OKI SHINJI 大木伸司

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Oki Shinji 大木伸司

OKI Shinji 大木伸司

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Researcher Number	50260328
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 特任研究室長
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 特任研究室長 2018 – 2024: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長 2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長 … More 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第六部, 第三研究室長 2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 第三研究室長 2009: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第六部, 第三研究室長 2008: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第六部, 第三室長 2007 – 2008: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第六部, 室長 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 51:Brain sciences and related fields / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 自己免疫疾患 / NR4A2 / 核内受容体 / 慢性炎症 / 実験的自己免疫性脳脊髄炎 / バイオマーカー / インターロイキン17 / 多発性硬化症 / Th17細胞 / 自己反応性T細胞 … More / 膠原病 / 異所性プロラクチン / 免疫就職 / 非下垂体性プロラクチン / 病原性T細胞 / 中枢神経疾患 / 非下垂体性 / 自己反応性Th細胞 / Eomes陽性Th細胞 / 抗原提示細胞 / 下垂体 / プロラクチン / インターロイキン１７ / 病態多様性 / 炎症性ミエロイド細胞 / 細胞間相互作用 / 糖脂質 / アレルギー疾患 / IL-17 / レチノイン酸 / サイトカイン / NKT細胞 / 免疫学 … More Except Principal Investigator Eomes陽性Th細胞 / UPS / FMRP / Fmr1 / miR199 / マイクロRNA / アンチエイジング / 細胞外マイクロRNA / 機能性核酸 / 老化 / NRP1陽性Th細胞 / 神経免疫 / Th17細胞 / 甲状腺ホルモン / EAE / 神経・内分泌・免疫制御 / 神経・免疫・内分泌連関 / 中枢神経慢性炎症 / 神経・免疫・内分泌相関 / 内分泌性制御因子 / Eomes+ Th細胞 / プロラクチン / 環境因子 / 内分泌性免疫制御因子 / 免疫性神経疾患 Less

L1レトロ転移を介したS期神経細胞の合成致死性の研究Principal Investigator
- Principal Investigator
  
  大木伸司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  National Center of Neurology and Psychiatry
Neuroinflammatory and degenerative pathogenesis mediated by new T cell subsets
- Principal Investigator
  
  山村隆
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  National Center of Neurology and Psychiatry
Identification of extracellular microRNAs in the blood associated with aging and development of anti-aging functional nucleic acids
- Principal Investigator
  
  北條浩彦
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
  National Center of Neurology and Psychiatry
Functional significance of non-pituitary prolactin on autoimmune diseases in the central nervous systemPrincipal Investigator
- Principal Investigator
  
  Oki Shinji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  National Center of Neurology and Psychiatry
Cross-talk between endocrine and environmental factors in neuroimmune disorders
- Principal Investigator
  
  Yamamura Takashi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Center of Neurology and Psychiatry
Analyses of cellular component involved in heterogeneous inflammatory pathogenesis of autoimmne diseases in the CNSPrincipal Investigator
- Principal Investigator
  
  OKI SHINJI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Center of Neurology and Psychiatry
NR4A2-mediated regulation of IL-17-producing T cells for novel therapeutic strategy of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  OKI Shinji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Center of Neurology and Psychiatry
Immunoregulatory roles of glycolipid ligand-stimulated natural killer T cellsPrincipal Investigator
- Principal Investigator
  
  OKI Shinji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Center of Neurology and Psychiatry

[Book] 臨床免疫・アレルギー科　第76巻第5号2021
- Author(s)
  大木伸司
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K07895
[Book] 創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術2021
- Author(s)
  大木伸司
- Total Pages
  12
- Publisher
  技術情報協会
- ISBN
  4861048567
- Data Source
  KAKENHI-PROJECT-20K07895
[Book] 実験医学増刊 Vol.39 No.15 神経免疫メカニズムと疾患2021
- Author(s)
  大木伸司
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  4758103976
- Data Source
  KAKENHI-PROJECT-20K07895
[Book] 臨床免疫・アレルギー科2020
- Author(s)
  大木伸司
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K07895
[Book] Chembiomolecular Science: At the Frontier of Chemistry and Biology2012
- Author(s)
  2. Oki S., Raveney B.J.E., Yamamura T
- Total Pages
  7
- Publisher
  Springer, Tokyo
- Data Source
  KAKENHI-PROJECT-24590108
[Book] サイトカインネットワークのパラダイムシフト Frontiers in Rheumatology & Clinical Immunology 第1巻第2号2008
- Author(s)
  大木伸司
- Data Source
  KAKENHI-PROJECT-19590095
[Book] 初めての国際学会と英語プレゼンテーション Frontiers in Rheumatology & Clinical Immunology第3巻第2号2008
- Author(s)
  大木伸司
- Data Source
  KAKENHI-PROJECT-19590095
[Book] 生化学辞典(第4版)2008
- Author(s)
  大木伸司
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-19590095
[Book] Topics/Review : 多発性硬化症の新しい治療戦略HUMAN SCIENCE(ヒューマンサイエンス振興財団編)第19巻第4号2008
- Author(s)
  大木伸司、山村隆
- Data Source
  KAKENHI-PROJECT-19590095
[Book] 改変糖脂質抗原によるNKT細胞を介した免疫制御生化学(日本生化学会編)第79巻2007
- Author(s)
  大木伸司
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Pathogenic Potential of Eomesodermin‐Expressing T‐Helper Cells in Neurodegenerative Diseases2024
- Author(s)
  Kanazawa Tomomi、Sato Wakiro、Raveney Ben J.E.、Takewaki Daiki、Kimura Atsuko、Yamaguchi Hiromi、Yokoi Yuma、Saika Reiko、Takahashi Yuji、Fujita Tsuneo、Saiki Shinji、Tamaoka Akira、Oki Shinji、Yamamura Takashi
- Journal Title
  
