Ishii Ken 石井健

… Alternative Names

ISHII Ken 石井健

石井健イシイケン

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Researcher Number	50296670
Other IDs	https://orcid.org/0000-0002-5486-2795
Affiliation (Current)	2025: 東京歯科大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京歯科大学, 歯学部, 教授 2015 – 2021: 東邦大学, 医学部, 准教授 2012 – 2013: 東邦大学, 医学部, 准教授 2010 – 2011: 帝京大学, 医学部, 准教授 2010: Keio University, 医学部, 准教授 … More 2010: 慶應義塾大学, 医学部, 助教 2009: Keio University, 医学部, 講師 2008: Keio University, 医学部, 助教 2002: 帝京大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology
Keywords	Principal Investigator 天疱瘡 / 自己免疫 / 細胞接着 / 自己抗体 / 細胞間接着 / 自己免疫性疾患 / 皮膚科学 / 水疱症 / カドヘリン / 皮膚診断学 … More Except Principal Investigator … More 天疱瘡 / デスモソーム / 水疱症 / 免疫電顕 / 自己免疫 / 電子顕微鏡 / 自己免疫性水疱症 / 棘融解 / デスモグレイン3 / デスモグレイン / aurora A kinase / Aurora A kinase / 中心体 / Bowen病 / 扁平上皮癌 Less

デスモグレイン・デスモコリン接着阻害活性に注目した天疱瘡自己抗体の解析Principal Investigator
- Principal Investigator
  
  石井健
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Tokyo Dental College
  Toho University
Analysis of blister formation mechanism in pemphigus by a novel in vitro bead aggregation assayPrincipal Investigator
- Principal Investigator
  
  ISHII Ken
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Toho University
Mechanisms of blister formation in pemphigus foliacues analyzed by anti-Dsg1 monoclonal antibodiesPrincipal Investigator
- Principal Investigator
  
  ISHII Ken
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
detailed characterization of autoantibodies in paraneoplastic pemphigus by phage displayPrincipal Investigator
- Principal Investigator
  
  ISHII Ken
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
  Teikyo University
Analysis of pathomechanism of blister formation in pemphigus vulgaris using post-embedding immuno-electron microscopy
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Toho University
Development of new objective methods to assess disease activity in pemphigus using monoclonal single-chain- variable-fragment antibodiesPrincipal Investigator
- Principal Investigator
  
  ISHII Ken
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Analysis of mechanism for blister formation in pemphigus foliaceus using novel monoclonal antibody with pathogenic activity
- Principal Investigator
  
  ISHIKO Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
The analysis of centrosome replication cycle in Bowen's disease
- Principal Investigator
  
  KUBO Akiharu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
天疱瘡患者血清中抗体の病的活性の測定法の開発Principal Investigator
- Principal Investigator
  
  石井健
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Teikyo University

[Book] In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus. Molecular Dermatology Methods and Protocols Methods Mol Biol. Vol. 9612013
- Author(s)
  Ishii K, Amagai M
- Publisher
  Springer Science
- Data Source
  KAKENHI-PROJECT-23591628
[Journal Article] 自己抗体と天疱瘡2023
- Author(s)
  吉田憲司，石井健
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 79 Pages: 232-238
- Data Source
  KAKENHI-PROJECT-21K08335
[Journal Article] 新・皮膚科セミナリウム　水疱症アップデート　天疱瘡の水疱形成機構アップデート2023
- Author(s)
  石井健
- Journal Title
  
  日本皮膚科学会雑誌
  
  Volume: 133 Pages: 2799-2804
- Data Source
  KAKENHI-PROJECT-21K08335
[Journal Article] 天疱瘡自己抗体の最新の知見2022
- Author(s)
  石井健
- Journal Title
  
  皮膚科
  
  Volume: 2 Pages: 167-172
- Data Source
  KAKENHI-PROJECT-21K08335
[Journal Article] 増刊号特集最近のトピックス2021　Clinical Dermatology 2021 2.皮膚疾患の病態天疱瘡自己抗体はデスモグレインとデスモコリンのヘテロフィリック結合を直接阻害する2021
- Author(s)
  石井健
- Journal Title
  
