hasegawa minoru 長谷川稔

… Alternative Names

Hasegawa Minoru 長谷川稔

HASEGAWA Minoru 長谷川稔

長谷川稔ハセカ゛ワミノル

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Researcher Number	50283130
Other IDs	https://orcid.org/0000-0003-3738-2682
External Links
Affiliation (Current)	2024: 福井大学, 学術研究院医学系部門, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 福井大学, 学術研究院医学系部門, 教授 2016 – 2017: 福井大学, 学術研究院医学系部門, 教授 2013 – 2015: 福井大学, 医学部, 教授 2011 – 2012: 金沢大学, 大学病院, 講師 2009 – 2011: Kanazawa University, 附属病院, 講師 … More 2006 – 2007: 金沢大学, 医学部附属病院, 講師 2003 – 2004: 金沢大学, 医学部附属病院, 講師 2002: 金沢大学, 医学部附属病院, 助手 2001: 金沢大学, 医学部・附属病院, 助手 2000: Kanazawa University School of Medicine, Assistant Professor, 医学部・附属病院・皮膚科, 助手 1998: 金沢大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology / Dermatology
Keywords	Principal Investigator 強皮症 / 線維化 / サイトカイン / 治療 / 血管障害 / 内皮間葉移行 / 治療薬 / CD20 / Tight skin mouse / マウス … More / 皮膚 / B細胞 / ケモカイン / 全身性強皮症 / 上皮間葉移行 / 化合物 / マウスモデル / 動物モデル / マクロファージ / 疾患モデル / 新規治療 / CX3CL1 / autoimmunity / fibrosis / cytokine / aintbody-therapy / B cell / systemic sclerosis / 自己抗体 / 自己免疫 / 抗体治療 / Th17 / IL-17 / CXCL8 / ICOS ligand / 肺 / ブレオマイシン / ICOSL / ICOS / ノックアウトマウス / 補体 / 細菌感染 / 肺炎連鎖球菌 / 35 / CD21 / interleukin 18 / Fractalkine / CX_3CR1 / fractalkine … More Except Principal Investigator ICAM-1 / tight skin mouse 1 / CD22 / CD19 / 全身性強皮症 / B細胞 / マウス胎仔 / 末梢血液 / 間葉系幹細胞 / 遺伝子治療 / マウス胎仔治療 / L-selectin / Arthus reaction / vasculitis / Cell adhesion molecule / E-selectin / P-selectin / Immune complex / 好中球 / 肥満細胞 / ノックアウトマウス / 血管炎 / L-セレクチン / P-セレクチン / E-セレクチン / 細胞接着分子 / 免疫複合体 / アルサス反応 / animal model / autoimmunity / B lymphocytes / systemic sclerosis / tight skin mouse I / 動物モデル / 自己免疫 / 制御性B細胞 / IL-10 Less

内皮間葉移行阻害薬の探索と強皮症治療への応用Principal Investigator
- Principal Investigator
  
  長谷川稔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Fukui
Could epithelial-mesenchymal transition inhibitors be a novel treatment for systemic sclerosis?Principal Investigator
- Principal Investigator
  
  Hasegawa Minoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Fukui
Development of a novel therapy using anti-CX3CL1 antibody in systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Hasegawa Minoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  University of Fukui
Establishment of the novel embryonic cure system for an intractable skin disease mouse model by using a mesenchymal stem cells from the circulation blood of mouse embryo
- Principal Investigator
  
  Chino Takenao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  University of Fukui
Cytokine-targeted therapy of sclerodermaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Minoru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  University of Fukui
  Kanazawa University
The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models
- Principal Investigator
  
  TAKEHARA KAZUHIKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Investigation and therapeutic application of ICOS and ICOSL in systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Minoru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
B cell depletion therapy for the model mouse of sclerodermaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Minoru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
CD21/35欠損マウスの作成と解析Principal Investigator
- Principal Investigator
  
