Fukudome K 福留健司

… Alternative Names

Fukudome Kenji 福留健司

FUKUDOME Kenji 福留健司

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Researcher Number	50284625
Other IDs
Affiliation (Current)	2025: 佐賀大学, 農学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2022: 佐賀大学, 全学教育機構, 教授 2009 – 2012: 佐賀大学, 医学部, 准教授 2003 – 2006: 佐賀大学, 医学部, 助教授 2001: 佐賀医科大学, 医学部, 助教授 1997 – 2000: 佐賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences Except Principal Investigator Immunology
Keywords	Principal Investigator モノクローナル抗体 / 血管内皮 / 血栓 / プロテインC / thrombosis / レセプター / 受容体 / PAR / blood coagulation / receptor … More / 血液凝固 / endothelial cells / protein C / thrombomodulin / トロンボモジュリン / 血栓症 / マラリア / 重症マラリア / 受容体」 / inflammation / endothelial cell / トロンビン / 炎症 / monoclonal antibody / endothelial / Protein C / 梗塞 / direct-sequence / leukemia / anticoagulant / EPCR / ダイレクトシークエンス / PCR(polymerase chain reaction) / ダイレクト・シークエンス / 腫瘍 / プロテインCレセプター / 抗体 / アゴニスト / 敗血症 / TLR / TLR4 / ストレスシグナル / 粗面小胞体 / 血液免疫学 / ELISA / 乳癌 … More Except Principal Investigator LPS / MD-2 / pCAGG-S1 vector / epitope / NF κ B reporter gene / E coli expression / fusion protein / pET32 vector / pCAG-S1ベクター / pCAGG-S1ベクター / エピトープ / NFκBレポーター遺伝子 / 大腸菌発現系 / 融合蛋白 / pET32ベクター / 感染防御 / 自然免疫 / 刺激型抗体 / TLR4/MD-2 / 免疫賦活 / 抗体 Less

Development of humanized anti-EPCR mAbPrincipal Investigator
- Principal Investigator
  
  Fukudome Kenji
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Saga University
Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vesselPrincipal Investigator
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Structural and Functional Analysis of the MD-2 protein
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Regulation mechanism for inflammation mediated by endothelial cell protein C receptorPrincipal Investigator
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
  佐賀医科大学
プロテインCレセプターを指標とした乳癌の早期発見法の開発Principal Investigator
- Principal Investigator
  
  福留健司
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  佐賀医科大学
Anticoagulant Function of Arterial Endothelial CellsPrincipal Investigator
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga Medical School
Screening for diseases with molecular defects in protein C receptorPrincipal Investigator
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga Medical School

All 2022 2019 2013 2012 2011 2010 2009 2003

All Journal Article Presentation

[Journal Article] Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria2022
- Author(s)
  Niamh O'Regan Kristina Gegenbauer Eimear M. Gleeson Kenji Fukudome Jamie M. O'Sullivan Clive Drakeford Niall Dalton Alain Chion Teresa M. Brophy Owen P. Smith Roger J.S. Preston James S. O'Donnell
- Journal Title
  
  Haematologica
  
  Volume: 107 Issue: 8 Pages: 1950-1954
- DOI
  10.3324/haematol.2021.280450
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08333
[Journal Article] Hydrothermal processing of beta-Glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR ligands2019
- Author(s)
  N. Hayashi, Y. Shoubayashi, N. Kondo, K. Fukudome
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 511 Issue: 2 Pages: 318-322
- DOI
  10.1016/j.bbrc.2019.02.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08333
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 190(1) Pages: 195-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013
- Author(s)
  Nurlaely MR, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 25(2) Pages: 117-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, .
- Journal Title
  
  Int Immunol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Blocking endothelial protein C receptor (EPCR) accelerates thrombus development in vivo2010
- Author(s)
  Centelles MN, Puy C, Lopez-Sagaseta J, Fukudome K, Montes R, Hermida J
- Journal Title
  
  Thromb Haemost
  
  Volume: 03(6) Pages: 1239-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Organotypic culture of human bone marrow adipose tissue2010
- Author(s)
  Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E, Soejima H, Fukudome K, Sugihara H, Hotokebuchi T, Toda S
- Journal Title
  
  Pathol Int
  
  Volume: 60(4) Pages: 259-67
- NAID
  10029331372
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Blocking endothelial protein C receptor(EPCR) accelerates thrombus development in vivo2010
- Author(s)
  Centelles MN, Puy C, Lopez-Sagaseta J, Fukudome K, Montes R, Hermida J.
- Journal Title
  
  Thromb Haemost
  
  Volume: 103(6) Pages: 1239-44
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function2010
- Author(s)
  Minhas N, Xue M, Fukudome K, Jackson CJ
- Journal Title
  
  FASEB J
  
  Volume: 24(3) Pages: 873-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Activated protein C utilizes the angiopoietin/ Tie2 axis to promote endothelial barrier function2010
- Author(s)
  Minhas N, Xue M, Fukudome K, Jackson CJ.
- Journal Title
  
  FASEB J
  
  Volume: 24(3) Pages: 873-81
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Organotypic culture of human bone marrow adipose tissue2010
- Author(s)
  Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E, Soejima H, Fukudome K, Sugihara H, Hotokebuchi T, Toda S
- Journal Title
  
  Pathol Int
  
  Volume: 60(4) Pages: 259-67
- NAID
  10029331372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Effect of disease activity and corticosteroids on protein C receptor in patients with systemic lupus erythematosus2009
- Author(s)
  Koarada S, Tsuneyoshi N, Haruta Y, Tada Y, Mitamura M, Inoue H, Ohta A, Fukudome K, Nagasawa K.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 19(2) Pages: 173-9
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] MD-2蛋白の大腸菌での発現2003
- Author(s)
  福留健司
- Journal Title
  
  日本免疫学会総会誌 33
  
  Pages: 126-126
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591011
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/ MD-2 antibody2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody.2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharidebindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538

1. KIMOTO Masao (40153225)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. TSUNEYOSHI Naoko (80336114)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. TSUKAMOTO Hiroki (70423605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. WATANABE Keiichi (40191754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MOTOSHIMA Hiroyuki (20312275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Fukudome K 福留 健司

Fukudome Kenji 福留 健司

FUKUDOME Kenji 福留 健司

Research Projects

Research Products

Co-Researchers

Development of humanized anti-EPCR mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vesselPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and Functional Analysis of the MD-2 protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation mechanism for inflammation mediated by endothelial cell protein C receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プロテインCレセプターを指標とした乳癌の早期発見法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anticoagulant Function of Arterial Endothelial CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening for diseases with molecular defects in protein C receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrothermal processing of beta-Glucan from Aureobasidium pullulans produces a low molecular weight reagent that regulates inflammatory responses induced by TLR ligands2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013

Author(s)

Journal Title

Data Source

[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013

Author(s)

Journal Title

Data Source

[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012

Author(s)

Fukudome K 福留健司

Fukudome Kenji 福留健司

FUKUDOME Kenji 福留健司