KUME Hiroaki 久米裕昭

… Alternative Names

久米浩昭クメヒロアキ

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Researcher Number	50303631
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010 – 2015: 近畿大学, 医学部, 准教授 2007 – 2008: Nagoya University, 大学院・医学系研究科, 講師 2006: Nagoya University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 講師 2003 – 2005: 名古屋大学, 大学院・医学系研究科, 講師 1998: School of Medicine, Nagoya University Professor Associate, 医学部, 助手
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Pathological medical chemistry
Keywords	Principal Investigator 気管支喘息 / 気道平滑筋 / Rho / Rho-kinase / 気道過敏性 / 気道リモデリング / S1P / Ca^<2+>感受性 / airway smooth muscle / airway remodeling … More / 細胞増殖 / 気道過敏性亢進 / 好酸球 / βアドレナリン受容体 / 細胞骨格 / 細胞遊走 / 酸化ストレス / oxidative stress / airway hyperresponsiveness / eosinophil / β-adrenergic receptors / G_i / ケモカイン / IL-5 / 好酸球浸潤 / スタチン / Ca^<2+> mobilization / Ca^<2+> sensitization / β-adrenergic desensitization / bronchial hyperreactivity / bronchial asthma / βアドレナリン受容体耐性化 / 脂質メディエーター / Y-27632 / スフィンゴシン1リン酸 / β-アドレナリン受容体耐性化 / 気道過敏症 / Ca^<2+>動態 / β受容体耐性化 / β2アドレナリン受容体 / 細胞内Ca2+ 感受性 / 細胞内Ca2+ 動態 / Ca2+チャネル / β2アドレナリン受容体耐性化 / COPD / Ca2+ 動態 / Ｇ蛋白 / イオンチャネル / ムスカリン受容体 / beta2 アドレナリン受容体 / allosteric effect / KCa channel / Ca2+ signaling / G protein / phenotype change / 喘息 / サリドマイド / サイトカイン / フェノタイプ / 過剰進展刺激 / Ca2+動態 / リモデリング / 低分子量G蛋白 / β_2 アドレナリン受容体 / 肺血管内皮細胞 / 気道平滑筋細胞 / 化学メディエーター / 好酸球性気道炎症 / β耐性化 … More Except Principal Investigator NKH477 / uroguanylin / atrial natriuretic peptide / forskolin / beta-stimulant / Ca^<2+>-activated K^+ channels / tracheal smooth muscle / bronchial asthina / コレラ毒素 / 百日咳毒素 / イソプロテレノール / iberiotoxin / βアドレナリン受容体刺激剤 / Ca^<2+>依存性K^+チャンネル / 心房性ナトリウム利尿ペプチド / ウログアニリン / フオルスコリン / β刺激薬 / Ca^<2+>依存性K^+チャネル / 気管平滑筋細胞 / 気管支喘息 / siRNA法 / 膵液 / ノックアウトマウス / HCO_3輸送 / SLC26A6 Cl-HCO_3交換輸送体 / 膵外分泌 / HCO_3^-チャネル / HCO_3^-透過性 / 膜電位 / 細胞内pH / 単離小葉間膵管 / 膵導管細胞 / CFTR / 重炭酸イオン / 膵管 / 粘膜上皮 Less

Molecularly-targeted therapy for asthma with a focus on migration and contractility of airway smooth muscle cellsPrincipal Investigator
- Principal Investigator
  
  KUME Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kinki University
A molecular pharmacological therapy for asthma based on phenotype changing in the structural cells in airwaysPrincipal Investigator
- Principal Investigator
  
  KUME Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kinki University
Pathophysiology of mucosal lesion caused by defects of epithelial HCO_3^--CO_2 transport
- Principal Investigator
  
  KONDO Takaharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
A molecular target for preventing airway remodelingPrincipal Investigator
- Principal Investigator
  
  KUME Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
Therapy for bronchial asthma by regulating a small G protein as a targeting moleculePrincipal Investigator
- Principal Investigator
  
  KUME Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
Role of Rho in the pathophysiology of bronchial asthmaPrincipal Investigator
- Principal Investigator
  
  KUME Hiroaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University
The role of Ca^<2+>-activated K^+ channels of tracheal smooth musde on anti-asthmatic agents
- Principal Investigator
  
  TAKAGI Kenzo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagoya University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2003 Other

All Journal Article Presentation Book

[Book] Frontiers in Clinical Drug Research-Anti Allergy Agentsjavascript:onTransientSave()2016
- Author(s)
  Kume H
- Total Pages
  79
- Publisher
  Bentham
- Data Source
  KAKENHI-PROJECT-25461201
[Book] Muscle Cell and Tissue2015
- Author(s)
  Kume H
- Total Pages
  41
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-25461201
[Book] "Muscle Cell and Tissue", Ca2+ dynamics and Ca2+ sensitization in the regulation of airway smooth muscle tone2015
- Author(s)
  Kume H
- Publisher
  InTech Europe
- Data Source
  KAKENHI-PROJECT-25461201
[Book] Calcium Signaling In Airway Smooth Muscle Cells2013
- Author(s)
  Hiroaki Kume
- Total Pages
  469
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461201
[Book] 喘息治療薬2012
- Author(s)
  久米裕昭、東田有智
- Publisher
  カラー版内科学、門脇孝、永井良三編西村書店
- Data Source
  KAKENHI-PROJECT-22590846
[Book] カラー版内科学2012
- Author(s)
  久米裕昭
- Total Pages
  2004
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-22590846
[Book] 気管支拡張薬、総合アレルギー学2011
- Author(s)
  久米裕昭、東田有智
- Publisher
  福田健編南山堂
- Data Source
  KAKENHI-PROJECT-22590846
[Book] β_2 刺激薬アレルギー疾患イラストレイテッド2010
- Author(s)
  久米裕昭、牧野靖、東田有智
- Publisher
  永倉俊和、福田寛、足立満編メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590846
[Book] β_2刺激薬、"アレルギー疾患イラストレイテッド"、永倉俊和、他、編2010
- Author(s)
  久米裕昭, 他
- Total Pages
  301
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590846
[Book] 気管支拡張薬、"総合アレルギー学"福田健編2010
- Author(s)
  久米裕昭、東田有智
- Total Pages
  748
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-22590846
[Book] β_2刺激薬気管支拡張薬の吸入療法"21世紀の吸入療法"薬物吸入療法研究会編2008
- Author(s)
  久米裕昭
- Publisher
  仙台気道研究所仙台市
- Data Source
  KAKENHI-PROJECT-19590891
[Book] β_2刺激薬気管支拡張薬の吸入療法“21世紀の吸入療法"薬物吸入療法研究科会編2008
- Author(s)
  久米裕昭
- Publisher
  仙台気道研究所、仙台市
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Research and development of bronchodilators for asthma and COPD with a focus on G protein/KCa channel linkage and β2-adrenergic intrinsic efficacy.2015
- Author(s)
  Kume H, Fukunaga K, Oguma T
- Journal Title
  
  Pharmacol Ther
  
  Volume: 156 Pages: 75-89
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] 気道平滑筋による気道過敏性機序とその治療2014
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギーの臨床
  
  Volume: 34 Pages: 227-232
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] 好酸球性気道炎症が潜伏する慢性閉塞性肺疾患に対する吸入長時間作用性β2刺激薬、吸入ステロイド薬併用の有効性　Asthma-COPD Overlap Syndrome(ACOS)の概念を踏まえて2014
- Author(s)
  久米裕昭、東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 21 Pages: 1966-1976
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] Effects of inhaled aminophylline on airway constriction and inflammation in ovalbumin-sensitized guinea pigs.2014
- Author(s)
  Muraki M, Wada S, Ohno T, Hanada S, Sawaguchi H, Iwanaga T, Kume H, Tohda Y
- Journal Title
  
  Drug Deliv.
  
  Volume: 21 Pages: 321-327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] SMART療法の有効性と安全性の検討2014
- Author(s)
  久米裕昭
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 61 Pages: 513-519
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] ムスカリン受容体を介する気道平滑筋収縮に対する長時間作用性抗コリン薬、およびβ2刺激薬の抑制効2013
- Author(s)
  久米裕昭, 岩永賢司, 忌部周, 佐藤隆司, 西山理, 東本有司, 中島宏和, 東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 766-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] ムスカリン受容体刺激による気道平滑筋収縮に対する長時間作用性抗コリン薬と長時間作用性β2刺激薬の相乗作用2013
- Author(s)
  久米裕昭, 西山理, 東本有司, 中島宏和, 村木正人, 東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 1856-1864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] RhoA/Rho-kinase系に基づく喘息の分子標的療法開発の可能性2013
- Author(s)
  久米裕昭
- Journal Title
  
  Progress in Medicine
  
  Volume: 33 Pages: 2741-2750
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] オーキシスの薬理学的特性2013
- Author(s)
  久米裕昭, 東田有智
- Journal Title
  
  吸入療法
  
  Volume: 5 Pages: 21-31
- Data Source
  KAKENHI-PROJECT-25461201
[Journal Article] Possible Involvement of Sphingosine-1-Phosphate/Gi/RhoA pathways in adherence of eosinophils to pulmonary endothelium.2012
- Author(s)
  Sashio T, Kume H, Takeda N, Asano T, Tsuji S, Kondo M, Hasegawa Y, Shimokata K
- Journal Title
  
  Allergol Int
  
  Volume: 61 Pages: 283-93
- NAID
  130004477122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma2012
- Author(s)
  Kotani H, Kishi R, Mouri A, Sashio T, Shindo J, Shiraki A, Hiramatsu T, Iwata S, Taniguchi H, Nishiyama O, Iwata M, Suzuki R, Gonda H, Niwa T, Kondo M, Hasegawa Y, Kume H, Noda Y
- Journal Title
  
  J Clin Pharm Ther
  
  Volume: 371 Pages: 112-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] Role of sphingosine-1-phosphate in r-adrenoceptor desensitization via Ca2+ sensitization in airway smooth muscle2012
- Author(s)
  Makino Y, Kume H, Oguma T, Sugishita M, Shiraki A, Hasegawa Y, Honjo H, Kamiya K
- Journal Title
  
  Allergol Int
  
  Volume: 61 Pages: 311-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] インダカテロール(新規超長時間作用性β_2刺激薬)の薬理学的特性とそれに基づく臨床的有用性2011
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギー・免疫
  
  Volume: 18 Pages: 1-858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] インダカテロール(新規超長時間作用性β_2 刺激薬)の薬理学的特性とそれに基づく臨床的有用性2011
- Author(s)
  久米裕昭, 忌部周, 塚本啓造, 沖本奈美, 深井有美, 山藤啓史, 牧野靖, 西山理, 岩永賢司, 東本有司, 中島宏和, 東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 18 Pages: 1858-1868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] COPD 治療におけるβ_2 刺激薬の特性2011
- Author(s)
  久米裕昭、東田有智
- Journal Title
  
  吸入療法
  
  Volume: 3 Pages: 30-40
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] 慢性閉塞性肺疾患に潜伏する好酸球性気道炎症に対する制御と吸入ステロイド薬/長時間作用性β_2刺激薬配合剤の有用性-あらたな臨床病型の可能性2010
- Author(s)
  久米裕昭, 他
- Journal Title
  
  アレルギー・免疫
  
  Volume: 17 Pages: 2056-2065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] 慢性閉塞性肺疾患の肺機能改善における短時間作用性 β_2 刺激薬の有効性―固有活性に基づいた効果の検討2010
- Author(s)
  久米裕昭、白木晶、綿谷奈々瀬、西川裕作、川内映理、佐藤隆司、東本有司、宮良高維、中島宏和、東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 17 Pages: 1230-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] 慢性閉塞性肺疾患に潜伏する好酸球性気道炎症に対する制御と吸入ステロイド薬/長時間作用性 β_2 刺激薬配合剤の有用性―あらたな臨床病型の可能性2010
- Author(s)
  久米裕昭、辻清太、塚本啓造、忌部周、山藤啓史、綿谷奈々瀬、宮嶋宏之、西川裕作、中島宏和、東田有智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 17 Pages: 2056-2065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] 慢性閉塞性肺疾患の肺機能改善における短時間作用性β_2刺激薬の有効性-固有活性に基づいた効果の検討2010
- Author(s)
  久米裕昭, 他
- Journal Title
  
  アレルギー・免疫
  
  Volume: 17 Pages: 1230-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells2010
- Author(s)
  Ito S, Suki B, Kume H, Numaguchi Y, Ishii M, Iwaki M, Kondo M, Naruse K, Hasegawa Y, Sokabe M
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 43 Pages: 26-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma2010
- Author(s)
  Asano T, Kume H, Taki F, Ito S, Hasegawa Y
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 33 Pages: 1028-32
- NAID
  130000247974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590846
[Journal Article] Regulation of endothelin-1-induced interleukin-6 production by Ca2+influx in human airway smooth muscle cells2009
- Author(s)
  Iwata S, Ito S, Iwaki M, Kondo M, Sashio T, Takeda N, Sokabe M, Hasegawa Y, Kume H
- Journal Title
  
  Eur J Pharmacol 605
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Role of Ca2+mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle2009
- Author(s)
  Shiraki A, Kume H, Oguma T, Makino Y, Ito S, Shimokata K, Honjo H, Kamiya K
- Journal Title
  
  Clin Exp Allergy 39
  
  Pages: 236-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] A novel Ca2+influx pathway activated by mechanical stretch in human airway smooth muscle cells2008
- Author(s)
  Ito S, Kume H, Naruse K, Kondo M, Takeda N, Iwata S, Hasegawa Y, Sokabe M
- Journal Title
  
  Am J Respir Cell Mol Biol 38
  
  Pages: 407-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] RhoA/Rho-kinase as a therapeutic target in asthma2008
- Author(s)
  Kume H
- Journal Title
  
  Curr Med Chem 15
  
  Pages: 2876-2885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] ホルモテロールの薬理学的特性-長時間作用性、かつ、即効性に基づく臨床的有効性2008
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギー・免疫 15
  
  Pages: 12-130
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Dual pathway activated by tert-butyl hydroperoxide in human airway anion secretion2008
- Author(s)
  Matsuno T, Ito Y, Ohashi T, Morise M, Takeda N, Shimokata K, Imaizumi K, Kume H, Hasegawa Y
- Journal Title
  
  J Pharmacol Exp Ther 327(2)
  
  Pages: 453-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590303
[Journal Article] ホルモテロールの薬理学的特性-長時間作用性、かつ、即効性に基づく臨床的有効性.2008
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギー・免疫 15
  
  Pages: 120-130
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Mast cell tryptase causes homologous desensitization of beta-adrenoceptors by Ca2+sensitization in tracheal smooth muscle2008
- Author(s)
  Kobayashi M, Kume H, Oguma T, Makino Y, Ito Y, Shimokata K
- Journal Title
  
  Clin Exp Allergy 38
  
  Pages: 135-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Role of Ca2+mobilization in desensitization of beta-adrenoceptors by platelet-derived growth factor in airway smooth muscle2008
- Author(s)
  Ikenouchi T, Kume H, Oguma T, Makino Y, Shiraki A, Ito Y, Shimokata K
- Journal Title
  
  Eur J Pharmacol 591
  
  Pages: 259-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction2008
- Author(s)
  Ito S, Kume H, Shiraki A, Kondo M, Makino Y, Kamiya K, Hasegawa Y
- Journal Title
  
  Pulm Pharmacol Ther 21
  
  Pages: 812-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] 症状が安定している気管支喘息患者に潜む好酸球性気道炎症-気道炎症と肺機能との乖離2007
- Author(s)
  久米裕昭, 他
- Journal Title
  
  呼吸 26
  
  Pages: 481-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Role of airway smooth muscle in the pathphysiology of asthma2007
- Author(s)
  Kume H, Ito S
- Journal Title
  
  Kokyu to Junkann 55(1)
  
  Pages: 57-64
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Effects of Rho-kinase inactivation on eosinophilia and Hyper-reactivity in murine airways by allergen challenges2007
- Author(s)
  Taki F, Kume H, Kobayashi T, Ohta H, Aratake H Shimokata K
- Journal Title
  
  Clin Exp Allergy (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 喘息における気道平滑筋の役割2007
- Author(s)
  久米裕昭、伊藤理
- Journal Title
  
  呼吸と循環 55
  
  Pages: 57-64
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Direct effects of hydrogen peroxide on airway smooth muscle tone : roles of Ca2+influx and Rho-kinase2007
- Author(s)
  Kojima K, Kume H, Ito S, Oguma T, Shiraki A, Kondo M, Ito Y, Shimokata K
- Journal Title
  
  Eur J Pharmacol 556
  
  Pages: 151-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Sphingosine 1-phosphate causes airway hyper-reactivity by Rho-mediated myosin phosphatase inactivation2007
- Author(s)
  Kume H et al.
- Journal Title
  