  Annals of Neurology
  
  Volume: - Issue: 6 Pages: 1093-1098
- DOI
  10.1002/ana.26920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24802
[Journal Article] Neuropilin‐1 (<scp>NRP1</scp>): A new marker for pathogenic autoreactive T‐helper cells in autoimmune disease2023
- Author(s)
  Raveney Ben J. E.、Yamamura Takashi、Oki Shinji
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 14 Issue: 3 Pages: 126-127
- DOI
  10.1111/cen3.12751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24802
[Journal Article] Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells2023
- Author(s)
  Zhang Chenyang、Raveney Ben、Takahashi Fumio、Yeh Tzu-wen、Hohjoh Hirohiko、Yamamura Takashi、Oki Shinji
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 6 Pages: 868-868
- DOI
  10.3390/cells12060868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04045, KAKENHI-PROJECT-20K07775, KAKENHI-PROJECT-20K07895, KAKENHI-PROJECT-21K20787, KAKENHI-PROJECT-23K24802
[Journal Article] Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease.2022
- Author(s)
  Raveney BJ, El-Darawish Y, Sato W, Arinuma Y, Yamaoka K, Hori S, Yamamura T, Oki S
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 14 Issue: 10 Pages: 1-20
- DOI
  10.15252/emmm.202215864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19422, KAKENHI-PLANNED-22H05191, KAKENHI-PROJECT-18H04045, KAKENHI-PROJECT-21H04801, KAKENHI-PROJECT-20K07775, KAKENHI-PROJECT-20K07895
[Journal Article] Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-12022
- Author(s)
  Takahashi Fumio、Zhang Chenyang、Hohjoh Hirohiko、Raveney Ben、Yamamura Takashi、Hayashi Nobuhiro、Oki Shinji
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 5 Pages: 104278-104278
- DOI
  10.1016/j.isci.2022.104278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16294, KAKENHI-PROJECT-20K07895, KAKENHI-PROJECT-20K07775, KAKENHI-PROJECT-23K24802
[Journal Article] Involvement of cytotoxic Eomes-expressing CD4+ T cells in secondary progressive multiple sclerosis2021
- Author(s)
  Raveney Ben J. E.、Sato Wakiro、Takewaki Daiki、Zhang Chenyang、Kanazawa Tomomi、Lin Youwei、Okamoto Tomoko、Araki Manabu、Kimura Yukio、Sato Noriko、Sano Terunori、Saito Yuko、Oki Shinji、Yamamura Takashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 11 Pages: 2021818118-2021818118
- DOI
  10.1073/pnas.2021818118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07775, KAKENHI-PROJECT-20K07895, KAKENHI-PROJECT-20K16294, KAKENHI-PROJECT-18H04045
[Journal Article] An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation2021
- Author(s)
  Inoue Yukiko U.、Morimoto Yuki、Yamada Mayumi、Kaneko Ryosuke、Shimaoka Kazumi、Oki Shinji、Hotta Mayuko、Asami Junko、Koike Eriko、Hori Kei、Hoshino Mikio、Imayoshi Itaru、Inoue Takayoshi
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 5 Pages: 1076-1076
- DOI
  10.3390/cells10051076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-INTERNATIONAL-16K21734, KAKENHI-PUBLICLY-19H04895, KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K06667, KAKENHI-PROJECT-20K07895, KAKENHI-PROJECT-20H02932
[Journal Article] Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating chronic neuroinflammation2019
- Author(s)
  Zhang C, Raveney BJE, Hohjoh H, Tomi C, Oki S, ＆ Yamamura T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 42 Pages: 21131-21139
- DOI
  10.1073/pnas.1906438116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04045
[Journal Article] Eomes-expressing T-helper cells as potential target of therapy in chronic neuroinflammation2018
- Author(s)
  Oki S
- Journal Title
  
  Neurochem Int
  
  Volume: S0197-0186 (18) Pages: 30302-4
- DOI
  10.1016/j.neuint.2018.11.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04045
[Journal Article] Towards understanding the role of orphan nuclear receptor NR4A2 in Th17 cell- mediated CNS autoimmunity: An experimental approach employing an animal model of multiple sclerosis.2014
- Author(s)
  Shinji Oki
- Journal Title
  
  Clin. Exp. Neuroimmunol.
  
  Volume: 5 Pages: 137-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590108
[Journal Article] 多発性硬化症の動物モデル; 横断的アプローチによる病態解明と治療標的の探索2014
- Author(s)
  大木　伸司、山村　隆
- Journal Title
  
  日本臨床
  
  Volume: 72 Pages: 1935-1940
- Data Source
  KAKENHI-PROJECT-24590108
[Journal Article] NR4A2 orchestrates pathogenic Th17 development and initiates autoimmune inflammation2013
- Author(s)
  Raveney, B.J.E
- Journal Title
  
  PLOS ONE
  
  Volume: 8 Issue: 2 Pages: e56595-e56595
- DOI
  10.1371/journal.pone.0056595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229006, KAKENHI-PROJECT-24590108
[Journal Article] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica.2013
- Author(s)
  Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamoto T, Murata M, Toda T, Miyake S, Yamamura T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e83036-e83036
- DOI
  10.1371/journal.pone.0083036
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23390261, KAKENHI-PROJECT-24590108
[Journal Article] 多発性硬化症の自己免疫病態と新規治療戦略2010
- Author(s)
  大木伸司
- Journal Title
  
  ファルマシア(日本薬学会編)
  
