Takamatsu Yoshiki 高松芳樹

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TAKAMATSU Yoshiki 高松芳樹

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Researcher Number	50250204
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主任研究員
Affiliation (based on the past Project Information) *help	2015 – 2016: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 2014: 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 2000: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員 1999: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCE, STAFF SCIENTIST, 東京都神経科学総合研究所, 主事研究員 1999: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 主事研究員 … More 1995 – 1998: (財)東京都神経科学総合研究所, 神経細胞生物学研究部門, 主事研究員 1994: 東京都神経科学総合研究所, 細胞生物, 主事研究員 1993: 東京都神経科学総合研究所, 細胞生物, 研究員 1992: 東京都神経科学総合研究所, 遺伝学, 主事研究員 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology Except Principal Investigator Neurochemistry/Neuropharmacology
Keywords	Principal Investigator トランスジェニックフライ / CaMキナーゼII / ショウジョウバエ / 架橋剤 / 赤血球 / 重合開始メカニズム / 立体構造認識抗体 / 四量体 / Trap1 / シヌクレイン … More / ミトコンドリア / TRAP1 / テトラマー / パーキンソン病 / αシヌクレイン / 記憶学習 / FasII / Kenyon細胞 / 学習記憶 / 脳高次機能 / 単クローン抗体 / 発現解析 / キノコ体 / 転写活性化 / ルシフェラーゼアッセイ / lacZ遺伝子 / 転写制御領域 / 遺伝子発現 / 脳、神経系特異的 / in situハイブリダイゼーション法 / ゲルシフトアッセイ / 転写制御因子 / シスエレメント / LacZ遺伝子 / 神経系特異的遺伝子発現制御 … More Except Principal Investigator Drosophila / Activator / Repressor / Transcription / Helix-Loop-Helix / Neural development / ヘリックス・ループ・ヘリックス / 神経発生 / 転写調節 / シスエレメント / トランスジェニック / 脳神経系 / 転写 / 可塑性 / CaMキナーゼII / ショウジョウバエ / カルモデュリン / Differentiation / C2HC-type Zn finger / UAS / Gal4 / C2HC型Znフィンガー / dNZF-1 / 抹消神経系 / アクティベーター / Dnzf-1 / 中枢神経系 / 末梢神経系 / C2HCタイプZnフィンガー / アクティペーター / 転写因子 / 神経発生、分化 / WRPW motif / Corepressor / Schneider細胞 / ヘリックス・ループ・へリックス / WRPWモティーフ / アクティベータ- / コリプレッサー / リプレッサー / 高次機能 / キノコ体 / 組織特異性 / 発現 / 遺伝子発現 / プロテインキナーゼ / 発達過程 / 母体由来転写産物 / アイソフォーム / カムキナーゼII / 神経組織 / 胚発生 / スプライシング / CDNAの発現 / 遺伝子 / カルモデュリン依存性プロテインキナーゼ Less

Screening of molecules involved in the disease-associated conformational change of alpha-synuclein.Principal Investigator
- Principal Investigator
  
  TAKAMATSU Yoshiki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
CaMキナーゼIIリン酸化カスケード下流で発現が増加する可塑性遺伝子の同定Principal Investigator
- Principal Investigator
  
  高松芳樹
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
STUDIES ON THE MECHANISMS BY WHICH HELIX-LOOP-HELIX TRANSCRIPTION FACTORS REGULATE NEURAL DEVELOPMENT
- Principal Investigator
  
  OHSAKO Shunji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH
  Tokyo Metropolitan Institute for Neuroscience
神経可塑性におけるCaMキナーゼIIリン酸化カスケードの分子遺伝学的解析
- Principal Investigator
  
  大迫俊二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
CaMキナーゼIIの脳、神経系特異的転写制御因子の同定Principal Investigator
- Principal Investigator
  
  高松芳樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
THE MECHANISMS BY WHICH HELIX-LOOP-HELIX TRANSCRIPTION
- Principal Investigator
  
  OHSAKO Shunji
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCE
神経可塑性におけるCaMキナーゼIIリン酸化カスケードの分子遺伝子的解析
- Principal Investigator
  
  大迫俊二
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
CaMキナーゼIIの脳、神経系特異的な発現調節機構の解析Principal Investigator
- Principal Investigator
  
  高松芳樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
ショウジョウバエを用いたカルモデュリン依存性ブロテインキナーゼIIの機能解析
- Principal Investigator
  
  山内卓
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ショウジョウバエを用いたカルモデュリン依存性プロテインキナーゼIIの機能解析
- Principal Investigator
  
  山内卓
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ショウジョウバエを用いたカルモデュリン依存性プロテインキナーゼIIの機能解析
- Principal Investigator
  
  山内卓
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience

All 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] 脳内環境辞典2017
- Author(s)
  高松芳樹、小池和佳子、藁谷正明、杉野弘、橋本款
- Total Pages
  2
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26640033
[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014
- Author(s)
  高松芳樹、関山一成、橋本款
- Total Pages
  566
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-26640033
[Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016
- Author(s)
  Sekiyama K, Takamatsu Y, Koike W, Waragai M, Takenouchi T, Sugama S, Hashimoto M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: in press Issue: 3 Pages: 831-841
- DOI
  10.3233/jad-151015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K09820
[Journal Article] Protection against neurodegenerative diseases on Earth and in space2016
- Author(s)
  Takamatsu Y, Koike W, Takenouchi T, Sugama S, Waragai M, Wei J, Sekiyama K,Hashimoto M.
- Journal Title
  
  npj Microgravity
  
  Volume: 2 Issue: 1 Pages: 16013-16013
- DOI
  10.1038/npjmgrav.2016.13
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033
[Journal Article] Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer’s Disease.2016
- Author(s)
  Waragai M, Adame A, Trinh I, Sekiyama K, Takamatsu Y, Une K, Masliah E, Hashimoto M
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: in press Issue: 4 Pages: 1453-1459
- DOI
  10.3233/jad-151116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-15K09820
[Journal Article] Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease2016
- Author(s)
  Sugama S, Sekiyama K, Kodama T, Takamatsu Y, Takenouchi T, Hashimoto M, Conti B, Kakinuma Y
- Journal Title
  
  Brain Behav Immun
  
  Volume: 51 Pages: 39-46
- DOI
  10.1016/j.bbi.2015.08.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06783, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25460333, KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-16K08560
[Journal Article] Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases.2016
- Author(s)
  Takamatsu Y, Ho G, Koike W, Sugama S, Takenouchi T, Waragai M, Wei J, Sekiyama K, Hashimoto M.
- Journal Title
  
  npj Parkinson’s Disease
  
  Volume: 3 Issue: 1 Pages: 4-4
- DOI
  10.1038/s41531-016-0001-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-15K06783
[Journal Article] Role of α- and β-synucleins in the axonal pathology of Parkinson’s disease and related　synucleinopathies.2015
- Author(s)
  Akio Sekigawa, Yoshiki Takamatsu, Kazunari Sekiyama, Makoto Hashimoto
- Journal Title
  
  Biomolecules
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640033
[Journal Article] Role of α- and β-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.2015
- Author(s)
  Sekigawa A, Takamatsu Y, Sekiyama K, Hashimoto M.
- Journal Title
  
  Biomolecules.
  