  長谷川稔
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Relative contribution of various adhesion molecules to tissue injury induced by immune complex deposition
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
全身性強皮症とそのモデルマウスにおけるサイトカインおよびケモカインの関与Principal Investigator
- Principal Investigator
  
  長谷川稔
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Development of the new animal model for systemic sclerosis using the immunologic function of CD19 and CD22
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University

All 2022 2021 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006

All Journal Article Presentation

[Journal Article] The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling2022
- Author(s)
  Utsunomiya A, Hasegawa M, et al.
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 24 Issue: 1 Pages: 94-94
- DOI
  10.1186/s13075-022-02773-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08769, KAKENHI-PROJECT-21K08321, KAKENHI-PROJECT-20K17313
[Journal Article] The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients.2014
- Author(s)
  Hatta Y, Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24 Issue: 2 Pages: 377-9
- DOI
  10.3109/14397595.2013.854073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] A crucial role of L-selectin in C protein-induced experimental polymyositis of mice.2014
- Author(s)
  Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: mar 18 Issue: 7 Pages: 1864-71
- DOI
  10.1002/art.38630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-25461686
[Journal Article] Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.2014
- Author(s)
  Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 2 Pages: e88150-e88150
- DOI
  10.1371/journal.pone.0088150
- NAID
  120006986537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.2014
- Author(s)
  Minoru Hasegawa, Yoshihide Asano, Hirahito Endo, Manabu Fujimoto, Daisuke Goto, Hironobu Ihn, Katsumi Inoue, Osamu Ishikawa, Yasushi Kawaguchi. Masataka Kuwana, Fumihide Ogawa, Hiroki Takahashi, Sumiaki Tanaka, Shinichi Sato, Kazuhiko Takehara
- Journal Title
  
  PLoS One
  
  Volume: 9
- NAID
  120006986537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591644
[Journal Article] Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement.2014
- Author(s)
  Kaji K, Fertig N, Medsger TA Jr, Satoh T, Hoshino K, Hamaguchi Y, Hasegawa M, Lucas M, Schnure A, Ogawa F, Sato S, Takehara K, Fujimoto M, Kuwana M.
- Journal Title
  
  Arthritis Care Res
  
  Volume: 66 Issue: 4 Pages: 575-84
- DOI
  10.1002/acr.22163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-26461471
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Tedder TF, Fujimoto M.
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, T akehara K, T edder TF, Fujimoto M
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 16 Pages: 3274-83
- DOI
  10.1182/blood-2012-11-465658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-24659523
[Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study2013
- Author(s)
  Hasegawa M
- Journal Title
  
  Mod Rheumatol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591644
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72 Issue: 1 Pages: 151-153
- DOI
  10.1136/annrheumdis-2012-201736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-25461672
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M, Matsushita T, Hamaguchi Y, Kaji K, Asano Y, Ogawa F, Yamaoka T, Fujikawa K, Tsukada T, Sato K, Echigo T, Hasegawa M, Takehara K.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 72 Pages: 151-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press Issue: 6 Pages: 1624-35
- DOI
  10.1002/art.37933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24659523, KAKENHI-PROJECT-25461686
[Journal Article] High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies2013
- Author(s)
  Hamaguchi Y, Matsushita T, Hasegawa M, Ueda-Hayakawa I, Sato S, Takehara K, Fujimoto M
- Journal Title
  
