ディスペプシア患者を対象としたcamostat mesilate, pancrelipase, rabeprazole投与群との比較検討2018
- Author(s)
  二神生爾、山脇博士、岩切勝彦
- Organizer
  第15回　日本消化管学会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 早期慢性膵炎の膵酵素とEUS スコアの経年的変化―治療介入を通して―2018
- Author(s)
  樋口和寿、二神生爾
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09294
[Presentation] 食道癌組織においてROS刺激下に誘導されるApurinic/apyrimidinic endonuclease-1(APE-1)およびCOX-2発現意義の解析2013
- Author(s)
  名児耶浩幸、二神生爾、坂本長逸
- Organizer
  日本消化管学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] LPS前投与urocortin 1脳槽内投与ラットにおける胃排出能および小腸通過時間の比較検討2013
- Author(s)
  山脇博士，二神生爾，他.
- Organizer
  第50回日本臨床生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] FD患者におけるGN-βおよびghrelin の遺伝子多型と胃排出能との相関関係2013
- Author(s)
  新福摩弓，二神生爾、他
- Organizer
  第50回日本臨床生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] 機能性ディスペプシア患者における空腹感スコアとGHRL遺伝子多型との相関関係の検討2013
- Author(s)
  二神生爾，山脇博士，新福摩弓，他
- Organizer
  日本消化器病学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] CD44陽性胃癌幹細胞のCOX-2発現の解析2012
- Author(s)
  山脇博士，二神生爾，河越哲郎，小高康裕，名児耶浩幸，他
- Organizer
  日本ヘリコバクター学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] 機能性ディスペプシア患者における空腹感スコアとghrelin, preproghrelinの遺伝子多型との相関関係の解析2012
- Author(s)
  二神生爾、新福摩弓、坂本長逸
- Organizer
  第8回日本消化管学会総会
- Place of Presentation
  仙台
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 機能性ディスペプシア患者における空腹感スコアとghrelin, preproghrelinの遺伝子多型との相関関係の検討2012
- Author(s)
  二神生爾, 他
- Organizer
  第8回日本消化管学会
- Place of Presentation
  仙台
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] COX-2のSNPを用いたH. pylori胃炎患者のハイリスク群の絞り込みの検討2012
- Author(s)
  小高康裕、二神生爾、山脇博士、他
- Organizer
  日本消化器病学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] 食道癌組織におけるApurinic/apyrimidinic endonuclease-1発現意義の解析2012
- Author(s)
  名児耶浩幸、二神生爾、河越哲郎、小高康裕、新福摩弓, 他
- Organizer
  第8回日本消化管学会総会
- Place of Presentation
  仙台
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] FD患者における随伴症状としての胃食道逆流症状、睡眠障害と胃排出能との相関関係の解析2012
- Author(s)
  泉日輝、二神生爾, 他
- Organizer
  日本消化器病学会
- Place of Presentation
  博多
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 感染後FD患者における十二指腸粘膜局所の炎症細胞浸潤と胃排出能の解析2011
- Author(s)
  二神生爾、新福摩弓、坂本長逸
- Organizer
  第97回日本消化器病学会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 食道癌組織におけるapurinic/apyrimidinic endonuclease-1(APE-1)発現の解析2011
- Author(s)
  名児耶浩幸、二神生爾、河越哲郎、小高康裕、新福摩弓, 他
- Organizer
  第97回日本消化器病学会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] Celecoxib inhibits CD133-positive cell migration via reduction of CCR2 in Helicobacter pylori-infected Mongolian gerbils2011
- Author(s)
  Kodaka Y, Futagami S, et al
- Organizer
  Digestive Disease Week
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] H. pylori陽性胃炎患者に対するCOX-2遺伝子多型を用いたハイリスク群の絞り込みの検討2011
- Author(s)
  小高康裕、二神生爾、河越哲郎、名児耶浩幸、新福摩弓, 他
- Organizer
  第97回日本消化器病学会
- Place of Presentation
  東京
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] Migration of eosinophils and CCR2-/CD68-double positive cells into the duodenal mucosa of patients with post-infectious functional dyspepsia2011
- Author(s)
  Futagami S, Shimpuku M, Kawagoe T, Kusunoki M, et al
- Organizer
  Digestive Disease Week
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] Nizatidine administration improves clinical symptoms and gastric emptying of the patients with functional dyspepsia accompanying with impaired gastric emptying2011
- Author(s)
  Futagami S, Shimpuku M, Kodaka Y, et al.
- Organizer
  Digestive Disease Week
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] H. pylori胃癌モデルおよびヒト胃癌組織におけるCD133陽性細胞発現の検討2010
- Author(s)
  二神生爾, 他
- Organizer
  第16回日本ヘリコバクター学会
- Place of Presentation
  京都
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] H.pylori感染胃癌モデルおよびヒト胃癌組織におけるCD133陽性細胞発現の検討2010
- Author(s)
  二神生爾, 他
- Organizer
  ヘリコバクター学会
- Place of Presentation
  京都
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] クロスオーバー法を用いたニザチジンによるFD患者に対する臨床症状と胃排出能への影響の解析-2010
- Author(s)
  二神生爾、新福摩弓、河越哲郎、進藤智隆、楠正典、三宅一昌、岩切勝彦、坂本長逸
- Organizer
  第6回日本消化管学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 胃粘膜障害修復過程の解析-MCP-1刺激とCOX-2発現-2009
- Author(s)
  二神生爾、辰口篤志、河越哲郎、新福摩弓、進藤智隆、三宅一昌、坂本長逸
- Organizer
  第39回日本創傷治癒学会
- Place of Presentation
  サピアタワー (東京)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 選択的COX-2阻害剤celecoxibを用いたH.pylori感染胃癌モデルにおけるAPE-1および胃癌発生抑制の検討2009
- Author(s)
  二神生爾、河越哲郎、坂本長逸
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  北海道厚生年金会館 (札幌)
- Year and Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590796
[Presentation] 選択的COX-2阻害剤によるH.pylori感染胃癌モデルによるHPG発現抑制の検討2008
- Author(s)
  二神生爾, ほか
- Organizer
  日本消化管学会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Presentation] 選択的COX-2阻害剤を用いたcelecoxibによる胃癌発生抑制の検討2007
- Author(s)
  二神生爾, ほか
- Organizer
  第13回日本ヘリコバクター学会
- Place of Presentation
  大津
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Presentation] Apurinic/apyrimidinic endonucleas-1 (APE-1)によるSTAT 3を介した食道癌進展機構の解析
- Author(s)
  3.名児耶浩幸、二神生爾、坂本長逸
- Organizer
  第100回　日本消化器病学会
- Place of Presentation
  東京
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] H. pylori陽性胃炎患者におけるCOX-2のSNPを用いた除菌後ハイリスク群の絞込み
- Author(s)
  小高康裕、二神生爾、坂本長逸
- Organizer
  第100回　日本消化器病学会
- Place of Presentation
  東京
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] EPS-PDS overlap群における睡眠障害、QOL、胃排出能の比較検討の試み
- Author(s)
  2.山脇博士、二神生爾、新福摩弓、坂本長逸
- Organizer
  第46回胃病態機能研究会
- Place of Presentation
  横浜
- Year and Date
  2014-08-12 – 2014-08-13
- Data Source
  KAKENHI-PROJECT-24590928
[Presentation] Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation.
- Author(s)
  Futagami, S., Hiratsuka, T., et. al.
- Place of Presentation
  AGA, Los Angeles, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590686
[Presentation] ROS刺激下流の新規分子マーカー，apurinic/apyrimidinic endonuclease-1 (APE-1)を用いた食道癌進展および化学療法感受性の解析
- Author(s)
  名児耶浩幸，二神生爾，他
- Organizer
  第99回日本消化器病学会　大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590928

1. SAKAMOTO Choitsu (30196092)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
2. 屋嘉比康治 (90182295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Futagami Seiji 二神 生爾

FUTAGAMI Seiji 二神 生爾

二神 生爾 フタガミ セイジ

Research Projects

Research Products

Co-Researchers

CCR2/CD68 double positive cells were increased the expression levels of MBP protein in the duodenal mucosa of the FD patientsPrincipal Investigator

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Analysis of molecular mechanisms and ips genes in mesenchymal stem cells of the patients with advanced gastric cancer.Principal Investigator

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Analysis of homing system for bone marrow derived cells into gastric cancer tissues through MCP-1 stimulationPrincipal Investigator

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Investigation of APE-1 regulation induced by gamma/delta T cells in intestinal cellsPrincipal Investigator

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消化管上皮細胞を介した粘膜内T細胞への刺激伝達の解析Principal Investigator

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[Book] 症候群ハンドブック2011

Author(s)

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[Book] FD診察Q & A2011

Author(s)

Total Pages

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[Book] FD診察Q&A2011

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[Book] Helicobacter pylori感染の最近の知見-Helicobacter感染動物モデルの有用性2008

Author(s)

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Description

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[Book] Helicobacter pylori感染の最近の知見-Helicobacter感染動物モデルの有用性2008

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[Book] H.pylori除菌と消化性潰瘍・関連疾患-基礎と臨床研究のアップデート-胃粘膜中IL-7, IL-1beta発現とgamma delta T cell浸潤の検討2005

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[Journal Article] Camostat mesilate, pancrelipase and rabeprazole combination therapy improves epigastric pain in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme2018

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DOI

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[Journal Article] New classification Rome IV functional dyspepsia and subtypes2018

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[Journal Article] Comparison of clinical symptoms, gastric motility and fat intake in the early chronic pancreatitis patients with anti-acid therapy-resistant functional dyspepsia patients2018

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[Journal Article] Management of functional dyspepsia: state of the art and emerging therapies2018

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Futagami Seiji 二神生爾

FUTAGAMI Seiji 二神生爾

二神生爾フタガミセイジ