  臨床皮膚科
  
  Volume: 75 Issue: 5 Pages: 56-60
- DOI
  10.11477/mf.1412206333
- ISSN
  0021-4973, 1882-1324
- Year and Date
  2021-04-10
- Data Source
  KAKENHI-PROJECT-18K08278
[Journal Article] Pemphigus Vulgaris and Foliaceus IgG Autoantibodies Directly Block Heterophilic Transinteraction between Desmoglein and Desmocollin2020
- Author(s)
  Ishii Ken、Yoshida Kenji、Stanley John R.、Yamagami Jun、Amagai Masayuki、Ishiko Akira
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 140 Issue: 10 Pages: 1919-1926.e7
- DOI
  10.1016/j.jid.2020.02.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08278
[Journal Article] Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering2017
- Author(s)
  Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Shiraishi K, Shirakata Y, Stanley JR, Ishiko A.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 85 Issue: 3 Pages: 197-207
- DOI
  10.1016/j.jdermsci.2016.12.010
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-15K09749
[Journal Article] Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris2017
- Author(s)
  Yoshida Kenji、Ishii Ken、Ishiko Akira
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 44 Issue: 11
- DOI
  10.1111/1346-8138.13957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09749
[Journal Article] Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis2013
- Author(s)
  Yoshida K, Yokouchi M, Nagao K, Ishii K, Amagai M, Kubo A
- Journal Title
  
  J Dermatol Sci
  
  Volume: 71 Issue: 2 Pages: 89-99
- DOI
  10.1016/j.jdermsci.2013.04.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249044, KAKENHI-PROJECT-23591628, KAKENHI-PROJECT-25670507
[Journal Article] Sporadic VACTERL association in a Japanese family with Sjogren-Larsson syndrome.2013
- Author(s)
  Takeichi T, Sugiura K, Arai H, Ishii K, Kono M, Akiyama M.
- Journal Title
  
  Acta Dermato-Venereol
  
  Volume: 93 Issue: 5 Pages: 579-580
- DOI
  10.2340/00015555-1526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249058, KAKENHI-PROJECT-23591628, KAKENHI-PROJECT-24591646, KAKENHI-PROJECT-24659526
[Journal Article] In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus2013
- Author(s)
  Ishii, K.
- Journal Title
  
  Methods Mol Biol
  
  Volume: 961 Pages: 219-225
- DOI
  10.1007/978-1-62703-227-8_13
- ISBN
  9781627032261, 9781627032278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-23591628
[Journal Article] Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display2012
- Author(s)
  Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M
- Journal Title
  
  J Invest Dermatol
  
  Volume: 132(4) Issue: 4 Pages: 1141-1148
- DOI
  10.1038/jid.2011.449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-23591628, KAKENHI-PROJECT-23791291
[Journal Article] Development of NC1 and NC2 domains of type VII collagen ELISA for the diagnosis and analysis of the time course of epidermolysis bullosa acquisita patients2011
- Author(s)
  Saleh MA
- Journal Title
  
  J Dermatol Sci
  
  Volume: 62 Issue: 3 Pages: 169-175
- DOI
  10.1016/j.jdermsci.2011.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-23591628
[Journal Article] Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity2010
- Author(s)
  Yamagami J, Payne AS, Kacir S, Ishii K, Siegel DL, Stanley JR
- Journal Title
  
  J Clin Invest. 120(11)
  
  Pages: 4111-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Immune response towards amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus2010
- Author(s)
  Chan PT, Ohyama B, Nishifuji K, Yoshida K, Ishii K, Hashimoto T, Amagai M
- Journal Title
  
  Br J Dermatol. 162(6)
  
  Pages: 1242-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.2009
- Author(s)
  Yamagami J, Kacir S, Ishii K, Payne AS, Siegel DL, Stanley JR
- Journal Title
  
  J Immunol. 183
  
  Pages: 5615-5621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.2009
- Author(s)
  Yokouchi M, Saleh MA, Kuroda K, Hachiya T, Stanley JR, Amagai M, Ishii K
- Journal Title
  
  J Invest Dermatol. 129
  
  Pages: 2156-2166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Pathogenic anti-desmoglein monoclonal antibodies demonstrate variable ELISA activity due to preferential binding of mature versus proprotein isoforms of desmoglein 32009
- Author(s)
  Sharma P, Choi EJ, Kuroda K, Hachiya T, Ishii K, Payne AS
- Journal Title
  
  J Invest Dermatol. 129
  
  Pages: 2309-2312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence2009
- Author(s)
  Yokouchi M, Saleh MA, Kuroda K, Hachiya T, Stanley JR, Amagai M, Ishii K
- Journal Title
  
  J Invest Dermatol. 129
  
  Pages: 2156-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus2009
- Author(s)
  Yamagami J, Kacir S, Ishii K, Payne AS, Siegel DL, Stanley JR
- Journal Title
  
  J Immunol. 183(9)
  
