Ohgane Jun 大鐘潤

… Alternative Names

OHGANE Jun 大鐘潤

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Researcher Number	50313078
Other IDs
Affiliation (Current)	2025: 明治大学, 農学部, 専任教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 明治大学, 農学部, 専任教授 2016 – 2018: 明治大学, 農学部, 専任准教授 2014 – 2015: 明治大学, 農学部, 准教授 2013: 東京大学, 大学院農学生命科学研究科, 助教 2010 – 2013: 明治大学, 農学部, 講師 … More 2012: 東京大学, 大学院・農学生命科学研究科, 助教 2009 – 2010: 東京大学, 大学院・農学生命科学研究科, 助教 2008: 東京大学, 大学院農・学生命科学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Integrative animal science / Genome biology Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Environmental risk control and evaluation / Integrative animal science / Applied molecular and cellular biology / 基礎ゲノム科学 / Biological Sciences
Keywords	Principal Investigator エピジェネティクス / エピゲノム改変 / DNAメチル化 / ハプロ不全優性遺伝病 / エピジェネティックなゆらぎ / エピゲノム編集 / ハプロ不全 / 非コードRNA / 非コード(nc）RNA / 生活習慣病 … More / 食肉形質 / 非コード（nc）RNA / 分化転換 / 細胞分化 / 内在性非コードRNA / 遺伝子発現制御 … More Except Principal Investigator エピジェネティクス / ブタ / ゲノム / 胚性幹細胞 / 幹細胞 / 栄養膜細胞 / DNAメチル化 / DPF / ヒトへの適合性 / 我が国初 / 異種移植 / 化学物質 / スクリーニング / 環境 / バイオインフォマティクス / 生殖発生毒性 / 予防対策 / in vitro / 放射線 / 毒性予測 / 有害物質 / 影響評価 / 化学物質管理 / エピジェネティック / 応用動物 / 遺伝学 / 発生工学 / メチル化修飾 / CpG shore / マルファン症候群モデル / ハプロ不全 / 常染色体優性遺伝病 / 遺伝子改変動物 / 分化転換 / 細胞分化 / 性染色体 / 常染色体 / 性依存性 / 発生分化 / DNAメチル化プロフィール / 子宮筋腫 / ヒストンH1 / 性差DNAメチル化領域 / 組織依存 / ホルモン依存 / 次世代シークエンス / ヒストン修飾 / 性差 / T-DMR / ゲノムネットワーク / エピゲノム / 栄養芽層 / 栄養膜幹細胞 / クローン / 初期胚 / 胎盤 / 栄養外胚葉 / 内部細胞塊 / 胚盤胞 / マウス Less

Generation of pigs for human transplantation and establishment of a system to assess their suitability for human use.
- Principal Investigator
  
  長屋昌樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Meiji University
Epigenetic fluctuation associated with onset and severity of haploinsufficient dominant diseasesPrincipal Investigator
- Principal Investigator
  
  Ohgane Jun
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Meiji University
Elucidation of etiology and phenotypic control in a porcine autosomal dominant genetic disease model
- Principal Investigator
  
  Nagashima Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Integrative animal science
- Research Institution
  Meiji University
Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
- Principal Investigator
  
  Sone Hideko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental risk control and evaluation
- Research Institution
  Yokohama College of Pharmacy
  National Institute for Environmental Studies
Understanding favorable trait of domestic animal and chronic disease of human based on epigenome engineeringPrincipal Investigator
- Principal Investigator
  
  Ohgane Jun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrative animal science
- Research Institution
  Meiji University
Optimization of epigenomic modification with regulatory RNAs considering the presence of endogenous non-coding RNAsPrincipal Investigator
- Principal Investigator
  
  OHGANE Jun
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Meiji University
Analysis of Sex-dependent Epigenome
- Principal Investigator
  
  SHIOTA Kunio
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  基礎ゲノム科学
- Research Institution
  The University of Tokyo
Epigenetics on transdifferentiation of ES cells toward TS cells
- Principal Investigator
  
