Ishii Toshiaki 石井利明

… Alternative Names

石井利明イシイトシアキ

ISHII Toshiaki 石井利明

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Researcher Number	50264809
Other IDs
Affiliation (Current)	2025: 帯広畜産大学, 畜産学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 帯広畜産大学, 畜産学部, 教授 2008 – 2010: Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 教授 2005 – 2006: 帯広畜産大学, 畜産学部, 助教授 2004: 国立大学法人帯広畜産大学, 畜産学部, 助教授 2002 – 2003: 帯広畜産大学, 畜産学部, 助教授 1999 – 2000: Obihiro University, School of Veterinary Medicine, Pharmacology, Associate Professor, 畜産学部, 助教授 1995 – 1998: 大阪府立大学, 農学部, 助手
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / Basic Section 42020:Veterinary medical science-related / Basic veterinary science/Basic zootechnical science / Veterinary medical science Except Principal Investigator Basic veterinary science/Basic zootechnical science / Biological pharmacy
Keywords	Principal Investigator ILK / 脳腸相関 / プロバイオティクス / ビフィズス菌 / 海馬 / MPTP / パーキンソン病 / Neurite / Tau / GSK-3β … More / p38 MAP kinase / N1E-115 cell / 海馬歯状回 / Ca^<2+>-ATPase / K^+-ATPase / Na^+ / Neuropsin / Akt / Integrin-linked kinase / Pentylenetetrazole / キンドリングマウス / てんかん / 難治性認知症 / neuropsin / 脳-腸-微生物相関 / 記憶消去 / 難治生認知障害 / B. breve A1 [MCC1274] / 獣医学 / 薬理学 / 脳・神経 / 神経科学 / 脳神経疾患 / Rolipram / Phosphodiesterase IV 阻害薬 / cAMP-PKAシグナル / prucalopride / velusetrag / セロトニン5-HT4受容体 / PKA / cAMP / Phosphodiesterase阻害薬 / セロトニン5-HT4受容体作動薬 / 認知障害 / learning and memory / brain / aberrant phosphorylation / tau / animal model / Alzheimer's disease / paired helical filament / 痴呆 / タウタンパク質 / 記憶学習 / 脳 / 異常リン酸化 / タウタンパク / 病態モデル / アルツハイマー病 / 神経原線維変化 / Differentiation / Integrin / 神経突起 / 神経分化 / N1E-115 / p38MAP kinase / neurite / LK / 分化 / インテグリン / Me5 / 固執 / 学習 / 記憶 / カンナビノイド受容体 / 自給本能 / 離乳 / 遺伝子発現 / 転写抑制 / HeLa細胞 / ウアバイン / K-ATPaseα1サブユニット / Na / c-fos / HeLa Cell / Ouabain / Na^+,K^+-ATPase / イオンポンプ / Ptype ATPase / イオンセンサー / SR Ca^<2+>-ATPase … More Except Principal Investigator ナトリウムポンプ / gene expression / sodium pump / ouabain / yeast / chimera / ion channel / Na,K-ATPase / palytoxin / Na-Ca交換 / 血管 / カルシウムイオン / 陽イオンチャネル / Ca-ATPアーゼ / 強心配糖体 / 遺伝子発現 / ウアバイン / 酵母 / キメラ遺伝子 / イオンチャネル / Na,K-ATPアーゼ / パリトキシン / オリゴマイシン / K-ATPアーゼ / Na Less

Action mechanism of probiotics effective in preventing the onset of epilepsy and brain-gut correlationPrincipal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Action Mechanism of probiotics effective in preventing the onset of intractable dementia and brain-gut correlation.Principal Investigator
- Principal Investigator
  
  Ishii Toshiaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
The onset mechanism of intractable cognitive impairment caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta.Principal Investigator
- Principal Investigator
  
  Ishii Toshiaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
自給本能発現における海馬歯状回の神経幹細胞増殖とカンナビノイド受容体の役割Principal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Attempt to develop animal model for the formation of paired helical filaments in the brains of Alzheimer's disease patients via sustained inactivation of integrin-linked kinase in mouse brain.Principal Investigator
- Principal Investigator
  
  ISHII Toshiaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Role of integrin-linked kinaae in neurite outgrowth and axon guidance on neuronal repairPrincipal Investigator
- Principal Investigator
  
  ISHII Toshiaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
ウアバインによるNa^+,K^+-ATPase遺伝子の発現調節機構の解明Principal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Na^+,K^+-ATPaseのイオン輸送機構の解明Principal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Osaka Prefecture University
Biological significance of palytoxin-sensitive ion channel associated with NaィイD1+ィエD1,KィイD1+ィエD1-ATPase molecule
- Principal Investigator
  
