• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

HIRATA Youko  平田 洋子

ORCIDConnect your ORCID iD *help
… Alternative Names

平田 洋子  ヒラタ ヨウコ

HIRATA Yoko  平田 洋子

Less
Researcher Number 50271523
Other IDs
Affiliation (Current) 2025: 岐阜大学, 高等研究院, 特任教授
Affiliation (based on the past Project Information) *help 2023: 岐阜大学, 高等研究院, 特任教授
2019 – 2022: 岐阜大学, 工学部, 教授
2009 – 2011: Gifu University, 工学部, 准教授
2007: Gifu University, Factclty of Engineering, Associate Professor
2004 – 2006: 岐阜大学, 工学部, 助教授
1996 – 1997: 理化学研究所, 運動遺伝子研究チーム, フロンティア研究員
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Basic Section 59040:Nutrition science and health science-related / Neurochemistry/Neuropharmacology
Except Principal Investigator
Basic Section 33020:Synthetic organic chemistry-related / Living organism molecular science
Keywords
Principal Investigator
Nurr1 / NGFI-B(Nur77) / 蛍光プローブ / オキシトーシス / 鉄イオン / 酸化ストレス / フェロトーシス / prostaglandin / caspase-3 / Parkinson's disease … More / manganese / rotenone / apoptosis / 活性酸素種 / ドーパミン / 神経保護物質 / ドーバミン神経 / プロスタグランディン / カスパーゼ-3 / パーキンソン病 / マンガン / ロテノン / アポトーシス / Rat brain / Protein Kinase Cbeta / Limited proteolysis / Calpain / Protein kinase C beta / NGFI-B kinase / ラット脳 / プロテイン キナーゼCβ / 限定分解 / カルパイン / シクロペンテノン / 脳虚血 / シクロペンテノン誘導体 / MAPキナーゼ / C6グリオーマ細胞 / 神経成長因子 / 脳由来神経栄養因子 / グリア細胞株由来神経栄養因子 … More
Except Principal Investigator
リン原子キラリティ / ビナフチルチオホスホン酸エステル / 計算化学 / リン原子キラリティー / 円偏光発光 / 反応経路理論解析 / 小胞体ストレス / リン原子上置換反応 / キラリティー転写 / ビナフチル基 / P-キラルホスフィン酸エステル / キラリティー転写反応 / 中心性キラリティー / 軸性キラリティー / P-キラル有機リン化合物 / Molecular Probe / Keapl / Prostaglandin / Apoptosis / Parkinson's disease / Cyclopentenone / Neuroprotective / NEPP / スルファニル置換体 / 抗アポトーシス / 分子プローブ / Keap1 / プロスタグランジン / アポトーシス / パーキンソン病 / シクロペンテノン / 神経保護 Less
  • Research Projects

    (6 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (7 People)
  •  Development of feroptosis inhibitors based on the novel antioxidative mechanismPrincipal Investigator

    • Principal Investigator
      平田 洋子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Gifu University
  •  Development of syntehtic reactions based on the tetracoorinate phosphorus compounds with a chrality

    • Principal Investigator
      Murai Toshiaki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 33020:Synthetic organic chemistry-related
    • Research Institution
      Gifu University
  •  Up-regulation of glial cell line-derived neurotrophic factor by newly synthesized cyclopentenone derivatives : Studies on cellular mechanisms in vitro and effectiveness in vivoPrincipal Investigator

    • Principal Investigator
      HIRATA Yoko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gifu University
  •  Synthesis and Application of Novel Cyclopentenone Molecular Probes with Neuroprotective Activity

    • Principal Investigator
      FURUTA Kyoji
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      Gifu University
  •  Studies of molecular mechanisms of rotenone-induced apoptosis and neurotrophic substances for dopaminergic neuronsPrincipal Investigator

    • Principal Investigator
      HIRATA Yoko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Gifu University
  •  Studies for the phosphorylation and signaling pathway of a transcription factor induced by neuronal defferentiationPrincipal Investigator

    • Principal Investigator
      HIRATA Yoko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The Institute of Physical and Chemical Research (RIKEN)

All 2023 2022 2020 2011 2010 2009 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Structural features localizing the ferroptosis inhibitor GIF-2197-r to lysosomes2023

    • Author(s)
      Hirata Y, Hashimoto T, Ando K, Kamatari YO, Takemori H, Furuta K
    • Journal Title

      RSC Adv

      Volume: 13 Issue: 46 Pages: 32276-32281

    • DOI

      10.1039/d3ra06611h

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K11824, KAKENHI-PROJECT-23K28190
  • [Journal Article] Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities2023

    • Author(s)
      Takahashi M, Hamamoto A, Oh-Hashi K, Takemori H, Furuta K, Hirata Y.
    • Journal Title

      ACS Chem Neurosci.