  Volume: 46 Pages: 745-749
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] 多発性硬化症における病原性T細胞のサイトカイン産生制御機構2010
- Author(s)
  大木伸司
- Journal Title
  
  生化学(日本生化学会編)
  
  Volume: 82 Pages: 745-750
- NAID
  130006948538
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] Ustekinumabの有効性と疾患2010
- Author(s)
  吉村元、大木伸司
- Journal Title
  
  Frontiers in Rheumatology & Clinical Immunology
  
  Volume: 4 Pages: 57-60
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] Ustekinumabの有効性と疾患Frontiers in2010
- Author(s)
  吉村元、大木伸司
- Journal Title
  
  Rheumatology & Clinical Immunology
  
  Volume: 4 Pages: 57-60
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] Retinoid signals and Th17-mediated pathology2009
- Author(s)
  Christian Klemann, Benjamin JE Raveney, Shinji Oki and Takashi Yamamura
- Journal Title
  
  日本臨床免疫学会会誌 32巻1号
  
  Pages: 20-28
- NAID
  10024961769
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE2009
- Author(s)
  Christian Klemann, Benjamin JE Raveney, Anna K Klemann, Tomoko Ozawa, Stephan von Horsten, Koichi Shudo, Shinji Oki, Takashi Yamamura
- Journal Title
  
  Am. J. Pathol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Identification of a possible therapeutic target through pathogenic T cell analysis of multiple sclerosis2009
- Author(s)
  Shinji Oki and Takashi Yamamura
- Journal Title
  
  日本臨床免疫学会会誌印刷中
  
  Pages: 0-0
- NAID
  10026352065
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE Am2009
- Author(s)
  Klemann C, Raveney BJE, Klemann AK, Ozawa T, von Horsten S, Shudo K, Oki S, Yamamura T
- Journal Title
  
  J. Pathol
  
  Volume: 174 Pages: 2234-45
- URL
  http://www.sciencedirect.com/science/article/pii/S0002944010610826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora2008
- Author(s)
  Hiroaki Yokote, Sachiko Miyake, J. Ludovic Croxford, Shinji Oki, Hidehiro Mizusawa, and Takashi Yamamura
- Journal Title
  
  Am. J. Pathol. 173
  
  Pages: 1714-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora2008
- Author(s)
  Hiroaki Yokote, Sachiko Miyake, John L. Croxford, Shinji Oki, Hidehiro Mizusawa, Takashi Yamamura
- Journal Title
  
  Am. J. Pathol. 173
  
  Pages: 1714-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines2008
- Author(s)
  Yoshimitsu Doi, Shinji Oki, Tomoko Ozawa, Hirohiko Hohjoh, Sachiko Miyake, Takashi Yamamura
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 8381-8386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines2008
- Author(s)
  Yoshimitsu Doi, Shinji Oki, Tomoko Ozawa, Hirohiko Hohjoh, Sachiko Miyake, and Takashi Yamamura
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 8381-8386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Invariant NKT cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation.2007
- Author(s)
  Kaori Sakuishi, Shinji Oki, Manabu Araki, Steven A. Porcelli, Sachiko Miyake, Takashi Yamamura
- Journal Title
  
  J. Immunol. 179
  
  Pages: 3452-3462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Journal Article] Versatile orphan nuclear receptor NR4A2 as a promising molecular target for multiple sclerosis and other autoimmune diseases
- Author(s)
  Oki S, Raveney BJE, Doi Y, Yamamura T
- Journal Title
  
  Uehara Memorial Foundation Proceedings ; Chembiomolecular Science : at the Frontier of Chemistry and Biology
  
  Volume: 2,012(印刷中)
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] Versatile orphan nuclear receptor NR4A2 as a promising molecular target for multiple sclerosis and other autoimmune diseases
- Author(s)
  Oki S, Raveney BJE, Doi Y, Yamamura T
- Journal Title
  
  Uehara Memorial Foundation Proceedings ; Chembiomolecular Science : at the Frontier of Chemistry and Biology
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-21590087
[Journal Article] Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE
- Author(s)
  Christian Klemann, Benjamin JE Raveney, Anna K Klemann, Tomoko Ozawa, Stephan von Horsten, Koichi Shudo, Shinji Oki, Takashi Yamamura
- Journal Title
  
  Am. J. Pathol. 印刷中
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590095
[Patent] 自己免疫疾患阻害剤2021
- Inventor(s)
  大木　伸司、ベン・レイバニー、山村　隆
- Industrial Property Rights Holder
  国立研究開発法人国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07895
[Patent] 多発性硬化症抑制剤2018
- Inventor(s)
  大木　伸司、山村　隆、佐藤和貴郎、ベン・レイバニー
- Industrial Property Rights Holder
  国立精神・神経医療センター
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H04045
[Patent] 進行型免疫性脱髄疾患治療剤2015
- Inventor(s)
  大木　伸司、山村　隆
- Industrial Property Rights Holder
  独立行政法人国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-006142
- Filing Date
  2015-01-15
- Data Source
  KAKENHI-PROJECT-24590108
[Patent] 進行型免疫性脱髄疾患治療剤2014
- Inventor(s)
  大木　伸司、北條　浩彦、山村　隆
- Industrial Property Rights Holder
  独立行政法人国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-135630
- Filing Date
  2014-07-01
- Data Source
  KAKENHI-PROJECT-24590108
[Patent] IL-17に起因する炎症を改善するための医薬組成物2008
- Inventor(s)
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Rights Holder
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Number
  2009-501299
- Filing Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-21590087
[Patent] IL-17産生抑制物質及びそのスクリーニング方法2008
- Inventor(s)
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Rights Holder
  (財)ヒューマンサイエンス振興財団
- Patent Publication Number
  2008-211985
- Filing Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-19590095
[Patent] IL-17に起因する炎症を改善するための医薬組成物2008
- Inventor(s)
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Rights Holder
  (財)ヒューマンサイエンス振興財団
- Filing Date
  2008-02-28
- Data Source
  KAKENHI-PROJECT-19590095
[Patent] IL-17産生抑制物質及びそのスクリーニング方法2007
- Inventor(s)
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Rights Holder
  大木伸司、北條浩彦、三宅幸子、山村隆
- Industrial Property Number
  2007-049768
- Filing Date
  2007-02-28
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Critical roles of IFN-I- and MHC-II-associated microglia on the development and regulation of Eomes-expressing helper T cells under neurodegeneration2024
- Author(s)
  Tzu-wen Yeh, Chenyang Zhang, Ben Raveney, Fumio Takahashi, Marco Prinz, Takashi Yamamura, Shinji Oki1
- Organizer
  第46回日本免疫学会学術集会、千葉
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] NRP-1+ helper T cells promote the expansion of CD11c+ B cells and orchestrate IgG antibody-mediated autoimmune diseases2024
- Author(s)
  Eiichiro Amano, Ben JE Raveney, Takashi Yamamura, Shinji Oki
- Organizer
  第46回日本免疫学会学術集会、千葉
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] L1レトロ転移を介した成熟神経細胞の細胞周期依存的な自律的細胞死の分子機序の解析2023
- Author(s)
  髙橋文緒、張　晨陽、山村　隆、大木伸司
- Organizer
  第46回日本分子生物学会年会、神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] 神経変性病態の形成過程における免疫依存性神経細胞障害の意義2023
- Author(s)
  大木伸司
- Organizer
  第35回日本神経免疫学会学術集会、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] Immune-mediated neuron cell death and its relevance to pathogenesis of neurodegenerative diseases.2023
- Author(s)
  Shinji Oki
- Organizer
  第64回日本神経学会学術大会、千葉
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] 膠原病モデルマウスを用いた自己反応性ヘルパーT細胞の選択的バイオマーカーの探索2023
- Author(s)
  大木伸司
- Organizer
  第35回日本神経免疫学会学術集会、東京
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] Multilayered neuronal disorders caused by derepression of LINE-12023
- Author(s)
  Fumio Takahashi, Chenyang Zhang, Takashi Yamamura, Shinji Oki
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会、神戸
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] Regulation of CD11c+B cell by NRP-1+ T-helper cells in an animal model of autoimmune diseases2023
- Author(s)
  Eiichiro Amano, Ben JE Raveney, Takanori Yokota, Takashi Yamamura, Shinji Oki
- Organizer
  第64回日本神経学会学術大会、千葉
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] 神経変性疾患の病態形成に関わる免疫依存性神経細胞障害の分子機序2022
- Author(s)
  大木　伸司、張　晨陽、北條浩彦、Ben Raveney、山村　隆、林　宣宏、高橋　文緒
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Targeting lymphocytes in SPMS: Th cells populations as a biomarker to predict efficacy of Siponimod2022
- Author(s)
  Ben JE Raveney, A. Katsumoto, R. Kurosawa, Y. Lin, Y. Takahashi, T. Okamoto, S. Oki, W. Sato, T. Yamamura
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Pathogenic mechanism of immune-mediated neurotoxicity and its relevance to neurodegenerative diseases2022
- Author(s)
  Fumio Takahashi, C. Zhang, H. Hohjoh, B. Raveney, T. Yamamura, N. Hayashi, S. Oki
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Gut microbiota regulated miRNA disturbs BBB integrity in EAE.2022
- Author(s)
  Manu Mallahalli, Hirohiko Hohjoh, Wakiro Sato, Shinji Oki, Takashi Yamamura.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24802
[Presentation] Induction of Eomes-expressing Th cells via upregulation of type I interferon2022
- Author(s)
  Yeh Tzu-wen, C. Zhang, B. Raveney, F. Takahashi, M. Prinz, T. Yamamura, S. Oki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Immune cell profiles as biomarkers in treatment of SPMS with Siponimod: towards precision medicine2022
- Author(s)
  Ben JE Raveney, A. Katsumoto, R. Kurosawa, Y. Lin, Y. Takahashi, T. Okamoto, S. Oki, W. Sato, T. Yamamura
- Organizer
  PACTRIMS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] 免疫依存性神経細胞障害におけるレトロトランスポゾンLINE-1活性化の意義2022
- Author(s)
  高橋文緒、山村　隆、大木伸司
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Investigating the relation ship between Siponimod efficacy in Secondary progressive multiple sclerosis and pathogenic Th cell populations2022
- Author(s)
  Ben JE Raveney, A. Katsumoto, R. Kurosawa, Y. Lin, Y. Takahashi, T. Okamoto, S. Oki, W. Sato, T. Yamamura
- Organizer
  ECTRIMS 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Nrp-1 marks a pathogenic self-reactive Th subset in autoimmune disease2022
- Author(s)
  Ben JE Raveney, S. Hori, W. Sato, T. Yamamura, S. Oki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Disease-associated microglia as a pathogenic hub in immune cell-mediated neurodegeneration.2021
- Author(s)
  Shinji Oki, Ben Raveney, Fumio Takahashi, Takashi Yamamura, Chenyang Zhang
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Biomarkers for precision medicine of MS/NMO2021
- Author(s)
  Yamamura T, Raveney, B., Sato, W., and Oki, S
- Organizer
  20th Annual Congress. Israel Society of Neuroimmunology. Joint Meeting with the Japanese Society of Neuroimmunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] Pathogenic mechanism of immune-mediated neurotoxicity and its relevance to neurodegenerative diseases.2021
- Author(s)
  Fumio Takahashi, Chenyang Zhang, Hirohiko Hohjoh, Ben Raveney, Takashi Yamamura, Nobuhiro Hayashi, Shinji Oki
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] Eomes-expressing T cells in secondary progressive multiple sclerosis2021
- Author(s)
  Yamamura T, and Oki S
- Organizer
  PACTRIMS 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] 神経変性病態における免疫依存性神経細胞障害機序の解明2020
- Author(s)
  大木伸司、張晨陽、山村　隆
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] 進行型多発性硬化症の動物モデルとその応用2020
- Author(s)
  山村隆, 大木伸司, Ben Raveney
- Organizer
  第38回日本神経治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] 神経変性病態に伴う慢性炎症環境の分子機序の解明2020
- Author(s)
  大木伸司、張晨陽、山村　隆
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07895
[Presentation] MS/EAEの病態に関わるヘルパーT細胞の病原性を規定する因子の探索2019
- Author(s)
  大木伸司，Ben Raveney，山村隆
- Organizer
  第31回日本神経免疫学会・学術集会
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] Immunological aspects of a possible biomarker and therapeutic target for secondary progressive multiple sclerosis2019
- Author(s)
  Oki S
- Organizer
  Neuro2019 (第42回日本神経科学大会・第62回日本神経化学会大会合同学会)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] Extrapituitary prolactin promotes the generation of Eomes-positive helper T cells mediating chronic neuroinflammation2019
- Author(s)
  Zhang C, Raveney B, Oki S, Yamamura T
- Organizer
  17th International Congress of Immunology (IUIS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] Extrapituitary prolactin promotes the generation of Eomes-positive helper T cells mediating chronic neuroinflammation2018
- Author(s)
  Chenyang Zhang, Ben J.E. Raveney, Shinji Oki, and Takashi Yamamura
- Organizer
  第47回日本免疫学会学術集会．福岡
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] Increases in Eomes-expressing Th cells in secondary progressive multiple sclerosis reveal patients at risk of increased disability2018
- Author(s)
  Ben JE Raveney, Wakiro Sato, Daiki Takewaki, Youwei Lin, Tomoko Okamoto, Manabu Araki, Shinji Oki and Takashi Yamamura
- Organizer
  14th ISNI．Brisbane
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] ncreases in Eomes-expressing Th cells in secondary progressive multiple sclerosis reveal patients at risk of Increased disability2018
- Author(s)
  Ben Raveney, Wakiro Sato, Daiki Takewaki, Youwei Lin, Tomoko Okamoto, Manabu Araki, Shinji Oki, Takashi Yamamura
- Organizer
  FOCIS2018．San Francisco
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] 二次進行型多発性硬化症の病態とEomes陽性Th細胞2018
- Author(s)
  山村隆、佐藤和貴郎、大木伸司
- Organizer
  第36回日本神経治療学会学術集会．東京
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] 新規動物モデルを用いた慢性進行型多発性硬化症の創薬研究2018
- Author(s)
  大木伸司
- Organizer
  第59回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04045
[Presentation] 中枢神経系の炎症性自己免疫病態形成に関わる病原性T細胞群の解析2013
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  海峡メッセ下関、山口
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] NR4A2 controls distinct populations of Th17 cells2013
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  13th Annual Conference of FOCIS (FOCIS2013)
- Place of Presentation
  The Boston Seaport Hotel and World Trade Center, Boston, USA
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] Acute autoimmune inflammation of the central nervous system is controlled by 2 waves of T cells: acute NR4A2-dependent and chronic NR4A2-independent2013
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] NR4A2 Modulation during Autoimmune Inflammation of the Central Nervous System Reduces Pathogenic T cell Responses and Ameliorates Clinical Disease2013
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  PACTRIMS2013
- Place of Presentation
  The Westin Miyako Kyoto Hotel, Kyoto, JAPAN
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] 病原性IL-17産生T細胞のNR4A2発現維持に関わる細胞間相互作用2013
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  第25回日本神経免疫学会総会
- Place of Presentation
  海峡メッセ下関、山口
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] Activated Plasmablasts Migrate to the Central Nervous System2012
- Author(s)
  Chihara N., S. Oki, T. Matsuoka, W. Sato, Y. Lin, T. Okamoto, M. Ogawa, T. Toda, S. Miyake, T. Aranami, T. Yamamura
- Organizer
  12th Annual Conference of FOCIS (FOCIS2012)
- Place of Presentation
  Vancouver Convention Centre, Vancouver, CANADA
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] Acute autoimmune inflammation of the central nervous system by IL-17-secreting T cells is controlled by NR4A22012
- Author(s)
  S. Oki, Raveney B., T. Yamamura
- Organizer
  International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
- Place of Presentation
  東京大学伊藤謝恩ホール（東京）
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] NR4A2 controls Th17-mediated autoimmunity2012
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  Keystone Symposia 2011 : Th17 Cells in Health and Disease (Q2)
- Place of Presentation
  米国・キーストーンKeystone Resort Conference Center
- Year and Date
  2012-02-05
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2 controls Th17-mediated autoimmunity Keystone Symposia 20112012
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  Th17 Cells in Health and Disease(Q2)
- Place of Presentation
  Keystone USA
- Year and Date
  2012-02-05
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2 controls Th17-mediated autoimmunity2012
- Author(s)
  Raveney B., S. Oki, T. Yamamura
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場他（兵庫）
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] Acute autoimmune inflammation of the central nervous system by IL-17-secreting T cells is controlled by NR4A22012
- Author(s)
  Raveney B., S. Oki, T. Yamamura
- Organizer
  The 10th International Congress of Neuroimmunology
- Place of Presentation
  The Westin Copley Place, Boston, USA
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] 中枢神経系の炎症性自己免疫病態形成に関わるIL-17産生性T細胞群の解析2012
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  第24回日本神経免疫学会学術集会
- Place of Presentation
  軽井沢プリンスホテルウェスト（長野）
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] NR4A2 controls Th17-mediated autoimmunity2012
- Author(s)
  Raveney B., S. Oki, T. Yamamura
- Organizer
  12th Annual Conference of FOCIS (FOCIS2012)
- Place of Presentation
  Vancouver Convention Centre, Vancouver, CANADA
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] T細胞のInterleukin-9産生に対するレチノイドの制御作用2011
- Author(s)
  野口真行、大木伸司、山村隆
- Organizer
  第22回日本レチノイド研究会
- Place of Presentation