  Pages: 5615-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Journal Article] Isolation of Pathogenic Monoclonal Anti-Desmoglein 1 Human Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies2008
- Author(s)
  Ishii K, Lin C, Siegel DL, Stanley JR
- Journal Title
  
  J Invest Dermatol. 128(4)
  
  Pages: 939-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] 水疱性類天疱瘡と粘膜優位型尋常性天疱瘡を合併した１例2023
- Author(s)
  吉田憲司，今井杏里，栗田昂幸，橋本由起，兼古晃輔，石井健，石河晃
- Organizer
  第44回水疱症研究会
- Data Source
  KAKENHI-PROJECT-21K08335
[Presentation] Direct inhibition of heterophilic transinteraction between desmogleins and desmocollins by pemphigus autoantibodies2023
- Author(s)
  Ken Ishii
- Organizer
  ISID2023 Tokyo satellite meeting, The International Symposium on Autoimmunity Targeting the Skin Pemphigus, Pemphigoid, and Beyond
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08335
[Presentation] 天疱瘡の水疱形成機構アップデート．2022
- Author(s)
  石井健
- Organizer
  第121回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08335
[Presentation] Antibodies to desmocollin (Dsc) 3, but not Dsc1, in pemphigus sera directly block heterophilic transinteraction between desmoglein and Dsc.2021
- Author(s)
  Ken Ishii, Norito Ishii, Akira Ishiko, Takashi Hashimoto
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-21K08335
[Presentation] 組換えデスモグレイン／デスモコリン- ビーズ凝集法による天疱瘡の疾患活動性評価2021
- Author(s)
  漆畑真理、石井健、石河晃
- Organizer
  120回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] Antibodies to desmocollin (Dsc) 3, but not Dsc1, in pemphigus sera directly block heterophilic transinteraction between desmoglein and Dsc2021
- Author(s)
  Ken Ishii, Norito Ishii, Akira Ishiko, Takashi Hashimoto
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] Pemphigus autoantibodies directly inhibit heterophilic desmoglein -desmocollin adhesion by steric hindrance2019
- Author(s)
  Ken Ishii, Kenji Yoshida, Jun Yamagami, Masayuki Amagai, John R Stanley, Akira Ishiko
- Organizer
  44th Annual meeting of Japanese society of investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] 落葉状天疱瘡自己抗体はデスモグレイン1とデスモコリン1のトランス結合を阻害する．2019
- Author(s)
  石井健†，吉田憲司†，John R.Stanley, 石河晃†
- Organizer
  第40回水疱症研究会
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] Pemphigus vulgaris IgG autoantibodies directly inhibit heterophilic desmoglein 3-desmocollin 3 adhesion by steric hindrance2019
- Author(s)
  Ken Ishii, Jun Yamagami, Masayuki Amagai, John R Stanley, Akira Ishiko
- Organizer
  77th Annual Meeting of Society of investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] Pemphigus foliaceus IgG autoantibodies block heterophilic trans-interaction of desmoglein 1 and desmocollin 1 without intracellular signaling.2018
- Author(s)
  Ishii K†, Yoshida K†, JR. Stanley , Ishiko A.
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08278
[Presentation] Desmoglein 1 clustering in pemphigus foliaceus patients’ skin.2017
- Author(s)
  Kenji Yoshida, Ken Ishii1, Mari Nakagawa, Akira Ishiko
- Organizer
  Tne 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] Polyclonal nature of pemphigus foliaceus IgG antibodies enhances pathogenic effect for blister formation in association with p38MAPK-dependent desmoglein 1 clustering.2016
- Author(s)
  Yoshida K, Ishii K , Shimizu A , Yokouchi M , Amagai M ,John R.Stanley , Ishiko A
- Organizer
  Pathogenesis of pemphigus and pemhigoid 2016 the open blister/mind meeting,
- Place of Presentation
  ミュンヘン大学（ドイツ、ミュンヘン）
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] p38MAPK contributes to loss of cell adhesion through clustering of desmoglein 1 but is not required for blistering in pemphigus foliaceus .2016
- Author(s)
  Yoshida K , Ishii K, Shimizu A , Yokouchi M , Amagai M ,John R.Stanley, Ishiko A
- Organizer
  第41回日本研究皮膚科学会学術大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] p38 MAPK signaling is necessary for desmoglein 1 clustering and enhances pathogenic effect, but is not required for blistering in pemphigus foliaceus2015
- Author(s)
  Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Stanley JR, Ishiko A
- Organizer
  45th Annual European Society of Dermatological Research Meeting
- Place of Presentation
  オランダ、ロッテルダム
- Year and Date
  2015-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09749
[Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering2014
- Author(s)
  Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
- Organizer
  73rd annual meeting of Society for Investigative Dermatology
- Place of Presentation
  Alvuquerque, New Mexico, USA (Oral presentation)
- Year and Date
  2014-05-09
- Data Source
  KAKENHI-PROJECT-23591629
[Presentation] 喉頭粘膜病変を主症状とした抗ラミニン332型粘膜類天疱瘡の1例2013
- Author(s)
  市村知佳、陳怡如、高田裕子、石井健、峯村佐和子、石井文人、橋本隆、石河晃
- Organizer
  第35会水疱症研究会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] Analysis of epitope profile of autoantibodies in pemphigus vulgaris using domain-swapped Dsg3/Dsg2 ELISAs2012
- Author(s)
  Saleh M, Ken Ishii, Jun Yamagami, Takahisa Hachiya, Masayuki Amagai
- Organizer