      Volume: - Issue: 10 Pages: 1826-1833

    • DOI

      10.1021/acschemneuro.3c00042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K17638, KAKENHI-PROJECT-22K11824, KAKENHI-PROJECT-23K04504
  • [Journal Article] Quercetin and resveratrol inhibit ferroptosis independently of Nrf2-ARE activation in mouse hippocampal HT22 cells,2023

    • Author(s)
      Kato K, Takahashi M, Oh-hashi K, Ando K, Hirata Y
    • Journal Title

      Food Chem Toxicol

      Volume: 172 Pages: 113586-113586

    • DOI

      10.1016/j.fct.2022.113586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K11824
  • [Journal Article] Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors2022

    • Author(s)
      Hirata Yoko、Oka Kohei、Yamamoto Shotaro、Watanabe Hiroki、Oh-hashi Kentaro、Hirayama Tasuku、Nagasawa Hideko、Takemori Hiroshi、Furuta Kyoji
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 13 Issue: 18 Pages: 2719-2727

    • DOI

      10.1021/acschemneuro.2c00398

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K11824, KAKENHI-PUBLICLY-22H04818, KAKENHI-PROJECT-23K23490
  • [Journal Article] Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress2022

    • Author(s)
      Hirata Yoko、Okazaki Ruidai、Sato Mina、Oh-hashi Kentaro、Takemori Hiroshi、Furuta Kyoji
    • Journal Title

      European Journal of Pharmacology

      Volume: 928 Pages: 175119-175119

    • DOI

      10.1016/j.ejphar.2022.175119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K11824
  • [Journal Article] Hormetic Effects of Binaphthyl Phosphonothioates as Pro-oxidants and Antioxidants2020

    • Author(s)
      Hirata Yoko、Kuwabara Kazuma、Takashima Madoka、Murai Toshiaki
    • Journal Title

      Chemical Research in Toxicology

      Volume: 33 Issue: 11 Pages: 2892-2902

    • DOI

      10.1021/acs.chemrestox.0c00345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H02712
  • [Journal Article] Neuroprotective effects of(arylthio) cyclo-pentenone derivatives on manganese-induced apoptosis in PC12 cells2009

    • Author(s)
      Shibata S., Maeda M., Furuta K., Suzuki M., Oh-Hashi K., Kiuchi K. and Hirata Y.
    • Journal Title

      Brain Res

      Volume: Vol.1294 Pages: 218-225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500348
  • [Journal Article] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPAR gamma-dependent pathway2009

    • Author(s)
      Shibata S., Furuta K., Maeda M., Suzuki M., Oh-Hashi K., Kiuchi K. and Hirata Y.
    • Journal Title

      Brain Res

      Volume: Vol.1296 Pages: 196-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500348
  • [Journal Article] Synthesls of Neuyoprotective Cyclopentenne Prostaglandin Analogs Suppresslon of Manganese-induced Apoptosis of PC12 Cells2007

    • Author(s)
      K.Furuta, M.Maeda, Y.Hirata, S.Shibata, K.Kiuchi, M.Suzuki
    • Journal Title

      Bioorg. Med. Chem. Lett. (in press)

    • Data Source
      KAKENHI-PROJECT-17310124
  • [Journal Article] p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells2006

    • Author(s)
      Yoshimasa Ito, Kentaro Oh-hashi, Kazutoshi Kiuchi, Yoko Hirata
    • Journal Title

      Brain Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16500240
  • [Journal Article] p44/42 MAP kinase and c-Jun N-termmal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells2006

    • Author(s)
      Yoshimasa Ito, Kentaro Oh-hashi, Kazutoshi Kiuchi, Yoko Hirata
    • Journal Title

      Brain Res (in press)

    • Data Source
      KAKENHI-PROJECT-16500240
  • [Journal Article] Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis2006

    • Author(s)
      Yoko Hirata, Tomotaka Meguro, Kazutoshi Kiuchi
    • Journal Title

      Journal of Neurochemistry (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16500240
  • [Journal Article] Rotenone and CCCP inhibit tyrosine hydroxylation m rat striatal slices2005

    • Author(s)
      Yoko Hirata, Toshiharu Nagatsu
    • Journal Title

      Toxicology 216

      Pages: 9-14

    • Data Source
      KAKENHI-PROJECT-16500240
  • [Journal Article] Rotenone and CCCP inhibit tyrosine hydroxylation in rat striatal slices2005

    • Author(s)
      Yoko Hirata, Toshiharu Nagatsu
    • Journal Title

      Toxicology 216

      Pages: 9-14

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16500240
  • [Presentation] Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor2011

    • Author(s)
      Y.HIRATA, M.S.M.ATTA, K.OH-HASHIl, H.YAMAMOTO, K.KIUCHI
    • Organizer
      Society for Neuroscience(北米神経科学会)
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-21500348
  • [Presentation] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARγ-dependent pathway2010

    • Author(s)
      Y.HIRATA, S.SHIBATA, K.FURUTA, M.SUZUKI, K.OH-HASHI, K.KIUCHI
    • Organizer
      Society for Neuroscience, 40th Annual Meeting
    • Place of Presentation
      San Diego (アメリカ)
    • Year and Date
      2010-11-16
    • Data Source
      KAKENHI-PROJECT-21500348
  • [Presentation] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARγ-dependent pathway2010

    • Author(s)
      Hirata Y, Shibata S, Furuta K, Suzuki M, Oh-Hashi K, Kiuchi K
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-16
    • Data Source
      KAKENHI-PROJECT-21500348
  • [Presentation] C6細胞におけるシクロペンテノン型プロスタグランジン類縁体NEPP11による神経栄養因子の誘導2009

    • Author(s)
      岡田文陽、古田享史、鈴木正昭、大橋憲太郎、木内一壽、平田洋子
    • Organizer
      日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21500348
  • 1.  FURUTA Kyoji (40173538)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 2.  KIUCHI Kazutoshi (30135339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Murai Toshiaki (70166239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  宇田川 太郎 (70509356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  今井 喜胤 (80388496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  竹森 洋 (90273672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  濱本 明恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi