YOSHIYAMA Yasumasa 吉山容正

… Alternative Names

吉山容正ヨシヤマヤスマサ

Less

Researcher Number	50292701
Affiliation (based on the past Project Information) *help	2015: 独立行政法人国立病院機構, 千葉東病院臨床研究センター, 室長 2012: 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 2012: 国立病院機構, 千葉東病院, 診療部長、神経内科医長、神経変性疾患研究室長 2011: 独立行政法人国立病院機構千葉東病院, 臨床研究センター, 神経変性疾患研究室長 2010: 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, 研究室長 … More 2008: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 臨床研究センター, 室長 2008: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 千葉東病院臨床研究センター, 室長 2007: Clinical research Center, Chiba-East National Hospital, National Hospital Organization, 分子生物学研究部, 発生工学室長 1999: 千葉大学, 医学部附属病院, 助手 1998: 千葉大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurology / Nerve anatomy/Neuropathology / Neurology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 神経変性 / タウ / 運動 / 糖尿病 / 生活習慣病 / アルツハイマー病 / 認知症 / 肥満 / タウ病理 / シナプス … More / マイクログリア / モデルマウス / タウオパチー / 神経変性疾患 / ラミニン / 血液・脳関門 / プラズミノーゲンアクチベーター / laminin / plasminogen actirator / 多発性硬化症 … More Except Principal Investigator オートファジー / アルツハイマー病 / モデル動物 / 神経炎症 / タウタンパク / イメージング / 薬学 / 脳疾患研究 / 認知症 / 生体分子 / 神経科学 Less

Molecular imaging of neurotoxic signaling in neurodegenerative disorders
- Principal Investigator
  
  Higuchi Makoto
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
Research for revealing the pathomechanism between metabolic syndrome and dementia: a study using a tauopathy mouse modelPrincipal Investigator
- Principal Investigator
  
  YOSHIYAMA Yasumasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  国立病院機構
   Clinical research Center, Chiba-East National Hospital, National Hospital Organization
Research for elucidation of pathomechanism in tauopathy using a tauopathy model mousePrincipal Investigator
- Principal Investigator
  
  吉山容正
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Clinical research Center, Chiba-East National Hospital, National Hospital Organization
多発性硬化症患者血清のプラズミノーゲンアクチベーター誘導能とその機能の検討Principal Investigator
- Principal Investigator
  
  吉山容正
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Chiba University

All 2013 2012 2011 2010 2008 2007 Other

All Journal Article Presentation

[Journal Article] Anticholinergics boost the pathological process of neurodegenerat ion with increased inflammation in a tauopathy mouse model2012
- Author(s)
  Yoshiyama Y, Kojima A, Itoh K, Uchiyama T, Arai K
- Journal Title
  
  Neurobiol Dis
  
  Volume: 45 Issue: 1 Pages: 329-36
- DOI
  10.1016/j.nbd.2011.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] Neuroimaging studies of diabetes and risk of Alzheimer's disease2012
- Author(s)
  Hirano S, Shimada H, Yoshiyama Y
- Journal Title
  
  Brain Nerve
  
  Volume: 64(12) Pages: 1411-9
- NAID
  40019510555
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: an immunohistochemical study2011
- Author(s)
  Shibuya K, Misawa S, Arai K, Nakata M, Kanai K, Yoshiyama Y, Ito K, Isose S, Noto Y, Nasu S, Sekiguchi Y, Fujimaki Y, Ohmori S, Kitamura H, Sato Y, Kuwabara S
- Journal Title
  
  Exp Neurol
  
  Volume: 232(2) Pages: 149-53
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis : an immunohistochemical study2011
- Author(s)
  Shibuya K, Misawa S, Arai K, Nakata M, Kanai K, Yoshiyama Y
- Journal Title
  
  Exp Neurol
  
  Volume: 232 Issue: 2 Pages: 149-53
- DOI
  10.1016/j.expneurol.2011.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590948, KAKENHI-PROJECT-23591269
[Journal Article] P301L(S)2011
- Author(s)
  Yoshiyama Y
- Journal Title
  
  Nihon Rinsho
  
  Volume: 69 Suppl 8 Pages: 262-6
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] 知症研究に用いられる動物・細胞実験モデル各論遺伝子改変モデルP301L(S2011
- Author(s)
  吉山容正
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 262-266
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model2010
- Author(s)
  Yoshiyama Y, Kojima A, Ishikawa C, Arai K
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 22(1) Pages: 295-306
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model2010
- Author(s)
  Yoshiyama Y
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 22 Pages: 295-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590948
[Journal Article] 神経変性と炎症:FTDP-17モデルマウスをもちいて2008
- Author(s)
  吉山容正
- Journal Title
  
  臨床神経 48
  
  Pages: 910-912
- NAID
  10024898570
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy2008
- Author(s)
  Ito K, Arai K, Yoshiyama Y, Kashiwado K, Sakakibara Y, Hattori T
- Journal Title
  