  日本大学会館(東京都)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2, a nuclear receptor that controls pathogenic Th17 responses during autoimmune disease, is induced in T cells by target organ antigen presenting cells2011
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Th17細胞依存性自己免疫応答に対するオーファン核内受容体NR4A2の機能的連関2011
- Author(s)
  大木伸司、ベンジャミン・レイバニー、山村隆
- Organizer
  日本薬学会第131会年会
- Place of Presentation
  静岡(静岡県コンベンションアーツセンター「グランシップ」、静岡県立大学大講堂、ツインメッセ静岡)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2, a nuclear receptor that controls pathogenic Th17 responses during autoimmune disease is induced in T cells by target organ antigen presenting cells2011
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2, a nuclear receptor that controls pathogenic Th17 responses during autoimmune disease, is induced in T cells by target organ antigen presenting cells2011
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  British Society of Immunology Congress
- Place of Presentation
  Liverpool UK
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Th17細胞依存性自己免疫応答に対するオーファン核内受容体NR4A2の機能的連関2011
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] T細胞のInterleukin-9産生に対するレチノイドの制御作用2011
- Author(s)
  野口真行、大木伸司、山村隆
- Organizer
  第22回日本レチノイド研究会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] NR4A2, a nuclear receptor that controls pathogenic Th17 responses during autoiommune disease, is induced in T cells by target organ antigen presenting cells2011
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  British Society of Immunology Congress 2011
- Place of Presentation
  英国・リバプールArena and Convention Center
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells.2010
- Author(s)
  Raveney B., S.Oki., T.Yamamura
- Organizer
  97h Annual Meeting of the American Association of Immunologist
- Place of Presentation
  Baltimore(Baltimore Convention Center), USA
- Year and Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] AM80, a synthetic retinoid, ameliorates Th17-mediated autoimmunity of the eye and central nervous system2010
- Author(s)
  Oki S, Raveney BJE, Klemann C, Yamamura T
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells.2010
- Author(s)
  Raveney B., S.Oki, T.Yamamura
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸(神戸ポートピアホテル、神戸国際展示場)
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] オーファン核内受容体NR4A2はIL-17産生性T細胞と自己免疫応答に強く連関する2010
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  第22回日本神経免疫学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] 多発性硬化症とサイトカインネットワーク2010
- Author(s)
  大木伸司
- Organizer
  第7回多発性硬化症フォーラム
- Place of Presentation
  東京(六本木アカデミーヒルズ49)
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] オーファン核内受容体NR4A2は1L-17産生性T細胞と自己免疫応答に強く連関する2010
- Author(s)
  大木伸司
- Organizer
  第22回日本神経免疫学会学術集会
- Place of Presentation
  東京、日経ホール
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] AM80, a synthetic retinoid, ameliorates Th17-mediated autoimmunity of the eye and central nervous system2010
- Author(s)
  S.Oki, Raveney B., Klemann C., T.Yamamura
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸(神戸ポートピアホテル、神戸国際展示場)
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells2010
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] 合成レチノイドAm80はTh17依存性眼炎症を抑制しFoxp3陽性T細胞を誘導する2010
- Author(s)
  小口翔、ベン・レイバニー、大木伸司、天竺桂弘子、佐藤準一、山村隆
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells2010
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  97h Annual Meeting of the American Association of Immunologist
- Place of Presentation
  Baltimore USA
- Year and Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] 実験的自己免疫性ブドウ膜炎(EAU)に対する合成レチノイドAm80の病態抑制効果2009
- Author(s)
  大木伸司, ベン・レイバニー, クリスチャン・クレマン, 首藤紘一, 山村隆
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells2009
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  9th Annual Conference of FOCIS
- Place of Presentation
  San Fransisco USA
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells2009
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  2nd European Congress of Immunology
- Place of Presentation
  Berlin Germany
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Nuclear receptors as therapeutic targets for multiple sclerosis2009
- Author(s)
  Oki S.
- Organizer
  2nd Conference of Germany and Japan Neuroimmunology
- Place of Presentation
  Eibsee Germany, Eibsee Hotel
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] 実験的自己免疫性ブドウ膜炎(EAU)に対する合成レチノイドAm80の病態抑制効果2009
- Author(s)
  大木伸司、レイバニー・ベン、クレマン・クリスチャン、首藤紘一、山村隆
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  新潟
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Nuclear receptors as therapeutic targets for multiple sclerosis2009
- Author(s)
  Oki S
- Organizer
  2nd Conference of Germany and Japan Neuroimmunology
- Place of Presentation
  Eibsee Germany
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] AM80, a synthetic retinoid, ameliorates Th17-mediated ocular autoimmunity and promotes the infiltration of Foxp3+T cells into the eye2009
- Author(s)
  大木伸司、ベン・レイバニー、山村隆
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] AM80, a synthetic retinoid, ameliorates Th17-mediated ocular autoimmunity and promotes the infiltration of Foxp3+ T cells into the eye2009
- Author(s)
  大木伸司
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Expression of the orphan nuclear receptor NR4A2 is required for IL-17 production by Th17 cells2009
- Author(s)
  Raveney BJE, Oki S, Yamamura T
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590087
[Presentation] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines(シンポジウム招待講演)2008
- Author(s)
  Shinji Oki, Yoshimitsu Doi, Benjamin JE Raveney, Tomoko Ozawa, Hirohiko Hohjoh, Sachiko Miyake, Takashi Yamamura
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Synthetic Retinoid Am80 ameliorates EAE by attenuating Th17-mediated inflammation2008
- Author(s)
  Christian Klemann, Shinji Oki, Anna K Klemann, Tomoko Ozawa, Yoshimitsu Doi, Koichi Shudo, Takashi Yamamura
- Organizer
  The 9th International Congress of Neuroimmunology
- Place of Presentation
  Fort Worth
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional involvement of NR4A2 in the pathogenesis of inflammatory demyelinating disease.2008
- Author(s)
  Shinji Oki, Yoshimitsu Doi, Tomoko Ozawa, Sachiko Miyake, Takashi Yamamura
- Organizer
  Keystone Symposia 2008 : Nuclear Receptors: Orphan Brothers (Z1)
- Place of Presentation
  Whistler CA
- Year and Date
  2008-04-01