  Mod Rheumatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.2013
- Author(s)
  Hasegawa M, Higashi K, Matsushita T, Hamaguchi Y, Saito K, Fujimoto M, Takehara K.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 70 Issue: 1 Pages: 34-41
- DOI
  10.1016/j.jdermsci.2013.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] BLNK expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells2013
- Author(s)
  Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Huu DL, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 131 Issue: 6 Pages: 1674-1682
- DOI
  10.1016/j.jaci.2013.01.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] Potential roles of interleukin-17A in the development of skin fibrosis in mice.2012
- Author(s)
  Okamoto Y, Hasegawa M
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64 Pages: 3726-3735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591644
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis.2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, Takehara K.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64 Issue: 11 Pages: 3726-35
- DOI
  10.1002/art.34643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24220011
[Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.2012
- Author(s)
  Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 71 Pages: 1259-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Host-derived MCP-1 and MIP-1αregulate protective anti-tumor immunity to localized and metastatic B16 melanoma2012
- Author(s)
  Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 180(1) Issue: 1 Pages: 365-74
- DOI
  10.1016/j.ajpath.2011.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study.2012
- Author(s)
  Hasegawa M
- Journal Title
  
  Rheumatology
  
  Volume: 51 Pages: 129-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study.2012
- Author(s)
  Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 51 Issue: 1 Pages: 129-133
- DOI
  10.1093/rheumatology/ker333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591618, KAKENHI-PROJECT-23591640
[Journal Article] Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins2012
- Author(s)
  Fujimoto M, Hamaguchi Y, Kaji K, Matsushita T, Ichimura Y, Kodera M, Ishiguro N, Ueda-Hayakawa I, Asano Y, Ogawa F, Fujikawa K, Miyagi T, Mabuchi E, Hirose K, Akimoto N, Hatta N, Tsutsui K, Higashi A, Igarashi A, Seishima M, Hasegawa M, Takehara K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64(2) Issue: 2 Pages: 513-22
- DOI
  10.1002/art.33403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24590185
[Journal Article] Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies : possible association with malignancy2012
- Author(s)
  Ichimura Y, Matsushita T, Hamaguchi Y, Kaji K, Hasegawa M, Tanino Y, Inokoshi Y, Kawai K, Kanekura T, Habuchi M, Igarashi A, Sogame R, Hashimoto T, Koga T, Nishino A, Ishiguro N, Sugimoto N, Aoki R, Ando N, Abe T, Kanda T, Kuwana M, Takehara K, Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71(5) Issue: 5 Pages: 710-3
- DOI
  10.1136/annrheumdis-2011-200697
- NAID
  120004442395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis2011
- Author(s)
  Hasegawa M, Fujimoto M, Hamaguchi Y, Matsushita T, Inoue K, Sato S, Takehara K
- Journal Title
  
  J Rheumatol
  
  Volume: 38(5) Issue: 5 Pages: 877-84
- DOI
  10.3899/jrheum.100591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Association between nail-fold capillary findings and disease activity in dermatomyositis2011
- Author(s)
  Mugii N, Hasegawa M, Matsushita T, Hamaguchi Y, Horie S, Yahata T, Inoue K, Someya F, Fujimoto M, Takehara K
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 50(6) Issue: 6 Pages: 1091-8
- DOI
  10.1093/rheumatology/keq430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis.2011
- Author(s)
  Hasegawa M, et al.
- Journal Title
  
  Clin Rheumatol
  
  Volume: 30 Pages: 231-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591456
[Journal Article] Dermoscopy findings of nail fold capillaries in connective tissue diseases2011
- Author(s)
  Hasegawa M, et al.
- Journal Title
  
  J Dermatol
  
  Volume: 38 Pages: 66-70
- NAID
  10027902799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591456
[Journal Article] Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.2011
- Author(s)
  Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Muro Y, et al. （全37名中17番目）
- Journal Title
  
  Arch. Dermatol.
  