  42nd Annual European Society of Dermatology Research Meeting
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] 骨髄異形成症候群に合併した抗p200類天疱瘡の1例2012
- Author(s)
  小原芙美子,橋本由起,漆畑真理,鷲崎久美子,石井健,関東裕美,石河晃
- Organizer
  第34回水疱症研究会
- Place of Presentation
  青森
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] What's new in bullous disease? What's new session2011
- Author(s)
  Ishii K
- Organizer
  22nd World Congress of Dermatology
- Place of Presentation
  Seoul Korea
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] Human epidermal tight junctions are functional and allow penetration of activated Langerhans cell dendrites2011
- Author(s)
  Yoshida K, Kubo A, Yokouchi M, Ishii K, Kawasaki H, Ebihara T, Ohyama M, Nagao K, Amagai M
- Organizer
  71th Annual meeting for The Society For Investigative Dermatology
- Place of Presentation
  Phoenix
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] What’s new in bullous disease?2011
- Author(s)
  Ishii K
- Organizer
  22nd World Congress of Dermatology(招待講演)
- Place of Presentation
  韓国、ソウル
- Data Source
  KAKENHI-PROJECT-23591628
[Presentation] 天疱瘡におけるELISA法による血清診断とPDAIによる重症度判定シンポジウム3「自己免疫水疱症の診断・治療20102010
- Author(s)
  石井健
- Organizer
  第62回日本皮膚科学会西部支部学術大会
- Place of Presentation
  倉敷
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] 天疱瘡におけるELISA法による血清診断とPDAIによる重症度判定2010
- Author(s)
  石井健
- Organizer
  第62回日本皮膚科学会西部支部学術大会
- Place of Presentation
  倉敷
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Pathogenic pemphigus autoantibodies target the amino-terminal adhesive sites of desmogleins which are unmasked by proteolytic processing of prosequence2009
- Author(s)
  石井健
- Organizer
  International Pemphigus Meeting, Berne
- Place of Presentation
  Switzerland
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Pathogenic pemphigus autoantibodies target the amino-terminal adhesive sites of desmogleins which are unmasked by proteolytic processing of prosequence.2009
- Author(s)
  Ishii K
- Organizer
  International Pemphigus Meeting
- Place of Presentation
  スイス
- Year and Date
  2009-06-29
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] The majority of anti-desmoglein autoantibodies in pemphigus target epitopes which are unmasked by proteolytic processing of prosequence2009
- Author(s)
  Ishii K, Yokouchi M, Saleh MA, Amagai M
- Organizer
  The 4^<th> joint meeting of Japanese dermatology association and Australasian college of Dermatologists
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] The majority of anti-desmoglein autoantibodies in pemphigus target epitopes which are unmasked by proteolytic processing of prosequence.2009
- Author(s)
  Ishii K, Yokouchi M, Saleh MA, Amagai M
- Organizer
  The 4^<th> joint meeting of Japanese dermatology association and Australasian college of Dermatologists
- Place of Presentation
  札幌
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Two pathogenic anti-desmoglein 1 (Dsg1)monoclonal antibodies isolated from one pemphigus foliaceus (PF)patient define major Dsgl epitopes recognized by most pemphigus patients.2008
- Author(s)
  Ishii K
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] デスモグレイン(Dsg)ELISA法の改良を目指した天疱瘡自己抗体の病的エピトープの解析2008
- Author(s)
  石井健、横内麻里子、Marwah Adly、黒田慶子、蜂矢隆久、天谷雅行
- Organizer
  第822回日本皮膚科学会東京支部研究地方会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] デスモグレイン(Dsg)ELISA法の改良を目指した天庖瘡自己抗体の病的エピトープの解析2008
- Author(s)
  石井健
- Organizer
  第822回日本皮膚科学会東京支部研究地方会
- Place of Presentation
  東京
- Year and Date
  2008-12-20
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Proteolytic processing of precursor desmoglein 1 (Dsg1) unmasks pathogenic epitopes2008
- Author(s)
  Yokouchi M, Ishii K, Stanley JR, Amagai M
- Organizer
  Post IID 2008 satellite international meeting on autoimmune bullous diseases
- Place of Presentation
  Otsu, Japan
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Two pathogenic anti-desmoglein 1 (Dsg1) monoclonal antibodies isolated from one pemphigus foliaceus (PF) patient define major Dsg1 epitopes recognized by most pemphigus patients2008
- Author(s)
  Ishii K, Adly M, Yokouchi M, Stanley JR, Amagai M
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] カドヘリンスーパーフアミリーの多様性デスモゾーマルカドヘリン天庖瘡自己抗体解析からの教訓2008
- Author(s)
  石井健
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591328
[Presentation] Combination of pemphigus foliaceus IgG monoclonal antibodies (mAbs) promotes desmoglein 1 clustering
- Author(s)
  Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, John Stanley, Akira Ishiko
- Organizer
  73rd Society for Investigative Dermatology
- Place of Presentation
  Albuquerque, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-23591629
[Presentation] Analysis of epitope profile of autoantibodies in pemphigus vulgaris using domain-swapped Dsg3/Dsg2 ELISAs
- Author(s)
  Saleh　M, Ken Ishii, Jun Yamagami, Takahisa Hachiya, Masayuki Amagai
- Organizer
  42nd Annual European Society of Dermatology Research Meeting
- Place of Presentation
  イタリア、ベニス
- Data Source
  KAKENHI-PROJECT-23591628