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 合成レチノイドAm80のTh17細胞分化制御を介した自己免疫応答抑制効果について2008
- Author(s)
  大木伸司、Christian Klemann、Benjamin JE Raveney、Anna K Klemann、小澤智子、首藤紘一、山村隆
- Organizer
  第19回日本レチノイド研究会
- Place of Presentation
  東京
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Alteration of Th17 differentiation by retinoic acid signals ameliorate EAE development2008
- Author(s)
  Christian Klemann, Shinji Oki, Tomoko Ozawa, Yoshimitsu Doi, & Takashi Yamamura
- Organizer
  第20回日本神経免疫学会学術集会
- Place of Presentation
  新潟
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Synthetic Retinoid Am80 ameliorates EAE by attenuating Th17-mediated inflammation2008
- Author(s)
  Christian Klemann, Shinji Oki, Anna K Klemann, Tomoko Ozawa, Yoshimutsu Doi, Koichi Shudo, Takashi Yamamura
- Organizer
  9th International Congress of Neuroimmunology (ISNI2008)
- Place of Presentation
  Fort Worth USA
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines2008
- Author(s)
  大木伸司, 土居芳充, Benjamin JE Raveney, 小澤智子, 北條浩彦, 三宅幸子, 山村隆
- Organizer
  第38回日本免疫学会総会・学術集会(招待講演)
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Synthetic Retinoid Am80 ameliorates EAE by attenuating Th17-mediated inflammation2008
- Author(s)
  Christian Klemann, Shinji Oki, Benjamin J.E. Raveney, Takashi Yamamura
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Th17細胞機能制御を介した合成レチノイドAm80の自己免疫応答抑制効果について2008
- Author(s)
  大木伸司, Christian Klemann, Benjamin JE Raveney, Anna K Klemann, 小澤智子, 首藤紘一, 山村隆
- Organizer
  日本レチノイド研究会・第19回学術集会
- Place of Presentation
  東京
- Year and Date
  2008-10-21
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] MR1拘束性Vα19iT細胞のコラーゲン誘導関節炎(CIA)における機能解析2008
- Author(s)
  八子徹、田島良亮、海江田信二郎、大木伸司、三宅幸子
- Organizer
  第52回日本リウマチ学会総会・学術集会・第17回国際リウマチシンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-04-20
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Synthetic retinoid Am80 ameliorates experimental autoimmune encephalomyelitis (EAE) by attenuating Th17-mediated inflammation2008
- Author(s)
  Christian Klemann, Shinji Oki, Anna K Klemann, Ben JE Raveney, Tomoko Ozawa, Koichi Shudo, Takashi Yamamura
- Organizer
  第36回日本臨床免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2008-10-17
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional involvement of NR4A2 in the pathogenesis of inflammatory demyelinating disease2008
- Author(s)
  Shinji Oki, Yoshimitsu Doi, Tomoko Ozawa, Sachiko Miyake, Takashi Yamamura
- Organizer
  Keystone Symposia'Nuclear Receptors : Orphan Brothers'
- Place of Presentation
  Whistler CA
- Year and Date
  2008-04-01
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional analysis of carcinoembryonic antigen-related cellular adhesion molecule 1 in experimental autoimmune encephalomyelitis2007
- Author(s)
  Shhji Oki
- Organizer
  6th Annual Conference of FOCIS
- Place of Presentation
  San Diego, USA
- Year and Date
  2007-06-10
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] SKGマウスにおける結核死菌投与による関節炎の誘導2007
- Author(s)
  海江田信二郎、田島良亮、大木伸司、坂口志文、三宅幸子
- Organizer
  第51回日本リウマチ学会総会・学術集会・第16回国際リウマチシンポジウム
- Place of Presentation
  横浜
- Year and Date
  2007-04-27
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional Involvement of NR4A2 in the Pathogenesis of Multiple Sclerosis2007
- Author(s)
  Yoshimitsu Doi, Shiji Oki, Sachiko Miyake, Takashi Yamamura
- Organizer
  第20回内藤コンファレンス
- Place of Presentation
  葉山、神奈川
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional analysis of carcinoembryonic antigen-related cellular adhesion molecule 1 in experimental autoimmune encephalomyelitis.2007
- Author(s)
  Shinji Oki, Mayumi Fujita, Takao Ootsuka, Miho Mizuno, Chiharu Tomi, Shinjiro Kaieda, Takashi Yamamura,Sachiko Miyake
- Organizer
  7th Annual Conference of FOCIS
- Place of Presentation
  San Diego
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 実験的自己免疫性脳脊髄炎における腸内フローラの役割に関する検討2007
- Author(s)
  横手裕明、J. Ludovic Croxford、水澤英洋、大木伸司、三宅幸子、山村隆
- Organizer
  第35回日本臨床免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] Functional involvement of NR4A2 in the pathogenesis of multiple sclerosis.2007
- Author(s)
  Yoshimitsu Doi, Shinji Oki, Sachiko Miyake, Takashi Yamamura
- Organizer
  7th Annual Conference of FOCIS
- Place of Presentation
  San Diego
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 多発性硬化症における病原性T 細胞のサイトカイン産生制御機構2007
- Author(s)
  土居芳充、大木伸司、三宅幸子、山村隆
- Organizer
  第19回日本神経免疫学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2007-04-12
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] MR1拘束性T細胞によるマウス関節炎モデルの抑制2007
- Author(s)
  八子徹、海江田信二郎、大木伸司、山村隆、三宅幸子
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] MR1-restricted Va19i T cells ameliorate murine models of arthritis.2007
- Author(s)
  Toru Yago, Ryosuke Tajima, Shinjiro Kaieda, Shinji Oki, Takashi Yamamura, Sachiko Miyake
- Organizer
  2007 Annual Scientific Meeting of ACR
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 実験的自己免疫性脳脊髄炎における腸内フローラの役割に関する検討2007
- Author(s)
  横手裕明、J. Ludovic Croxford、水澤英洋、大木伸司、三宅幸子、山村隆
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 多発性硬化症における病原性T細胞のサイトカイン産生制御機構2007
- Author(s)
  土居芳充、大木伸司、三宅幸子、山村隆
- Organizer
  第35回日本臨床免疫学会総会
- Place of Presentation
  大阪
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] プロテオミクスを用いたアナジーT細胞内タンパク質の解析2007
- Author(s)
  大木伸司
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  横浜
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] プロテオミクスを用いたアナジーT細胞内タンパク質の解析2007
- Author(s)
  大木伸司、市川大樹、山村隆、三宅幸子
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] 抗体誘導関節炎におけるNKT細胞の機能解析2007
- Author(s)
  田島良亮、海江田信二郎、大木伸司、三宅幸子
- Organizer
  第51回日本リウマチ学会総会・学術集会・第16回国際リウマチシンポジウム
- Place of Presentation
  横浜
- Year and Date
  2007-04-27
- Data Source
  KAKENHI-PROJECT-19590095
[Presentation] NR4A2 controls pathogenic 'switched' Th17 cells in the CNS during autoimmune inflammation
- Author(s)
  Raveney B., S. Oki, T. Yamamura
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館、京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590108
[Presentation] NR4A2 modulation during autoimmune inflammation of the central nervous system reduces pathogenic T cell responses and ameliorates clinical disease
- Author(s)
  Raveney B., S. Oki, T. Yamamura
- Organizer
  The 12th International Congress of Neuroimmunology
- Place of Presentation
  Rheingoldhalle, Mainz, Germany
- Year and Date
  2014-11-11 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-24590108