  Volume: 147 Issue: 4 Pages: 391-398
- DOI
  10.1001/archdermatol.2011.52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591618, KAKENHI-PROJECT-23591640
[Journal Article] Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production2011
- Author(s)
  Maeda S, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 179(5) Issue: 5 Pages: 2360-9
- DOI
  10.1016/j.ajpath.2011.07.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Inducible costimulator ligand(ICOSL) regulates bleomycin-induced Lung and skin fibrosis independently of the ICOS-ICOSL pathway2010
- Author(s)
  Tanaka C, Fujimoto M, Hamaguchi Y, Sato S, Takehara K, Hasegawa M
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62 Issue: 6 Pages: 1723-32
- DOI
  10.1002/art.27428
- NAID
  10029469768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591456
[Journal Article] B lymphocytes : shedding new light on the pathogenesis of systemic sclerosis2010
- Author(s)
  Hasegawa M.
- Journal Title
  
  J Dermatol 37
  
  Pages: 3-10
- NAID
  10027064811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591456
[Journal Article] Reduced red blood cell velocity in nail-fold capillaries as a sensitive and specific indicator of microcirculation injury in systemic sclerosis2009
- Author(s)
  Mugii N, Hasegawa M, et al.
- Journal Title
  
  Rheumatology (Oxford) 48
  
  Pages: 696-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591456
[Journal Article] Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases2006
- Author(s)
  Matsushita T, Hasegawa M, et. al.
- Journal Title
  
  Exp Dermatol 16
  
  Pages: 87-93
- NAID
  120005756481
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis2006
- Author(s)
  Hasegawa M, et. al.
- Journal Title
  
  The American Journal of Pathology 169
  
  Pages: 954-966
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases2006
- Author(s)
  Matsushita, T., Hasegawa, M., et. al.
- Journal Title
  
  Exp Dermatol 16
  
  Pages: 87-93
- NAID
  120005756481
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] The efficacy of self-administered stretching for finger joint motion in Japanese patients with systemic sclerosis.2006
- Author(s)
  Mugii N, Hasegawa M, et al.
- Journal Title
  
  J Rheumatol 33・8
  
  Pages: 1586-1592
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis2006
- Author(s)
  Minoru Hasegawa, Yasuhito Hamaguchi, Koichi Yanaba, Jean-David Bouaziz, Junji Uchida, Manabu Fujimoto, Takashi Matsushita, Yukiyo Matsushita, Mayuka Horikawa, Kazuhiro Komura, Kazuhiko Takehara, Shinichi Sato, Thomas F. Tedder
- Journal Title
  
  Am J Pathol 169
  
  Pages: 954-966
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases.2006
- Author(s)
  Matsushita T, Hasegawa M, et al.
- Journal Title
  
  Exp Dermatol 16・2
  
  Pages: 87-93
- NAID
  120005756481
- Data Source
  KAKENHI-PROJECT-18591238
[Journal Article] The efficacy of self-administered stretching for finger joint motion in Japanese patients with systemic sclerosis2006
- Author(s)
  Mugii N, Hasegawa M, et. al.
- Journal Title
  