  TANAKA Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  The University of Tokyo
Epigenome formation and cellular differentiation in mouse embryogenesis
- Principal Investigator
  
  TANAKA Satoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

[Journal Article] Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription.2024
- Author(s)
  Yutaro Kawa, Miyuki Shindo, Jun Ohgane, Masafumi Inui
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04755
[Journal Article] ブタをモデルとしたヒト遺伝性疾患のエピジェネティックなゆらぎの解析2023
- Author(s)
  日向史織、宮代梨央、大和屋健二、大鐘潤
- Journal Title
  
  遺伝子医学
  
  Volume: 13 Pages: 155-161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04755
[Journal Article] Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency2022
- Author(s)
  JACK Naomi、MUTO Tomoyuki、IEMITSU Keigo、WATANABE Tamaki、UMEYAMA Kazuhiro、OHGANE Jun、NAGASHIMA Hiroshi
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 68 Issue: 4 Pages: 233-237
- DOI
  10.1262/jrd.2022-027
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04755
[Journal Article] Epigenetic Effects of Exposure to Insecticide on Early Differentiation of Mouse Embryonic Stem Cells2019
- Author(s)
  Wang W, Otsuka S, Nansai H, Ito T, Abe K, Nakao Y, Ohgane J, Yoneda M, Sone H
- Journal Title
  
  bioRxiv
  
  Volume: なし Pages: 628487-628487
- DOI
  10.1101/628487
- Data Source
  KAKENHI-PROJECT-15H01749
[Journal Article] Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women2017
- Author(s)
  Maekawa Ryo、Ito Rie、Iwasaki Yusuke、Saito Koichi、Akutsu Kazuhiko、Takatori Satoshi、Ishii Rie、Kondo Fumio、Arai Yoshikazu、Ohgane Jun、Shiota Kunio、Makino Tsunehisa、Sugino Norihiro
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 16 Issue: 4 Pages: 337-348
- DOI
  10.1002/rmb2.12049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-15H02480, KAKENHI-PROJECT-16K16193
[Journal Article] Involvement of DNA methylation in regulating rat Prop1 gene expression during pituitary organogenesis2017
- Author(s)
 Nishihara H, Yoshida S, Kanno N, Nishimura N, Ueharu H, Ohgane J, Kato T, Kato Y
- Journal Title
 
 J. Reprod. Dev.
 
 Volume: 63 Issue: 1 Pages: 37-44
- DOI
 10.1262/jrd.2016-102
- NAID
 130005332293
- ISSN
 0916-8818, 1348-4400
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H02480, KAKENHI-PROJECT-15J11564, KAKENHI-PROJECT-15J11568, KAKENHI-PROJECT-26292166, KAKENHI-PROJECT-15K07771
[Journal Article] Establishment of DNA methylation patterns of the Fibrillin1 (FBN1) gene in porcine embryos and tissues2017
- Author(s)
 Arai Y, Umeyama K, Takeuchi K, Okazaki N, Hichiwa N, Yashima S, Nakano K, Nagashima H, Ohgane J
- Journal Title
 
 J. Reprod. Dev.
 
 Volume: 63 Issue: 2 Pages: 157-165
- DOI
 10.1262/jrd.2016-158
- NAID
 130007314629
- ISSN
 0916-8818, 1348-4400
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-15H02480, KAKENHI-PROJECT-16K16193
[Journal Article] ハプロ不全優性遺伝病発症の新たな視点：分子メカニズムとしてエピジェネティクスが関与する可能性2016
- Author(s)
  竹内健太、牧野智宏、新井良和、大鐘潤
- Journal Title
  
  明治大学農学部研究報告
  
  Volume: 65 Pages: 96-103
- NAID
  120005941792
- Data Source
  KAKENHI-PROJECT-15H02480
[Journal Article] Ultra-Deep Bisulfite Sequencing to Detect Specific DNA Methylation Patterns of Minor Cell Types in Heterogeneous Cell Populations: An Example of the Pituitary Tissue2016
- Author(s)
  Arai Y, Fukukawa H, Atozi T, Matsumoto S, Hanazono Y, Nagashima H, and Ohgane J.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 1 Pages: e0146498-e0146498
- DOI
  10.1371/journal.pone.0146498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02480, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-15H01749
[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells2015
- Author(s)
  Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R,Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J
- Journal Title
  
  BioMed Res Int
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25450472
[Journal Article] An epigenetic regulatory element of the Nodal gene in the mouse and human genomes2015
- Author(s)
  Daisuke Arai, Koji Hayakawa, Jun Ohgane, Mitsuko Hirosawa, Yoichi Nakao, Satoshi Tanaka, Kunio Shiota
- Journal Title
  
  Mechanisms of Development
  
  Volume: 136 Pages: 143-154
- DOI
  10.1016/j.mod.2014.12.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25850219, KAKENHI-PROJECT-26850230, KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-25303008, KAKENHI-PROJECT-15H01749
[Journal Article] Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.2015
- Author(s)
  Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 1-13
- DOI
  10.1155/2015/876047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07836, KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-15H01749, KAKENHI-PROJECT-26252052
[Journal Article] DNA methylation profiles provide a viable index for porcine pluripotent stem cells.2013
- Author(s)
  Arai Y, Ohgane J, Fujishiro SH, Nakano K, Matsunari H, Watanabe M, Umeyama K, Azuma D, Uchida N, Sakamoto N, Makino T, Yagi S, Shiota K, Hanazono Y, Nagashima H.
- Journal Title
  
  Genesis
  
  Volume: 51 Issue: 11 Pages: 763-776
- DOI
  10.1002/dvg.22423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450472, KAKENHI-PROJECT-21221008
[Journal Article] Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency2012
- Author(s)
  Hayakawa K, Ohgane J, Tanaka S, Yagi S, Shiota K
- Journal Title
  
  Epigenetics
  
  Volume: 7(9) Pages: 1029-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily2012
- Author(s)
  Hayakawa K, Nakanishi MO, Ohgane J, Tanaka S, Hirosawa M, Soares MJ, Yagi S, Shiota K
- Journal Title
  
  Mamm Genome
  
  Volume: 23(5-6) Issue: 5-6 Pages: 336-45
- DOI
  10.1007/s00335-011-9383-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples2011
- Author(s)
  Arai Y, Ohgane J, Yagi S, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Shiota K
- Journal Title
  
  J Reprod Dev
  
  Volume: 57 Pages: 507-517
- NAID
  10029593320
- Data Source
  KAKENHI-PROJECT-22710181
[Journal Article] Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples2011
- Author(s)
  Arai Y, Ohgane J, Yagi S, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Shiota K
- Journal Title
  
  J Reprod Dev
  
  Volume: 57(4) Pages: 507-17
- NAID
  10029593320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells2010
- Author(s)
  Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K
- Journal Title
  
  Genes Cells
  
  Volume: 15(6) Issue: 6 Pages: 607-18
- DOI
  10.1111/j.1365-2443.2010.01404.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development2010
- Author(s)
  Ikegami, K., Ohgane, J., Tanaka, S., Yagi, S., and Shiota, K
- Journal Title
  
  Int. J. Dev. Biol
  
  Volume: 53 Pages: 203-214
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062003
[Journal Article] Enrichment of short interspersed transposable elements to embryonic stem cell-specific hypomethylated gene regions2010
- Author(s)
  Muramoto H, Yagi S, Hirabayashi K, Sato S, Ohgane J, Tanaka S, Shiota K
- Journal Title
  
  Genes Cells
  
  Volume: 15(8) Issue: 8 Pages: 855-65
- DOI
  10.1111/j.1365-2443.2010.01423.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells2010
- Author(s)
  Sato S, Ohgane, J, et al
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 607-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710181
[Journal Article] Enrichment of short interspersed transposable elements to embryonic stem cell-specific hypomethylated gene regions2010
- Author(s)
  Muramoto, H., Yagi, S., Hirabayashi, K., Sato, S., Ohgane, J., Tanaka, S., and Shiota, K
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 855-865
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062003
[Journal Article] Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells2010
- Author(s)
  Sato, S., Yagi, S., Arai, Y., Hirabayashi, K., Hattori, N., Iwatani, M., Okita, K., Ohgane, J., Tanaka, S., Wakayama, T., Yamanaka, S., and Shiota, K
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 607-618
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062003
[Journal Article] Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions(T-DMRs) residing in mouse pluripotent stem cells2010
- Author(s)
  Sato S, Yagi S, Arai Y, Hirabayashi K, Hattori N, Iwatani M, Okita K, Ohgane J, Tanaka S, Wakayama T, Yamanaka S, Shiota K
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 607-618
- Data Source
  KAKENHI-PROJECT-22710181
[Journal Article] Enrichment of short interspersed transposable elements to embryonic stem cell-specific hypomethylated gene regions2010
- Author(s)
  Muramoto H, Yagi S, Hirabayashi K, Sato S, Ohgane J, Tanaka S, Shiota K
- Journal Title
  
  Genes Cells
  
  Volume: 15 Pages: 855-865
- Data Source
  KAKENHI-PROJECT-22710181
[Journal Article] Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos2009
- Author(s)
  Oda, M., Tanaka, S., Yamazaki, Y., Ohta, H., Iwatani, M., Suzuki, M., Ohgane, J., Hattori, N., Yanagimachi, R., Wakayama, T., and Shiota, K. (OM and TS contributed equally)
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 106 Pages: 16293-16297
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062003
[Journal Article] Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development2009
- Author(s)
  Ikegami K, Ohgane J, Tanaka S, Yagi S, Shiota K
- Journal Title
  
  Int J Dev Biol
  
  Volume: 53(2-3) Issue: 2-3 Pages: 203-14
- DOI
  10.1387/ijdb.082741ki
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21221008
[Journal Article] DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression2008
- Author(s)
  Yagi, S., Hirabayashi, K., Sato, S., Li, W., Takahashi, Y., Hirakawa, T., Wu, G., Hattori, N., Hattori, N., Ohgane, J., Tanaka, S., Liu, X.S., and Shiota, K
- Journal Title
  
  Genome Res
  
  Volume: 18 Pages: 1969-1978
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062003
[Presentation] 培養細胞をモデルとした加齢に伴うDNAメチル化変化によるFBN1発現制御の解析2023
- Author(s)
  宮代梨央、大和屋健二、梅山一大、長嶋比呂志、大鐘潤
- Organizer
  第116回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] ブタ初代培養繊維芽細胞におけるCas9誘導DNAメチル化編集によるFBN1 CpG island shoreの脱メチル化と生殖細胞におけるメチル化2023
- Author(s)
  大和屋健二、重松さとり、雨宮佑也、日向史織、宮代梨央、梅山一大、長嶋比呂志、大鐘潤
- Organizer
  第116回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] 受精能獲得に向けた精子先体赤道部膜裏打ち構造の制御機構2022
- Author(s)
  大和屋健二，大鐘潤
- Organizer
  第115回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] エピゲノム編集による Runx2 転写調節機構の解析2022
- Author(s)
  加和優多郎、大鐘潤、乾雅史
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] ハプロ不全疾患責任遺伝子FBN1のDNAメチル化異常の蓄積とエピゲノム改変による改善の試み2021
- Author(s)
  重松さとり、雨宮侑也、梅山一大、長嶋比呂志、大鐘潤
- Organizer
  第114回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-21H04755
[Presentation] DNAメチル化によるブタMSTN遺伝子の組織特異的発現調節機構の解析2018
- Author(s)
  隠地健斗、新井良和、長嶋比呂志、大鐘潤
- Organizer
  第124回日本畜産学会
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] DNA methylation as an epigenetic modifier of the FBN1 Transcription2018
- Author(s)
  Ohgane J, Arai Y, Takeuchi K, Okazaki N, Yashima S, Nakano K, Umeyama K, Nagashima H
- Organizer
  10th International Research Symposium on Marfan Syndrome and Related Disorders
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] Phenotype of homozygouse fibrillin-1 (FBN1) mutant pigs2018
- Author(s)
  Umeyama K., Arai Y., Nakano K., Uchikura A., Watanabe M., Matsunari H., Saito M., Saya H., Matsumoto M., Nagaya M., Ohgane J., Nagashima H
- Organizer
  10th International Research Symposium on Marfan Syndrome and Related Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] DNA methylation as an epigenetic modifier of the FBN1 transcription2018
- Author(s)
  Ohgane J., Arai Y., Takeuchi K., Okazaki N., Nakano K., Matsunari H., Watanabe M., Umeyama K., Nagashima H
- Organizer
  10th International Research Symposium on Marfan Syndrome and Related Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] ブタにおけるOTC欠損症原因遺伝子のエピジェネティック解析2018
- Author(s)
  茂田遼平、新井良和、松成ひとみ、長嶋比呂志、大鐘潤
- Organizer
  第124回日本畜産学会
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] アリルごとのDNAメチル化に着目したハプロ不全優性遺伝病の発症機序解明に向けた新たな試み：ブタフィブリリン1（FBN1）を例として2018
- Author(s)
  新井良和, 梅山一大, 岡崎なつみ, 隠地健斗, 福川斐昭, 高澤建, 西野光一郎, 長嶋比呂志, 大鐘潤
- Organizer
  第111回日本繁殖生物学会大会
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] DNAメチル化によるブタMSTN遺伝子の組織特異的発現調節機構の解析2018
- Author(s)
  茂田遼平、新井良和、松成ひとみ、長嶋比呂志、大鐘潤
- Organizer
  第124回日本畜産学会
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] DNAメチル化によるブタMSTN遺伝子の組織特異的発現調節機構の解2018
- Author(s)
  隠地健斗、新井良和、長嶋比呂志、大鐘潤
- Organizer
  第124回日本畜産学会
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] アリルごとのDNAメチル化に着目したハプロ不全優性遺伝病の発症機序解明に向けた新たな試み：ブタフィブリリン1 (FBN1)を例として2018
- Author(s)
  新井良和、梅山一大、岡崎なつみ、隠地健斗、福川斐昭、高澤健、西野光一郎、長嶋比呂志、大鐘潤
- Organizer
  第111回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] アリルごとのDNAメチル化状態に注目したエピジェネティクス解析の新たな試み2017
- Author(s)
  大鐘潤、新井良和
- Organizer
  日本農芸化学会年会
- Place of Presentation
  京都女子大学（京都）
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] アリルごとのDNAメチル化状態に注目したエピジェネティクス解析の新たな試み2017
- Author(s)
  大鐘潤、新井良和
- Organizer
  2017年日本農芸化学会年会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] Phenotypic variation in the cloned pigs with heterozygous fibrillin-1 mutation.2017
- Author(s)
  Kazuhiro Umeyama, Yoshikazu Arai, Kazuaki Nakano, Tooru Fukuda, Ikuma Umeki, Ayuko Uchikura, Yuri Kasai, Hitomi Matsunari, Masaki Nagaya, Masahito Watanabe, Jun Ohgane and Hiroshi Nagashima
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] Phenotypic variation in the cloned pigs with heterozygous fibrillin-1 mutation2017
- Author(s)
  Umeyama K, Arai Y, Nakano K, Fukuda T, Umeki I, Uchikura A, Kasai Y, Matsunari H, Nagaya M, Watanabe M, Ohgane J and Nagashima H
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] 変異型fibrillin-1遺伝子を有するブタの上行大動脈の病理解析2016
- Author(s)
  梅山一大, 新井良和, 中野和明, 内倉鮎子, 渡邊将人, 松成ひとみ, 齋藤正寛, 木村徳宏, 渡邊航太, 堀内圭輔, 北城雅照, 有馬好美, サンペトラオルテア, 小崎健次郎, 佐谷秀行, 松本守雄, 長屋昌樹, 大鐘潤, 長嶋比呂志
- Organizer
  第57回日本脈管学会総会
- Place of Presentation
  奈良
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] 変異型fibrillin-1遺伝子を有するブタの上行大動脈の病理解析2016
- Author(s)
  梅山一大、新井良和、中野和明、内倉鮎子、渡邊将人、松成ひとみ、齋藤正寛、木村徳宏、渡邉航太、堀内圭輔、北城雅照、有馬好美、サンペトラオルテア、小崎健次郎、佐谷秀行、松本守雄、長屋昌樹、大鐘潤、長嶋比呂志
- Organizer
  日本脈管学会
- Place of Presentation
  ホテル日航奈良（奈良）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] ホモ変異型fibrillin-1遺伝子を有するブタの表現型2016
- Author(s)
  梅山一大, 新井良和, 中野和明, 内倉鮎子, 渡邊將人, 松成ひとみ, 齋藤正寛, 佐谷秀行, 松本守雄, 長屋昌樹, 大鐘潤, 長嶋比呂志
- Organizer
  第48回日本結合組織学会学術大会
- Place of Presentation
  長崎
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] 体細胞核移植で継代されたクローンブタでのゲノムワイドDNAメチル化解析2016
- Author(s)
  新井良和、福川斐昭、飛知和尚美、松成ひとみ、長嶋比呂志、大鐘潤
- Organizer
  第10回日本エピジェネティクス研究会
- Place of Presentation
  大阪
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] エピジェネティック毒性物質の検出システムの開発2016
- Author(s)
  曽根秀子、阿部訓也、中尾洋一、大鐘潤、桂真理、藤渕航、五十嵐勝秀
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち(愛知）
- Year and Date
  2016-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H01749
[Presentation] ハプロ不全優成遺伝病の発生機序解明に向けた新たなアプローチ：ブタフィブリリン1（FBN1)2016
- Author(s)
  新井良和, 梅山一大, 竹内健太, 八島紗耶香, 中野和明, 長嶋比呂志, 大鐘潤
- Organizer
  第109回日本繁殖生物学会
- Place of Presentation
  相模原
- Year and Date
  2016-09-12
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] 体細胞連続核移植で作出されたクローンブタでのエピジェネティック解析：Human BeadChipを用いたゲノムワイドDNAメチル化解析の試み2015
- Author(s)
  新井良和、阿閉貴紀、福川斐昭、齊藤経、竹内健太、松成ひとみ、長嶋比呂志、大鐘潤
- Organizer
  第108回日本繁殖生物学会大会
- Place of Presentation
  宮崎県宮崎市
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15H02480
[Presentation] 次世代シークエンサーによるブタ精巣でのウルトラディープDNAメチル化解析2015
- Author(s)
  齋藤経、新井良和、阿閉貴紀、竹内健太、長嶋比呂志、大鐘潤
- Organizer
  第108回日本繁殖生物学会
- Place of Presentation
  宮崎大学
- Year and Date
  2015-09-16
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 体細胞連続核移植で作出されたクローンブタでのエピジェネティック解析：Human BeadChipを用いたゲノムワイドDNAメチル化解析の試み2015
- Author(s)
  新井良和、阿閉貴紀、福川斐昭、齋藤経、竹内健太、松成ひとみ、長嶋比呂志、大鐘潤
- Organizer
  第108回日本繁殖生物学会
- Place of Presentation
  宮崎大学
- Year and Date
  2015-09-16
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] GSK3がマウスES細胞のヘテロクロマチン構造に与える影響2011
- Author(s)
  山下翠、新井良和、伊藤修平、大鐘潤、広沢-高森瑞子、田中智、八木慎太郎、塩田邦郎
- Organizer
  第104回日本繁殖生物学会
- Place of Presentation
  盛岡
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] ヘテロクロマチン形成を指標とした環境・人体に残存する低レベル化学物質のエピ変異原性評価に向けて2011
- Author(s)
  大鐘潤、新井良和、塩田邦郎
- Organizer
  第6回環境エピゲノミクス研究会
- Place of Presentation
  東京
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] 卵特異的ヒストンH1fooはDNAメチル化プロフィール形成に関与する2011
- Author(s)
  早川晃司、大鐘潤、田中智、塩田邦郎、八木慎太郎
- Organizer
  第104回日本繁殖生物学会
- Place of Presentation
  盛岡
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] Epigenetic regulation of the Sall genes in embryonic and trophoblast stem cells and involvement of non-coding RNA2010
- Author(s)
  Ohgane J, et al
- Organizer
  Experimental Biology 2010
- Place of Presentation
  Anaheim, CA, USA
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] Epigenetic regulation of the Sall genes in embryonic and trophoblast stem cells and involvement of non-coding RNA2010
- Author(s)
  Ohgane J, Kumagai K, Takamatsu T, Yagi S, Tanaka S, Shiota K
- Organizer
  Experimental Biology
- Place of Presentation
  Anaheim, CA, USA
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] Enrichment of short interspersed transposable elements(SINEs) in hypomethylated genic regions in embryonic stem cells2010
- Author(s)
  Muramoto H, Yagi S, Hirabayashi K, Sato S, Ohgane J, Tanaka S, Shiota K
- Organizer
  Experimental Biology
- Place of Presentation
  Anaheim, CA, USA
- Year and Date
  2010-04-26
- Data Source
  KAKENHI-PROJECT-22710181
[Presentation] 脂肪細胞分化に関わる遺伝子の発現制御
- Author(s)
  内田奈緒美, 東大, 坂本望, 牧野智宏, 新井良和, 長嶋比呂志, 大鐘潤
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] エピジェネティック制御下にある新たなNodal遺伝子の制御領域
- Author(s)
  新井大祐, 大鐘潤, 田中智, 塩田邦郎
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 実物としてのマウス多能性幹細胞DNAメチル化プロフィールに基づく幹細胞評価：ブタiPS細胞を例として
- Author(s)
  新井良和, 大鐘潤, 藤城修平, 中野和明, 塩田邦郎, 花園豊, 長嶋比呂志
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] ブタHnf1a、Hnf4aの肝臓特異的発現にはDNAメチル化とアンチセンス非コードRNAが関与する
- Author(s)
  坂本望, 東大, 内田奈緒美, 牧野智宏, 新井良和, 長嶋比呂志, 大鐘潤
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 脳下垂体の一部の細胞で発現する遺伝子における次世代シークエンサーを用いたDNAメチル化可変領域検出のブタでの試み
- Author(s)
  新井良和、松本翔馬、阿閉貴紀、東大、内田奈緒美、坂本望、牧野智宏、長嶋比呂志、大鐘潤
- Organizer
  第107回日本繁殖生物学会
- Place of Presentation
  北海道
- Year and Date
  2014-08-20 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] Epigenetic assessment of environmental chemicals using mouse embryonic stem cells.
- Author(s)
  大鐘潤
- Organizer
  AsiaCORD 2013
- Place of Presentation
  兵庫
- Invited
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] ゼブラフィッシュゲノムに存在する2種類のG2A相同遺伝子の機能解析
- Author(s)
  一條祐太, 大鐘潤, 東森生, 松田恒平, 戸村秀明
- Organizer
  第28回日本下垂体研究会
- Place of Presentation
  岩手
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] Evaluation of porcine induced pluripotent stem cells based on the DNA methylation profile of mouse embryonic stem cell-specific hypomethylated loci.
- Author(s)
  Arai Y, Ohgane J, Fujishiro S, Nakano K, Matsunari H, Watanabe M, Umeyama K, Azuma D, Uchida N, Sakamoto N, Makino T, Yagi S, Shiota K, Hanazono Y, Nagashima H
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 骨格筋分化抑制遺伝子MstnのDNAメチル化による発現制御
- Author(s)
  東大, 内田奈緒美, 坂本望, 牧野智宏, 新井良和, 長嶋比呂志, 大鐘潤
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] マウス多能性幹細胞DNAメチル化プロフィールに基づくほ乳類の幹細胞評価：ブタiPS細胞を例として
- Author(s)
  大鐘潤
- Organizer
  明治大学・科学技術研究所シンポジウム
- Place of Presentation
  神奈川
- Invited
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 脳下垂体のホルモン産生細胞や前駆細胞で発現する遺伝子に注目した次世代シークエンサーでのDNAメチル化解析による新たな試み
- Author(s)
  新井良和、松本翔馬、阿閉貴紀、東大、内田奈緒美、坂本望、牧野智宏、長嶋比呂志、大鐘潤
- Organizer
  第29回日本下垂体研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-08-08 – 2014-08-10
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] ブタにおけるFbn1遺伝子のエピジェネティック制御解析
- Author(s)
  牧野智宏, 東大, 内田奈緒美, 坂本望, 新井良和, 松本守雄, 長嶋比呂志, 大鐘潤
- Organizer
  第106回日本繁殖生物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] 次世代シークエンサーによる組織全体を用いたDNAメチル化解析の新たな視点
- Author(s)
  新井良和、松本翔馬、阿閉貴紀、東大、内田奈緒美、坂本望、牧野智宏、長嶋比呂志、大鐘潤
- Organizer
  第8回日本エピジェネティクス研究会
- Place of Presentation
  東京
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25450472
[Presentation] Nodal遺伝子のエピジェネティック制御
- Author(s)
  新井大祐、早川晃司、大鐘潤、中尾洋一、田中智、塩田邦郎
- Organizer
  第8回日本エピジェネティクス研究会
- Place of Presentation
  東京
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25450472

1. TANAKA Satoshi (90242164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. SHIOTA Kunio (80196352)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. Nagashima Hiroshi (50318664)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. YAGI Shintaro (10420225)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. TANEMURA Kentaro (20332322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YAMANOUCHI Keitaro (70272440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NAKAYAMA Hiroyuki (40155891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIKUSUI Takefumi (90302596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FURUE Miho (80257310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Sone Hideko (60280715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 伊藤智彦 (60391067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 桂真理 (30436571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 藤渕航 (60273512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 中尾洋一 (60282696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 阿部訓也 (40240915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 乾雅史 (20643498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 長屋昌樹 (90329300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 渡邊將人 (00321688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宮川周士 (90273648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HIROSAWA Mitsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. Nansai Hiroko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. Kondo Masayo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Suzuki Shinnosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Otsuka Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 新井大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohgane Jun 大鐘 潤

OHGANE Jun 大鐘 潤

Research Projects

Research Products

Co-Researchers

Generation of pigs for human transplantation and establishment of a system to assess their suitability for human use.

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Epigenetic fluctuation associated with onset and severity of haploinsufficient dominant diseasesPrincipal Investigator

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Elucidation of etiology and phenotypic control in a porcine autosomal dominant genetic disease model

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Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach

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Understanding favorable trait of domestic animal and chronic disease of human based on epigenome engineeringPrincipal Investigator

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Optimization of epigenomic modification with regulatory RNAs considering the presence of endogenous non-coding RNAsPrincipal Investigator

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Analysis of Sex-dependent Epigenome

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Epigenetics on transdifferentiation of ES cells toward TS cells

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Epigenome formation and cellular differentiation in mouse embryogenesis

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[Journal Article] Epigenome editing revealed the role of DNA methylation of T-DMR/CpG island shore on Runx2 transcription.2024

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[Journal Article] ブタをモデルとしたヒト遺伝性疾患のエピジェネティックなゆらぎの解析2023

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[Journal Article] Genetically engineered animal models for Marfan syndrome: challenges associated with the generation of pig models for diseases caused by haploinsufficiency2022

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[Journal Article] Epigenetic Effects of Exposure to Insecticide on Early Differentiation of Mouse Embryonic Stem Cells2019

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[Journal Article] Evidence of exposure to chemicals and heavy metals during pregnancy in Japanese women2017

Ohgane Jun 大鐘潤

OHGANE Jun 大鐘潤