NAKAJIMA Toshiaki 中島敏晶

Researcher Number	50307956
Affiliation (based on the past Project Information) *help	2010 – 2011: 東京医科歯科大学, 大学院・疾患生命科学研究部, 准教授 2009: Tokyo Medical and Dental University, 疾患生命科学研究部, 准教授 2007: Tokyo Medical and Dental University, School of Biomedical Science, Associate Professor 2006: 東京医科歯科大学, 大学院疾患生命科学研究部, 助教授 2003: The University of Tokyo, Institute of Medical Science, Teaching Staff of Donation Laboratory, 医科学研究所, 寄付研究部門教員(常勤形態) … More 2003: 東京大学, 医科学研究所・寄附研究部門教員(常勤形態) 2000 – 2002: 東京大学, 医科学研究所, 寄付研究部門教員 1999: 日本医科大学, 老人病研究所, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Human genetics / Human genetics / Biological Sciences / Metabolomics Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 骨粗鬆症 / gonadotropin releasing hormone / polymorphisms / osteoporosis / ゴナドトロピン放出ホルモン / 遺伝子多型 / common disease / angiotensinogen / linkage diseciuilibulium(LD) mapping / 連鎖不平衡マッピング … More / アンギオテンシノーゲン遺伝子 / 疾患感受性遺伝子 / 連鎖不均衡マッピング / TLR (Toll-like receptor) / バージャー病 / 霊長類 / エンドトキシン / TLR(Toll-like receptor) / 分子遺伝学 / コラーゲンtype1 α-2遺伝子 / 罹患同胞対連鎖解析 / 脳動脈瘤 / くも膜下出血 / IL6 / 連鎖解析 / 同胞対解析 / DNA多形マーカー / TNFα / インターロイキン6 … More Except Principal Investigator OPLL / siRNA / differentiation / osteoblast / hMSC / Wntパスウェイ / RNAi / 骨芽細胞 / 遺伝子発現 / マイクロアレイ / 間葉系幹細胞 / collagen / association study / genomewide linkage / 羅患同胞対連鎖解析 / 後縦靭帯骨化症 / 感受性遺伝子 / 罹患同胞対連鎖解析 / ゲノム解析 / 後縦靱帯骨化症 Less

Molecular evolution of the TLR4 gene in the course of primate evolution and their sensitivities to the response to endotoxinPrincipal Investigator
- Principal Investigator
  
  NAKAJIMA Toshiaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University
Functional analysis for a leader sequence variation Trp16Ser in GnRH which is associated with low bone mineral density among adult womenPrincipal Investigator
- Principal Investigator
  
  NAKAJIMA Toshiaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
くも膜下出血(脳動脈瘤)の感受性遺伝子同定と発症前診断への応用Principal Investigator
- Principal Investigator
  
  中島敏晶
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Strategies for the identification of susceptibility genes underlying complex diseases through whole-genome linkage disequilibrium (LD) mappingPrincipal Investigator
- Principal Investigator
  
  NAKAJIMA Toshiaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  The University of Tokyo
Genomewide linkage study and identification of susceptibility of ossification of the posterior longitudinal ligament of the spine
- Principal Investigator
  
  INOUE Ituro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Gene expression profile during osteoblaslic differentiation of human mesenchymal cells
- Principal Investigator
  
  INOUE Ituro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
骨粗鬆症予防のための遺伝子マーカーの開発Principal Investigator
- Principal Investigator
  
  中島敏晶
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
  Nippon Medical School

All 2011 2010 2009 2007 2006

All Journal Article Presentation Book

[Book] Comparative genomics : insight into human health and disease. In The HLA Complex in Biology and Medicine : a resource book2009
- Author(s)
  Nakajima T, Kimura A
- Total Pages
  24
- Publisher
  Jaypee Brothers Medical Publishers (P) Ltd.
- Data Source
  KAKENHI-PROJECT-21590356
[Book] Comparative genomics : insight into human health and disease. In The HLA Complex in Biology and Medicine : aresource book2009
- Author(s)
  Nakajima T, Kimura A
- Publisher
  Jaypee Brothers Medical Publishers(P) Ltd.
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates2011
- Author(s)
  Ohtani H, Nakajima T, Akari H, Ishida T, Kimura A
- Journal Title
  