  J Rheumatol 33
  
  Pages: 1586-1592
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591238
[Presentation] A curcumin-derivative LG283 that inhibits TGF-β/Smad/Snail-dependent mesenchymal transition ameliorates bleomycin-induced skin fibrosis and vascular injury2021
- Author(s)
  A. Utsunomiya, T. Chino, N. Oyama, S. Niwa, M. Hasegawa
- Organizer
  2021 SID Virtual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08769
[Presentation] Blockade of CX3CL1-CX3CR1 pathway attenuates skin inflammation, fibrosis, and vascular injury in experimental mouse models of systemic sclerosis2018
- Author(s)
  Vu Huy Luong, Takenao Chino, Noritaka Oyama, Takashi Matsushita, Takashi Obara, Yoshikazu Kuboi, Naoto Ishii, Akihito Machinaga, Hideaki Ogasawara, Wataru Ikeda, Toshio Imai, Minoru Hasegawa
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09763
[Presentation] Anti-CX3CL1 antibody therapy attenuates the development of inflammation, fibrosis, and vascular injury2017
- Author(s)
  Vu H. Luong, Takenao Chino, Noritaka Oyama, Takashi Obara, Yoshikazu Kuboi, Naoto Ishii, Akihito Machinaga, Hideaki Ogasawara, Wataru Ikeda, Toshio Imai, Minoru Hasegawa
- Organizer
  日本研究皮膚科学会第42回年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-15K09763
[Presentation] Anti-CX3CL1 antiboby therapy attenuates the development of bleomycin-induced and growth factors-induced skin fibrosis in mice.2016
- Author(s)
  Vu H.Luong, Chino T, Oyama N, Kuboi Y, Obara T, Machinaga A, Ogasawara H, Ikeda W, Imai T, Hasegawa M.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県那覇市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K09763
[Presentation] Anti-CX3CL1 monoclonal antiboby: a promising therapy for systemic sclerosis.2015
- Author(s)
  Vu H.Luong, Chino T, Tokuriki A, Oyama N, Hasegawa M, Kuboi Y, Obara T, Yasuda N, Muramoto K, Imai T.
- Organizer
  日本研究皮膚科学会第40回年次学術大会・総会
- Place of Presentation
  岡山市
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-15K09763
[Presentation] Augmented ICOS-ICOS ligand signaling axis in patients with early diffuse cutaneous systemic sclerosis2011
- Author(s)
  Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K
- Organizer
  ACR/ARHP Scientific Meeting
- Place of Presentation
  マコーミックプレイス(シカゴ、USA)
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21591456
[Presentation] Augmented ICOS-ICOS ligand signaling axis in patients with early diffuse cutaneous systemic sclerosis2011
- Author(s)
  Minoru Hasegawa
- Organizer
  ACR/AEHP Scientific Meeting
- Place of Presentation
  マコーミックプレイス(シカゴ、USA)
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-21591456
[Presentation] A novel inhibitor of TGF-β/Smad signaling attenuates tissue fibrosis in mouse models of systemic sclerosis2010
- Author(s)
  Hasegawa M, et al.
- Organizer
  1'st Systemic Sclerosis World Congress
- Place of Presentation
  フィレンツェ (イタリア)
- Year and Date
  2010-02-12
- Data Source
  KAKENHI-PROJECT-21591456
[Presentation] B lymphocyte depletion reduces skin fibrosis and autoimmunity in tight-skin mice2007
- Author(s)
  Hasegawa M
- Organizer
  Professor E. Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591238
[Presentation] B lymphocyte depletion reduces skin fibrosis and autoimmunity in tight-skin mice2007
- Author(s)
  Hasegawa, M
- Organizer
  Professor E. Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591238

1. TAKEHARA KAZUHIKO (50142253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. SATO Shinichi (20215792)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUSHITA Takashi (60432126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. Chino Takenao (20521397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Tokuriki Atsushi (90397274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OGAWA Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
8. 室慶直

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

hasegawa minoru 長谷川 稔

Hasegawa Minoru 長谷川 稔

HASEGAWA Minoru 長谷川 稔

長谷川 稔 ハセカ゛ワ ミノル

Research Projects

Research Products

Co-Researchers

内皮間葉移行阻害薬の探索と強皮症治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Could epithelial-mesenchymal transition inhibitors be a novel treatment for systemic sclerosis?Principal Investigator

Principal Investigator

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Review Section

Research Institution

Development of a novel therapy using anti-CX3CL1 antibody in systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of the novel embryonic cure system for an intractable skin disease mouse model by using a mesenchymal stem cells from the circulation blood of mouse embryo

Principal Investigator

Project Period (FY)

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Research Institution

Cytokine-targeted therapy of sclerodermaPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation and therapeutic application of ICOS and ICOSL in systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

B cell depletion therapy for the model mouse of sclerodermaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD21/35欠損マウスの作成と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relative contribution of various adhesion molecules to tissue injury induced by immune complex deposition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性強皮症とそのモデルマウスにおけるサイトカインおよびケモカインの関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the new animal model for systemic sclerosis using the immunologic function of CD19 and CD22

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling2022

hasegawa minoru 長谷川稔

Hasegawa Minoru 長谷川稔

HASEGAWA Minoru 長谷川稔

長谷川稔ハセカ゛ワミノル