  Acta Neuropathol 115
  
  Pages: 623-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay2008
- Author(s)
  Hayakawa S, Mori M, Okuta A, Kamegawa A, Fujiyoshi Y. Yoshiyama Y, Mitsuoka K, Ishibashi K, Sasaki S, Hattori T, Kuwabara S
- Journal Title
  
  Jornal of Neuroimmunology 196
  
  Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay2008
- Author(s)
  Hayakawa S, Mori M, Okuta A, Kamegawa A, Fujiyoshi Y, Yoshiyama Y, Mitsuoka K, Ishibashi K, Sasaki S, Hattori T, Kuwabara S.
- Journal Title
  
  Journal of Neuroimmunology 196
  
  Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy2008
- Author(s)
  Ito K, Arai K, Yoshiyama Y, Kashiwado K, Sakakibara Y, Hattori T.
- Journal Title
  
  Acta Neuropathol 115
  
  Pages: 623-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] タウオパチーの歴史的経緯と概念2008
- Author(s)
  吉山容正
- Journal Title
  
  医事新報 4417
  
  Pages: 95-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Mode●2007
- Author(s)
  Yoshiyama Y, ほか
- Journal Title
  
  Neuron 53
  
  Pages: 337-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model2007
- Author(s)
  Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM
- Journal Title
  
  Neuron 53
  
  Pages: 337-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500315
[Journal Article] herapeutic strategies for tau mediated neurodegeneration
- Author(s)
  Yoshiyama Y, Lee VM, Trojanowski JQ
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 84 Pages: 784-95
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] メタボリックシンドロームのタウ病理増強作用:レプチンのグリア細胞に対する影響2013
- Author(s)
  吉山容正
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Year and Date
  2013-05-29
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] Voluntary exercise suppresses enhanced tau pathology by high calorie diet in a tauopathy mouse model2012
- Author(s)
  Yasumasa Yoshiyama
- Organizer
  5th Clinical Trials Conference on Alzheimer's Disease
- Place of Presentation
  Monte Carlo
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] タウオパチーモデルマウスを用いた神経変性に対する高カロリー摂取と運動の影響の検討-特にグリアにおけるレプチンレセプターの変化について-2012
- Author(s)
  吉山容正
- Organizer
  第27回老年精神医学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] 自発的運動により高カロリー摂取によるタウ病理の悪化が改善する:タウオパチーモデルマウスを用いた検討2011
- Author(s)
  吉山容正、伊藤喜美子、新井公人
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] 抗コリン薬は認知症の神経変性を増強するか:モデルマウスを用いた検討:P301S変異タウ遺伝子導入マウスを用いた生化学的・病理学的検討2011
- Author(s)
  吉山容正
- Organizer
  第26回老年精神医学会
- Place of Presentation
  東京
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] High calorie diet enhanced, but voluntary exercise restored tau pathology in a tauopathy model mouse2010
- Author(s)
  Yasumasa Yoshiyama
- Organizer
  Alzheimer's association international conference on Alzheimer's disease 2010
- Place of Presentation
  Honolulu
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] High calorie diet enhanced, but voluntary exercise restored tau pathology in a tauopathy model mouse2010
- Author(s)
  Yasumasa Yoshiyama
- Organizer
  Alzheimer's association international conference on Alzheimer's diease 2010
- Place of Presentation
  Honolulu, Hawaii
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] メタボリックシンドロームと神経変性:タウオパチーモデルマウスを用いた検討2010
- Author(s)
  吉山容正
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] 次世代の対認知症戦略2010
- Author(s)
  吉山容正
- Organizer
  第20回日本臨床精神薬理学会、第40回日本神経精神薬理学会
- Place of Presentation
  仙台
- Year and Date
  2010-09-15
- Data Source
  KAKENHI-PROJECT-22590948
[Presentation] Acetylcholine Slows Neurodegeneration In A Tauopathy Model Mouse2008
- Author(s)
  Yasumasa Yoshiyama
- Organizer
  International Conference on Alzheimer's Disease
- Place of Presentation
  Chicaog, Illinois, United States
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 筋萎縮性側索硬化症脊髄におけるTDP-43の病型別発現の検討2008
- Author(s)
  新井公人、吉山容正、石川千恵子、伊藤喜美子
- Organizer
  第49回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] Acetylcholine Slows Neurodegeneration In A Tauopathy Model Mouse2008
- Author(s)
  Yoshiyama Y
- Organizer
  International Conference on Alzheimer's Disease
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] アルツハイマー病スクリーニングテスト「脳の健康診断」2008
- Author(s)
  柏戸孝一、吉山容正
- Organizer
  第27回認知賞学会各術集会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 神経変性と炎症:FTDP-17モデルマウスを用いて2008
- Author(s)
  吉山容正
- Organizer
  第49回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 脳内アセチルコリンは神経変性、炎症に関与している2008
- Author(s)
  吉山容正
- Organizer
  第27回認知症学会各術集会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 筋萎縮性側索硬化症脊髄におけるTDP-43の病型別発現の検討2008
- Author(s)
  新井公人, 吉山容正, 石川千恵子, 伊藤喜美子
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] かかりつけ医外来で実施するアルツハイマー病スクリーニングテスト2008
- Author(s)
  柏戸孝一、吉山容正
- Organizer
  第49回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] タウオパチーモデルマウスにおける細胞小器官の変化2008
- Author(s)
  吉山容正
- Organizer
  第49回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] アルツハイマー病スクリーニングテスト「脳の健康診断」2008
- Author(s)
  柏戸孝一, 吉山容正
- Organizer
  第27回認知症学会各術集会
- Place of Presentation
  前橋
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 脳内アセチルコリンは神経変性、炎症に関与している2008
- Author(s)
  吉山容正
- Organizer
  第27回認知賞学会各術集会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] HLA-DR15はアルツハイマー病早期発症のリスクファクター2008
- Author(s)
  坂巻建夫, 大西民子, 岡村康子, 高橋千尋, 飯田好江, 吉山容正
- Organizer
  第17回日本組織適合性学会大会
- Place of Presentation
  大阪
- Year and Date
  2008-09-19
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] HLA-DR15はアルツハイマー病早期発症のリスクファクター2008
- Author(s)
  逆巻健夫、大西民子、岡村康子、高橋千尋、飯田好江、吉山容正
- Organizer
  第17回日本組織適合性学会大会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 多系統萎縮症の自然史に関する研究2007
- Author(s)
  新井公人、吉山容正、小河原一恵、石川千恵子
- Organizer
  第48回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] The natural history of multiple system atrophy2007
- Author(s)
  Arai, K, Yoshiyama Y, Ogawara K, Ishikawa C
- Organizer
  11^<th> International Congress of Parkinson's Disease and Movement Disorders
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 前頭側頭型認知症が疑われたLeukoencephalopaty with neuroaxonal spheroids(LENAS)2007
- Author(s)
  新井公人、吉山容正、小河原一恵、石川千恵子、伊藤喜美子、城謙輔、北村博司
- Organizer
  第48回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] IMPAIRMENTS OF SYNAPTIC FUNCTIONS OCCUR PRIOR TO NEURONAL LOSS IN A MUTANT TAU TRANSGENIC MOUSE2007
- Author(s)
  Shu-Ming Huang, Yasumasa Yoshiyama, Makoto Higuchi, Bin Zhang, Nobuhisa Iwata, Jun Maeda, Tetsuya Suhara, John Q, Trojanowski Virginia M, Y, Lee, Takaomi C. Saido
- Organizer
  8^<th> International Conference on Alzheimer's and Parkinson's Diseases(AD/PD 2007)
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] P301S tau transgenic mouseにおいてはマイクログリアの活性化がタウ病理、神経変性に先行2007
- Author(s)
  吉山容正, ほか
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] 神経変性疾患におけるTDP-43蓄積について2007
- Author(s)
  新井公人、吉山容正、小河原一恵、石川千恵子、伊藤喜美子
- Organizer
  第1157回千葉医学会例会
- Data Source
  KAKENHI-PROJECT-19500315
[Presentation] P301S tau transgenic mouseにおいてはマイクログリアの活性化がタウ病理、神経変性に先行する2007
- Author(s)
  吉山容正、樋口正人、John Q. Trojanowski、Virginia MY Lee
- Organizer
  第48回日本神経学会総会
- Data Source
  KAKENHI-PROJECT-19500315