1. YAMAMURA Takashi (90231670)

# of Collaborated Projects: 3 results

# of Collaborated Products: 44 results
2. 北條浩彦 (60238722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 佐藤和貴郎 (90469990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 林幼偉 (80392439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 大島登志男 (20311334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 服部正平 (70175537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 土居芳充 (20597174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荒木敏之 (70263275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 須田亙 (20590847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 北条浩彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. Raveney Benjamin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 堀昌平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 星野幹雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 今吉格

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 戸田達史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 張晨陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKI SHINJI 大木 伸司

Oki Shinji 大木 伸司

OKI Shinji 大木 伸司

Research Projects

Research Products

Co-Researchers

L1レトロ転移を介したS期神経細胞の合成致死性の研究Principal Investigator

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Neuroinflammatory and degenerative pathogenesis mediated by new T cell subsets

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Identification of extracellular microRNAs in the blood associated with aging and development of anti-aging functional nucleic acids

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Functional significance of non-pituitary prolactin on autoimmune diseases in the central nervous systemPrincipal Investigator

Principal Investigator

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Cross-talk between endocrine and environmental factors in neuroimmune disorders

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Analyses of cellular component involved in heterogeneous inflammatory pathogenesis of autoimmne diseases in the CNSPrincipal Investigator

Principal Investigator

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NR4A2-mediated regulation of IL-17-producing T cells for novel therapeutic strategy of autoimmune diseasesPrincipal Investigator

Principal Investigator

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Immunoregulatory roles of glycolipid ligand-stimulated natural killer T cellsPrincipal Investigator

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[Book] 臨床免疫・アレルギー科 第76巻第5号2021

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[Book] 創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術2021

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[Book] 実験医学増刊 Vol.39 No.15 神経免疫 メカニズムと疾患2021

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[Book] 臨床免疫・アレルギー科2020

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[Book] Chembiomolecular Science: At the Frontier of Chemistry and Biology2012

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OKI SHINJI 大木伸司

Oki Shinji 大木伸司

OKI Shinji 大木伸司

[Book] 臨床免疫・アレルギー科　第76巻第5号2021

[Book] 実験医学増刊 Vol.39 No.15 神経免疫メカニズムと疾患2021

[Book] 改変糖脂質抗原によるNKT細胞を介した免疫制御生化学(日本生化学会編)第79巻2007