Hashimoto Shigeru 橋本茂

… Alternative Names

橋本茂ハシモトシゲル

HASHIMOTO Shigeru 橋本茂

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Researcher Number	50311303
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 遺伝子病制御研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北海道大学, 遺伝子病制御研究所, 准教授 2017 – 2019: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門准教授 2012: 北海道大学, 医学(系)研究科(研究院), 准教授 2009 – 2012: Hokkaido University, 大学院・医学研究科, 准教授 2008: Osaka Bioscience Institute, 分子生物学部門, 研究員 … More 2007: Osaka Bioscience Institute, 分子生物学部門, 研究員 2002 – 2006: (財)大阪バイオサイエンス研究所, 分子生物学部門, 研究員 2000 – 2001: (財)大阪バイオサイエンス研究所, 第1研究部, 研究員 1999: 財団法人大阪バイオサイエンス研究所, 第1研究部, 研究員 1998: (財)大阪バイオサイエンス研究所, 第1研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 50010:Tumor biology-related / Tumor biology / Biological Sciences / Biological Sciences Except Principal Investigator Cell biology / Cell biology
Keywords	Principal Investigator Arf6 / AMAP1 / 癌浸潤 / GEP100 / EMT / ArfGEF / 乳癌 / 細胞運動 / インテグリン / EZH2 … More / エピジェネティクス / 癌転移 / 細胞接着 / パキシリン / 転移 / 免疫回避 / 間葉形質 / Arid5a / RNA結合タンパク質 / シグナル伝達 / 発現制御 / 癌 / 腎癌 / オートファジー / ミトコンドリア / 活性酸素種 / 腎明細胞癌 / 翻訳制御 / Lung cancer / Glioblastoma / Molecular target / Cancer invasion / Breast cancer / Arf / invadopodia / 肺癌 / glioblastoma / 分子標的 / 乳腺組織 / EPB41L5 / 乳腺幹細胞 / p53 / 細胞間融合 / 乳癌細胞 / マクロファージ / 癌幹細胞 / ポリコーム群遺伝子 / ポリコームグループ蛋白質群 / HIF / 細胞浸潤 / 低酸素 / EGFレセプター / PHドメイン / チロシンリン酸化 / レセプター / EGF / アクチン細胞骨格 / PAK / ARF-family低分子量G蛋白質 / Rho-family低分子量G蛋白質 / ARF GAP … More Except Principal Investigator endocytosis / ARFGAP / endosomal recycling / PAG3 / 細胞運動 / paxillin / パキシリン / インテグリン / AMAP2 / Arf6 / ArfGEF / amphiphysin / ArfGAP / ARF6 / membrane trafficing / cell motile activity / p130Cas / PAGs / ARF / 細胞接着 / マクロファージ / E3 ligase / non-ubiquitination / breast cancer / Cell invasion / Cell motility / AMAP1 / E3因子 / 非標準的ユビキチン化 / 乳癌 / 細胞浸潤 / cancer cell invasion / ArtGAP / Art6 / cell motility / 癌浸潤 / cndosomal recycling / cell migration / 貪食作用 / 形質膜 / アクチン細胞骨格 / integrin / PAG / lyrosine phosphorylation / 接触阻止 / 上皮間充織形質転換 / 斉一単層形成能 / カドヘリン / 蛋白質の細胞内動態 / アクチン骨格 / tyrosine phosphorylation / 細胞運動性 / 単球細胞 / 侵潤能 / 運動性 / Focal adhesion kinase / protein kinase B / Akt / Phosphatidyl 3 kinase / 単球 / 内皮細胞 / 細胞生存性 Less

RNA結合蛋白質Arid5aによる間葉形質及び免疫回避作動の連動性・多様性の研究Principal Investigator
- Principal Investigator
  
  橋本茂
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hokkaido University
Analysis of molecular bases of the relationship between mesenchymal phenotype and metabolic reprogram in clear cell renal cancerPrincipal Investigator
- Principal Investigator
  
  Hashimoto Shigeru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka University
乳腺組織リモデリングにおける細胞運動性の統合的制御機構の解明Principal Investigator
- Principal Investigator
  
  橋本茂
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Analysis of molecular mechanisms of the acquisition of tumor invasiveness and metastasisPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Sigeru
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
Analysis of molecular mechanisms of the acquisition of tumor invasivenessPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Sigeru
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
Analysis of molecular mechanisms of Arf6 activation during acquisition of tumor invasivenessPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Shigeru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka Bioscience Institute
Analysis of molecular machinery for the acquisition of breast cancer invasivenessPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Shigeru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka Bioscience Institute
Roles played by Arf6 in cell migration and invasion
- Principal Investigator
  
  SABE Hisataka
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  OSAKA BIOSCIENCE INSTITUTE
Cell motility and the backward bulk flow of the plasma membrane components
- Principal Investigator
  
  SABE Hisataka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  OSAKA BIOSCIENCE INSTITUTE
インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・浸潤能の解析Principal Investigator
- Principal Investigator
  
  橋本茂
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka Bioscience Institute
Role of paxillin-associatcd ARFGAPs in cell migration.
- Principal Investigator
  
  SABE Hisataka
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  OSAKA BIOSCIENCE INSTITUTE(OBI)
インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・侵潤能の解析
- Principal Investigator
  
  佐邊壽孝
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka Bioscience Institute
上皮細胞における細胞接着を介した生存性シグナルの解析Principal Investigator
- Principal Investigator
  
  橋本茂
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka Bioscience Institute
インテグリンを介した単球/マクロファージの細胞運動性制御機構の解析
- Principal Investigator
  
  佐邊壽孝
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka Bioscience Institute
単球・マクロファージ細胞の接着及び貧食過程におけるパキシリンの機能解析
- Principal Investigator
  
  SABE Hisataka
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka Bioscience Institute
Role of paxillin isoforms and their tyrosine phosphorylation in cell migration.
- Principal Investigator
  
  SABE Hisataka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  OSAKA BIOSCIENCE INSTITUTE(OBI)

[Book] 「EMT-基礎的観点から」乳癌レビュー20122012
- Author(s)
  橋本あり、杉野弘和、橋本茂、佐邊壽孝
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PUBLICLY-23111501
[Book] 「局所浸潤モデル-がんの浸潤転移に関わる分子装置の解析法」『疾患モデルの作製と利用-がん』2012
- Author(s)
  橋本あり、橋本茂、佐邊壽孝
- Publisher
  エル・アイ・シー(株)
- Data Source
  KAKENHI-PROJECT-21370092
[Book] 乳癌レビュー2012EMT-基礎的観点から2012
- Author(s)
  橋本あり、杉野弘和、橋本茂、佐邊壽孝
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21370092
[Book] 「局所浸潤モデルーがんの浸潤転移に関わる分子装置の解析法」『疾患モデルの作製と利用ーがん』2012
- Author(s)
  橋本あり、橋本茂、佐邊壽孝
- Total Pages
  11
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-21370092
[Book] 「局所浸潤モデルーがんの浸潤転移に関わる分子装置の解析法」『疾患モデルの作製と利用ーがん』2012
- Author(s)
  橋本あり、橋本茂、佐邊壽孝
- Total Pages
  11
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PUBLICLY-23111501
[Book] 「EMT-基礎的観点から」乳癌レビュー20122012
- Author(s)
  橋本あり、杉野弘和、橋本茂、佐邊壽孝
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21370092
[Book] 乳癌レビュー2012 EMT-基礎的観点から2011
- Author(s)
  橋本あり、杉野弘和、橋本茂、佐邊壽孝
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22657045
[Book] 乳癌レビュー2012EMT-基礎的観点から2011
- Author(s)
  橋本あり、杉野弘和、橋本茂、佐邊壽孝
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22657045
[Book] 乳癌レビュー2012 EMT-基礎的観点から2011
- Author(s)
  橋本あり、杉野弘和、橋本茂, 佐邊壽孝
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PUBLICLY-23111501
[Book] 乳癌レビュー2012EMT-基礎的観点から2011
- Author(s)
  橋本あり、杉野弘和、橋本茂, 佐邊壽孝
- Total Pages
  7
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21370092
[Book] 実験医学9月号2008
- Author(s)
  橋本茂
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19570190
[Book] 実験医学増刊号2008
- Author(s)
  橋本茂, 森重真毅, 小川栄治, 橋本あり, 小野寺康仁, 佐邊壽孝
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19570190
[Book] 癌の浸潤形質獲得過程における細胞接着・移動の変化.低分子量Gタンパク質Arf6の活性化との関連実験医学増刊号2008
- Author(s)
  橋本茂
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19570190
[Book] がんの浸潤形質獲得過程における低分子量Gタンパク質Arf6シグナル伝達実験医学増刊号2008
- Author(s)
  橋本茂、森重真毅、小川栄治、橋本あり、小野寺康仁、佐邊壽孝
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation2024
- Author(s)
  Naito Seiichiro、Tanaka Hiroki、Jiang Jing-Jing、Tarumi Masato、Hashimoto Ari、Tanaka Yuki、Murakami Kaoru、Kubota Shimpei I.、Hojyo Shintaro、Hashimoto Shigeru、Murakami Masaaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 703 Pages: 149666-149666
- DOI
  10.1016/j.bbrc.2024.149666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14551, KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-20H00502
[Journal Article] GM-CSF Promotes the Survival of Peripheral-Derived Myeloid Cells in the Central Nervous System for Pain-Induced Relapse of Neuroinflammation2023
- Author(s)
  Matsuyama Shiina、Yamamoto Reiji、Murakami Kaoru、Takahashi Nobuhiko、Nishi Rieko、Ishii Asuka、Nio Kobayashi Junko、Abe Nobuya、Tanaka Kumiko、Jiang Jing Jing、Kawamoto Tadafumi、Iwanaga Toshihiko、Shinohara Yuta、（４名省略）、Kubota Shimpei I、（４名省略）、Murakami Masaaki
- Journal Title
  
  The Journal of Immunology
  
  Volume: 211 Issue: 1 Pages: 34-42
- DOI
  10.4049/jimmunol.2200567
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-23K14551, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-21K06727, KAKENHI-PROJECT-21K07062, KAKENHI-PROJECT-21K07075, KAKENHI-PROJECT-20K15766, KAKENHI-PROJECT-20H00502
[Journal Article] High-precision rapid testing of omicron SARS-CoV-2 variants in clinical samples using AI-nanopore2023
- Author(s)
  Murakami Kaoru、Kubota Shimpei I.、Tanaka Kumiko、Tanaka Hiroki、Akabane Keiichiroh、Suzuki Rigel、Shinohara Yuta、Takei Hiroyasu、Hashimoto Shigeru、Tanaka Yuki、Hojyo Shintaro、Sakamoto Osamu、Naono Norihiko、Takaai Takayui、（１０名省略）、Taniguchi Masateru、Murakami Masaaki
- Journal Title
  
  Lab on a Chip
  
  Volume: 23 Issue: 22 Pages: 4909-4918
- DOI
  10.1039/d3lc00572k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-23K14551, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-20K15766, KAKENHI-PROJECT-20H00502, KAKENHI-PROJECT-23H00471
[Journal Article] ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity2023
- Author(s)
  Hashimoto Ari、Hashimoto Shigeru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 19 Pages: 14934-14934
- DOI
  10.3390/ijms241914934
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203
[Journal Article] Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients.2023
- Author(s)
  Takeshi Yamasaki, Noriyuki Nagata, Toru Atsumi, Rie Hasebe, Yuki Tanaka, Izuru Ohki, Shimpei Kubota, Yuta Shinohara, Yong Bin Teoh, Nozomu Yokoyama, Noboru Sasaki, Kensuke Nakamura, Hiroshi Ohta, Takehiko Katsurada, Yoshihiro Matsuno, Shintaro Hojyo, Shigeru Hashimoto, Mitsuyoshi Takiguchi, Masaaki Murakami.
- Journal Title
  
  International immunology
  
  Volume: - Issue: 7 Pages: 313-326
- DOI
  10.1093/intimm/dxad006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07062, KAKENHI-PROJECT-21K07075, KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-20H00502, KAKENHI-PROJECT-20K06423, KAKENHI-PROJECT-21K19364, KAKENHI-PROJECT-23K14551, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-20K15766
[Journal Article] Computer model of IL-6-dependent rheumatoid arthritis in F759 mice2023
- Author(s)
  Yamamoto Reiji、Yamada Satoshi、Atsumi Toru、Murakami Kaoru、Hashimoto Ari、Naito Seiichiro、Tanaka Yuki、Ohki Izuru、Shinohara Yuta、Iwasaki Norimasa、Yoshimura Akihiko、Jiang Jing-Jing、Kamimura Daisuke、Hojyo Shintaro、Kubota Shimpei I、Hashimoto Shigeru、Murakami Masaaki
- Journal Title
  
  International Immunology
  
  Volume: 35 Issue: 9 Pages: 403-421
- DOI
  10.1093/intimm/dxad016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-23K14551, KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-21K12131, KAKENHI-PROJECT-20K15766, KAKENHI-PROJECT-20H00502
[Journal Article] Dupuytren's contracture-associated SNPs increase SFRP4 expression in nonimmune cells including fibroblasts to enhance inflammation development2023
- Author(s)
  Kida H, Jiang JJ, Matsui Y, Takahashi I, Hasebe R, Kawamura D, Endo T, Shibayama H, Kondoh M, Nishio Y, Nishida K, Matsuno Y, Oikawa T, Kubota S, Hojyo S, Iwasaki N, Hashimoto S, Tanaka Y, Murakami M.
- Journal Title
  
  Int Immunol.
  
  Volume: dxad004 Issue: 7 Pages: 303-312
- DOI
  10.1093/intimm/dxad004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07075, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-22K15435, KAKENHI-PROJECT-20H00502, KAKENHI-PROJECT-21K19364, KAKENHI-PROJECT-23K14551
[Journal Article] A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling2023
- Author(s)
  Maemoto Taiga、Kitai Yuichi、Takahashi Runa、Shoji Haruka、Yamada Shunsuke、Takei Shiho、Ito Daiki、Muromoto Ryuta、Kashiwakura Jun-ichi、Handa Haruka、Hashimoto Ari、Hashimoto Shigeru、Ose Toyoyuki、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 1 Pages: 102724-102724
- DOI
  10.1016/j.jbc.2022.102724
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203, KAKENHI-PROJECT-21K15251, KAKENHI-PROJECT-21H02408
[Journal Article] Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma2022
- Author(s)
  Hashimoto Ari、Handa Haruka、Hata Soichiro、Hashimoto Shigeru
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 12 Pages: 1-27
- DOI
  10.3389/fonc.2022.1005566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203
[Journal Article] Roles of RNA-binding proteins in immune diseases and cancer2022
- Author(s)
  Hashimoto Shigeru、Kishimoto Tadamitsu
- Journal Title
  
  Seminars in Cancer Biology
  
  Volume: 86 Pages: 310-324
- DOI
  10.1016/j.semcancer.2022.03.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07203
[Journal Article] Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance2022
- Author(s)
  Hashimoto Shigeru、Hashimoto Ari、Muromoto Ryuta、Kitai Yuichi、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 16 Pages: 2618-2618
- DOI
  10.3390/cells11162618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06890, KAKENHI-PROJECT-22K07203
[Journal Article] 1.High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD¬L1 and fibrosis of pancreatic cancer2020
- Author(s)
  Tsutaho A, Hashimoto A, Hashimoto S, Hata S, Kachi S, Hirano S, and Sabe H.
- Journal Title
  
  Cell Communication and Signaling
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07151
[Journal Article] Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production2020
- Author(s)
  Metwally Hozaifa、Tanaka Toshio、Li Songling、Parajuli Gyanu、Kang Sujin、Hanieh Hamza、Hashimoto Shigeru、Chalise Jaya P.、Gemechu Yohannes、Standley Daron M.、Kishimoto Tadamitsu
- Journal Title
  
  Science Signaling
  
  Volume: 13 Issue: 624 Pages: 624-624
- DOI
  10.1126/scisignal.aay0574
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-19K23864
[Journal Article] Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein.2019
- Author(s)
  Mazaki, Y., Higashi, T., Onodera, Y., Nam, JM., Hashimoto, A., Hashimoto, S., Horinouchi, T., and Miwa, S.
- Journal Title
  
  FEBS Lett
  
  Volume: 593(6) Issue: 6 Pages: 644-651
- DOI
  10.1002/1873-3468.13347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-18K08423, KAKENHI-PROJECT-18K11654
[Journal Article] ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics and immune evasion of pancreatic cancer2019
- Author(s)
  Hashimoto, S*., Furukawa, S*., Hashimoto, A*., Tsutaho, A., Fukao, A., Sakamura, Y., Parajuli, G., Onodera, Y., Otsuka, Y., Handa, H., Oikawa, T., Hata, S., Nishikawa Y., Mizukami, Y., Kodama, Y., Murakami M., Fujiwara, T., Hirano, S., and Sabe, H. (*Equally contributed)
- Journal Title
  
  Proceedings of the National Academy of the Sciences of the United States of America
  
  Volume: 116 Issue: 35 Pages: 17450-17459
- DOI
  10.1073/pnas.1901765116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-18H02608, KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K09451, KAKENHI-PROJECT-17K09472
[Journal Article] Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis2019
- Author(s)
  Chalise Jaya Prakash、Hashimoto Shigeru、Parajuli Gyanu、Kang Sujin、Singh Shailendra Kumar、Gemechu Yohannes、Metwally Hozaifa、Nyati Kishan Kumar、Dubey Praveen Kumar、Zaman Mohammad Mahabub-Uz、Nagahama Yasuharu、Hamza Hanieh、Masuda Kazuya、Kishimoto Tadamitsu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 30 Pages: 15128-15133
- DOI
  10.1073/pnas.1906712116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16691, KAKENHI-PROJECT-17K07151
[Journal Article] Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells.2018
- Author(s)
  Handa, H*., Hashimoto, A*., Hashimoto S., Sugino, S., Oikawa, T., and Sabe, H.
- Journal Title
  
  Cell Commun. Signal.
  
  Volume: 16(1) Issue: 1 Pages: 94-94
- DOI
  10.1186/s12964-018-0302-6
- NAID
  120006585787
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-18H02608
[Journal Article] Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity2018
- Author(s)
  Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y and Sabe H
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1595-1595
- DOI
  10.1038/s41598-018-20043-7
- NAID
  120006414006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08569, KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-16K14603
[Journal Article] Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs.2018
- Author(s)
  Gemechu Y, Millrine D, Hashimoto S, Prakash J, Sanchenkova K, Metwally H, Gyanu P, Kang S, Kishimoto T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 115(46) Issue: 46 Pages: 11802-11807
- DOI
  10.1073/pnas.1814446115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07151
[Journal Article] Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model2018
- Author(s)
  Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, and Sabe H.
- Journal Title
  
  Cell Commun Signal
  
  Volume: 16(1) Issue: 1 Pages: 1-9
- DOI
  10.1186/s12964-017-0212-z
- NAID
  120006410532
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614
[Journal Article] Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma2017
- Author(s)
  Daimon T, Kosaka T, Kikuchi E, Mikami S, Miyazaki Y, Hashimoto A, Hashimoto S, Mizuno R, Miyajima A, Okada Y, Sabe H, and Oya M
- Journal Title
  
  Urol Oncol
  
  Volume: 35(9) Issue: 9 Pages: 543.e17-543.e24
- DOI
  10.1016/j.urolonc.2017.04.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07151, KAKENHI-PROJECT-17K08614, KAKENHI-PROJECT-15K10609
[Journal Article] Rab5c mediates AMAP1-PRKD2 complexto enhance β1 integrin recycling inEGF-induced cancer invasion2012
- Author(s)
  Onodera Y., Nam JM., Hashimoto A., Norman JC., Shirato H., Hashimoto S. and Sabe H
- Journal Title
  
  J.Cell Biol
  
  Volume: 197 Issue: 7 Pages: 983-996
- DOI
  10.1083/jcb.201201065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370092, KAKENHI-PROJECT-23590323, KAKENHI-PROJECT-23791376, KAKENHI-PUBLICLY-23111501, KAKENHI-PLANNED-23112008
[Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma2011
- Author(s)
  Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H.
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 9 Pages: e25301-e25301
- DOI
  10.1371/journal.pone.0025301
- NAID
  120003464637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247027, KAKENHI-PROJECT-21370092, KAKENHI-PROJECT-22657045, KAKENHI-PUBLICLY-23111501, KAKENHI-PLANNED-23112008, KAKENHI-PROJECT-23590323
[Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis2011
- Author(s)
  Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H.
- Journal Title
  
  PLoS One
  
  Volume: 6 Issue: 8 Pages: e23359-e23359
- DOI
  10.1371/journal.pone.0023359
- NAID
  120003295085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247027, KAKENHI-PROJECT-21370092, KAKENHI-PROJECT-22657045, KAKENHI-PUBLICLY-23111501, KAKENHI-PLANNED-23112008, KAKENHI-PROJECT-23590323
[Journal Article] The EGFR-GFP100-Arf6-AMP1 signaling pathway specific to breast cancer invasion and metastasis2009
- Author(s)
  H. Sabe, S. Hashimoto, M. Morishige, E. Ogawa, A. Hashimoto, J.-M. Nam, K. Miura, H. Yano Y. Onodera
- Journal Title
  
  Traffic (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.2009
- Author(s)
  Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y.
- Journal Title
  
  Traffic 10
  
  Pages: 982-993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370092
[Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis2009
- Author(s)
  Sabe H., Hashimoto S., Morishige M., Ogawa E., Hashimoto A., Nam JM., Miura K., Yano H.and Onodera Y.
- Journal Title
  
  Traffic
  
  Volume: 10 Issue: 8 Pages: 982-993
- DOI
  10.1111/j.1600-0854.2009.00917.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20247027, KAKENHI-PROJECT-21370092
[Journal Article] Fbx8 makes Arf6 refractory to function via ubiquitination2008
- Author(s)
  H. Yano, I. Kobayashi, Y. Onodera, F. Luton, M. Franco, Y. Mazaki, S. Hashimoto, K. Iwai, Z. Ronai and H. Sabe
- Journal Title
  
  Mol. Biol. Cell 19
  
  Pages: 822-832
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] GEP100 links EGFR signaling to Arf6 activation to induce breast cancer invasion2008
- Author(s)
  M. Morishige*, S. Hashimoto *, E. Ogawa, Y. Toda, H. Kotani, M. Hirose, S. Wei, A. Hashimoto, A. Yamada, H. Yano, Y. Mazaki, H. Kodama, Y. Nio, T. Manabe, H. Wada, H. Kobayashi and H. Sabe
- Journal Title
  
  Nature Cell Biol, (These authors contributed equally to this work) 10
  
  Pages: 85-92
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition2008
- Author(s)
  M. Hirano, S. Hashimoto, S. Yonemura, H. Sabe, S. Aizawa
- Journal Title
  
  J. Cell Biol. 182
  
  Pages: 1217-1230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer : Full invasiveness is not from the inside2008
- Author(s)
  H. Sabe, S. Hashimoto, M. Morishige, A. Hashimoto, E. Ogawa
- Journal Title
  
  Cell Adhesion & Migration 2
  
  Pages: 1-3
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] Fbx8 makes Arf6 refrectory to function via ubiquitination2008
- Author(s)
  H. Yano, I. Kobayashi, Y. Onodera, F. Luton, M. Franco, Y. Mazaki, S. Hashimoto, K. Iwai, Z. Ronai, & H. Sabe
- Journal Title
  
  Mol. Biol. Cell. 19
  
  Pages: 822-832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] GEP100 links EGFR signaling to Arf6 activation to induce breast cancer invasion2008
- Author(s)
  M. Morishige*, S. Hashimoto*, E. Ogawa, Y. Toda, H. Kotani, M. Hirose, S. Wei, A. Hashimoto, A. Yamada, H. Yano, Y. Mazaki, H. Kodama, Y. Nio, T. Manabe, H. Wada, H. Kobayashi, H. Sabe(*equal contribution)
- Journal Title
  
  Nature Cell Biol. 10
  
  Pages: 85-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition2008
- Author(s)
  M. Hirano, S. Hashimoto, S. Yonemura, H. Sabe, S. Aizawa
- Journal Title
  
  J. Cell Biol 182
  
  Pages: 1217-1230
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery2007
- Author(s)
  J.-M. Nam, Y. Onodera, Y. Mazaki, H. Miyoshi, S. Hashimoto and H. Sabe
- Journal Title
  
  EMBO J 26
  
  Pages: 647-656
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] Cb1-interacting multiadaptor protein, is a component of AMAP1-mediated breast cancer invasion machinery.2007
- Author(s)
  J.Nam, Y.Onodera, Y.Mazaki, H.Miyoshi, S.Hashimoto, H.Sabe
- Journal Title
  
  EMBO J. 26
  
  Pages: 647-656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Cbl-interactiong multiadaptor protein,is a component of AMAP1-mediated breast cancer invasion machinery2007
- Author(s)
  J.Nam, Y.Onodera, Y.Mazaki, H.Miyoshi, S.Hashimoto, H.Sabe
- Journal Title
  
  EMBO J. 26
  
  Pages: 647-656
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] CIN85,a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery2007
- Author(s)
  J.-M.Nam, Y. Onodera, Y. Mazaki, H. Miyoshi, S. Hashimoto, H. Sabe.
- Journal Title
  
  EMBO J. 26
  
  Pages: 647-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570190
[Journal Article] Cbl-interacting multiadaptor protein, is a component of AMAP1-mediated breast cancer invasion machinery.2007
- Author(s)
  J.Nam, Y.Onodera, Y.Mazaki, H.Miyoshi, S.Hashimoto, H.Sabe
- Journal Title
  
  EMBO J. 26
  
  Pages: 647-656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.2006
- Author(s)
  S.Hashimoto, M.Hirose, A.Hashimoto, M.Morishige, A.Yamada, H.Hosaka, K.Akagi, E.Ogawa, C.Oneyama, Agatsuma, T, M.Okada, H.Kobayashi, H.Wada, H.Nakano.T.Ikegami, A.Nakagawa, H.Sabe
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 103
  
  Pages: 7036-7041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.2006
- Author(s)
  Y.Mazaki, S.Hashimoto, T.Tsujimura, M.Morishige, A.Hashimoto, K.Aritake, A.Yamada, J.-M.Nam, H.Kiyonari, N.Kazuki, H.Sabe
- Journal Title
  
  Nat.Immunol. 7
  
  Pages: 724-731
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.2006
- Author(s)
  Y.Mazaki, S.Hashimoto, T.Tsujimura, M.Morishige, A.Hashimoto, K.Aritake, A.Yamada, J.-M.Nam, H.Kiyonari, N.Kazuki, H.Sabe
- Journal Title
  
  Nat. Immunol. 7
  
  Pages: 724-731
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Targeting AMAP01 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.2006
- Author(s)
  S.Hashimoto, M.Hirose, A.Hashimoto, M.Morishige, A.Yamada, H.Hosaka, K.Akagi, E.Ogawa, C.Oneyama, Agatsuma.T, M.Okada, H.Kobayashi, H.Wada, H.Nakano, T.Ikegami, A.Nakagawa, H.Sabe
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A. 103
  
  Pages: 7036-7041
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] ArfGAP family proteins in cell adhesion.migration,and tumor invasion.2006
- Author(s)
  H.Sabe, Y.Onodera, Y.Mazaki, S.Hashimoto
- Journal Title
  
  Gurr.Opin.Cell.Biol. 18
  
  Pages: 558-564
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] ArfGAP family proteins in cell adhesion, migration, and tumor invasion.2006
- Author(s)
  H.Sabe, Y.Onodera, Y.Mazaki, S.Hashimoto
- Journal Title
  
  Curr.Opin.Cell Biol. 18
  
  Pages: 558-564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.2006
- Author(s)
  S.Hashimoto, M.Hirose, A.Hshimoto, M.Mrishige, A.Yamada, H.Hosaka, K.Akagi, E.Ogawa, C.Oneyama, Agatsuma, T, M.Okada, H.kobayashi, SAH.Wada, H.Nakano, T.Ikegami, A.Nakagawa, H.Sabe
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 103
  
  Pages: 7036-7041
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Neutrophil direction sensing and superoxide production linked by the GTPase-activationg protein GIT2.2006
- Author(s)
  Y.Mazaki, S.Hashimoto, T.Tsujimura, M.MOrishige, A.Hahimoto, K.Aritake, A.Yamada, J.-M.Nam, H.Kiyonari, N.Kazuki, H.Sabe
- Journal Title
  
  Nat.Immunol. 7
  
  Pages: 724-731
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] ArfGAP family proteins in cell adhesion, migration, and tumor invasion.2006
- Author(s)
  H.Sabe, Y.Onodera, Y.Mazaki, S.Hashimoto
- Journal Title
  
  Curr. Opin. Cell Biol. 18
  
  Pages: 558-564
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function.2005
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, A., Onodera, Y., Sabe, H.
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 213-231
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.2005
- Author(s)
  Onodera, Y., Hashimoto, S., Hashimoto, A., Morishige, M., Mazaki, Y., Yamada, A., Ogawa, E., Adachi, M., Sakurai, T., Manabe, T., Wada, H., Matsuura, N., Sabe, H.
- Journal Title
  
  EMBO J 24
  
  Pages: 963-973
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to Inhibit breast cancer invasive activities.2005
- Author(s)
  Onodera, Y., Hashimoto, S., Hashimoto, A., Morishige, M., Mazaki, Y., Yamada, A., Ogawa, E., Adachi, M., Sakurai, T., Manabe, T., Wada, H., Matsuura, N., Sabe, H.
- Journal Title
  
  EMBO J. 24・5
  
  Pages: 963-973
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.2005
- Author(s)
  Y.Onodera, S.Hashimoto, A.Hashimoto, M.Morishige, Y.Mazaki, A.Yamada, E.Ogawa, M.Adachi, T.Sakurai, T.Manabe, H.Wada, N.Matsuura, H.Sabc
- Journal Title
  
  EMBO J. 24
  
  Pages: 963-973
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function.2005
- Author(s)
  S.Hashimoto, A.Hashimoto, A.Yamada, Y.Onodcra, H.Sabe
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 216-231
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Expression of AMAP1, an ArfGAP, Provides novel targets to inhibit breast cancer invasive activities.2005
- Author(s)
  Y.Onodera, S.Hashimoto, A.Hashimoto, M.Morishige, Y.Mazaki, A.Yamada, E.Ogawa, M.Adachi, T.Sakurai, T.Manabe, H.Wada, N.Matsuura, H.Sabe
- Journal Title
  
  EMBO J. in press
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Assays and properties of ArfGAPs, AMAPI and AMAP2 in Arf6 function. Methods Enzymol.2005
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, A., Onodera, Y., Sabe, H.
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 216-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function.2005
- Author(s)
  S.Hashimoto, A.Hashimoto, A.Yamada, Y.Onodera, H.Sabe.
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 216-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to in hibit breast cancer invasive activities.2005
- Author(s)
  Y.Onodera, S.Hashimoto, A.Hashimoto, M.Morishige, Y.Mazaki, A.Yamada, E.Ogawa, M.Adachi, T.Sakurai, T.Manabe, H.Wada, N.Matsuura, H.Sabe
- Journal Title
  
  EMBO J. 24
  
  Pages: 963-973
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function.2005
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, Onodera, Y., Sabe, H.
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 216-231
- Data Source
  KAKENHI-PROJECT-17570166
[Journal Article] Expression of AMAP1, an ArfGAP, provides novel targets to Inhibit breast cancer invasive activities.2005
- Author(s)
  Onodera, Y., Hashimoto, S., Hashimoto, A., Morishige, M., Mazaki, Y., Yamada, A., Ogawa, E., Adachi, M., Sakurai, T., Manabe, T., Wada, H., Matsuura, N., Sabe, H.
- Journal Title
  
  EMBO J. 24・5
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.2004
- Author(s)
  Romanova, L.Y., Hashimoto, S., Chay, K.O., Blagosklonny, M.V., Sabe, H., Mushinski, J.F.
- Journal Title
  
  J. Cell Sci. 117・17
  
  Pages: 3759-3768
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Requirement for Arf6 in breast cancer invasive activities.2004
- Author(s)
  S.Hashimoto, Y.Onodera, A.Hashimoto, M.Tanaka, M.Hamaguchi, A.Yamada, H.Sabe
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101・17
  
  Pages: 6647-6652
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Regulation of Bin1 SH3 domain binding by phosphoinositides2004
- Author(s)
  Kojima, C., Hashimoto, A., Yabuta, I., Hirose, M., Hashimoto, S., Kanaho, Y., Sumimoto, H., Ikegami, T., Sabe, H.
- Journal Title
  
  EMBO J. 23
  
  Pages: 4413-4422
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] A novel mode of action of an ArfGAP, AMAP2/PAG3/PAPalpha in Arf6 function.2004
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., Sabe, H.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 37677-37684
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Regulation of Bin1 SH3 domain binding by phosphoinositides.2004
- Author(s)
  C.Kojima, A.Hashimoto, I.Yabuta, M.Hirose, S.Hashimoto, Y.Kanaho, H.Sumimoto, T.Ikegami, H.Sabe
- Journal Title
  
  EMBO J. 23・22
  
  Pages: 4413-4422
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Requirement for Arf6 in breast cancer invasive activities.2004
- Author(s)
  Hashimoto, S., Onodera, Y., Hashimoto, A., Tanaka, M., Hamaguchi, M., Yamad, A., Sabe, H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 101・17
  
  Pages: 6647-6652
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.2004
- Author(s)
  L.Y.Romanova, S.Hashimoto, K.-O.Chay, M.V.Blagosklonny, H.Sabe, J.F.Mushinski
- Journal Title
  
  J.Cell.Sci. 117・17
  
  Pages: 3759-3768
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Regulation of Binl SH3 domain binding by phosphoinositides.2004
- Author(s)
  Kojima, C., Hashimoto, A., Yabuuta, I., Hirose, M., Hashimoto, S., Kanaho, Y., Sumimoto, H., Ikegawa, T.
- Journal Title
  
  EMBO J. 166・2
  
  Pages: 283-295
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Requirement for Arf6 in breast cancer invasive activities.2004
- Author(s)
  Hashimoto, S., Onodera, Y, Hashimoto, A., Tanaka, M., Hamaguchi, M., Yamada, A., Sabe, H.
- Journal Title
  
  Proc Natl Acad Sci USA 101
  
  Pages: 6647-6652
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] A novel mode of action of an ArfGAP, PAG3/AMAP2/Papα, in Arf6 function.2004
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., Sabe, H.
- Journal Title
  
  J. Biol. Chem. 279・36
  
  Pages: 37677-37684
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] A novel mode of action of an ArfGAP,PAG3/AMAP2/Papα, in Arf6 function.2004
- Author(s)
  S.Hashimoto, A.Hashimoto, A.Yamada, C.Kojima, H.Yamamoto, T.Tsutsumi, M.Higashi, A.Mizoguchi, R.Yagi, H.Sabe
- Journal Title
  
  J.Biol.Chem. 279・36
  
  Pages: 37677-37684
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] IL-3-induced phosphorylation of paxillin tyrosine residues 31 and 118 is required for polarization andmotility of pre-B lymphoid cells : TPA abolishes the effect of IL-3.2004
- Author(s)
  Romanova, L.Y., Hashimoto, S., Chay, K.O., Blagosklonny, M.V., Sabe, H., Mushinski, J.F.
- Journal Title
  
  J.Cell Sci. 117
  
  Pages: 3759-3768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function.
- Author(s)
  Hashimoto, S., Hashimoto, A., Yamada, A., Onodera Y., Sabe, H.
- Journal Title
  
  Methods Enzymol. 404
  
  Pages: 216-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis
- Author(s)
  H. Sabe, S. Hashimoto, M. Morishige, A. Hashimoto, E. Ogawa, A. Hashimoto, J.-M. Nam, K. Miura, H. Yano and Y. Onodera
- Journal Title
  
  Traffic (in press)
- Data Source
  KAKENHI-PROJECT-19570190
[Patent] 新規な膵がん治療剤およびそのスクリーニング方法2019
- Inventor(s)
  岸本忠三、橋本茂
- Industrial Property Rights Holder
  岸本忠三、橋本茂
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K07151
[Patent] 癌免疫療法併用剤2019
- Inventor(s)
  佐邊壽孝、平野聡、橋本あり、橋本茂
- Industrial Property Rights Holder
  佐邊壽孝、平野聡、橋本あり、橋本茂
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K07151
[Patent] 癌免疫療法併用剤2018
- Inventor(s)
  佐邊壽孝、平野聡、橋本あり、橋本茂
- Industrial Property Rights Holder
  佐邊壽孝、平野聡、橋本あり、橋本茂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-048179
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K07151
[Patent] 血管新生ならびに癌細胞のmesenchymal型およびamoeboid型浸潤を阻害するための薬剤2006
- Inventor(s)
  佐邊壽孝, 橋本あり, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2006-03-28
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2006
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2006-09-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 血管新生ならびに癌細胞のmesenchymal型および amoeboid型浸潤を阻害するための薬剤2006
- Inventor(s)
  佐邊壽孝, 橋本あり, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2006-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2006
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2006-09-28
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] ヒトがん細胞の浸潤および転移を阻害するペプチド、それをコードするポリヌクレオチドおよびそれらを含有する薬剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-14
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] ヒトがん細胞の浸潤および転移を阻害するペプチド、それをコードするポリヌクレオチドおよびそれらを含有する薬剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-29
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒト癌細胞の侵潤活性を阻害するオリゴリボヌクレオチド2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 古林秀則, 森重真毅
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒトがん細胞の浸潤活性を阻害するオリゴリボヌクレオチド2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 古林秀則, 森重真毅
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-30
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] ヒトがん細胞の浸潤および転移を阻害するベプチド、それをコードするポリヌクレオチドおよびそれらを含有する薬剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒトがん細胞の浸潤および転移を阻害するペプチド、それをコードするポリヌクレオチドおよびそれらを含有する薬剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-14
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒトがん細胞の浸潤活性を阻害するオリゴリボヌクレオチド2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 古林秀則, 森重真毅
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570166
[Patent] 非典型的なプロリンリッチ配列結合阻害剤2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 中野洋文, 我妻勉
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-29
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒトがん細胞の浸潤活性を阻害するオリゴリボヌクレオチド2005
- Inventor(s)
  佐邊壽孝, 橋本茂, 古林秀則, 森重真毅
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2005-09-30
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒト癌細胞の運動と浸潤を阻害する物質およびそのスクリーニング方法2004
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2004-09-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370090
[Patent] ヒト癌細胞の運動と浸潤を阻害する物質およびそのスクリーニング方法2004
- Inventor(s)
  佐邊壽孝, 橋本茂
- Industrial Property Rights Holder
  (財)大阪バイオサイエンス研究所
- Filing Date
  2004-09-06
- Data Source
  KAKENHI-PROJECT-16370090
[Presentation] ARF6-AMAP1 pathway is linked to induction of immunosuppressive chemokine expression for favor immune evasion2023
- Author(s)
  Ari Hashimoto, Haruka Handa, Soichiro Hata, Daisuke Okuzaki, Yoshizuki Fumoto, Akio Tsutaho, Yoshihiro Nishikawa, Yuzo Kodama, Satoshi Hirano, Shigeru Hashimoto, and Hisataka Sabe.
- Organizer
  第82回日本癌学会
- Data Source
  KAKENHI-PROJECT-22K07203
[Presentation] Arf6, the evolutionarily oldest G protein, is at the core of driving malignancy and immune evasion of pancreatic cancer cells2022
- Author(s)
  Soichiro Hata, Ari Hashimoto, Haruka Handa, Akio Tsutaho, Takao Yoshida, Yasuhito Onodera, Satoshi Hirano, Masahiro Sonoshita, Shigeru Hashimoto, and Hisataka Sabe
- Organizer
  The 7th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07203
[Presentation] Upregulation of eIF4A/4E-dependent mRNA translation is the major target of KRAS signaling2019
- Author(s)
  Hashimoto A., Hashimoto S., Furukawa S., Tsutaho A., Fukao A., Onodera Y., Handa H., Oikawa T., Hata S., Nishikawa Y., Mizukami Y., Kodama Y., Murakami M., Fujiwara T., Hirano S., and Sabe H.
- Organizer
  第19回蛋白質科学・第71回日本細胞生物合同年次大会、神戸
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] Arid5a orchestrates immunosuppressive environments via the Ido1-kynurenine-Treg axis in malignant pancreatic cancer2019
- Author(s)
  Parajuli G., Hashimoto S., and Kishimoto T.
- Organizer
  第48回日本免疫学会学術集会, 浜松
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] Pancreatic KRAS/TP53 mutations promote ARF6-based immune evasion via activating mRNA translation and protein prenylation2019
- Author(s)
  Hashimoto A., Hashimoto S., Furukawa S., Tsutaho A., Fukao A., Onodera Y., Handa H., Oikawa T., Hata S., Nishikawa Y., Mizukami Y., Kodama Y., Murakami M., Fujiwara T., Hirano S., and Sabe H.
- Organizer
  第78回日本癌学会学術総会, 京都
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] Pancreatic KRAS and TP53 oncogenes cooperatively activate ARF6-AMAP1 pathway to drive malignancy and immune evasion2018
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Shotaro Furukawa, Akio Tsutaho, Yasuhito Onodera, Yutaro Otsuka, Haruka Handa, Tsukasa Oikawa, Yusuke Mizukami, Masaaki Murakami, Satoshi Hirano, and Hisataka Sabe
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] 膵癌ドライバー変異はARF6経路を介して癌悪性度とPD-L1発現を促進する2017
- Author(s)
  橋本あり、橋本茂、古川聖太郎、蔦保暁生、大塚勇太郎、半田悠、小野寺康仁、及川司、平野聡、佐邊壽孝
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] メバロン酸代謝活性とArf6による癌悪性度進展の分子機序並びにスタチン有効性の解析2017
- Author(s)
  橋本あり、橋本茂、及川司、大塚勇太郎、半田悠、小野寺康仁、佐邊壽孝
- Organizer
  第116回北海道癌談話会
- Data Source
  KAKENHI-PROJECT-17K07151
[Presentation] Tissue morphogenesis by co-operative regulation of cellular proliferation and migration and diseases due to its breakdown2012
- Author(s)
  Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Mina Bissell, Shigeru Hashimoto, Hisataka Sabe
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2-mediated downregulation of miR-203 generates the Arf6-AMAP1 pathway pivotal for breast cancer invasiveness2012
- Author(s)
  Hirokazu Sugino,Shigeru Hashimoto, Ari Hashimoto, Yasuhito Onodera, Ayumu Yoshikawa, Yutaro Otsuka, Shizuka Mito, Haruka Handa, Hiroki Sato and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 suppresses miR-203 expression to promote cancer invasion2012
- Author(s)
  Shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu Yoshikawa, Yutaro Otsuka, Masanao Yoshino, Haruka Handa and Hisataka Sabe
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ1 signaling2012
- Author(s)
  Hisataka Sabe, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Sizuka Mito, Hiroki Sato, Jin-Min Nam, Yasuhito Onodera and Shigeru Hashimoto
- Organizer
  第8回OOTR年次学会
- Place of Presentation
  ウェスティン都ホテル京都（京都市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGFβ12012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Mutant-p53 generatesGEP100-Arf6-AMAP1 pathway to promotebreast cancer cell invasiveness in response toTGFβ12012
- Author(s)
  橋本あり
- Organizer
  第71回日本癌学会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 低分子量G蛋白質Arf6による細胞運動・極性制御と癌の浸潤・転移2012
- Author(s)
  橋本茂
- Organizer
  2012年度合同シンポジウム『生命現象の分子レベルでの解明』
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 suppresses miR-203 expression to promote cancer invasion2012
- Author(s)
  Shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu Yoshikawa, Yutaro Otsuka, Masanao Yoshino, Haruka Handa and Hisataka Sabe
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] GAB1 links c-Met signaling with GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2012
- Author(s)
  Ayumu Yoshikawa, Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Yutaro Otsuka, Shizuka Mito, Haruka Handa and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 suppresses miR-203expression to promote cancer invasion2012
- Author(s)
  橋本茂
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 regulates breast cancer invasiveness through GEP100-Arf6-AMAP1 signaling pathway.2012
- Author(s)
  H. Sugino, S. Hashimoto, A. Hashimoto, A. Yoshikawa, H. Handa, Shizuka Mito and H. Sabe.
- Organizer
  第45回日本発生生物学会・第64回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場（神戸市）
- Year and Date
  2012-05-28
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2-mediated downregulation of miR-203 generates the Arf6-AMAP1 pathway pivotal for breast cancer invasiveness2012
- Author(s)