  J Pharmacol Exp Ther 320 (2)
  
  Pages: 766-773
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] β_2-adrenergic receptor agonists2007
- Author(s)
  Kume H, Asano T
- Journal Title
  
  Medical Practice (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Sphingosine 1-phosphate causes airway hyper-reactivity by Rho-mediated myosin phosphatase inactivation2007
- Author(s)
  Kume H et al.
- Journal Title
  
  J Pharmacol Exp Ther 320(2)
  
  Pages: 766-773
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 喘息における気道平滑筋の役割2007
- Author(s)
  久米裕昭
- Journal Title
  
  呼吸と循環 55(1)
  
  Pages: 57-64
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 症状が安定している気管支喘息患者に潜む好酸球性気道炎症-気道炎症と肺機能との乖離2007
- Author(s)
  久米裕昭
- Journal Title
  
  呼吸 26
  
  Pages: 481-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges2007
- Author(s)
  Taki F, Kume H, Kobayashi T, Ohta H, Aratake H, Shimokata K
- Journal Title
  
  Clin Exp Allergy 37
  
  Pages: 599-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] 喘息と気道平滑筋2007
- Author(s)
  久米裕昭
- Journal Title
  
  日胸 66
  
  Pages: 51-60
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation2007
- Author(s)
  Kume H, Takeda N, Oguma T, Ito S, Kondo M, Ito Y, Shimokata K
- Journal Title
  
  J Pharmacol Exp Ther 320
  
  Pages: 766-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Roles of P2X receptors and Ca2+sensitization in extracellular adenosine triphosphate-induced hyperresponsiveness in airway smooth muscle2007
- Author(s)
  Oguma T, Ito S, Kondo M, Makino Y, Shimokata K, Honjo H, Kamiya K, Kume H
- Journal Title
  
  Clin Exp Allergy 37
  
  Pages: 893-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Direct effects of hydrogen peroxide on airway smooth muscle tone : Ca^<2+> influx and Rho-kinase2007
- Author(s)
  Kojima K, Kume H, Ito S, Oguma T, Shiraki A, Kondo M, Ito Y, Shimokata K
- Journal Title
  
  Eur J Pharmacol 556(1-3)
  
  Pages: 151-156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 喘息における気道平滑筋の役割2007
- Author(s)
  久米裕昭、伊藤理
- Journal Title
  
  呼吸と循環 55
  
  Pages: 57-64
- Data Source
  KAKENHI-PROJECT-19590891
[Journal Article] Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.2007
- Author(s)
  Kume H, Takeda N, Oguma T, Ito S, Kondo M, Ito Y, Shimokata K
- Journal Title
  
  J Pharmacol Exp Ther. 320
  
  Pages: 766-773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590303
[Journal Article] β_2刺激薬2007
- Author(s)
  久米裕昭
- Journal Title
  
  Medical Practice (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Sphingosine 1-phosphate causes airway hyperreactivity by Rho-mrdiated myosin phosphatase inactivation2007
- Author(s)
  Kume H, Takeda N, Oguma T, Ito S, Kondo M, Ito Y, Shimokata K
- Journal Title
  
  J Pharmacol Exp Ther 320(2)
  
  Pages: 766-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Role of P2X receptors and Ca^<2+> sensitization in extracellular ATP-induced hyperresponsiveness in airway smooth muscle2007
- Author(s)
  Oguma T, Ito S, Kondo M, Makino Y, Shimokata K, Honjo H Kamiya K, Kume H
- Journal Title
  
  Clin Exp Allergy (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Role of stretch-activated cation channel and Rho-kinase in the spontaneouscontraction of airway smooth muscle.2006
- Author(s)
  Ito S, Kume H, Oguma T, Ito Y, Kondo M, Shimokata K, Bela S, Naruse K
- Journal Title
  
  Eur J Pharmacol 556(1-3)
  
  Pages: 135-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 長時間作用性β_2刺激薬を有効かつ安全に使用するための理論と実際2006
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギーの臨床 26(4)
  
  Pages: 66-78
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by symvastatin2006
- Author(s)
  Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H
- Journal Title
  
  Am J Pespir Cell Mol Biol 35(6)
  
  Pages: 722-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Rational use of long-acting β_2-adrenergic receptor agonists for patients with bronchial asthma2006
- Author(s)
  Kume H
- Journal Title
  
  Arerugi no rinshou 26(4)
  
  Pages: 66-78
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue : roles of mechanical force and the cytoskeleton2006
- Author(s)
  Ito S, Majumdar A, Kume H, Shimokata K, Naruse K, Lutchen KR, Stamenvic D, Suki B
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 290(6)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Involvement of reduced sensitivity to Ca^<2+> in β-adrenergic action on airway smooth muscle2006
- Author(s)
  Oguma T, Kume H, Ito S, Takeda N, Honjo H, Kodama I, Shimokata K, Kamiya K
- Journal Title
  
  Clin Exp Allergy 36(2)
  
  Pages: 183-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 長時間作用性β_2刺激薬を有効かつ安全に使用するための理論と実際2006
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギーの臨床 26 (4)
  
  Pages: 66-78
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 固有活性からみたリリーバー、コントローラーの使い分け2005
- Author(s)
  久米裕昭
- Journal Title
  
  アレルギー科 20 (6)
  
  Pages: 589-596
- NAID
  40007116937
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Rho-kinaseと気道平滑筋2005
- Author(s)
  久米裕昭
- Journal Title
  
  呼吸 24
  
  Pages: 661-667
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Rational use of β_2-adrenergic receptor agonists Based on their intrinsic efficacy2005
- Author(s)
  Kume H, Ikenouchi T
- Journal Title
  