  Volume: 5 Issue: 2 Pages: 1000-1011
- DOI
  10.3390/biom5021000
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26640033, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25290019
[Journal Article] Role of genomics in translational research for Parkinson's disease.2014
- Author(s)
  Sekiyama, K., Takamatsu, Y., Waragai, M., Hashimoto, M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 452 (2) Issue: 2 Pages: 226-235
- DOI
  10.1016/j.bbrc.2014.06.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25290019, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-26640033
[Journal Article] Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathie2014
- Author(s)
  Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada A, Masliah E, Hashimoto M
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 1 Issue: 7 Pages: 479-489
- DOI
  10.1002/acn3.77
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249040, KAKENHI-PROJECT-25640030, KAKENHI-PROJECT-25830044, KAKENHI-PROJECT-26640033
[Presentation] Possible involvement of adiponectin in the pathogenesis of Alzheimer’s disease.2016
- Author(s)
  Hashimoto M. Takamatsu Y, Masliah E, Waragai M
- Organizer
  第51回日本神経科学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] シヌクレイノパチーの病態に対する重力の影響2016
- Author(s)
  橋本款、高松芳樹
- Organizer
  第35回日本認知症学術集会
- Place of Presentation
  東京国際フォ－ラム（東京都千代田区）
- Year and Date
  2016-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] α及びβシヌクレインを共発現させたトランスジェニックフライモデルでの網羅的トランスクリプトーム解析2016
- Author(s)
  高松芳樹、小池和佳子、本多芳子、児玉亨、井上聡、橋本款
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] レビー小体型認知症で同定された２種類の変異型β シヌクレイン（P123H 、V70M ）は、ショウジョウバエ脳において異なるメカニズムで神経変性を引き起こす2015
- Author(s)
  高松芳樹、関山一成、井上聡、本多芳子、児玉亨、橋本款
- Organizer
  第３８回日本分子生物学会年会第８８回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] Adiponectin, the anti-diabetic adipokine, has a therapeutic effect in models of α-synucleinopathies.2015
- Author(s)
  Sekiyama, K., Waragai, M., Takamatsu, Y., Hashimoto, M.
- Organizer
  ADPD 2015
- Place of Presentation
  ニース（フランス）
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] P3-325 Disease Modifying Effect of Adiponectin in a Model of α-Synucleinopathies in Vitro and in Vivo.2015
- Author(s)
  Masaaki Waragai, Kazunari Sekiyama, Yoshiki Takamatsu, Masayo Fujita, Akio Sekigawa, Naomichi Iwai, Edward Rockenstein, Satoshi Inoue, Albert R. La Spada, Elizer Masliah, Makoto Hashimoto
- Organizer
  Alzheimer's Association International Conference (AAIC2015)
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] レビー小体型認知症で見出された変異型βシヌクレインを発現するショウジョウバエは神経変性様表現型を示す2014
- Author(s)
  高松芳樹、関山一成、本多芳子、児玉亨、橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26640033
[Presentation] アディポネクチンはα-シヌクレイノパチー細胞モデルのインスリンシグナルを亢進し神経変性の病態を改善する2014
- Author(s)
  関山一成，高松芳樹，橋本款
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-26640033

1. OHSAKO Shunji (50152103)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 山内卓 (90041813)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAKENOUCHI Takato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SUGAMA Syuei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 橋本款

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
6. 井上聰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 柿沼由彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. Conti Bruno

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takamatsu Yoshiki 高松 芳樹

TAKAMATSU Yoshiki 高松 芳樹

Research Projects

Research Products

Co-Researchers

Screening of molecules involved in the disease-associated conformational change of alpha-synuclein.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CaMキナーゼIIリン酸化カスケード下流で発現が増加する可塑性遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDIES ON THE MECHANISMS BY WHICH HELIX-LOOP-HELIX TRANSCRIPTION FACTORS REGULATE NEURAL DEVELOPMENT

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

神経可塑性におけるCaMキナーゼIIリン酸化カスケードの分子遺伝学的解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

CaMキナーゼIIの脳、神経系特異的転写制御因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE MECHANISMS BY WHICH HELIX-LOOP-HELIX TRANSCRIPTION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経可塑性におけるCaMキナーゼIIリン酸化カスケードの分子遺伝子的解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

CaMキナーゼIIの脳、神経系特異的な発現調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ショウジョウバエを用いたカルモデュリン依存性ブロテインキナーゼIIの機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ショウジョウバエを用いたカルモデュリン依存性プロテインキナーゼIIの機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ショウジョウバエを用いたカルモデュリン依存性プロテインキナーゼIIの機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] 脳内環境辞典2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 遺伝子治療・診断の最先端技術と新しい医薬品・診断薬の開発2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Insight into the dissociation of behavior from histology in Synucleinopathies and in related neurodegenerative diseases2016

Author(s)

Journal Title

DOI

Takamatsu Yoshiki 高松芳樹

TAKAMATSU Yoshiki 高松芳樹

[Journal Article] Role of α- and β-synucleins in the axonal pathology of Parkinson’s disease and related　synucleinopathies.2015