  Hirokazu Sugino,Shigeru Hashimoto, Ari Hashimoto, Yasuhito Onodera, Ayumu Yoshikawa, Yutaro Otsuka, Shizuka Mito, Haruka Handa, Hiroki Sato and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌市）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to be activated by TGFβ1 and receptor tyrosine kinases to promote cancer invasion2012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa et al
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Tissue morphogenesis by co-operative regulation of cellular proliferation and migration and diseases due to its breakdown2012
- Author(s)
  Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Mina Bissell, Shigeru Hashimoto, Hisataka Sabe
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2 regulates breast cancer invasiveness through GEP100-Arf6-AMAP1 signaling pathway2012
- Author(s)
  Hirokazu Sugino, Shigeru Hashimoto, Ari Hashimoto, Ayumu Yoshikawa, Haruka Handa, Sizuka Mito, Hisataka Sabe
- Organizer
  第45回日本発生生物学会・第64回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] MUTANT-p53 GENERATES GEP100-Arf6-AMAP1 PATHWAY TO PROMOTE BREAST CANCER CELL INVASIVENESS IN RESPONSE TO TGFβ12012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
- Organizer
  第31回札幌国際がんシンポジウム２０１２
- Place of Presentation
  北海道大学（札幌市）
- Year and Date
  2012-07-23
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] GAB1 links c-Met signaling with GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2012
- Author(s)
  Ayumu Yoshikawa, Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Yutaro Otsuka, Shizuka Mito, Haruka Handa and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  北海道（札幌市）ロイトン札幌（札幌市）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] MUTANT-p53 GENERATES GEP100-Arf6-AMAP1 PATHWAY TO PROMOTE BREAST CANCER CELL INVASIVENESS IN RESPONSE TO TGFβ12012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
- Organizer
  第31回札幌国際がんシンポジウム2012
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 低分子量G蛋白質Arf6による細胞運動・極性制御と癌の浸潤・転移2012
- Author(s)
  橋本茂
- Organizer
  2012年度合同シンポジウム『生命現象の分子レベルでの解明』
- Place of Presentation
  北海道大学（札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2-mediated downregulation of miR-203 generates the ARF6-AMAP1 pathway pivotal for breast cancer invasiveness.2012
- Author(s)
  H. Sugino, S. Hashimoto, A. Hashimoto, A. Yoshikawa, H. Handa and H. Sabe.
- Organizer
  Beatson International Cancer Conference 2012 "Membrane dynamics in cancer"
- Place of Presentation
  Beatson Institute (UK)
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGFβ12012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera and Hisataka Sabe
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌市）
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ1 signaling2012
- Author(s)
  Hisataka Sabe, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Sizuka Mito, Hiroki Sato, Jin-Min Nam, Yasuhito Onodera and Shigeru Hashimoto
- Organizer
  第8回OOTR年次学会
- Place of Presentation
  ウェスティン都ホテル京都（京都市）
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] 低分子量G蛋白質Arf6による細胞運動・極性制御と癌の浸潤・転移2012
- Author(s)
  橋本茂
- Organizer
  2012年度合同シンポジウム『生命現象の分子レベルでの解明』
- Place of Presentation
  北海道大学（札幌市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to be activated by TGFβ1 and receptor tyrosine kinases to promote cancer invasion2012
- Author(s)
  Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa et al
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2-mediated downregulation of miR-203 generates the ARF6-AMAP1 pathway pivotal for breast cancer invasiveness.2012
- Author(s)
  H. Sugino, S. Hashimoto, A. Hashimoto, A. Yoshikawa, H. Handa and H. Sabe.
- Organizer
  Beatson International Cancer Conference 2012 "Membrane dynamics in cancer"
- Place of Presentation
  Beatson Institute (UK)
- Year and Date
  2012-07-01
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2 regulates Arf6 activity necessary for invasiveness of some breast cancer cells under normoxia and hypoxia2011
- Author(s)
  橋本茂
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1-and hypoxiainduced invasiveness of breast cancer cells2011
- Author(s)
  橋本茂
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 regulates Arf6 activitynecessary for invasiveness of some breastcancer cells under normoxia and hypoxia2011
- Author(s)
  橋本茂
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 is essential to Arf6 activationnecessary for TGFss1- and hypoxia-induced invasiveness of breast cancer cells2011
- Author(s)
  橋本茂
- Organizer
  第70回日本癌学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1- and hypoxia-induced invasiveness of breast cancer cells2011
- Author(s)
  橋本茂
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PUBLICLY-23111501
[Presentation] EZH2 regulates Arf6 activation necessary for invasiveness of some breast cancer cells under normoxia and hypoxia2011
- Author(s)
  橋本茂
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] EZH2 regulates Arf6 activity necessary for invasiveness of some breast cancer cells under normoxia and hypoxia2011
- Author(s)
  橋本茂
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1- and hypoxia-induced invasiveness of breast cancer cells2011
- Author(s)
  橋本茂
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1-and hypoxia-induced invasiveness of breast cancer cells2011
- Author(s)
  橋本茂
- Organizer
  第70回日本癌学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation2010
- Author(s)
  橋本茂
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation2010
- Author(s)
  橋本茂
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] Arf6 activation under hypoxia andits relationship to invasion, EMT conversion and stemness of breast cancer cells2010
- Author(s)
  橋本茂
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and stemness of breast cancer cells2010
- Author(s)
  橋本茂
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and stemness of breast cancer cells2010
- Author(s)
  橋本茂
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Hypoxia-induced invasive activity of breast cancer cells involves Arf6 activation2010
- Author(s)
  橋本茂
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] Arf6 activation under hypoxia and its relationship to invasion, EMT conversion and sternness of breast cancer cells2010
- Author(s)
  橋本茂
- Organizer
  BMB 2010
- Place of Presentation
  神戸ポートアイランド(神戸布)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22657045
[Presentation] Hypoxia-induced invasive activityof breast cancer cells involves Arf6 activation2010
- Author(s)
  橋本茂
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 微小環境の変化に連動した癌の浸潤形質獲得の分子機序2009
- Author(s)
  橋本茂
- Organizer
  特別学術講演会
- Place of Presentation
  北海道大学薬学部臨床薬学講義室(札幌市)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 乳がん浸潤形質獲得の分子機序2009
- Author(s)
  橋本茂
- Organizer
  平成21年度大学院「先端医療トピックス」
- Place of Presentation
  神戸大学医学部B講義室(神戸市)
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 乳がん浸潤形質獲得の分子機序2009
- Author(s)
  橋本茂
- Organizer
  平成21年度大学院「先端医療トピックス」
- Place of Presentation
  神戸大学(兵庫県)
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] 微小環境の変化に連動した癌の浸潤形質獲得の分子機序2009
- Author(s)
  橋本茂
- Organizer
  特別学術講演会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21370092
[Presentation] The EGFR-GEP100-Arf6 pathway in breast cancer invasion and metastasis(ポスター発表)2008
- Author(s)
  橋本茂
- Organizer
  第20回欧州癌研究治療機関・米国国立ガン研究所・米国ガン学会合同シンポジウム『分子標的とがん治療』
- Place of Presentation
  ジュネーブ・スイス
- Year and Date
  2008-10-22
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] Comprehensive analysis for the acquisition of invasiveness of mammary epithelial cells under hypoxia and EMT2008
- Author(s)
  橋本茂
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  Workshop : 10-3 Cell adhesion, motility and invasion(3)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] EMTと低酸素下での浸潤活性獲得に共通なエピジェネティック変化BMB20082008
- Author(s)
  橋本茂
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸(ポスター発表)
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] EMTと低酸素下での浸潤活性獲得に共通なエピジェネティック変化2008
- Author(s)
  橋本茂
- Organizer
  BMB2008(第31回日本分子学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  Poster session
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] The EGFR-GEP100-Arf6 pathway in breast cancer invasion and metastasis2008
- Author(s)
  橋本茂
- Organizer
  第20回欧州癌研究治療機関・米国国立ガン研究所・米国ガン学会合同シンポジウム『分子標的とがん治療』
- Place of Presentation
  Poster session
- Year and Date
  2008-10-22
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] Comprehensive analysis for the acquisition of invasiveness of mammary epithelial cells under hypoxia and EMT(口頭発表)2008
- Author(s)
  橋本茂
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] GEP100links epidermal growth factor signaling to Arf6 activation to induce breast cancer invasion2007
- Author(s)
  橋本茂
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  Workshop:10-6 Cell motility/invasion(2)
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] Growth factor receptor signaling and tumor invasion and metastasis(口頭発表)2007
- Author(s)
  橋本茂
- Organizer
  BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] Growth factor receptor signaling and tumor invasion and metastasis2007
- Author(s)
  橋本茂
- Organizer
  BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
- Place of Presentation
  Workshop:2W19がん形質とチロシンリン酸化シグナル
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19570190
[Presentation] GEP100 links epidermal growth factor signaling to Arf6 activation to induce breast cancer invasion(口頭発表)2007
- Author(s)
  橋本茂
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19570190