  Arerugi ka 20(6)
  
  Pages: 589-596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Clinical use of β_2-adrenergic receptor agonists based on their intrinsic efficacy2005
- Author(s)
  Kume H
- Journal Title
  
  Allergology International 54
  
  Pages: 89-97
- NAID
  10014468835
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590805
[Journal Article] Mast cells and airway smooth muascle2005
- Author(s)
  Kume H, Kojima K
- Journal Title
  
  Zensoku 18(3)
  
  Pages: 49-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 肥満細胞と気道平滑筋2005
- Author(s)
  久米裕昭
- Journal Title
  
  喘息 18 (3)
  
  Pages: 49-53
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Rho-kinaseと気道平滑筋2005
- Author(s)
  久米裕昭
- Journal Title
  
  呼吸 24 (8)
  
  Pages: 661-667
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] 肥満細胞と気道平滑筋2005
- Author(s)
  久米裕昭
- Journal Title
  
  喘息 18
  
  Pages: 49-53
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Clinical use of β_2-adrenergic receptor agonists besed on their intrinsin efficacy2005
- Author(s)
  Kume H
- Journal Title
  
  Allergology International 54
  
  Pages: 89-97
- Data Source
  KAKENHI-PROJECT-15590805
[Journal Article] Clinical use of β_2-adrenergic receptor agonists besed on their intrinsic efficacy.2005
- Author(s)
  Kume H.
- Journal Title
  
  Allergology International 54
  
  Pages: 89-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590805
[Journal Article] Rho-kinase and airway smooth muscle2005
- Author(s)
  Kume H, Ito S
- Journal Title
  
  Kokyu 24(8)
  
  Pages: 661-667
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590785
[Journal Article] Involvement of Ca^<2+> mobilization in tachyphylaxis to β-adrenergic receptors in trachealis2003
- Author(s)
  Kume H
- Journal Title
  
  Am J Respir Cell Mol Biol 29
  
  Pages: 359-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590805
[Journal Article] Involvement of Ca^<2+> mobilization in tachyphylaxis to β-adrenergic receptors in trachalis.2003
- Author(s)
  Kume H, Ishkawa T, Oguma T, Ito S, Shimokata K, Kotlikoff MI
- Journal Title
  