  ITO Katsuaki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  University of Miyazaki
Na^+,K^+-ATPaseのNa^+遊離部位の同定
- Principal Investigator
  
  誉田晴夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyorin University
骨格筋における筋小胞体Ca^<2+>-ATPase (SERCA1)の活性調節機構に関する研究Principal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Osaka Prefecture University
P型ATPaseの構造と機能Principal Investigator
- Principal Investigator
  
  石井利明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Osaka Prefecture University

All 2023 2022 2021 2020 2019 2017 2010 2009 2007 2006 2005

All Journal Article Presentation Patent

[Journal Article] Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson’s Disease2021
- Author(s)
  Ishii Toshiaki、Furuoka Hidefumi、Kaya Motohiro、Kuhara Tetsuya
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 2 Pages: 167-167
- DOI
  10.3390/biomedicines9020167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06425
[Journal Article] Serotonin 5-HT4 Receptor Agonists Improve Facilitation of Contextual Fear Extinction in An MPTP-Induced Mouse Model of Parkinson’s Disease2019
- Author(s)
  Ishii、Kinoshita、Muroi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 21 Pages: 5340-5340
- DOI
  10.3390/ijms20215340
- NAID
  130007811243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08071
[Journal Article] Short-Term But Not Long Term Exercise Ameliorates Depressive Behavior in Mice2019
- Author(s)
  Yashima Hiroki、Matsushita Aya、Kinoshita Ken ichi、Muroi Yoshikage、Ishii Toshiaki
- Journal Title
  
  Neuropsychiatry
  
  Volume: 09 Issue: 01 Pages: 2120-2130
- DOI
  10.4172/neuropsychiatry.1000557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08071
[Journal Article] Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.2017
- Author(s)
  Kinoshita, K., Muroi, Y., Unno, T., and Ishii, T.
- Journal Title
  
  Journal of Pharmavological Sciences
  
  Volume: 134 Issue: 1 Pages: 55-58
- DOI
  10.1016/j.jphs.2017.04.002
- NAID
  120006391018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08071, KAKENHI-PROJECT-17K08076
[Journal Article] Bilateral lesions of the mesencephahc trigeminal sensory nucleus Stimulate hippocampal neurogenesis but lead to severe deficits in Spatial memory resetting.2010
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Bilateral lesions of the mesencephalic trigeminal sensory nucleus Stimulate hippocampal neurogenesis but lead to severe deficits in Spatial memory resetting.2010
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Research
  
  Volume: 1342 Pages: 74-84
- NAID
  120006390517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Lactoferrin stimulates cell growth and survival in neuronal cells viaactivation of integrin-dependent signals.2010
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Current Topics in Pharmacology(Review) (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells.2009
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Life Sciences 84
  
  Pages: 530-536
- NAID
  120006390414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells2009
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Life Sciences 84
  
  Pages: 530-536
- NAID
  120006390414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Lactoferrin stimulates cell growth and survival in neuronal cells via activation of integrin-dependent signals.2009
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Current Topics in Pharmacology (Review)
  
  Volume: 13 Pages: 67-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380158
[Journal Article] Chronic intracerebroventricular administration of anti-neuropeptide Y antibody stimulates starvation-induced feeding via compensatory responses in the hypothalamus.2007
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Res. 1144
  
  Pages: 91-100
- NAID
  120006390256
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] The mesencephalic trigeminal sensory nucleus is involved in acquisition of active exploratory behavior induced by changing from a diet of exclusively milk formula to food pellets in mice.2006
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Res. 1111
  
  Pages: 153-161
- NAID
  120006390180
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] The mesencephalic trigeminal sensory nucleus is involved in the control of feeding and exploratory behavior in mice.2005
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Research 1048
  
  Pages: 80-86
- NAID
  120006390082
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] Comparison of growth and exploratory behavior in mice fed an exclusively milk formula diet and mice fed a food-pellet diet post weaning.2005
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Life Sciences 78
  
  Pages: 174-179
- NAID
  120006390106
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] Comparison of growth and exploratory behavior in mice fed an exclusively milk formula diet and mice fed a food-pellet diet post weaning.2005
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Life Sci. 78
  
  Pages: 174-179
- NAID
  120006390106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] Role of integrin-linked kinase in neuronal cells.2005
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Current Enzyme Inhibition 1
  