1. SABE Hisataka (40187282)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. YANO Hajime (00284414)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. MAZAKI Yuichi (60311304)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. YAGI Ryohei (00321703)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HASHIMOTO Ari (60390803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
6. MIURA Koichi (20360349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村邦明 (70311305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MARIUS Sudol

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. DONALD E. Ingber

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. JOAN S. Brugge

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 近藤明子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OIKAWA Tsukasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. HASEBE Rie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 佐邉寿孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 20 results
15. 久保田晋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. STANDLEY Daron

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 北條慎太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. シンシャイレンドラ・クマール

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 田中勇希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 柏倉淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashimoto Shigeru 橋本 茂

橋本 茂 ハシモト シゲル

HASHIMOTO Shigeru 橋本 茂

Research Projects

Research Products

Co-Researchers

RNA結合蛋白質Arid5aによる間葉形質及び免疫回避作動の連動性・多様性の研究Principal Investigator

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Analysis of molecular bases of the relationship between mesenchymal phenotype and metabolic reprogram in clear cell renal cancerPrincipal Investigator

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乳腺組織リモデリングにおける細胞運動性の統合的制御機構の解明Principal Investigator

Principal Investigator

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Review Section

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Analysis of molecular mechanisms of the acquisition of tumor invasiveness and metastasisPrincipal Investigator

Principal Investigator

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Research Institution

Analysis of molecular mechanisms of the acquisition of tumor invasivenessPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Analysis of molecular mechanisms of Arf6 activation during acquisition of tumor invasivenessPrincipal Investigator

Principal Investigator

Project Period (FY)

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Analysis of molecular machinery for the acquisition of breast cancer invasivenessPrincipal Investigator

Principal Investigator

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Research Institution

Roles played by Arf6 in cell migration and invasion

Principal Investigator

Project Period (FY)

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Research Institution

Cell motility and the backward bulk flow of the plasma membrane components

Principal Investigator

Project Period (FY)

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Research Institution

インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・浸潤能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of paxillin-associatcd ARFGAPs in cell migration.

Principal Investigator

Project Period (FY)

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Research Institution

インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・侵潤能の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

上皮細胞における細胞接着を介した生存性シグナルの解析Principal Investigator

Principal Investigator

Project Period (FY)

Hashimoto Shigeru 橋本茂

橋本茂ハシモトシゲル

HASHIMOTO Shigeru 橋本茂