1. ISHIKO Akira (10202988)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. KUBO Akiharu (70335256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. AMAGAI Masayuki (90212563)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. YOSHIDA Kenji

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. FUNAKOSHI Takeru (80365353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OUCHI Takeshi (30528419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMIZU Atsushi (60383733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 永尾圭介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 河野通浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 杉浦一充

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 秋山真志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishii Ken 石井 健

ISHII Ken 石井 健

石井 健 イシイ ケン

Research Projects

Research Products

Co-Researchers

デスモグレイン・デスモコリン接着阻害活性に注目した天疱瘡自己抗体の解析Principal Investigator

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Analysis of blister formation mechanism in pemphigus by a novel in vitro bead aggregation assayPrincipal Investigator

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Mechanisms of blister formation in pemphigus foliacues analyzed by anti-Dsg1 monoclonal antibodiesPrincipal Investigator

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detailed characterization of autoantibodies in paraneoplastic pemphigus by phage displayPrincipal Investigator

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Analysis of pathomechanism of blister formation in pemphigus vulgaris using post-embedding immuno-electron microscopy

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Development of new objective methods to assess disease activity in pemphigus using monoclonal single-chain- variable-fragment antibodiesPrincipal Investigator

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Analysis of mechanism for blister formation in pemphigus foliaceus using novel monoclonal antibody with pathogenic activity

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The analysis of centrosome replication cycle in Bowen's disease

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天疱瘡患者血清中抗体の病的活性の測定法の開発Principal Investigator

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[Book] In vitro pathogenicity assay for anti-desmoglein autoantibodies in pemphigus. Molecular Dermatology Methods and Protocols Methods Mol Biol. Vol. 9612013

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[Journal Article] 自己抗体と天疱瘡2023

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[Journal Article] 新・皮膚科セミナリウム 水疱症アップデート 天疱瘡の水疱形成機構アップデート2023

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[Journal Article] 天疱瘡自己抗体の最新の知見2022

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[Journal Article] 増刊号特集 最近のトピックス2021 Clinical Dermatology 2021 2.皮膚疾患の病態 天疱瘡自己抗体はデスモグレインとデスモコリンのヘテロフィリック結合を直接阻害する2021

Author(s)

Journal Title

DOI

Ishii Ken 石井健

ISHII Ken 石井健

石井健イシイケン

[Journal Article] 新・皮膚科セミナリウム　水疱症アップデート　天疱瘡の水疱形成機構アップデート2023

[Journal Article] 増刊号特集最近のトピックス2021　Clinical Dermatology 2021 2.皮膚疾患の病態天疱瘡自己抗体はデスモグレインとデスモコリンのヘテロフィリック結合を直接阻害する2021