Koide Naoki 小出直樹

… Alternative Names

小出直樹コイデナオキ

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Researcher Number	50308962
External Links
Affiliation (based on the past Project Information) *help	2015 – 2019: 愛知医科大学, 医学部, 教授 2013 – 2014: 愛知医科大学, 医学部, 准教授 2009 – 2011: Aichi Medical University, 医学部, 准教授 2003 – 2006: 愛知医科大学, 医学部, 講師 2000 – 2001: 愛知医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including mycology) / Bacteriology (including Mycology) Except Principal Investigator Chemical biology
Keywords	Principal Investigator LPS / エンドトキシン / IFN-gamma / RANKL / Akt / 炎症性サイトカイン / CREB / マクロファージ / 誘導型NO合成酵素 / 肺傷害 … More / ガラクトシルセラミド / リポ多糖 / NTK cell / Fas / ガラクトサミン(D-GalN) / リポ多糖(LPS) / エンドトキシンショック / TNF-alpha / Ngaマウス / NC / ガラクトサミン / IFN-beta / Nitric oxide / B-1細胞 / Nitric Oxide / 内皮傷害 / マウス血管内皮細胞 / p38MAPK / ELAM-1 / 接着分子 / DIC / アポトーシス / 尿細管壊死 … More Except Principal Investigator 阻害剤 / 微生物 / 生理活性物質 / IKK-beta / スクリーニング / 放線菌 / 転移 / DHMEQ / ketomycin / I-kappa B kinase / NF-kappa B / 浸潤 / 遊走 / 三次元培養 / がん細胞 Less

Screening of cancer cell 3D invasion inhibitors from microbial metabolites
- Principal Investigator
  
  Umezawa Kazuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
involvement of CREB regulatory molecule in sepsis and enteritis modelPrincipal Investigator
- Principal Investigator
  
  Koide Naoki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Aichi Medical University
ヒト敗血症ショックの実験的モデルにおける一酸化窒素誘導の機序と治療法の確立Principal Investigator
- Principal Investigator
  
  小出直樹
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University
ガラクトサミンを用いたエンドトキシンショック低感受性マウスの解析Principal Investigator
- Principal Investigator
  
  小出直樹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University
マウスB-1細胞とマクロファージのLPSへの応答の相違におけるIFN-βの役割Principal Investigator
- Principal Investigator
  
  小出直樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University
エンドトキシンショックにおける急性尿細管壊死・RDS(respiratory distress syndrome)へのアポトーシスの関与Principal Investigator
- Principal Investigator
  
  小出直樹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Aichi Medical University

All 2020 2019 2018 2017 2016 2015 2014 2010 2009 2007 2006 2004

All Journal Article Presentation Book Patent

[Book] エンドトキシンショックの分子機構解析のための新規モデル2009
- Author(s)
  小出直樹, 横地高志
- Total Pages
  162
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018
- Author(s)
  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
- Journal Title
  
  Mol Med Rep
  
  Volume: 18 Pages: 5279-5285
- DOI
  10.3892/mmr.2018.9533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00937, KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-26305023
[Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review.2018
- Author(s)
  Y. Lin, T. Ukaji, N. Koide and K. Umezawa
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: - Issue: 3 Pages: 729-729
- DOI
  10.3390/ijms19030729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models2018
- Author(s)
  K. Umezawa, I. Kojima, S. Simizu, Y. Lin, H. Fukatsu, N. Koide, Y. Nakade and M. Yoneda
- Journal Title
  
  Human Cell
  
  Volume: 31 Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.2017
- Author(s)
  K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Pages: 562-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion.2017
- Author(s)
  T. Ukaji, N. Koide, Y. Lin, K. Banno, S. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology
  
  Volume: 7 (4) Pages: 16-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells.2016
- Author(s)
  .Ando T, Komatsu T, Naiki Y, Takahashi K, Yokochi T, Watanabe D, Koide N.
- Journal Title
  
  Immunopharmacol Immunotoxicol.
  
  Volume: 38 Issue: 4 Pages: 298-302
- DOI
  10.1080/08923973.2016.1192191
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460550
[Journal Article] Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide.2015
- Author(s)
  Koide N, Kaneda A, Yokochi T, Umezawa K.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 25 Issue: 1 Pages: 162-168
- DOI
  10.1016/j.intimp.2015.01.004
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460550, KAKENHI-PROJECT-25460551
[Journal Article] Pretreatment of LPS inhibits IFN-β-induced STAT1 phosphorylation through SOCS3 induced by LPS.2015
- Author(s)
  Ando T, Komatsu T, Naiki Y, Yokochi T, Watanabe D, Koide N.
- Journal Title
  
  Biomed Pharmacother.
  