  Immunogenetics
  
  Volume: 63(7) Pages: 417-428
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] A single nucleotide polymorphism in the 3'-untranslated region of MyD 88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese2011
- Author(s)
  Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A
- Journal Title
  
  J Hum Genet
  
  Volume: 56 Issue: 7 Pages: 545-547
- DOI
  10.1038/jhg.2011.44
- NAID
  10030660317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590356, KAKENHI-PUBLICLY-23132507
[Journal Article] Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese2011
- Author(s)
  Takahashi M, Chen Z, Watanabe K, Kobayashi H, Nakajima T, Kimura A, Izumi Y
- Journal Title
  
  Open Dent J
  
  Volume: 5 Pages: 190-194
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese2011
- Author(s)
  Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A
- Journal Title
  
  J Hum Genet
  
  Volume: 56(7) Pages: 545-547
- NAID
  10030660317
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage2010
- Author(s)
  An J, Nakajima T, Kuba K, Kimura A
- Journal Title
  
  Hypertension Res. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism inhuman THP-1 macrophage2010
- Author(s)
  An J, Nakajima T, Kuba K, Kimura A
- Journal Title
  
  Hypertension Res
  
  Volume: 33(8) Pages: 831-835
- Data Source
  KAKENHI-PROJECT-21590356
[Journal Article] Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.2007
- Author(s)
  Ezura Y, Nakajima T, Urano T, Sudo Y, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Emi M.
- Journal Title
  
  Bone 40(4)
  
  Pages: 997-1005
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591680
[Journal Article] Association of a single-nucleotide variation (AI330V) in the low-density Iipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women.2007
- Author(s)
  Ezura Y, Nakajima T, Urano T, Sudo Y, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Emi M.
- Journal Title
  
  Bone 40(4)
  
  Pages: 997-1005
- Data Source
  KAKENHI-PROJECT-18591680
[Presentation] A Genetic Screening of Osteoporosis Susceptibility Genes Via 1315 Common Missense Single Nucleotide Polymorphisms: A Leader Sequence Variant (16-S) of Gonadotropin-Releasing Hormone (GnRH) Had Reproducibly Associated with Low Bone Mineral Density among Adult Women2006
- Author(s)
  Ezura Y, Nakajima T, Inoue S, Hosoi T, Suzuki T, Shiraki M, Emi M, Noda M
- Organizer
  28th ASBMR (米国骨代謝学会)
- Place of Presentation
  アメリカ合衆国、フィラデルフィア
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591680

1. INOUE Ituro (00192500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KIMURA Akinori (60161551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. KOMIYA Setsurou (30178371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 恩田英明 (60185692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 古賀公明 (20274821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAJIMA Toshiaki 中島 敏晶

Research Projects

Research Products

Co-Researchers

Molecular evolution of the TLR4 gene in the course of primate evolution and their sensitivities to the response to endotoxinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis for a leader sequence variation Trp16Ser in GnRH which is associated with low bone mineral density among adult womenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

くも膜下出血(脳動脈瘤)の感受性遺伝子同定と発症前診断への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategies for the identification of susceptibility genes underlying complex diseases through whole-genome linkage disequilibrium (LD) mappingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomewide linkage study and identification of susceptibility of ossification of the posterior longitudinal ligament of the spine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression profile during osteoblaslic differentiation of human mesenchymal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨粗鬆症予防のための遺伝子マーカーの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Comparative genomics : insight into human health and disease. In The HLA Complex in Biology and Medicine : a resource book2009

Author(s)

Total Pages

Publisher

Data Source

[Book] Comparative genomics : insight into human health and disease. In The HLA Complex in Biology and Medicine : aresource book2009

Author(s)

Publisher

Data Source

[Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates2011

Author(s)

Journal Title

Data Source

[Journal Article] A single nucleotide polymorphism in the 3'-untranslated region of MyD 88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese2011

Author(s)

Journal Title

Data Source

[Journal Article] A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage2010

Author(s)

Journal Title

Data Source

[Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism inhuman THP-1 macrophage2010

Author(s)

NAKAJIMA Toshiaki 中島敏晶