  Am J Respir.Cell Mol Biol 29
  
  Pages: 359-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590805
[Presentation] ムスカリン受容体を介する気道平滑筋収縮に対する LAMA、SABA の相乗作用と G タンパク/KCa チャネル連関の役割2015
- Author(s)
  久米裕昭
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Effects of combination LABA with ICS on COPD with airway eosinophilia2015
- Author(s)
  Kume H
- Organizer
  20th Congress Asia Pacific Society of Respirology
- Place of Presentation
  Kuala Lumpur Convention Centre（マレーシア・クアラルンプール）
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] 抗コリン薬、beta2 刺激薬の相乗作用における L 型 Ca2+　channel (VDC) / Ca2+-activated2015
- Author(s)
  久米裕昭
- Organizer
  第55回日本呼吸器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] beta2刺激薬の展望と問題点を探る2015
- Author(s)
  久米裕昭
- Organizer
  第55回日本呼吸器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Invited
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] 薬物の特性とデバイスの特徴の両面から－質の高い吸入療法を目指して2015
- Author(s)
  久米裕昭
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪（東京）
- Year and Date
  2015-05-26
- Invited
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] 慢性閉塞性肺疾患の気管支拡張療法におけるLABA、LAMA併用の有効性2015
- Author(s)
  久米裕昭
- Organizer
  第55回日本呼吸器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] ムスカリン受容体刺激による気道平滑筋収縮の抑制におけるLAMA、LABA併用効2013
- Author(s)
  久米裕昭, 深井有美, 忌部周, 牧野靖, 山縣俊之, 佐野博幸, 岩永賢司, 東本有司, 吉田耕一郎, 東田有智
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Possible intracellular mechanisms underlying the synergistic action between LAMAs and LABAs against muscarinic contraction in airway smooth muscle.2013
- Author(s)
  H. Kume, S. Imbe, O. Nishiyama, T. Iwanaga, H. Sano, H. Nakajima, Y. Tohda
- Organizer
  18th Congress of the Asia Pasific Society of Respirology
- Place of Presentation
  Yokohama City, Japan
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] 気道過敏性の分子メカニズムと治療気道平滑筋の過敏性獲得機構2013
- Author(s)
  久米裕昭, 東田有智
- Organizer
  第25回日本アレルギー学会春季臨床大会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Involvement of G proteins in the synergistic effects between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle.2013
- Author(s)
  H. Kume, S. Imbe, T. Iwanaga, O. Nishiyama, Y. Higashimoto, Y. Tohda
- Organizer
  2013ATS International Conference
- Place of Presentation
  Philadelphia, PA, U.S.A.
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Involvement of the BK channels/G proteins processes in the synergistic effects between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle.2013
- Author(s)
  H. Kume, S. Imbe, T. Iwanaga, O. Nishiyama, Y. Higashimoto, Y. Tohda
- Organizer
  ERS Annual Congress 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Future Risk の予防に求められる LABAの必要性とその特性 Next stage of asthma treatment2012
- Author(s)
  久米裕昭、東田有智
- Organizer
  第24回日本アレルギー学会春季臨床大会
- Place of Presentation
  大阪市(ランチプログラム)
- Year and Date
  2012-05-13
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 気道炎症からみた喘息とCOPDの接点2012
- Author(s)
  久米裕昭
- Organizer
  第62回日本アレルギー学会秋季学術大会
- Place of Presentation
  大阪国際会議場、大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Future Risk の予防に求められる LABA の必要性とその特性2012
- Author(s)
  久米裕昭
- Organizer
  第24回日本アレルギー学会春季臨床大会
- Place of Presentation
  大阪国際会議場、大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 好酸球性気道炎症に基づく吸入ステロイド薬の有効性2012
- Author(s)
  久米裕昭
- Organizer
  第24回日本アレルギー学会春季臨床大会
- Place of Presentation
  大阪国際会議場、大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Synergistic effects of glycopyronium bromide and indacaterol on muscarinic agonist-induced contraction in airway smooth muscle.2012
- Author(s)
  Kume H
- Organizer
  ERS Annual Congress-Vienna 2012
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 気道炎症からみた喘息とCOPD の接点喘息とCOPD の接点2012
- Author(s)
  久米裕昭、東田有智
- Organizer
  第62回日本アレルギー学会秋季学術大会
- Place of Presentation
  大阪市(シンポジウム)
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Inhibitory effects of Indacaterol on muscarinic activation- and oxidative stress-induced contraction in airway smooth muscle2012
- Author(s)
  Kume H, Imbe S, Nishiyama O, Sano H, Yamagata T, Iwanaga T, Higashimoto Y, Nakajima H, Tohda Y
- Organizer
  ATS 2012 International Conference
- Place of Presentation
  San Francisco, California, U.S.A(Poster Discussion Session)
- Year and Date
  2012-05-20
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 慢性閉塞性肺疾患の新たな表現型-好酸球性気道炎症と気道過敏性からみた病型分類2012
- Author(s)
  久米裕昭、沖本奈美、深井有美、忌部周、宮嶋宏之、西山理、岩永賢司、東本有司、に鹿島宏和、東田有智
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 好酸球性気道炎症に基づく吸入ステロイド薬の有効性 COPD と喘息:治療の接点2012
- Author(s)
  久米裕昭、東田有智
- Organizer
  第24回日本アレルギー学会春季臨床大会
- Place of Presentation
  大阪市(シンポジウム)
- Year and Date
  2012-05-13
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Indacaterol(超長時間作用性β_2 アドレナリン受容体刺激薬)の特徴とそれに基づく臨床的有用性2012
- Author(s)
  久米裕昭、忌部周、塚本敬造、深井有美、牧野靖、佐藤隆司、西山理、佐野博幸、岩永賢司、東田有智
- Organizer
  第52回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2012-04-22
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] あらたな喘息分子薬理療法の可能性-標的分子としてのRhoA/Rho-kinase 系2012
- Author(s)
  久米裕昭、東田有智
- Organizer
  第32回六甲カンファレンス
- Place of Presentation
  京都市
- Year and Date
  2012-07-29
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Synergistic effects of glycopyronium bromide and indacaterol on muscarinic agonist-induced contraction in airway smooth muscle2012
- Author(s)
  Kume H, Imbe S, Iwanaga T, Tohda Y
- Organizer
  ERS Annual Congress-Vienna 2012
- Place of Presentation
  Austria(Poster Discussion)
- Year and Date
  2012-09-05
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Inhibitory effects of Indacaterol on muscarinic activation- and oxidative stress-induced contraction in airway smooth muscle.2012
- Author(s)
  Kume H
- Organizer
  ATS 2012 International Conference
- Place of Presentation
  San Francisco, California, U.S.A.
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Indacaterol(超長時間作用性β_2 アドレナリン受容体刺激薬)の薬理学的特性について2011
- Author(s)
  久米裕昭、塚本敬造、忌部周、牧野靖、岩永賢司、中島宏和、東田有智
- Organizer
  第61回日本アレルギー学会秋季術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-10
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] A novel classification and rational use ofβ_2-sdrenerigic agonists based on their intrinsic efficacy2011
- Author(s)
  Kume H, Sugishita M, Maino Y, Tohda y
- Organizer
  ATS 2011 International Conference
- Place of Presentation
  Denver, Colorado, U.S.A.
- Year and Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 喘息と末梢気道閉塞呼吸機能検査の未来への第一歩:末梢気道閉塞を問い直す2011
- Author(s)
  久米裕昭、岩永賢司、東田有智
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京(シンポジウム)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Novel classification and rational use of β_2-adrenergic receptor agonists based on their intrinsic efficacy2011
- Author(s)
  Kume H
- Organizer
  2011 ATS International Conference
- Place of Presentation
  米国コロラド州デンバー市
- Year and Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] COPD 治療の向上に求められるβ_2 刺激薬の薬理学的特性 COPD の治療戦略―アシストユースの有用性―2010
- Author(s)
  久米裕昭、東田有智
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都市(イブニングシンポジウム)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 高齢者喘息喘息を取り巻く最近の話題2010
- Author(s)
  久米裕昭、東田有智
- Organizer
  第60回日本アレルギー学会秋季学実大会
- Place of Presentation
  東京(イブニングシンポシウム)
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 吸入ステロイド薬に対する反応-高齢者喘息とCOPDの類似点・相違点2010
- Author(s)
  久米裕昭
- Organizer
  第60回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 高齢者喘息の問題点～患者に適した治療を求めて～2010
- Author(s)
  久米裕昭、東田有智
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都市(ランチチョンセミナー)
- Year and Date
  2010-04-25
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 気管支喘息の病態におけるエンドセリン-1 の役割ーあらたな炎症マーカーとしての可能性2010
- Author(s)
  久米裕昭、辻清太、牧野靖、西山理、東田有智
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都市
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 高齢者喘息-喘息を取り巻く最近の話題2010
- Author(s)
  久米裕昭
- Organizer