  Volume: 76 Pages: 1-5
- DOI
  10.1016/j.biopha.2015.10.019
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460550
[Journal Article] Inhibition of receptor activator of nuclear factor-κB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.2014
- Author(s)
  Koide N, Kondo Y, Odkhuu E, Ulziisaikhan J, Ukaji T, Yokochi T, Umezawa K.
- Journal Title
  
  Immunol Lett.
  
  Volume: １６１ Issue: 1 Pages: 31-37
- DOI
  10.1016/j.imlet.2014.04.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460550, KAKENHI-PROJECT-25460551
[Journal Article] Endotoxin-induced lung injury in α-galactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung natural killer T cells.2010
- Author(s)
  Dagvadorj J, Koide N, et al.
- Journal Title
  
  Clinical Experimental Immunology
  
  Volume: 162 Pages: 169-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] Low susceptibility of NC/Nga mice to the lipopolysaccharide-mediated lethality with D-galactosamine sensitization and the involvement of fewer natural killer T cells.2010
- Author(s)
  Koide N, et al.
- Journal Title
  
  Innate Immunity
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] Nystatin-induced nitric oxide production in mouse macrophage-like cell line RAW264.7.2009
- Author(s)
  Koide N, et al.
- Journal Title
  
  Microbiology and Immunology 53
  
  Pages: 295-300
- NAID
  10027686627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α and nitric oxide production and protects mice from lethal endotoxic shock2009
- Author(s)
  Tumurkhuu G, Koide N, et al.
- Journal Title
  
  Innate Immunity (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] Thalidomide inhibits lipopolysaccharide-induced nitric oxide production and prevents lipopolysaccharide-mediated lethality in mice2009
- Author(s)
  Noman AS, Koide N, et al.
- Journal Title
  
  FEMS Immunology Med Microbiology 56
  
  Pages: 204-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590499
[Journal Article] MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling.2007
- Author(s)
  Tumurkhuu G, Koide N, Yokochi T et al.
- Journal Title
  
  FEMS Immunol Med Microbiol. 49/2
  
  Pages: 304-311
- Data Source
  KAKENHI-PROJECT-17790293
[Journal Article] Lethal endotoxic shock using alpha-galactosylceramide sensitization as a new experimental model of septic shock.2006
- Author(s)
  Ito H, Koide N, Yokochi T et al.
- Journal Title
  
  Laboratory Investigation 86・3
  
  Pages: 254-261
- Data Source
  KAKENHI-PROJECT-17790293
[Journal Article] Defective responsiveness of CD5+B1 cells to lipopolysaccharide in cytokine production.2006
- Author(s)
  Koide N, Morikawa A, Yokochi T et al.
- Journal Title
  
  J Endotoxin Res. 12・6
  
  Pages: 346-351
- Data Source
  KAKENHI-PROJECT-17790293
[Journal Article] The enhancing action of D-galactosamine on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells.2004
- Author(s)
  Morikawa A, Koide N, Sugiyama T, Mu MM, Ito H, Yoshida T, Yokochi T
- Journal Title
  
  EMS Immunol Med Microbiol. 41
  
  Pages: 211-218
- Data Source
  KAKENHI-PROJECT-15790229
[Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-beta production.2004
- Author(s)
  Sugiyama T, Fujita M, Koide N, Mori I, Yoshida T, Yokochi T
- Journal Title
  
  Microbiol Immunol. 48
  
  Pages: 957-963
- Data Source
  KAKENHI-PROJECT-15790229
[Patent] 外用組成物の生産方法2018
- Inventor(s)
  梅澤一夫、小出悠紀子
- Industrial Property Rights Holder
  ブルネエズ株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] クマササ含有成分および誘導体によるLPSに誘導される炎症反応の抑制2020
- Author(s)
  林音知、深津仁見、小嶋しおり、梅澤一夫、小出直樹
- Organizer
  第93回日本細菌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 新しいI-κB kinase β阻害剤ketomycinによる細胞の遊走・浸潤および炎症性サイトカイン産生の抑制。2019
- Author(s)
  Lin Yinzhi、杉浦信夫、小嶋しおり、小出直樹、梅澤一夫
- Organizer
  第14回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] クマササ含有成分および誘導体によるLPS作用の阻害。2019
- Author(s)
  Lin Yinzhi、深津仁見、小嶋しおり、梅澤一夫、小出直樹
- Organizer
  第65回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 深海カビAspergillusが産生するcyclopeninによる炎症誘起因子発現の抑制とハエ学習障害モデルの改善。2019
- Author(s)
  林音知、王立岩、Wu Yanhua、小出直樹、梅澤一夫
- Organizer
  新規素材探索研究会第18回セミナー
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫の細胞浸潤抑制と抗がん剤感受性の増強。2019
- Author(s)
  Lin Yinzhi、小出直樹、梅澤一夫
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Inhibition of titanium dioxide nanoparticle-induced inflammatory reaction by NF-κB inhibitor DHMEQ in human macrophage-like cells2018
- Author(s)
  Hitomi Fukatsu, Tamami Ukaji, Saeko Tada-Oikawa, Kiyora Izuoka, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide, Akihiko Ikegami, Sahoko Ichihara, Kazuo Umezawa
- Organizer
  21st International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] PM2.5モデルTiO2ナノ粒子に誘導されるマクロファージのIL-1 beta産生とNF-kappa B阻害剤DHMEQによる抑制2018
- Author(s)
  深津仁見、梅澤一夫、森田奈央子、内記良一、小松孝行、小出直樹
- Organizer
  新規素材探索研究会第17回セミナー
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制2017
- Author(s)
  宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
- Organizer
  第64回トキシンシンポジウム（若手奨励講演）
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるナノ粒子誘導IL-1β産生の抑制2017
- Author(s)
  深津仁見、宇梶珠、及川佐枝、出岡、市原佐保、小出直樹、梅澤一夫
- Organizer
  第12回日本ケミカルバイオロジー学会 2017.6.7-9
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Inhibition of TiO2 nanoparticle-induced inflammatory reaction in macrophages by NF-κB inhibitor DHMEQ2017
- Author(s)
  Kazuo Umezawa, Hitomi Fukatsu, Tamami Ukaji and Naoki Koide
- Organizer
  13th Keio-Yonsei Joint Symposium（招待講演）（国際学会）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Molecular design of sugar-free migracin analog migracinal that inhibits cancer cell migration and invasion2017
- Author(s)
  Tamami Ukaji, Yinzhi Lin, Naoki Koide, and Kazuo Umezawa
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] RANKL或いはLPSによる破骨細胞形成のCREB制御を介したコノフィリンによる抑制2014
- Author(s)
  小出直樹、Erdenezaya Odkhuu、内記良一、小松孝行、高橋和子、吉田友昭、横地高志
- Organizer
  日本細菌学会
- Place of Presentation
  東京、船堀
- Data Source
  KAKENHI-PROJECT-25460550
[Presentation] α-galactosylceramide を用いたエンドトキシンショックモデルにおける肺傷害へのサイトカインとNOの関与2009
- Author(s)
  小出直樹
- Organizer
  第15回日本エンドトキシン研究会
- Place of Presentation
  東京医科大学(東京都)
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-21590499

1. Umezawa Kazuo (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. OIKAWA Saeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results

Koide Naoki 小出 直樹

小出 直樹 コイデ ナオキ

Research Projects

Research Products

Co-Researchers

Screening of cancer cell 3D invasion inhibitors from microbial metabolites

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

involvement of CREB regulatory molecule in sepsis and enteritis modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト敗血症ショックの実験的モデルにおける一酸化窒素誘導の機序と治療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ガラクトサミンを用いたエンドトキシンショック低感受性マウスの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウスB-1細胞とマクロファージのLPSへの応答の相違におけるIFN-βの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エンドトキシンショックにおける急性尿細管壊死・RDS(respiratory distress syndrome)へのアポトーシスの関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] エンドトキシンショックの分子機構解析のための新規モデル2009

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models2018

Author(s)

Journal Title

Data Source

[Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.2017

Author(s)

Journal Title

Data Source

[Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion.2017

Author(s)

Journal Title

Data Source

[Journal Article] GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pretreatment of LPS inhibits IFN-β-induced STAT1 phosphorylation through SOCS3 induced by LPS.2015

Author(s)

Koide Naoki 小出直樹

小出直樹コイデナオキ