1. Higuchi Makoto (10373359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. SUHARA Tetsuya (90216490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MAEDA Jun (30415426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIYAMA Yasumasa 吉山 容正

吉山 容正 ヨシヤマ ヤスマサ

Research Projects

Research Products

Co-Researchers

Molecular imaging of neurotoxic signaling in neurodegenerative disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for revealing the pathomechanism between metabolic syndrome and dementia: a study using a tauopathy mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for elucidation of pathomechanism in tauopathy using a tauopathy model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

多発性硬化症患者血清のプラズミノーゲンアクチベーター誘導能とその機能の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anticholinergics boost the pathological process of neurodegenerat ion with increased inflammation in a tauopathy mouse model2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroimaging studies of diabetes and risk of Alzheimer's disease2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: an immunohistochemical study2011

Author(s)

Journal Title

Data Source

[Journal Article] Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis : an immunohistochemical study2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P301L(S)2011

Author(s)

Journal Title

Data Source

[Journal Article] 知症研究に用いられる動物・細胞実験モデル各論遺伝子改変モデルP301L(S2011

Author(s)

Journal Title

Data Source

[Journal Article] Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model2010

Author(s)

Journal Title

Data Source

[Journal Article] Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model2010

Author(s)

Journal Title

Data Source

[Journal Article] 神経変性と炎症:FTDP-17モデルマウスをもちいて2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy2008

Author(s)

Journal Title

Data Source

[Journal Article] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay2008

Author(s)

Journal Title

Data Source

[Journal Article] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay2008

Author(s)

Journal Title

YOSHIYAMA Yasumasa 吉山容正

吉山容正ヨシヤマヤスマサ

[Presentation] 抗コリン薬は認知症の神経変性を増強するか:モデルマウスを用いた検討:P301S変異タウ遺伝子導入マウスを用いた生化学的・病理学的検討2011