  第60回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] 吸入ステロイド薬に対する反応高齢者喘息とCOPD の類似点・相違点2010
- Author(s)
  久米裕昭、東田有智
- Organizer
  第60回日本アレルギー学会秋季学実大会高齢者喘息とCOPD の類似点・相違点
- Place of Presentation
  東京(ワークショップ)
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] COPD治療の向上に求められるβ_2刺激薬の薬理学的特性2010
- Author(s)
  久米裕昭
- Organizer
  第50回日本呼吸器学会学術講演会
- Place of Presentation
  京都市
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22590846
[Presentation] Involvement of endothelin-1 in migration of human airway smooth muscle cells2008
- Author(s)
  Kume H, Tsuji S, Sasio T, Takeda N, Ito S, Kondo M, Hasegawa Y, Shimokata K
- Organizer
  ATS 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Role of sphingosine-1-phosphate for adhesion molecules expression in human pulmonary microvascular endothelial cells2008
- Author(s)
  Sashio T, Kume H, Takeda N, Ito S, Kondo M, Hasegawa Y
- Organizer
  ATS 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Role of hydrogen peroxide in β-adrenergic receptor desensitization of tracheal smooth muscle2008
- Author(s)
  Makino Y, Kume H, Shiraki A, Ito S, Hasegawa Y, Honjo H, Kamiya K
- Organizer
  ATS 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 酸化ストレスに対するβ_2刺激薬の抑制効果2008
- Author(s)
  久米裕昭
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] ヒト肺微小血管内皮細胞におけるstretch-activated Ca2+ influxの制御2008
- Author(s)
  伊藤理、久米裕昭、岩木舞、岩田晋、指尾豊和、近藤征史、今泉和良、橋本直純、長谷川好規
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-17
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Rho/Rho-kinase in airway smooth muscle as a therapeutic target for asthma2008
- Author(s)
  Kume H
- Organizer
  Seminar in Center for Cardiovascular Sciences, Albany Medical College
- Place of Presentation
  Albany NY, U.S.A
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 気道平滑筋のβアドレナリン受容体機能に対する酸化ストレスの影響2008
- Author(s)
  牧野靖、久米裕昭、白木晶、伊藤理、長谷川好規
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] COPDの気道炎症に対するLABAの抑制効果2008
- Author(s)
  久米裕昭、辻清太、岩木舞、浅野俊明、牧野靖、指尾豊和、白木晶、長谷川好規、下方薫
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 気道平滑筋とアレルギー2008
- Author(s)
  久米裕昭
- Organizer
  第58回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Rho/Rho-kinase in airway smooth muscle as a therapeutic target for asthma2008
- Author(s)
  Kume H
- Organizer
  Seminar in the Center for Cardiovascular Sciences, Albany Medical College
- Place of Presentation
  Albany, NY, U.S.A.
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 最適な喘息治療戦略-LABAの立場から2008
- Author(s)
  久米裕昭
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Role of intracellular Ca2+for endothelin-1-induced IL-6 production in human airway smooth muscle cells2008
- Author(s)
  Iwata S, Ito S, Iwaki M, Sashio T, Kondo M, Sokabe M, Hasegawa Y, Kume H
- Organizer
  ATS 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 酸化ストレスに対するβ2刺激薬の抑制効果2008
- Author(s)
  久米裕昭、白木晶、牧野靖、伊藤理、長谷川好規、下方薫
- Organizer
  第48回日本呼吸器学会学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Mechanical stretch activates Ca^<2+> influx in human lung microvascular endothelial cells2008
- Author(s)
  Ito S, Kume H, Iwaki M, Sashio T, Iwata S, Kondo M, Imaizumi K, Naruse K, Sokabe M, Hasegawa Y
- Organizer
  ATS 2008 International Conference
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] The effects of β_2-agonist intrinsic efficacy on oxidative stress-induced contraction in airway smooth muscle2007
- Author(s)
  Kume H, et. al.
- Organizer
  ATS 2007 International Conference
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] モニタリングからみた誘発喀痰検査と肺機能2007
- Author(s)
  久米裕昭
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Intracellular mechanisms of isoprostane-induved contraction in tracheal smooth muscle2007
- Author(s)
  Shiraki A, Kume H, Ito S, Kondo M, Honjo H, Kamiya K, Shimokata K
- Organizer
  ATS 2007 International Conference
- Place of Presentation
  San Francisco, U.S.A
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] エンドセリンが及ぼす気管支平滑筋細胞の遊走能への影響2007
- Author(s)
  辻清太、久米裕昭、武田直也、伊藤理、近藤征史、今泉和良、長谷川好規、下方薫
- Organizer
  第57回日本アレルギー学会秋季学術大会
- Place of Presentation
  横浜市
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Mechanobiology of airway smooth muscle cells : Effects of mechanical stretch2007
- Author(s)
  Ito S, Kume H, Naruse K, Iwata S, Takeda N, Kondo M, Hasegawa Y, Shikata K
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Losartanはイソプロスタンによる気道収縮を抑制する2007
- Author(s)
  白木晶、久米裕昭、伊藤理、辻清太、長谷川好規
- Organizer
  第57回日本アレルギー学会秋季学術大会
- Place of Presentation
  横浜市
- Year and Date
  2007-11-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] The role of voltage-dependent Ca2+channels on β-adrenergic desensitization by platelet-derived growth factor in tracheal smooth muscle2007
- Author(s)
  Ikenouchi T, Kume H, Oguma T, Shiraki A, Ito S, Kondo M, Shimokata K
- Organizer
  ATS 2007 International Conference
- Place of Presentation
  San Francisco, U.S.A
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] The effects of β^2-agonists intrinsic efficacy on oxidative stress-induced contraction in airway smooth muscle2007
- Author(s)
  Kume H, Shiraki A, Ikenouchi T, Makino Y, Ito S, Kondo M, Shimokata K
- Organizer
  ATS 2007 International Conference
- Place of Presentation
  San Francisco, U.S.A
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Endothelin-1刺激による培養ヒト気道平滑筋細胞のIL-6産生能に対する影響2007
- Author(s)
  岩田晋、伊藤理、武田直也、指尾豊和、岩木舞、近藤征史、長谷川好規、下方薫、久米裕昭
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] イソプロスタン(8-iso-PGF2α)による気道平滑筋収縮におけるCa2+動態とCa2+感受性の関与2007
- Author(s)
  白木晶、久米裕昭、伊藤理、牧野靖、近藤征史、下方薫
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] L-メンソールによる細胞内Ca2+流入抑制を介した気道平滑筋弛緩効果2007
- Author(s)
  伊藤理、久米裕昭、白木晶、近藤征史、岩田晋、長谷川好規、下方薫
- Organizer
  第19回日本アレルギー学会春季臨床大会
- Place of Presentation
  横浜市
- Year and Date
  2007-06-09
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 気道平滑筋のβアドレナリン受容体機能に対するアンギオテンシンIIの影響2007
- Author(s)
  牧野靖、久米裕昭、白木晶、池ノ内紀祐、武田直也、伊藤理、近藤征史、今泉和良、長谷川好規、下方薫
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] Mentholは寒冷受容体を介して気導平滑筋を弛緩させる2007
- Author(s)
  伊藤理、久米裕昭、近藤征史、池ノ内紀祐、白木晶、岩田晋、長谷川好規、下方薫
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 好酸球性気道炎症に対する吸入ステロイド薬と長時間作用性β_2刺激薬との併用療法の有用性2007
- Author(s)
  久米裕昭、辻清太、岩木舞、中島治典、浅野俊明、白木晶、指尾豊和、下方薫
- Organizer
  第57回日本アレルギー学会秋季学術大会
- Place of Presentation
  横浜市
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] ヒト気道平滑筋細胞のメカノバイオロジー : ストレッチによるMAP-kinase系活性化2007
- Author(s)
  岩田晋、伊藤理、武田直也、指尾豊和、岩木舞、近藤征史、長谷川好規、下方薫、久米裕昭
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590891
[Presentation] 高齢者喘息とCOPDの鑑別、そしてICS投与の理論と実際
- Author(s)
  久米裕昭
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-25 – 2014-04-27
- Invited
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] SMART療法への期待ー患者さんのニーズに応え、より良い喘息コントロールを提供する治療法とは
- Author(s)
  久米裕昭
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪市
- Year and Date
  2014-04-25 – 2014-04-27
- Invited
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Involvement of regulation of KCa channels via Gi, Gs in the synergistic action between anticholinergic agents and beta2-adrenergic receptor agonists in airway smooth muscle.
- Author(s)
  Kume H
- Organizer
  2014 ATS International Conference
- Place of Presentation
  San Diego, California, U.S.A.
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] Role of L-type Ca2+ channel/KCa channel linkage in the synergistic response between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle.
- Author(s)
  Kume H
- Organizer
  19th Congress of the Asian Pacific Society of Respirology
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25461201
[Presentation] 慢性閉塞性肺疾患に潜む好酸球性気道炎症と気道過敏性亢進ー喘息合併の検索
- Author(s)
  久米裕昭
- Organizer
  第26回日本アレルギー学会春季臨床大会
- Place of Presentation
  京都市
- Year and Date
  2014-05-09 – 2014-05-11
- Data Source
  KAKENHI-PROJECT-25461201