  Pages: 3-10
- NAID
  120006390079
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380195
[Journal Article] The mesencephalic trigeminal sensory nucleus is involved in the control of feeding and exploratory behavior in mice.2005
- Author(s)
  Toshiaki Ishii
- Journal Title
  
  Brain Res. 1048
  
  Pages: 80-86
- NAID
  120006390082
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16380195
[Patent] 抗てんかん用組成物2022
- Inventor(s)
  石井利明
- Industrial Property Rights Holder
  石井利明
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-089546
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K06425
[Patent] パーキンソン病に併発した認知障害の治療剤2017
- Inventor(s)
  石井利明、木下健一
- Industrial Property Rights Holder
  石井利明、木下健一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-064344
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K08071
[Patent] パーキンソン病に併発した認知障害の治療剤2017
- Inventor(s)
  石井利明、木下健一
- Industrial Property Rights Holder
  石井利明、木下健一
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K08071
[Presentation] Effect of oral administration of probiotic Bifidobacterium breve on epileptic seizures in a pentylenetetrazole-induced kindling mouse model.2023
- Author(s)
  Ishii, T, Kaya, M., & Muroi, Y.
- Organizer
  第97回日本薬理学会年会(2023年12月14-16日・神戸)
- Data Source
  KAKENHI-PROJECT-23K05531
[Presentation] Serotonin 5-HT4 receptor agonists improve facilitation of contextual fear extinction in an MPTP-induced mouse model of Parkinson's disease.2020
- Author(s)
  Ishii, T. & Muroi, Y.
- Organizer
  第93回日本薬理学会年会 (横浜)
- Data Source
  KAKENHI-PROJECT-17K08071
[Presentation] Short-term but not long-term exercise ameliorates chronic mild stress-induced depression-like behavior in a comparable manner to a single administration of ketamine in mice.2019
- Author(s)
  Yashima, H., Matsushita, A. Kinoshita, K., Muroi, Y., & Ishii, T.
- Organizer
  第92回日本薬理学会年会 (大阪)
- Data Source
  KAKENHI-PROJECT-17K08071
[Presentation] Short-term but not long-term exercise ameliorates chronic mild stress-induced depression-like behavior in a comparable manner to a single administration of ketamine in mice.2019
- Author(s)
  Yashima Hiroki、Matsushita Aya、Kinoshita Ken ichi、Muroi Yoshikage、Ishii Toshiaki
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08071
[Presentation] マウスの三叉神経中脳路核を電気破壊すると空間記憶の更新に障害が起こる2010
- Author(s)
  石井利明
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-20380158
[Presentation] Integrin-linked kinaseはPC12細胞のラクトフェリンによる接着非依存性の細胞増殖と生存に関与している2009
- Author(s)
  石井利明
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20380158

1. NISHIMURA Masakazu (50011995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 誉田晴夫 (30086574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 古林与志安 (20301971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Katsuaki (70136795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKEYASU Kunio (40135695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IKEDA Masahiro (60281218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYAZAWA Takayuki (80282705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FURUOKA Hidefumi (60238665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishii Toshiaki 石井 利明

石井 利明 イシイ トシアキ

ISHII Toshiaki 石井 利明

Research Projects

Research Products

Co-Researchers

Action mechanism of probiotics effective in preventing the onset of epilepsy and brain-gut correlationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Action Mechanism of probiotics effective in preventing the onset of intractable dementia and brain-gut correlation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The onset mechanism of intractable cognitive impairment caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

自給本能発現における海馬歯状回の神経幹細胞増殖とカンナビノイド受容体の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Attempt to develop animal model for the formation of paired helical filaments in the brains of Alzheimer's disease patients via sustained inactivation of integrin-linked kinase in mouse brain.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of integrin-linked kinaae in neurite outgrowth and axon guidance on neuronal repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ウアバインによるNa^+,K^+-ATPase遺伝子の発現調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Na^+,K^+-ATPaseのイオン輸送機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological significance of palytoxin-sensitive ion channel associated with NaィイD1+ィエD1,KィイD1+ィエD1-ATPase molecule

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Na^+,K^+-ATPaseのNa^+遊離部位の同定

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨格筋における筋小胞体Ca^<2+>-ATPase (SERCA1)の活性調節機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

P型ATPaseの構造と機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oral Administration of Probiotic Bifidobacterium breve Improves Facilitation of Hippocampal Memory Extinction via Restoration of Aberrant Higher Induction of Neuropsin in an MPTP-Induced Mouse Model of Parkinson’s Disease2021

Author(s)

Ishii Toshiaki 石井利明

石井利明イシイトシアキ

ISHII Toshiaki 石井利明