1. KONDO Takaharu (20135388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. ISHIGURO Hiroshi (90303651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMAMOTO Akiko (60402385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KO Shigeru (90402578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TAKAGI Kenzo (50093050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AKIBA Yasutada

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUME Hiroaki 久米 裕昭

久米 浩昭 クメ ヒロアキ

Research Projects

Research Products

Co-Researchers

Molecularly-targeted therapy for asthma with a focus on migration and contractility of airway smooth muscle cellsPrincipal Investigator

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A molecular pharmacological therapy for asthma based on phenotype changing in the structural cells in airwaysPrincipal Investigator

Principal Investigator

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Pathophysiology of mucosal lesion caused by defects of epithelial HCO_3^--CO_2 transport

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A molecular target for preventing airway remodelingPrincipal Investigator

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Therapy for bronchial asthma by regulating a small G protein as a targeting moleculePrincipal Investigator

Principal Investigator

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Role of Rho in the pathophysiology of bronchial asthmaPrincipal Investigator

Principal Investigator

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The role of Ca^<2+>-activated K^+ channels of tracheal smooth musde on anti-asthmatic agents

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[Book] Frontiers in Clinical Drug Research-Anti Allergy Agentsjavascript:onTransientSave()2016

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[Book] Muscle Cell and Tissue2015

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[Book] "Muscle Cell and Tissue", Ca2+ dynamics and Ca2+ sensitization in the regulation of airway smooth muscle tone2015

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[Book] Calcium Signaling In Airway Smooth Muscle Cells2013

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[Book] 喘息治療薬2012

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[Book] カラー版内科学2012

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[Book] 気管支拡張薬、総合アレルギー学2011

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[Book] β_2 刺激薬 アレルギー疾患イラストレイテッド2010

KUME Hiroaki 久米裕昭

久米浩昭クメヒロアキ

[Book] β_2 刺激薬アレルギー疾患イラストレイテッド2010

[Book] β_2刺激薬気管支拡張薬の吸入療法“21世紀の吸入療法"薬物吸入療法研究科会編2008

[Journal Article] 好酸球性気道炎症が潜伏する慢性閉塞性肺疾患に対する吸入長時間作用性β2刺激薬、吸入ステロイド薬併用の有効性　Asthma-COPD Overlap Syndrome(ACOS)の概念を踏まえて2014